Nootropics, also known as “smart drugs” or “cognitive enhancers,” are used to improve brain function. It includes medications, supplements, and other substances. There are more and more nootropic products on the market. Its nootropics ingredients have also begun to arouse widespread discussion. Today, Nutri Avenue would like to discuss and recommend three Nootropics Ingredients, including Phosphatidylserine powder, alpha GPC, and PQQ.
3 Best Nootropics Ingredients For 2024
Phosphatidylserine Powder: The 3rd Generation Of Smart Nutrients
There is a nutrient called “brain nutrient,” and some people say it is a “new weapon for activating the brain.” In 1942, Phosphatidylserine (PS) was extracted from the cow brain by Jordi Folch, a neurochemist at Harvard University in the United States.
It is known as the third generation of emerging “smart nutrients” after choline and DHA. This ingredient is the nutrient most promising for saving memory and cognitive function.
Phosphatidylserine is a member of the phospholipid family. Others include phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol. Phospholipids are critical to the integrity and function of cell membranes.
2 Special Features Of Phosphatidylserine
First, Phosphatidylserine is most abundant in the brain. It is six times that of other organs.
Second, Phosphatidylserine carries a negative charge. Therefore, it is involved in the signaling system of the nervous system, as well as in the activation of various proteases. For example, protein kinase B (PKB) is dependent. PKB can protect and repair neurons when activated. It also activates PKC. It is very important for the memory and learning process. PS is also the theoretical basis for improving memory and cognitive functions.
In addition, this ingredient enhances cell metabolism and the transmission of biochemical information by regulating the function of cell membrane proteins and affecting membrane fluidity. It regulates cell receptors, enzymes, ion channels, and signaling molecules. Through these functions, Phosphatidylserine directly affects endocrine and cognitive functions.
Research Confirms
- Phosphatidylserine PS improves memory and cognitive function.
Gindin’s first study involved 57 people aged 60-80 with memory loss taking Phosphatidylserine powder (dose 300mg/day). The course of treatment is three months. It was found that their memory and mood improved significantly.
In another randomized double-blind controlled RCT study, 79 Japanese elderly people complained of memory loss. They take Phosphatidylserin powder 100mg/day or 300mg/day. The course of treatment is six months. It was found that the memory score of the PS treatment group increased significantly. A daily intake of 100mg PS is effective. Moreover, the most interesting thing is that after stopping PS for three months, its memory-improving effect still exists.
At the same time, Phosphatidylserin’s memory-improving effects are not limited to the elderly. One hundred twenty students aged 17-18 years took PS 100mg for 40 days. The students improved directed memory, associative learning, free memory for images, recognition of meaningless people, and associative memory for portrait features, as assessed by a computer-tested Clinical Memory Scale.
In the United States, this ingredient is a medical food for children with ADHD. It can improve children’s attention and hyperactivity symptoms. Many clinical trials have shown improvements in ADHD symptoms in children when supplemented with PS. In one study, 200 children with ADHD were studied for 15 weeks. This double-blind study also found that children who took Phosphatidylserine powder combined with omega-3 had significantly improved ADHD symptoms, especially restlessness and impulsivity, compared with the placebo group.
Alpha GPC
Alpha GPC (Glycerylphosphorylcholine) is also called Alphoglycerylcholine, choline glyceryl phosphate. It is also as one of the best nootropics ingredients. It has obvious effects in the treatment of neurodegenerative diseases such as cerebral ischemic stroke, Alzheimer’s disease, and multiple cerebral infarct dementia. It has few side effects and is well tolerated. As early as 1990, Italy first developed Alpha GPC raw materials and finished pharmaceutical preparations.
Years of clinical research have shown that Alpha GPC improves people’s memory and cognition and significantly affects brain circulation decline and Alzheimer’s disease. Therefore, it is called the “anti-aging nutrient” of the brain. Alpha GPC has been used in Europe for the past few decades to treat Alzheimer’s disease and stroke. Currently, there are also related dietary supplement products on the market.
Alpha GPC’s Mechanism Action
Alpha GPC is a water-soluble substance. It can cross the blood-brain barrier and enter the brain. It provides the raw material – choline – for synthesizing acetylcholine and phosphatidylcholine. It is the biosynthetic precursor of both. They influence the transmission of chemical messages in the brain and help brain cells store and read data. They are important nutrients for maintaining normal brain memory, reactions, and healthy mood.
In addition to synthesizing neurotransmitters, Alpha GPC can also promote the secretion of growth hormone, a major hormone that promotes tissue maintenance and regeneration.
Pyrroloquinolinequinone Disodium Salt PQQ (NutriPQQ®)
The main component of pyrroloquinoline quinone disodium salt is Pyrroloquinoline quinone (PQQ). It is a new type of water-soluble vitamin and a coenzyme of oxidoreductase.
How Does PQQ Powder Work?
As we age, nerve cells in the human nervous system and brain continue to degenerate. It will reduce memory and concentration, thus affecting people’s mobility and cognitive level. The three mechanisms by which PQQ protects nerves are as follows.
- It can enhance the growth and maintenance of NGF (nerve growth factor) required for peripheral and sensory nerves.
- It inhibits the death of nerve cells and the activity of reactive oxygen species that promote cell aging.
- It promotes mitochondrial regeneration.
Japanese researchers recruited 17 male and female volunteers to conduct an open-label experiment on oral administration of PQQ. Experimental results show that this nootropics ingredients can significantly alleviate the effects of stress, sleep, and fatigue on subjects.
A study of 41 Japanese older adults tested the effects of PQQ on their mental state. For 12 weeks, the subjects were divided into two groups and received either 20 mg of PQQ or a placebo. Cognitive tests show that PQQ significantly improves memory and attention. Brain scans revealed increased blood flow.
Conclusion
Phosphatidylserine powder, alpha GPC, and PQQ are three nootropics ingredients proven by detailed research and entered the market. These three nootropics ingredients can not only be used individually but can also be used in combination, such as PQQ and PS, to achieve double their effectiveness.
Nutri Avenue offers such nootropics ingredients at wholesale prices, including these three recommended today. In particular, PQQ powder has our own special trademark product – NutriPQQ®. Welcome to contact us for more product information, such as COA, the latest quotation, etc.
