Everything About Alpha-GPC You Should Know


What Is Alpha-GPC?

Alpha GPC, also known as Choline Alfoscerate and L-alpha-glycerylphosphorylcholine, is a member of the phospholipid family. It is one of the phosphatidylcholine derivatives. It plays an important role in the health of cell membranes. It is a naturally occurring precursor of water-soluble phospholipids and neurotransmitters in the body. It is a precursor for the synthesis of the neurotransmitter choline of acetylcholine.

The primary physiological function of Alpha GPC is to cross the blood-brain barrier and provide essential choline for the biosynthesis of acetylcholine and phosphatidylcholine. It can cross the blood-brain barrier more than traditional choline sources.

In 2012, the FDA recognized this ingredient as a GRAS substance (at no more than 196.2 mg alpha-gpc dosage/person/day). Currently, Alpha GPC is widely used in dietary supplements, food supplements, and nutritional function foods in the US, Canada, Japan, Netherlands, and UK markets. It is also used as a drug in Europe, Russia, Korea, India, and other markets.

Alpha GPC VS Beta GPC

There is another form of phosphatidylcholine called Beta-Glycerophosphatidylcholine (Beta-GPC).

Beta GPC contributes very little to the total GPC, about 1%. Alpha GPC is hydrolyzed to phosphocholine and helps supply choline to the liver and choline for myelin synthesis.

Therefore, Alpha GPC is more beneficial than beta GPC.

Alpha-GPC VS CDP Choline (Cytidine) VS Phosphatidylserine PS

  • Sources

Alpha-GPC can be obtained either naturally from soy lecithin or by synthetic routes.CDP choline is mainly synthetic. Phosphatidylserine (PS) can be extracted from soy lecithin, sunflower lecithin, etc.

  • Benefits

CDP Choline mainly acts as a brain metabolizer and neuroactivator. It promotes brain cell respiration, improves brain function, enhances the function of the upward reticular activating system, promotes recovery, and reduces cerebrovascular resistance.

Phosphatidylserine, also known as complex neuronic acid, is an active substance in cell membranes. Its role is to improve nerve cells’ function, regulate nerve impulse conduction, and enhance the brain’s memory function. Due to its strong lipophilicity, after absorption, it quickly enters the brain through the blood-brain barrier, soothes the smooth muscle cells of blood vessels, and increases the blood supply to the brain.

What Does Alpha GPC Work?

After absorption, the substance is broken down into choline and glycerophosphate by the action of enzymes in the body. Choline is involved in the biosynthesis of acetylcholine. Glycerophosphate is a derivative of lecithin. It is involved in the synthesis of lecithin.

The main pharmacological effects of Choline Alfoscerate include the protection of choline metabolism and ensuring the synthesis of acetylcholine and lecithin in nerve membranes.

Health Benefits Of Alpha GPC

For Cognitive Skills

It improves cognitive skills, including memory, attention, observation, and concentration. It improves neurodegenerative symptoms of aging. It improves learning ability and test scores. It improves information processing and increases work efficiency.

For Sport Nutrition

Taken before exercise, it can enhance the body’s strength and performance.

For Anxiety And Sleep

It relieves anxiety and stabilizes mood. It can support to improve the quality of sleep.

For Fertility

It has some benefits for both women and men, including sperm performance and fertilization.


This ingredient stimulates the production of growth hormones. It aids in adolescent growth and development and height growth. It also helps with kidney and liver function, including renewal and detoxification.

L-Alpha-Glycerophosphatidylcholine Used For

Dietary Supplements

  • Students (to improve academic performance)
  • Office workers (work pressure, need to process a lot of information)
  • Fitness and sports enthusiasts (to delay fatigue and improve performance)
  • Middle-aged and elderly people (delayed neurodegenerative symptoms)
  • Children adolescents (to promote growth and development)

This ingredient can be customized into soft/hard capsules, beverages, soft candies, solid beverages, protein powders, sports functional drinks, etc.

Pharmaceutical Intermediates

Its main indications include cerebral ischemic attack within ten days (stroke or transient ischemic attack) and mild to moderate Alzheimer’s dementia. It is also used in patients with multiple cerebral infarcts of dementia and is a good hepatoprotective drug.

What is of interest here is that the indications for Alpha-GPC when declared as a drug vary from country to country.

For example, in South Korea, the ingredient is used for Alzheimer’s disease, memory loss, and depression. In Russia, it is used for brain ischemia stroke treatment, Alzheimer’s disease, and memory loss. In Vietnam, it is used for post-stroke rehabilitation, craniocerebral trauma, trauma recovery, Alzheimer’s disease, confusion, and memory loss in the elderly.

Supplied By Nutri Avenue To Worldwide

We have Alpha GPC 50%/99% in powder form and 85% in liquid form.

Our Advantages

Unlike Italy’s semi-synthetic Alpha GPC, we offer a fully synthetic version. It means higher bioavailability in the body and no soy endotoxins or allergens.

Simply put, Nutri Avenue’s Alpha-GPC is highly bioavailable and non-toxic. It is also backed by excellent technical support and consistent productivity. We also provide all the data, documentation, and instructions needed, including GMP, SMF, DMF, third-party testing, non-GMO, etc.

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