branded ingredient Apicalm™
Apicalm™ (Apigenin) is a naturally occurring flavonoid compound widely found in many plants, such as chamomile, celery, parsley, and citrus fruits. It has garnered significant attention for its numerous health benefits, improving sleep and relieving stress. Its demand is steadily increasing in the natural health sector.
The Benefits for Apicalm™
Promotes sleep
Apicalm™ (Apigenin) helps relieve sleep disorders
Controls depression
Apicalm™ (Apigenin) effectively relieves and controls depression
Fights tumors
Apicalm™ (Apigenin) inhibits cancer cells
Antioxidant
Apicalm™ (Apigenin) removes free radicals in the body
Protects nerves
Apicalm™ (Apigenin) regulates the excitability of nerve cells
Lowers blood pressure
Apicalm™ (Apigenin) assists in the treatment of hypertension
Branded ingredient
What Is Apicalm™ ?
Apicalm™ is a branded ingredient of Nutri Avenue. Apigenin, a unique flavonoid, has a variety of amazing biological activities.
Apigenin has anti-cancer effects in the body through multiple pathways. It has anti-inflammatory, anti-tumor, anti-spasmodic properties and acts as an antioxidant. At the same time, it can promote intestinal health, reduce the growth of harmful bacteria in the intestines, and help the development of beneficial bacteria in the intestines.
Apigenin was discovered in 1938 by the Hungarian biochemist Albert Szent-Györgyi as part of the flavonoid family.
Apigenin (Apicalm™) is a natural dietary flavonoid. It has been shown to have anticancer effects on prostate and ovarian cancer cells.
Apigenin Extract (Apicalm™)
Our Advantage
branded ingredient Apicalm™ from Nutri Avenue Inc
usa fresh stock
We have prepared sufficient inventory in both CA and FL warehouses in the US, which can provide you with stable supply demand.
Safer & Better
Compared with other flavonoids (quercetin and kaempferol), it has the characteristics of low toxicity and non-mutagenicity.
3rd party test report
Through HPLC test reports, ensure that the purity of apigenin exceeds 98%. And, we can provide ISO, heavy metal, microbial, HNMR, and other test reports
Free samples
We can provide free samples from our warehouses in USA and China for your inspection before the order.
SCIENCE
Apicalm™ Overview
Apicalm™ is a branded ingredient of Nutri Avenue. Celery contains an important component called apigenin, one of the plants’ most widely distributed flavonoids. It can effectively control blood pressure and has anti-inflammatory, anti-tumor, and antioxidant effects.
Chemical Name | Apigenin |
CAS Number | 520-36-5 |
Catalog No. | CFN98843 |
Physical Description | Yellow Powder |
Application | Dietary supplements |
Serving Size | 20mg to 50mg per day |
Storage | Protected from air and light, refrigerate or freeze |
Function | Anti-oxidation, anti-enzymatic change, improved nutrition, nutritional fortification |
What is Apigenin (Apicalm™)?
Apigenin(Apicalm™), a naturally occurring plant flavone (4′, 5, 7,-trihydroxyflavone) abundantly present in common fruits and vegetables including parsley, onions, oranges, tea, chamomile, wheat sprouts, and some seasonings, has been shown to possess remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties【1】.
Apigenin (Apicalm™) Benefits
【POSSIBILITY OF IMPROVING SKIN】
One of apigenin’s most significant benefits lies in its antioxidant properties, which help strengthen the skin’s natural defense mechanisms against environmental stressors. Studies have also indicated its potential role in preventing certain types of skin cancer, though more research is needed in this area. Scientists are currently working on developing improved delivery systems to enhance this compound’s oral and topical bioavailability, which could increase its effectiveness in skincare applications.
Despite these promising findings from preclinical studies, it’s important to note that clinical research in humans is still pending. While the compound demonstrates an acceptable safety profile, more comprehensive clinical trials are needed to validate its effectiveness and safety in skincare products fully. Given the positive results from existing research, apigenin shows potential as a natural ingredient for future dermatological treatments. However, further scientific validation through human studies is essential before making definitive claims about its benefits.
Much research has been conducted on the beneficial effects of apigenin on various skin conditions such as dermatitis, wrinkles, skin spots, UV-induced inflammation, and skin cancers【2】.
【POTENTIAL AGAINST CANCERS】
It is promising in preventing some cancers and is not limited to leukemia, gastrointestinal, and ovarian cancers. This is because of its ability to block and reduce excess estrogen. 【3】
Apigenin (Apicalm™) may have the potential for prevention and therapy for prostate cancer, apigenin treatment resulted in the induction of apoptosis as determined by DNA fragmentation, PARP cleavage, fluorescence microscopy, and flow cytometry, and also resulted in down-modulation of the constitutive expression of NF-kappaB/p65.【4】
Apigenin (Apicalm™) has anti-hepatoma activity and is as effective as 5-FU and its apoptotic mechanism might be mediated through the p53-dependent pathway and the induction of p21 expression.【5】
It possesses therapeutic potential against cancers, the combination of gemcitabine and apigenin enhances anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction【6】
【POWERFUL FLAVONOID】
A flavonoid commonly found in fruits and vegetables has emerged as a promising compound for various dermatological applications. Research has demonstrated its potential to protect against UV-induced skin damage, making it valuable for sun protection strategies. The compound’s remarkable anti-inflammatory properties work by suppressing pro-inflammatory cytokines and inflammatory mediators, showing particular promise in treating conditions like vitiligo and dermatitis.
It also can improve the immune system. The anti-inflammatory properties of apigenin are evident in studies showing suppression of LPS-induced cyclooxygenase-2 and nitric oxide synthase-2 activity and expression in mouse macrophages.【7】
【CALM YOUR NERVOUS SYSTEM】
Studies suggest that the natural components of Apigenin help reduce stress levels. Our Apigenin (Apicalm™) supplement incorporates potent natural ingredients, known for its potential stress-reducing properties, thereby helping to lower stress levels and indirectly promoting brain health and overall well-being.
【PROVIDES A RESTFUL SLEEP】
It can be found in many plants, including chamomile, parsley, and celery. It may support sleep, relaxation, immunity & brain health. It supports immune system health, normal sleep patterns, relaxation, skin & brain health, and cognition. It works by activating chloride ion channels, calming overall neuronal activity in the forebrain, and allowing the body to enter a more restful state.
Source of Apigenin (Apicalm™)
Apigenin (Apicalm™) is present principally as glycosylated in significant amounts in vegetables (parsley, celery, onions) fruits (oranges), herbs (chamomile, thyme, oregano, basil), and plant-based beverages (tea, beer, and wine).
Could commonly be prepared from its raw materials via solvent extraction with alcohol, and further purification steps.
Production Process of Apigenin (Apicalm™)
Clinical Trials Concerning Apigenin【8】
Natural Dietary Sources of Apigenin
The name apigenin derives from the Apiaceae genus Apium, also known as Umbelliferae and is a unique ingredient in chamomile (Matricaria chamomilla), an annual herb native to western Asia and Europe. Drinks prepared from chamomile contain from 0.8% to 1.2% of apigenin. Apigenin is abundant in a variety of other dietary sources [16], including fruits and vegetables (Figure 2), such as celery seeds (78.65 mg/100 g), spinach (62.0 mg/100 g), parsley (45.04 mg/100 g), marjoram (4.40 mg/100 g), Italian oregano (3.5 mg/100 g), sage (2.40 mg/100 g), chamomile (3 to 5 mg/100 g) and pistachio (0.03 mg/100 g), but the richest sources are the respective dried sources.【9】
Formula for a Dietary Supplement (Per Capsule or Serving):
Functionality: Antioxidant, Immunity enhancer
Lif Extent | Amount per serving | Life Extent, antiaging | Amount per serving |
Vitamin C | 470 mg | Theaflavins | 245 mg |
Vitamin E | 67 mg | Bio-quercetin phytosome | 74 mg |
Niacin | 50 mg | Apigenin (active ingredient) | 50 mg (98% pure) |
Iodine | 150 mcg | Silica | Certain amount |
Magnesium | 100 mg | Microcrystalline cellulose | Adjusted to fit |
Zinc | 25 mg | Vegetable stearate | Adjusted to fit |
Inositol | 50 mg | ||
Apigenin (active ingredient) | 5 mg (98% pure) |
Application as Dietary supplements
Functionality: Effects on depression and insomnia.
Natur way, stimulate digestion | Amount per serving | Life Extent-Herbal sleep | Amount per serving |
Fennel (seed) | 237 mg | Theaflavins | 120 mg |
Ginger (root) | 237 mg | Bio-quercetin phytosome | 300 mg |
Wild yam (root) | 237 mg | Apigenin (98% pure) | 127.6 mg |
Slippery elm (bark) | 125 mg | Silica | Certain amount |
Chamomile flower extract (98% ) | 0.76 mg | Microcrystalline cellulose | Certain amount |
Marshmallow | 50 mg | Vegetable stearate | Certain amount |
Maltodextrin | Certain amount |
Application as Hair Caring
Functionality: Hair Nutrition
Ingredients 1 (Dallas-Thickening spray) | Ingredients 2 (R+Co-Strong Hold gel spray) | Ingredients 3 (Artnaturals- hair conditioner) |
Kiwi fruit extract | Glycerin | Aloe vera |
Aloe vera leaf extract | Acrylates copolymer | Rosemary |
Oleanolic acid | Panthenol | Apigenin |
Amino acids | Tocopherol | Argan oil |
Apigenin | Oleanolic acid | Biotinoyl tripeptide |
Peg – 12 | Apigenin | Glyceryl stearate |
Dimethicone | C12-15 Pareth-9 | Retinyl palmitate |
Sodium lactate | Citral | Tocopheryl acetate |
…… | … … | … … |
Apigenin (Apicalm™) – HNMR
Apigenin (Apicalm™) – HPLC(Sample Information)
Certificate of Analysis
Apigenin (Apicalm™) MOA
Why Choose US?
- Natural appearance
Most apigenin on the market is usually gray due to low purity and impurities. Our apigenin has a light yellow appearance.
- Physical control
After strict physical control, our finished product achieves 5% NMT drying loss and 95% 80 mesh particle size.
- USP standard quality control
As a pioneer in biosynthesis technology, the international USP standard is adopted to strictly control the content of three heavy metals in the finished product, lead, arsenic, mercury, and three microorganisms.
We can provide apigenin of different specifications to meet customers’ various formulation requirements. The existing inventory ensures timely delivery, stable product quality, and sample testing is available.
ITEM | SPECIFICATION | Result |
Description: Appearance Odor Taste Extract Solvents Particle size | Light-yellow Powder Characteristic Characteristic Water and Ethanol 100% pass through 80 mesh sieve | Complies Complies Complies Complies Complies |
Tests: Loss on drying(5h at 105℃) Ash(3h at 600℃) Total Heavy Metals Lead Arsenic | <2% <2% <20ppm <2ppm <2ppm | 0.67% 0.45% Complies Complies Complies Complies |
Assay:(byHPLC) Apigenin | 98% | 98.16% |
Microbial: Total bacterial count Yeast & Mould Escherichia coli presence Salmonella | Max.1000cfu/g Max.100cfu/g Negative Negative | Complies Complies Complies Complies |
The packaging of Apigenin (Apicalm™)
Packaging & Storage Packaging
– For 1 kilogram: packed in aluminum foil bags.
– For 25 kilograms: packed in paper drums (both round and square) or paper drums with iron rings.
Storage conditions
Store in a well-ventilated and dry environment, avoiding direct exposure to strong light and high-temperature conditions.
FAQ
Q: What are the precautions for taking products containing Apigenin (Apicalm™)?
A: Try to avoid alcohol, caffeine-containing foods, or beverages after taking it. Based on the principle of caution, pregnant women, teenagers, and children should avoid taking it. Based on the principle of caution, it should be avoided to be taken simultaneously with medications.
Q: What are the main functions of Apigenin (Apicalm™)?
A: This substance exhibits multiple beneficial effects, including anti-tumor and chemotherapy sensitization effects, antioxidant and anti-inflammatory effects, the ability to lower blood pressure, improvement in heart health, and relief of anxiety.
Q: How is Apigenin (Apicalm™) consumed?
A: It can be obtained through the diet by consuming foods rich in apigenin, like the aforementioned parsley and celery. Some dietary supplements also contain apigenin in various forms, such as capsules or tablets. However, it’s important to note that taking supplements should be done under the guidance of a healthcare professional to ensure appropriate dosage and safety.
References
【1】Patel D, Shukla S, Gupta S. Int J Oncol, 2007, 30(1):233-45.
【2】Bahadır Acıkara et al., 2019; Choi et al., 2016; Man et al., 2012; Zhao et al., 2017
【3】Mackey S. Promoting lifestyle modification for cancer prevention. Journal of the American Dietetic Association. 2004;104:1568–1569. doi: 10.1016/j.jada.2004.08.015.
【4】Gupta S, Afaq F, Mukhtar H. Oncogene, 2002, 21(23):3727-38.
【5】Chiang, Lien-Chai, Ng, et al. Cancer Lett, 2006, 237(2):207-14.
【6】Lee S H, Ryu J K, Lee K Y, et al. Cancer Lett, 2008, 259(1):39-49.
【7】Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF, Lin JK. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 1999;20:1945–1952. doi: 10.1093/carcin/20.10.1945.
【8】Bahare Salehi, etc., The Therapeutic Potential of Apigenin, Int. J. Mol. Sci. Int. J. Mol. Sci. 2019, 20, 1305 2019.
【9】McKay, D.L.; Blumberg, J.B. A review of chamomile tea’s bioactivity and potential health benefits (Matricaria recutita L.). Phytother. Res. 2006, 20, 519–530.