Apocynin is a naturally occurring compound in plants believed to have effects in the prevention of various neurodegenerative conditions. It is claimed that the compound has certain actions as a non-narcotic analgesic and an NADPH oxidase inhibitor. Apocynin also exhibits anti-inflammatory actions especially in the prevention of rheumatoid arthritis.
What is Apocynin?
Apocynin is a plant metabolite considered a peripheral nervous system drug. It is structurally related to Vanillin and is an aromatic ketone. The compound was first isolated in the early 1900s from a plant source which was used traditionally for edema and other heart problems. It was then subjected to several health studies to determine its efficacy and application in pharmacology. Apocynin is known to prevent the development of free radicals. It is also believed to work as an inhibitor of the action of NADPH oxidase which, in turn, improves overall immunity responses of the body.
The compound is also known as acetovanillone, 1-(4-Hydroxy-3-methoxyphenyl) ethan-1-one, and 4-Hydroxy-3-methoxyacetophenone, among others. It can be identified as having CAS number 498-02-2 and molecular formula C9H10O3. The molecular weight of the compound is 166.17 g/mol.
In terms of appearance, the compound is a whitish crystalline powder that is essentially soluble in organic solvents like ethanol and DMSO. Apocynin is also sparingly soluble in aqueous buffers.
Apocynin Herbal Sources
Apocynin can be isolated from several plant sources. The most common source of the compound is Apocynum venetum which is a well-known traditional Chinese herb used to promote diuresis. The compound is often derived from the leaves of the said herb.
The compound Apocynin may also be obtained from the roots of Canadian hemp or Apocynum cannabinum. In the 1970s, experts were also able to derive the compound from a plant that grows at high altitudes in the western Himalayas known as Picrorhiza kurroa.
Apocynin forms and specifications
When used in the formulation of dietary supplement products, Apocynin is usually included in powder form at 98% purity assay. Apocynin powder 98% is available at several ingredient suppliers like Nutriavenue.
Our company offers high-quality Apocynin powder in bulk or smaller quantities. You may get a free quote for Apocynin when you visit our page at Nutriavenue.com. When bought in bulk, the product is usually packed in paper bags with two layers of poly bags inside. You may also choose a different packaging option that fits your needs and preference.
How does Apocynin work?
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase or NOX is a naturally occurring enzyme in the human body that mediates electron transfers to molecular oxygen. The action of NOX results in the production of superoxide, a chemical that causes hydroxyl-radical formation and damage to the DNA. The dietary supplement compound Apocynin helps reduce superoxide formation by serving as an NADPH oxidase inhibitor or a NOX inhibitor. Thus, by preventing the action of NADPH oxidase, the formation of superoxide is effectively controlled.
The NADPH oxidase inhibition properties of Apocynin are brought about by its effect in interfering with the assembly of the NOX complex structure. Notwithstanding its action, Apocynin is believed to protect the immune system and not interfere with the phagocytic action of some immunity cells.
Also, it is believed that the compound may promote health by serving as an antioxidant that reduces circulating free radicals in the human body.
The use of Apocynin may provide various health benefits which include the following:
It may serve as a senolytic
Compounds with senolytic effects help prevent rapid aging of cells and protect individuals from age-related illnesses. It is claimed that the NOX inhibitor Apocynin may possess certain senolytic effects, thereby suggesting that it may be used to suppress senescence. The compound may provide anti-cancer benefits among individual users. It may also improve cognition and memory which are often compromised among persons with neurologic age-related conditions.
It may work against inflammation
Inflammatory diseases caused by oxidative stress through NOX activity are said to be prevented with Apocynin supplementation. Studies reveal that the compound may also help reduce lung inflammation, thereby improving overall respiratory activity. It may also work as an anti-asthmatic compound which may prevent bronchial obstruction.
It is likewise claimed that the compound may reduce inflammatory joint conditions and musculoskeletal pains by interfering with the action of neutrophils. However, the compound may not reverse a full-blown inflammatory response as it only works to suppress neutrophil formation.
It may work against hypertension
Reactive Oxygen Species (ROS) production is among the critical factors which increase blood pressure among mammals. In several studies, it was found that the action of Apocynin in inhibiting NADPH oxidase has significantly resulted in the reduction of ROS. In effect, the compound is said to work against hypertension and prevent debilitating effects of long-term increased blood pressure. The compound is found in a separate study to help prevent arterial stiffness.
It is useful for skin care product formulations
The compound Apocynin is believed to promote collagen and protein synthesis. Hence, it may be useful in promoting skin health and preventing rapid skin cell degeneration. Through its antioxidant properties, the compound may also help eliminate free radicals in skin health and promote cellular health.
Apocynin side effects
Taking Apocynin from dietary supplement formulations is not associated with serious side effects, provided that the compound is taken within recommended doses. Nonetheless, some users have reported having experienced mild gastrointestinal symptoms following Apocynin supplementation. These symptoms include stomach irritation and diarrhea.
Users who experience severe adverse effects are advised to immediately consult their physician and discontinue the use of the compound.
There is no specific recommended dose for Apocynin use. However, in one study, it was provided that it should not be used at more than 3.75 to 5 mg/kg body weight as it may increase brain hemorrhage. The recommended dose may be determined based on the individual user’s age, weight, and overall health condition. Pregnant and lactating women are advised to consult their physicians before using the compound.
Where to buy bulk Apocynin powder?
Bulk Apocynin powder is available at Nutriavenue, an FDA-registered ingredient supplier offering high-quality products at very affordable prices. Our company is also recognized and certified by Halal, Kosher, and GMP.
Aside from Apocynin, we also offer several other ingredients which may be used for dietary supplement formulations and research purposes. We also offer shipping services for your convenience through the air, sea, or couriers like UPS or FedEx.
For more details on our products and services, you may contact our technical support staff on our page.