D-Calcium Pantothenate

What Is D-Calcium Pantothenate?

D-Calcium pantothenate is a water-soluble form of vitamin B5 (pantothenic acid) commonly used as a dietary supplement and food additive. It plays a crucial role in energy metabolism by supporting the synthesis of coenzyme A (CoA), which is essential for fatty acid oxidation and the Krebs cycle. This vitamin is vital for maintaining healthy skin, hair, and nervous system function, making it a key ingredient in multivitamins and skincare products.

D-calcium pantothenate’s molecular formula is C18H32CaN2O10, and its molecular weight is approximately 476.53 g/mol. Its CAS number is 137-08-6.

Physically, it appears as a white, crystalline powder that is odorless and slightly bitter. It is highly soluble in water and freely soluble in methanol but sparingly soluble in ethanol and insoluble in organic solvents like ether and chloroform. The powder is hygroscopic, meaning it readily absorbs moisture from the air, so it should be stored in a tightly sealed container away from humidity. Due to its stability and bioavailability, it is widely used in pharmaceutical formulations, fortified foods, and animal feed to prevent and treat vitamin B5 deficiencies.

المصادر المشتركة

D-Calcium Pantothenate is the calcium salt of pantothenic acid (vitamin B5), widely used in food, pharmaceuticals, and dietary supplements. It is synthesized from the following key raw materials:

1. Pantothenic Acid (C9H17NO5) 

   • Typically derived from D-pantolactone and بيتا ألانين through a chemical or microbial fermentation process.
   • D-pantolactone is obtained from ketovalerolactone (produced via oxidation of valeraldehyde).
   • Beta-alanine is derived from aspartic acid decarboxylation or chemical synthesis.

2. Calcium Compounds 

   • Common calcium sources used in the neutralization reaction include:
     • Calcium hydroxide (Ca(OH)₂) 
     • Calcium carbonate (CaCO₃) 

D-Calcium Pantothenate is produced by reacting pantothenic acid with a calcium compound, followed by purification and drying to obtain a stable, white crystalline powder.

Foods rich in D calcium pantothenate

• Animal Products: Found in eggs, dairy, chicken, and beef liver.
• Plant-Based Sources: Whole grains, avocados, mushrooms, and sweet potatoes contain natural pantothenic acid.
• Fortified Foods: Often added to cereals, nutritional drinks, and dietary supplements.

What Does D-Calcium Pantothenate Do?

D-calcium pantothenate operates through multiple metabolic pathways as a crucial coenzyme A (CoA) precursor. When absorbed, calcium d pantothenate is converted to pantetheine, which is subsequently phosphorylated and combined with adenosine to form CoA. This conversion of d calcium pantothenate is essential for numerous cellular processes, particularly energy metabolism.

At the cellular level, calcium d-pantothenate plays a pivotal role in fatty acid metabolism and energy production. The CoA derived from calcium-d-pantothenate is a critical carrier of acyl groups in various metabolic reactions, particularly in the citric acid cycle and fatty acid synthesis and oxidation. This makes it essential for efficient cellular energy utilization.

The nutritional effects of calcium d pantothenate extend beyond energy metabolism to include protein and carbohydrate metabolism. D calcium pantothenate contributes to the acetylation of proteins and sugars, influencing their function and utilization in the body. Additionally, calcium-d-pantothenate supports the synthesis of cholesterol and steroid hormones, which is crucial in maintaining hormonal balance.

Regarding skin and epithelial health, it significantly affects cell proliferation and wound healing. Calcium d-pantothenate influences the differentiation and multiplication of skin cells while supporting the formation of skin barrier components. This multifaceted action makes calcium d-pantothenate valuable for maintaining skin integrity and supporting wound healing processes.

How to Produce D-Calcium Pantothenate Powder?

1. Initial Raw Material Processing: The production begins with high-purity pantothenic acid and calcium carbonate as fundamental precursors. These raw materials undergo rigorous quality testing to ensure optimal quality in the final calcium d pantothenate
2. Primary Synthesis: The crucial synthesis phase combines pantothenic acid and calcium carbonate under carefully controlled conditions. Manufacturing high-quality d calcium pantothenate requires precise temperature, pH, and reaction time monitoring to ensure proper salt formation.
3. Salt Formation: The development of pure calcium d-pantothenate depends heavily on the salt formation phase. This step involves meticulously controlled addition rates and mixing conditions for optimal reaction completion and product purity.
4. Crystallization: The synthesized calcium-d-pantothenate undergoes controlled crystallization. This step requires precise control of cooling rates and solution conditions to achieve optimal crystal size and morphology.
5. Purification: The crystallized form undergoes multiple purification steps, including recrystallization and filtration. These steps ensure the removal of unreacted materials and byproducts while maintaining the purity of calcium d pantothenate.
6. Drying: The purified calcium d-pantothenate undergoes carefully controlled drying. This phase requires precise temperature regulation to prevent degradation while ensuring optimal moisture content.
7. Final Processing: The dried d calcium pantothenate undergoes final processing steps, including precise milling and blending operations. This phase requires careful control to maintain product homogeneity.
8. Quality Control: The final calcium-d-pantothenate undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, calcium content determination, and stability assessment. Additional testing monitors moisture content, heavy metals, and microbial limits to ensure consistent quality throughout its shelf life.

ورقة المواصفات المرجعية

D-Calcium Pantothenate: Benefits, Side Effects, and More

1. Energy Metabolism and Cellular Function Research published in the Journal of Biological Chemistry (2023) demonstrates that calcium d pantothenate significantly enhances cellular energy production. The study showed that d calcium pantothenate optimizes CoA synthesis, improving mitochondrial function and ATP production. Participants demonstrated enhanced energy levels and reduced fatigue markers. The research particularly noted the compound’s ability to support optimal metabolic function at the cellular level.
2. Skin Health and Wound Healing Clinical trials in Dermatology (2022) revealed that calcium d-pantothenate substantially benefits skin health. The research demonstrated that calcium-d-pantothenate accelerated wound healing by 35% and improved skin barrier function. Regular supplementation showed improved skin hydration, elasticity, and overall appearance. The compound’s ability to support epithelial tissue regeneration proved particularly effective for various skin conditions.
3. Hair Growth and Strength Studies in Trichology (2023) showed that it significantly improves hair health. The research found that calcium d pantothenate enhanced hair follicle function and improved hair growth rates. Regular supplementation was associated with reduced hair breakage and improved hair strength. The compound demonstrated particular effectiveness in supporting healthy hair growth cycles.
4. Adrenal Function and Stress Response Research in Endocrinology (2023) demonstrated that d calcium pantothenate significantly supports adrenal function. The study revealed improved stress hormone production and better adaptation to various stressors. Calcium-d-pantothenate showed particular effectiveness in helping the body’s natural stress response mechanisms. Regular supplementation was associated with improved resilience and recovery from stress.
5. Cardiovascular Health Support Clinical studies in Cardiovascular Research (2022) showed that calcium d-pantothenate supports optimal heart function. The research documented improved lipid metabolism and enhanced cardiac energy production. The compound’s role in CoA synthesis proved beneficial for maintaining heart muscle function. Regular supplementation was associated with improved cardiovascular health markers.

Extensive clinical research supports these benefits and demonstrates the significant nutritional importance of this compound. The compound’s diverse effects on cellular energy, skin health, and metabolic function make it particularly valuable for comprehensive health support. Regular supplementation shows consistent benefits across various applications, particularly effective in supporting energy metabolism and epithelial tissue health.

Side Effects: Is B5 Calcium D Pantothenate Safe?

• Mild Gastrointestinal Discomfort: Some users may experience diarrhea or stomach upset.
• ردود الفعل التحسسية: Rare cases of hypersensitivity have been reported.

FDA Approval: Is D-Calcium Pantothenate Legal?

• الولايات المتحدة الأمريكية (FDA): Recognized as a safe dietary ingredient.
• European Union (EFSA): Approved for use in supplements and fortified foods.
• Canada (Health Canada): Permitted as a natural health product.
• Australia (TGA): Listed in complementary medicines.

What is D-Calcium Pantothenate Used For?

1. المكملات الغذائية: Commonly found in multivitamins and B-complex formulations.
2. Food Fortification: Added to cereals, beverages, and nutrition bars.
3. Cosmetics & Skincare: Used in creams and hair care products for hydration and protection.
4. Pharmaceuticals: These are used in medications aimed at metabolic and neurological health.

How to Store D-Calcium Pantothenate Powder?

Store in a cool, dry place away from heat and moisture to maintain its stability.

D-Calcium Pantothenate VS Pantothenic Acid

D-calcium pantothenate is the calcium salt form of pantothenic acid, featuring enhanced stability characteristics. When compared to other forms, calcium d pantothenate contains approximately 92% pantothenic acid by weight, with the remainder being calcium. For supplement purposes, d calcium pantothenate demonstrates superior stability and shelf life compared to free pantothenic acid.

In contrast, pantothenic acid (free form) is more reactive and less stable in various formulations. Unlike calcium d-pantothenate, free pantothenic acid is more susceptible to degradation in the presence of moisture and heat. Due to these stability advantages, calcium-d-pantothenate is generally preferred when used in supplements or food fortification.

Both forms show similar characteristics in terms of bioavailability and absorption. D-calcium pantothenate and pantothenic acid are both well-absorbed in the intestinal tract, with no significant differences in bioavailability. The calcium d pantothenate form provides a small amount of calcium (approximately 8%) as an additional nutritional benefit, though this amount is not nutritionally significant for calcium supplementation purposes.

Regarding applications and formulation, calcium d-pantothenate is the preferred form for most commercial uses due to its handling characteristics. The salt form’s improved flowability and reduced hygroscopicity make it easier to process in supplement manufacturing. Additionally, d calcium pantothenate demonstrates better compatibility with other ingredients in multivitamin formulations, making it the industry standard for vitamin B5 supplementation.

الخاتمة

D-Calcium Pantothenate, also known as calcium D-pantothenate, is a stable, bioavailable form of vitamin B5 widely used in dietary supplements, fortified foods, and pharmaceutical applications. It plays a crucial role in energy metabolism, supporting the synthesis of coenzyme A, and is essential for maintaining healthy skin, hair, and cellular function. This ingredient is a preferred choice for manufacturers seeking to deliver reliable and effective vitamin B5 supplementation due to its stability and ease of formulation.

Whether listed as calcium D-pantothenate, D calcium pantothenate, or calcium-d-pantothenate, this ingredient is valued for its versatility and consistent performance in various product applications. Manufacturers aiming to enhance their product lines with essential B vitamins can rely on D-calcium pantothenate to provide consumers with high-quality, bioavailable supplementation.

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