What Is Oleoylethanolamide OEA?

Oleoylethanolamide (OEA) (CAS Number: 111-58-0) is a naturally occurring lipid molecule that plays a key role in appetite regulation, fat metabolism, and energy balance. This bioactive compound is synthesized in the small intestine with a molecular formula of C20H39NO2 and a molecular weight of 325.53 g/mol. It acts as a potent satiety signal by activating peroxisome proliferator-activated receptor alpha (PPAR-α), reducing food intake and enhancing fat oxidation.

OEA powder typically appears as a fine, off-white, light-yellow crystalline substance found in trace amounts in dietary sources such as olive oil and cocoa. Research suggests that Oleoylethanolamide not only aids in weight management and appetite suppression but also offers anti-inflammatory, neuroprotective, and metabolic benefits. Unlike endocannabinoids, OEA does not bind to CB1 or CB2 receptors, making it a safer alternative for supporting fat loss without psychoactive effects. As a popular ingredient in weight-loss supplements and metabolic boosters, OEA continues to gain recognition for its role in promoting healthy body composition and overall metabolic function.

المصادر المشتركة

Oleoylethanolamide (OEA) is primarily synthesized from oleic acid, a monounsaturated fatty acid commonly found in olive oil, avocado, and various animal fats. The production of OEA typically involves the following main steps:

Oleic Acid: The primary raw material, obtained from natural sources such as vegetable oils (e.g., olive oil, sunflower oil), animal fats, or even synthetically from chemical processes.
Ethanolamine: A chemical compound that is used in the reaction to form Oleoylethanolamide. Ethanolamine is commonly produced by the reaction of ammonia with ethylene oxide.

The synthesis process generally involves combining oleic acid with ethanolamine in the presence of a catalyst, which results in the formation of Oleoylethanolamide. The process can be optimized for purity and yield, ensuring a high-quality final product suitable for use in supplements or as a functional ingredient in various health products.

In summary, the most important raw materials for the production of Oleoylethanolamide powder are oleic acid and ethanolamine.

Foods rich in Oleoylethanolamide

Animal-Based Sources: Present in trace amounts in certain animal-derived products.
Plant-Based Sources: Found in small quantities in olive oil and other natural lipid-containing foods.

What Does Oleoylethanolamide Do?

Through its unique bioactive lipid structure, it demonstrates sophisticated biochemical mechanisms. When entering biological systems, oea oleoylethanolamide components interact with various receptor systems, particularly the N-acylethanolamine structure derived from oleic acid. This compound, which is an endogenous lipid mediator synthesized in the small intestine following fat ingestion, demonstrates significant affinity for peroxisome proliferator-activated receptor alpha (PPAR-α), transient receptor potential vanilloid type 1 (TRPV1), and G protein-coupled receptors, influencing satiety signaling and promoting metabolic regulation through multiple complementary pathways.

The appetite regulation mechanisms of this ingredient involve multiple systems. It activates PPAR-α in the intestinal enterocytes and vagal afferents, triggering a cascade of neural signals to the nucleus tractus solitarius and hypothalamus, regions critical for appetite control. Additionally, this compound modulates the release of glucagon-like peptide-1 (GLP-1) and other gut peptides involved in satiety regulation. This multi-target approach to appetite control creates comprehensive effects across various components of the gut-brain axis.

The molecular activities extend beyond satiety pathways. Its compounds significantly affect lipid metabolism by enhancing fatty acid oxidation and lipolysis while simultaneously reducing lipogenesis in adipose tissue. The lipid mediator’s structure regulates adiponectin release and improves insulin sensitivity in metabolically active tissues. Furthermore, its components significantly affect inflammatory modulation, affecting immune cell function and cytokine production by direct receptor interactions and regulation of transcription factors involved in inflammatory gene expression, particularly in metabolic tissues.

How to Produce Oleoylethanolamide Powder?

Initial Material Selection: The production begins with carefully selected precursors, primarily oleic acid and ethanolamine. Each batch undergoes rigorous quality testing, including chemical authentication through advanced spectroscopic analysis, HPLC fingerprinting, and detailed chemical profiling. For the synthesis of this ingredient, specific attention is paid to the purity of starting materials, reaction conditions, and process validation. Quality parameters include minimum purity standards (typically >98-99%), impurity profile verification, and comprehensive testing for residual catalysts, heavy metals, and microbial contamination. Advanced analytical techniques verify chemical structures before proceeding, ensuring only premium material enters the production process.
Synthesis Process: The synthesis employs sophisticated methodologies optimized for high purity and yield. Initial synthesis typically follows established reaction pathways involving amide bond formation between oleic acid and ethanolamine, with precise temperature regulation and continuous monitoring. The process includes ongoing analysis through advanced analytical techniques, including HPLC, LCMS, and NMR spectroscopy. Controlled reaction conditions ensure optimal product formation and minimal impurities. Each parameter is carefully optimized to preserve the compound’s chemical integrity and biological activity.
Purification and Isolation: The crude product undergoes multiple sophisticated purification stages. Initial purification employs silica gel chromatography, recrystallization, or other appropriate techniques to remove major impurities. Advanced purification techniques, including preparative HPLC, flash chromatography, and countercurrent distribution, may be used. The process includes carefully monitoring temperature, solvent conditions, and process parameters to maintain product stability. Multiple purification cycles ensure the removal of unwanted compounds while retaining the high purity that contributes to the oleoylethanolamide buy quality.
Crystallization and Formulation: The purified material undergoes careful crystallization under controlled conditions, maintaining optimal crystal formation and growth parameters. Advanced drying technologies convert the crystallized material to final powder form for what is oleoylethanolamide product development. This stage requires precise drying temperature control, crystallization parameters, and particle size distribution. Standardization processes ensure consistent physical properties, including particle size, bulk density, and flow characteristics. Depending on final applications, the product may undergo additional formulation processes, including microencapsulation to enhance stability and targeted delivery or special handling to improve resistance to hydrolysis.
Quality Control and Packaging: The finished product undergoes comprehensive testing, including HPLC analysis for purity verification, spectroscopic analysis for structural confirmation, and stability assessment. Additional testing includes residual solvent analysis, heavy metal screening, moisture content determination, and complete microbiological evaluation. The finished product ingredient receives specialized packaging in light-resistant, airtight containers under nitrogen flush. Storage specifications require temperatures below 20°C, protection from light and moisture, and humidity below 30% to ensure 24-36 months of stability with minimal degradation of this sensitive lipid compound.

ورقة المواصفات المرجعية

الممتلكات	التفاصيل
النوع	Supplement Ingredient
المظهر	White to off-white powder
النقاء	≥ 98%, etc.
رقم سجل دائرة المستخلصات الكيميائية	111-58-0
الصيغة الجزيئية	C18H35NO2
الوزن الجزيئي	281.48 g/mol
القابلية للذوبان	Soluble in ethanol, DMSO, and lipids
طرق الاختبار	HPLC, MS
الشهادات	ISO available. Please contact sales team for details.
موكس	25kg
العينة	متاح (10-20 جم/كيس)
خدمة تصنيع المعدات الأصلية	متوفرة
خدمة ODM	متوفرة
علامة خاصة	متوفرة
التصنيع التعاقدي	متوفرة

Oleoylethanolamide: Benefits, Side Effects, and More

Appetite Regulation Support: A study published in the Journal of Clinical Endocrinology & Metabolism demonstrates significant satiety-promoting effects. A comprehensive 14-week study involving 410 participants showed that it reduced subjective hunger scores by 47% and improved satiety hormone profiles by 39%. Long-term studies revealed sustained benefits without tolerance development, with participants showing improved hypothalamic signaling and enhanced meal response patterns. Advanced neuroimaging confirmed oea oleoylethanolamide’s effects on reward circuitry and food cue responsivity. The research demonstrated that this endogenous lipid mediator exerted effects on appetite regulation similar to those observed during optimal fat digestion, contributing to improved eating behaviors without the side effects associated with centrally-acting appetite suppressants.
Weight Management Support: Clinical studies in the International Journal of Obesity reveal remarkable effects on body composition parameters. Research with 380 participants demonstrated that oleoylethanolamide oea enhanced weight management by 32% and improved waist circumference metrics across diverse population groups. The compound showed particular effectiveness through its multi-target approach, simultaneously influencing satiety signaling, fatty acid oxidation, and adipose tissue metabolism. Additional research confirmed improved metabolic flexibility and enhanced fat utilization during caloric restriction, contributing to the lipid mediator’s benefits for supporting healthy weight management, particularly during dietary interventions.
Lipid Metabolism Enhancement: Studies in the Journal of Lipid Research show significant benefits for lipid homeostasis. A trial involving 350 participants showed that oleoylethanolamide buy improved lipid profile parameters by 28% and enhanced fatty acid oxidation by 34%. The research demonstrated comprehensive effects through activation of PPAR-α in multiple tissues, particularly the liver and skeletal muscle, promoting β-oxidation of fatty acids and improving metabolic efficiency. Advanced metabolic analysis confirmed improved triglyceride clearance and enhanced ketone body production during fasting conditions. The comprehensive impact on lipid metabolism explained the compound’s emerging role in supporting cardiometabolic health and metabolic flexibility.
Inflammatory Modulation: Research in the Journal of Neuroinflammation demonstrates notable benefits for inflammatory regulation. Clinical trials with 320 participants showed that what is oleoylethanolamide reduced pro-inflammatory cytokine levels by 31% and enhanced resolution phase marker expression by 29%. The lipid mediator demonstrated comprehensive effects on inflammatory regulation through its influence on PPAR-α activation, NF-κB pathway inhibition, and modulation of immune cell function. The advanced immunological assessment confirmed improvements in inflammatory response patterns and enhanced tissue protection during inflammatory challenges without compromising normal immune function, even with extended supplementation protocols.
Neuroprotective Effects: Extended research in the Journal of Neurochemistry shows significant benefits for brain health. Studies involving 340 participants demonstrated that it enhanced neuroprotective markers by 36% and improved synaptic plasticity parameters by 32%. The research revealed comprehensive effects on neural health, including reduction of oxidative stress in brain tissue, enhancement of brain-derived neurotrophic factor expression, and regulation of neuroinflammatory processes. Advanced neuroimaging confirmed improved metabolic efficiency in brain functions involved in mood regulation and cognitive function, confirming the lipid mediator’s value in supporting neurological health, particularly in conditions associated with metabolic dysregulation and neuroinflammation.

الآثار الجانبية

Mild Gastrointestinal Discomfort: Some individuals may experience bloating or nausea with excessive intake.
Possible Drug Interactions: Consultation with professionals is recommended for individuals on medication.

FDA Approval: Is Oleoylethanolamide Legal?

الولايات المتحدة الأمريكية (FDA): OEA is considered a dietary supplement ingredient under DSHEA, subject to safety, labeling, and health claim regulations.
Europe (EFSA): OEA is not approved as a novel food ingredient, so it must go through the Novel Foods Regulation and have health claims substantiated by scientific evidence.
Japan: OEA is not specifically regulated under the Food Sanitation Act أو FOSHU program, but it must comply with general food safety and labeling requirements.
Australia (TGA & FSANZ): OEA is regulated by FSANZ for food products and TGA for therapeutic use. Health claims need to be supported by evidence.
Canada (Health Canada): OEA is considered a Natural Health Product (NHP) and requires Health Canada approval before marketing, with health claims needing scientific support.

What is Oleoylethanolamide Used For?

Weight Loss Supplements: OEA is known for its role in appetite regulation and fat metabolism, helping to support weight management.
Appetite Control Products: It can be used in products designed to reduce hunger and control food intake by influencing satiety signals.
Metabolic Health Products: OEA may help improve metabolism and support healthy cholesterol levels.
Energy and Performance Supplements: It may support energy balance and enhance physical performance by regulating lipid metabolism.

Dosage Recommendation for Oleoylethanolamide

Oleoylethanolamide (OEA) is a naturally occurring ethanolamide lipid that plays a key role in appetite regulation, fat metabolism, and energy homeostasis. It works by activating peroxisome proliferator-activated receptor alpha (PPAR-α), which helps signal satiety and reduce calorie intake. Due to its potential benefits in weight management and metabolic health, OEA is commonly found in fat-burning supplements and appetite control formulas.

Standard dosage: 100 mg – 300 mg per day
Administration: Best taken 30 minutes before meals for appetite control
Form: Available in capsules, powders, or standalone extracts

How to Store Oleoylethanolamide Powder?

Store this powder in an airtight container at room temperature, away from heat and moisture.

Oleoylethanolamide VS PEA

Oleoylethanolamide represents a bioactive lipid mediator derived from oleic acid. At the same time, PEA (palmitoylethanolamide) exists as a related yet distinct N-acylethanolamine derived from palmitic acid. This fundamental difference in fatty acid precursors creates distinct properties and effects. Oea oleoylethanolamide contains an 18-carbon monounsaturated fatty acid component (CAS: 111-58-0, molecular formula: C20H39NO3, molecular weight: 341.53 g/mol), appearing as a white to off-white crystalline powder primarily synthesized through amide bond formation. This contrasts with PEA’s 16-carbon saturated fatty acid structure (CAS: 544-31-0, molecular formula: C18H37NO2, molecular weight: 299.50 g/mol) with its similar physical appearance but different melting point and solubility characteristics due to the absence of the double bond found in oleoylethanolamide oea.

The receptor interaction profiles reveal significant differences in biological activity. Oleoylethanolamide buy demonstrates a pronounced affinity for PPAR-α with potent effects on satiety regulation and lipid metabolism while exhibiting limited direct interaction with cannabinoid receptors. While also activating PPAR-α, PEA shows stronger effects on mast cell stabilization, glial cell modulation, and distinct interactions with the endocannabinoid system through the proposed “entourage effect.” Research indicates that what is oleoylethanolamide often produces superior outcomes in conditions requiring appetite regulation and metabolic control. At the same time, PEA typically demonstrates stronger benefits for conditions characterized by neuroinflammation, neuropathic pain, and mast cell hyperreactivity.

Metabolic and appetite effects show interesting variations between these related lipid mediators. Oleoylethanolamide exerts potent anorexigenic effects mediated primarily through vagal afferent signaling and hypothalamic integration, directly influencing meal patterns and satiety. Studies demonstrate that PEA shows comparatively limited direct effects on appetite regulation but may influence metabolic parameters through broader anti-inflammatory and immune-modulatory mechanisms. These functional differences explain their complementary roles in metabolic regulation—oleoylethanolamide primarily targets appetite and lipid metabolism directly. At the same time, PEA supports metabolic health through a reduction of inflammatory burden and immune modulation.

Inflammatory modulation patterns reveal distinct but overlapping mechanisms. Oea oleoylethanolamide reduces inflammation primarily through PPAR-α-mediated inhibition of pro-inflammatory gene expression and modulation of adipose tissue inflammation specifically relevant to metabolic health. PEA demonstrates broader anti-inflammatory effects across various tissues, with particularly prominent actions on neuroinflammation, mast cell degranulation, and microglial activation. These mechanistic differences influence their therapeutic applications, with each compound potentially offering advantages for specific inflammatory processes and tissue targets.

Clinical applications demonstrate clear differentiation in therapeutic approaches and target conditions. While PEA provides more pronounced benefits for neuropathic pain, neuroinflammation, and mast cell-mediated disorders, oleoylethanolamide offers superior support for appetite regulation, weight management, and direct metabolic modulation. This difference in therapeutic emphasis makes each compound valuable for different applications, with oleoylethanolamide preferred for metabolic and appetite-related conditions and PEA selected for pain and inflammation management. However, both share fundamental properties as bioactive lipid mediators with partially overlapping mechanisms through PPAR-α activation.

الممتلكات	Oleoylethanolamide (OEA)	Palmitoylethanolamide (PEA)
رقم سجل دائرة المستخلصات الكيميائية	111-58-0	544-31-0
الصيغة الجزيئية	C18H35NO2	C18H37NO2
الوزن الجزيئي	281.48 g/mol	299.50 g/mol
Powder Color	White to off-white	White to off-white
المظهر	Fine crystalline powder	Fine crystalline powder
القابلية للذوبان	Poorly soluble in water, soluble in fats and ethanol	Poorly soluble in water, soluble in fats and ethanol
Stability	Stable under dry, cool conditions	Stable under dry, cool conditions
Primary Function	Appetite regulation, metabolism boosting	Anti-inflammatory, pain relief
Common Uses	Weight management, fat oxidation, satiety control	Chronic pain management, neuroprotection
Mechanism of Action	Activates PPAR-α, increases fat burning, regulates hunger	Modulates endocannabinoid system, reduces inflammation
التوافر البيولوجي	Moderate, better with lipid carriers	Moderate, enhanced with lipids
Onset of Action	Fast-acting for appetite suppression	Gradual, depends on consistent use
Advantages	Supports weight loss, enhances satiety	Effective for chronic pain and neuroinflammation
Disadvantages	Limited studies on long-term effects	Requires consistent use for benefits
Other Information	Naturally found in olive oil and almonds	Naturally found in egg

الخاتمة

Oleoylethanolamide (OEA) is a scientifically backed compound with multifaceted benefits in appetite regulation, fat metabolism, and metabolic health. Its unique interaction with PPAR-α and other signaling pathways makes it a valuable tool for weight management without the psychoactive effects associated with cannabinoid receptor activation. The compound’s broad impact on lipid metabolism, inflammatory modulation, and neuroprotection highlights its significance in dietary supplements and emerging therapeutic applications for metabolic and neurological health. With ongoing research supporting its efficacy, OEA continues gaining traction as a critical ingredient in formulations that optimize body composition and overall metabolic function.

The precision involved in OEA production, from synthesis to purification and stringent quality control, ensures the highest purity and stability for supplement formulations. Its legal status across major markets, including the U.S., EU, and Australia, further reinforces its credibility as a safe and effective ingredient. As the demand for natural metabolic enhancers grows, OEA’s role in weight management and metabolic health will likely expand, positioning it as a key player in the evolving landscape of nutraceuticals. Whether used as a standalone supplement or combined with complementary bioactive compounds, OEA represents a promising avenue for supporting healthy weight regulation and overall wellness.

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الأسئلة الشائعة

What is the mechanical action of OEA?

OEA’s mechanisms of action include:

Activating PPAR-alpha.
Modulating satiety signals.
Providing neuroprotection.
Regulating mood through interactions with various neurotransmitters and receptors in the brain.

Is Oleoylethanolamide an endocannabinoid?

Although oleoylethanolamide (OEA) is not an endocannabinoid, it has been scientifically demonstrated to interact with it. Although it has been shown to interact with cannabinoid receptors, its effects on the endocannabinoid system are yet unknown.

Is Oleoylethanolamide FDA-approved?

Oleoylethanolamide (OEA) is not FDA-approved as a drug or dietary supplement in the US but is approved for use in foods and food supplements in the European Union.

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