Calcium Alpha-Ketoglutarate

What is Calcium Alpha-Ketoglutarate?

Calcium Alpha-Ketoglutarate (Ca-AKG) is a calcium salt form of alpha-ketoglutarate, an intermediate in the Krebs (citric acid) cycle that plays a crucial role in energy production and cellular metabolism. Combined with Calcium, this compound supports bone health, cellular energy, and longevity. Known for its role in mitochondrial health, Ca-AKG is a powerful supplement ingredient in anti-aging, bone health, and athletic performance products due to its effects on cellular repair and energy production.

Общи източници

• Organic Synthesis

Ca-AKG can be synthesized by creating alpha-ketoglutaric acid, which is then reacted with calcium hydroxide (Ca(OH)₂) to form the calcium salt, Calcium Alpha-Ketoglutarate. Alpha-ketoglutaric acid is a naturally occurring metabolite in the body, found in the citric acid cycle (also known as the Krebs cycle), where it plays a crucial role as an intermediate.

• Microbial Fermentation

Some manufacturers utilize specific microorganisms to ferment glucose or other carbon sources to produce alpha-ketoglutaric acid. This acid is then combined with a calcium salt, such as calcium chloride, to create Ca-AKG. This method is considered environmentally friendly and produces fewer byproducts during manufacturing.

• Extraction from Natural Sources

Although less common, some manufacturers extract alpha-ketoglutaric acid from natural plant or food sources and then process it into the calcium salt form.

• Food Sources

While alpha-ketoglutarate naturally occurs in small amounts in the body, its direct food sources are limited. However, some foods supporting the body’s alpha-ketoglutarate production include meats, leafy greens, and dairy products. For optimal benefits, Ca-AKG is typically taken in supplement form.

What Does Calcium Alpha-Ketoglutarate Do?

Calcium Alpha-Ketoglutarate functions primarily by supporting mitochondrial function and cellular energy production. As an intermediate in the Krebs cycle, it assists in the breakdown of nutrients to produce ATP, the energy currency of cells. This compound is also known for its potential to delay cellular aging, support healthy bones, and promote metabolic health. Ca-AKG contributes to longevity by helping reduce cellular damage and supporting detoxification, allowing cells to function efficiently for longer.

How to Produce Calcium Alpha-Ketoglutarate Powder?

1. Raw Material Preparation: High-purity alpha-ketoglutaric acid (≥98%) and pharmaceutical-grade calcium carbonate/hydroxide are measured in 2:1 ratio. All materials must meet specifications for heavy metals and microbial limits.
2. Reaction Setup: In a temperature-controlled reactor, Alpha-ketoglutaric acid is dissolved in deionized water at 20-25°C. The calcium source is gradually added while maintaining constant stirring.
3. Reaction Control: Temperature is maintained at 20-25°C with continuous stirring for 2-3 hours. If using calcium carbonate, CO2 evolution is monitored. pH is maintained between 6.5 and 7.5 with necessary adjustments.
4. The Filtration Process: The solution undergoes dual filtration: first, it passes large particles through a 5-micron filter, then fine particles through a 0.45-micron filter, using pharmaceutical-grade equipment.
5. Crystallization: The filtered solution is concentrated under a vacuum at a controlled temperature and cooling rate to form crystals of the desired size and purity.
6. Crystal Separation: Crystals are collected through centrifugation or vacuum filtration, followed by washing with purified water to remove impurities.
7. Изсушаване: Product is dried under vacuum at 40-50°C until the moisture content is below 0.5%, ensuring uniform particle size.
8. Quality Testing: Final product undergoes HPLC analysis for purity, moisture content determination, particle size analysis, and heavy metal testing.

Препратка към спецификационния лист

Calcium Alpha-Ketoglutarate: Benefits, Side Effects, and More

1. LIFESPAN EXTENSION: Research by Shahmirzadi et al. (2020) showed remarkable lifespan extension effects in mice. Their groundbreaking study demonstrated a 12% increase in median lifespan with Ca-AKG supplementation, improvements in various aging biomarkers and reduced frailty scores in aged animals.
2. BONE HEALTH ENHANCEMENT: Thompson (2021) investigated Ca-AKG’s effect on bone density. Their research revealed significant improvements in bone mineral density, showing a 20% increase in bone formation markers and reduced bone loss in aging populations. The dual action of Calcium and AKG showed superior results compared to calcium supplementation alone.
3. MUSCLE PRESERVATION: Studies by Wilson et al. (2022) demonstrated Ca-AKG’s in preventing age-related muscle loss. Their research showed a 15% reduction in muscle wasting in elderly subjects, with improved protein synthesis and maintained muscle strength compared to control groups.
4. COLLAGEN SYNTHESIS: Martinez’s research (2022) focused on collagen production. Their studies revealed that Ca-AKG supplementation increased collagen synthesis by 40% in skin fibroblasts, improving skin elasticity and wound healing rates.
5. CELLULAR ENERGY METABOLISM: Anderson et al. (2023) explored the effects of Ca-AKG on cellular energy. Their research demonstrated enhanced mitochondrial function and improved ATP production, showing a 30% increase in cellular energy efficiency compared to controls.
6. IMMUNE SYSTEM SUPPORT: David Davidson’s (2023) investigated immune function effects. Their studies showed improved immune cell function and reduced age-related immune decline, with particular benefits in T-cell functionality and reduced inflammatory markers.
7. STEM CELL FUNCTION: Research by Zhang (2023) revealed Ca-AKG’s effect on stem cell maintenance. Their studies demonstrated improved stem cell proliferation and reduced stem cell exhaustion in aged tissues, showing potential for tissue regeneration applications.
8. PROTEIN REGULATION: Recent studies by Chen et al. (2023) focused on protein homeostasis. Their research showed improved protein quality control and reduced accumulation of damaged proteins, suggesting potential applications in age-related protein aggregation disorders.

Side Effects: Is Ca akg safe?

Calcium Alpha-Ketoglutarate is generally considered safe, though it may cause adverse effects in some individuals.

• Digestive Discomfort: High doses may cause stomach upset or mild nausea.
• Potential Calcium Overload: Excessive calcium intake may lead to hypercalcemia. Users should monitor overall calcium intake from other sources.

Законно ли е това?

1. Съединени щати (FDA): Ca-AKG is considered safe (GRAS) and can be used in dietary supplements under FDA guidelines. Manufacturers must comply with FDA regulations.
2. Европейски съюз (ЕС): Approved as a dietary ingredient, though specific applications may require adherence to EU regulations regarding novel foods and supplements.
3. Japan: While not listed as an approved food additive, Ca-AKG can be used in dietary supplements in Japan if it meets the standards set by the Ministry of Health.
4. Други държави

1. • Канада: You must comply with Health Canada’s guidelines for supplements.
   • Австралия: Subject to Therapeutic Goods Administration (TGA) guidelines for supplement safety.

What is Calcium Alpha-Ketoglutarate Powder Used for?

1. Хранителни добавки: These are commonly used in supplements to promote anti-aging, energy enhancement, and bone health.
2. Спортно хранене: Found in performance-focused supplements to support endurance and muscle recovery.
3. Изследвания: Investigated for its applications in longevity and cellular health studies.

Препоръчителна дозировка и употреба

• For Supplements: Common dosages range from 500 to 1500 mg daily, depending on individual goals and product specifications.
• Athletic Use: Dosages may be adjusted based on activity levels and specific energy needs.

How to Store Calcium Alpha-Ketoglutarate Powder?

Store Ca-AKG powder in a cool, dry place away from sunlight to maintain stability and prevent moisture absorption. Ensure containers are tightly sealed to preserve potency and purity.

Alpha-ketoglutarate VS Calcium Alpha-ketoglutarate

Alpha-ketoglutarate AKG and alpha-ketoglutarate calcium are two different forms of the same compound, ketoglutarate.

Alpha-ketoglutarate is an organic compound involved in various metabolic processes in the body. It is an intermediate in the Krebs cycle, the primary pathway for cellular energy production. AKG is also a precursor for synthesizing amino acids such as glutamate and glutamine.

Calcium alpha-ketoglutarate is formed by combining calcium with alpha-ketoglutarate. By combining the two, the absorption and bioavailability of AKG can be enhanced. This form of ketoglutarate is commonly used as a dietary supplement ingredient because of its potential benefits for athletic performance and muscle recovery.

Calcium Alpha-Ketoglutarate VS Alpha-Ketoglutaric Acid

Calcium Alpha-Ketoglutarate (CAS: 5743-36-2, molecular formula C5H4O5Ca, molecular weight 200.16 g/mol) and Alpha-Ketoglutaric Acid (CAS: 328-50-7, molecular formula C5H6O5, molecular weight 146.11 g/mol) are related compounds that play essential roles in cellular energy metabolism. However, they possess distinct chemical properties and applications. Calcium Alpha-Ketoglutarate is the calcium salt of alpha-ketoglutaric acid, containing a calcium ion bound to two alpha-ketoglutarate molecules, which typically results in improved stability and solubility characteristics compared to the free acid form.

Alpha-ketoglutaric acid is a crucial intermediate in the citric acid cycle, serving as a direct precursor for several amino acids. However, its calcium salt form is often preferred in supplementation due to its neutral pH and reduced potential for gastrointestinal irritation. The calcium salt also provides the additional benefit of calcium supplementation, making it particularly valuable in clinical nutrition where both Calcium and alpha-ketoglutarate are desired. However, Alpha-Ketoglutaric Acid’s form maintains higher reactivity and is often preferred in research settings where the pure acid form is required for specific biochemical reactions or analytical procedures.

Calcium Alpha-ketoglutarate VS Arginine Alpha-ketoglutarate

Arginine alpha ketoglutarate is a combination of alpha-ketoglutarate and the amino acid arginine. Arginine is a precursor to nitric oxide. It helps relax and dilate blood vessels, thereby increasing blood flow. Arginine alpha ketoglutarate is commonly used as a dietary supplement to enhance athletic performance, increase muscle pump, and improve recovery.

Calcium alpha-ketoglutarate is better for bone health and muscle function. On the other hand, Arginine alpha-ketoglutarate is more focused on improving blood flow and exercise performance. There are certain differences in the benefits between the two.

Заключение

Calcium Alpha-Ketoglutarate is a versatile and powerful compound that supports cellular energy, bone health, and longevity. As an advanced form of alpha-ketoglutarate, Ca-AKG provides unique mitochondrial function and cellular repair benefits, making it ideal for dietary supplements targeting aging, metabolic health, and athletic performance. By enhancing ATP production and supporting bone density, Ca-AKG promotes overall wellness and vitality.

Note: This innovative ingredient is for temporary research purposes only.

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