How Does Calcium Alpha-Ketoglutarate Produce In One Factory?

Calcium Alpha-Ketoglutarate produce

How Does Calcium Alpha-Ketoglutarate Produce In One Factory?

What Is Calcium Alpha-Ketoglutarate?

Alpha-ketoglutaric acid and calcium are combined to create calcium alpha-ketoglutarate. An organic acid called alpha-ketoglutaric acid participates in the Krebs cycle, a set of chemical .processes in cells to provide energy. Calcium alpha-ketoglutarate is frequently taken as a dietary supplement to support strong bones and joints, enhance exercise performance, and speed up muscle recovery. Moreover, it is occasionally added to food to enhance specific products’ nutrition.

Calcium alpha-ketoglutarate Specification:

  • Chemical formula: C5H4CaO5·H2O
  • CAS no.  71686-01-6
  • Molecular weight: 202.17 g/mol
  • Calcium content: around 9-10% by weight
  • Appearance: white to off-white powder
  • Solubility: soluble in water
  • pH (1% solution): 6.5-8.5
  • Heavy metal content: <10 ppm
  • Loss on drying: <5%
  • Assay (by titration): >98%

Is Alpha Ketoglutarate Activated By Calcium?

The complexes formed by alpha-ketoglutarate (AKG) and various metal ions, such as calcium, can have various biological effects. Calcium alpha-ketoglutarate is widely used as a dietary supplement due to its possible health benefits.

Alpha-ketoglutarate can be made more stable and soluble by adding calcium, and in some circumstances, this may also increase its biological activity. Calcium alpha-ketoglutarate, for instance, has been demonstrated to maintain strong bones and joints and enhance athletic performance and muscle recovery.

The effects of calcium alpha-ketoglutarate can differ based on the dose, the person’s health, and other variables, so it’s crucial to keep that in mind. More research is required to comprehend the mechanisms of action of calcium alpha-ketoglutarate fully and to ascertain its possible advantages and disadvantages.

What Is The Natural Source Of AKG Powder?

The powdered alpha-ketoglutarate (AKG) can be made from natural and artificial sources.

Animal items like meat, fish, and dairy are natural sources of AKG. The body can also produce AKG when metabolizing amino acids, particularly glutamate.

Chemical synthesis or fermentation employing microorganisms like Corynebacterium glutamicum or Pseudomonas fluorescens are two ways to make synthetic AKG powder. The resultant powder is offered online as a dietary supplement in health food stores.

How To Manufacture Ca-AKG Bulk Powder?

To produce Ca-AKG bulk powder, the following general processes may be taken:

  • Synthesis of alpha-ketoglutaric acid

Alpha-ketoglutaric acid (AKG) can be produced chemically or by microbial fermentation. Usually, a liquid form of the AKG is created.

  • Formation of calcium alpha-ketoglutarate

Calcium alpha-ketoglutarate is created by mixing the AKG solution with a calcium source, such as calcium carbonate or hydroxide. The reaction can be conducted in a controlled environment for temperature, pH, and agitation.

  • Filtration and drying

The resulting calcium alpha-ketoglutarate solution is purified by filtering, drying, and ground into a powder. Numerous drying techniques, such as vacuum, freeze, and spray drying, can be utilized.

  • Testing and quality control

Ca-AKG powder is tested to ensure it satisfies purity, particle size, calcium content, and other characteristics. For usage as a dietary supplement, the substance may be presented in bulk containers or individual servings.

What Is Alpha-Ketoglutarate Used For The Synthesis Of?

The versatile chemical alpha-ketoglutarate (AKG) is a precursor for synthesizing many other substances, including amino acids, neurotransmitters, and molecules involved in energy. The following are some instances of AKG being employed in synthesis:

Amino acids

AKG can be transformed into glutamate, a non-essential amino acid necessary for the production of proteins and metabolism. Furthermore, glutamate can be transformed into amino acids like arginine, proline, and histidine.


The neurotransmitter gamma-aminobutyric acid can be produced from glutamate, which can be produced from AKG (GABA). GABA is an inhibitory neurotransmitter that affects anxiety, sleep, and mood.

Energy-related molecules

The Krebs cycle, a set of chemical events in cells to produce energy, uses AKG as a crucial intermediary. Succinyl-CoA, a precursor for producing heme, a component of hemoglobin and other proteins, can be produced from AKG.


Many pharmacological molecules, such as antibiotics and antihypertensive drugs, have been synthesized using AKG as a starting material.

Is Ca AKG Anti-Aging?

The anti-aging supplement calcium alpha-ketoglutarate (Ca-AKG) is occasionally advertised. However, there is little proof that it works.

By enhancing energy metabolism, lowering oxidative stress, and fostering healthy bones and joints, Ca-AKG is suggested to enhance healthy aging. More studies are required to substantiate the effects of Ca-AKG supplementation on exercise performance, muscular recovery, and cognitive function in older persons.

Additionally, some evidence supports the notion that Ca-AKG may encourage collagen formation and enhance skin health, both of which may lessen the appearance of aging. The ideal Ca-AKG supplementation dosage and time frame must be determined through further study.

It’s important to remember that the aging process is intricate and varied, and no one supplement or therapy can completely stop or reverse it. Instead of relying on a single product or intervention, maintaining better aging is supported by a healthy lifestyle, regular exercise, a balanced diet, and stress management.

What Are Calcium Alpha-Ketoglutarate Benefits?

The dietary supplement calcium alpha-ketoglutarate (Ca-AKG) is frequently advertised for its purported health advantages. Among the alleged advantages of Ca-AKG are the following:

Improved exercise performance

Ca-AKG may enhance athletic performance by boosting energy production, lowering muscle exhaustion, and fostering muscle recovery.

Increased muscle mass

Ca-AKG may contribute to increased muscle protein synthesis and decreased muscle breakdown, enhancing muscle mass.

Joint health

Ca-AKG may benefit joint health by encouraging collagen synthesis, essential cartilage, and connective tissue elements.

Improved bone health

Increased calcium absorption and decreased calcium loss from bones are two ways that Ca-AKG may aid in promoting bone health.

Anti-aging effects

Ca-AKG may slow aging by lowering oxidative stress, enhancing energy metabolism, and maintaining strong bones, skin, and joints.

Where Is Alpha Ketoglutarate Used?

Alpha-ketoglutarate (AKG) has applications in many different industries. Here are a few instances:

Dietary supplements: AKG is frequently added to dietary supplements due to its possible health advantages, which include enhancing athletic performance, boosting muscle mass, and encouraging healthy aging.

Food and beverage industry: AKG is a flavor enhancer and acidity regulator in various food and beverage products, including cheese, pork, and carbonated beverages.

Agriculture: AKG is occasionally applied as fertilizer to encourage plant development and boost crop production.

Pharmaceuticals: The synthesis of many pharmacological molecules, such as antibiotics, antihypertensive medicines, and immunosuppressive medications, begins with the production of AKG.

Research: Since AKG is a crucial intermediary in the Krebs cycle and a crucial regulator of numerous metabolic pathways, it is frequently used to study cellular metabolism.

How To Test The Quality Of Calcium Ketoglutarate Powder In Bulk?

The quality of calcium alpha-ketoglutarate (Ca-AKG) powder in bulk can be tested using various methods. Here are some common techniques for quality testing:

Identity testing confirms that the substance being tested is indeed Ca-AKG. Methods for identity testing may include Fourier transform infrared (FTIR) spectroscopy or nuclear magnetic resonance (NMR) spectroscopy.

Purity testing determines the percentage of Ca-AKG present in the bulk powder sample. Methods for purity testing may include high-performance liquid chromatography (HPLC) or gas chromatography (GC).

Heavy metal testing determines the levels of heavy metals present in the bulk powder sample. Heavy metals can be toxic in high concentrations and cause health problems if consumed. Methods for heavy metal testing may include inductively coupled plasma mass spectrometry (ICP-MS) or atomic absorption spectroscopy.

Microbial testing determines the bacteria, yeast, and mold levels in the bulk powder sample. Methods for microbial testing may include plate count methods, such as total viable count and yeast and mold count.

Residual solvent testing determines the levels of residual solvents present in the bulk powder sample. Residual solvents can be hazardous if present in high concentrations. Methods for residual solvent testing may include gas chromatography (GC) or headspace analysis.

Several test methods can be used to assess the quality of calcium alpha-ketoglutarate (Ca-AKG), including:

  1. HPLC (High-Performance Liquid Chromatography)
  2. FTIR (Fourier Transform Infrared Spectroscopy)
  3. Elemental Analysis
  4. Microbiological Testing
  5. Heavy Metal Testing

Does Alpha-Ketoglutarate AKG Have Side Effects?

Mild side effects are possible in some people, especially when taken in large doses. These negative impacts could consist of the following:

High doses of AKG might result in gastrointestinal problems such as nausea, diarrhea, and stomach cramps.

Electrolyte Imbalance: Taking AKG supplements might throw off the body’s electrolyte balance, resulting in symptoms including weariness, weakness, and irregular heartbeats.

Medication Interaction: AKG and several medicines, including antacids, diuretics, and anti-inflammatory treatments, may interact. Before taking AKG supplements, discussing your prescription regimen with your doctor is imperative.

AKG or other components in AKG supplements may cause allergic reactions in some people, which can manifest as symptoms like hives, itching, or breathing difficulties.

Is Calcium Alpha-Ketoglutarate Powder Approved By FDA?

The US FDA has classified calcium alpha-ketoglutarate (Ca-AKG) as generally recognized as safe (GRAS). FDA implies that when used by good manufacturing procedures and at the prescribed levels, it is considered safe for use as intended in food and dietary supplements. It’s crucial to remember that the FDA does not approve dietary supplements or the components that go into them in the same manner that it does medicines. The FDA does not regulate dietary supplements the same way it does medications; rather, it is up to the manufacturers to ensure the safety and quality of their products.

Which Ingredients Supplier Is The Top To Sell Calcium AKG Powder?

The top bulk raw ingredients supplier of calcium Alpha-Ketoglutarate is Nutri Avenue. FDA-registered Nutri Avenue as a supplier offers various ingredients for different industries, such as dietary supplements, food additives, cosmetics, etc. Our calcium alpha-ketoglutarate bulk powder is tested by a third party and certified by Kosher, Halal, GMP, etc. Therefore, you can choose to trust the quality of our products.

Except for Ca alpha ketoglutarate powder, Nutri Avenue also offers other ingredients. If you need any help in getting high-quality bulk raw ingredients, don’t hesitate to get in touch with us to let our team know, and we can support you kindly.

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