Can We Use Paraxanthine Powder AS A Caffeine Alternative?

Paraxanthine improves performance and endurance

Can We Use Paraxanthine Powder AS A Caffeine Alternative?


Because of the unsure FDA policy, Nutri Avenue regrets to inform you that we have decided to suspend the sale of paraxanthine powder. If we have the latest news, we will update you in time. The following information is available for those interested in this ingredient to study and research paraxanthine. Nutri Avenue will also try our best to find the best paraxanthine alternatives for you. If you want to know more, please contact us.

Paraxanthine powder is a natural compound found in tea and coffee known for enhancing energy, improving cognitive function, and potentially aiding in weight loss and athletic performance. As a caffeine alternative, Paraxanthine powder offers similar benefits with fewer negative side effects, making it a promising option for those looking to refresh themselves and boost their energy and focus healthily. However, it’s important to remember that Paraxanthine powder should be used cautiously, like any supplement. It’s best to follow recommended dosages and usage guidelines and consult a healthcare professional before use, especially if you have preexisting medical conditions or are taking other medications.

What Is Paraxanthine?

Paraxanthine is a dimethyl derivative of xanthine that contains two methyl groups located at positions 1 and 7. It is structurally related to caffeine and is known to have similar effects to the said compounds on the central nervous system. According to research, Paraxanthine is the primary metabolite of caffeine in humans, as roughly 84% of caffeine is demethylated into paraxanthine after intake.

Paraxanthine is also known as 1,7-Dimethylxanthine and 1,7-Dimethyl-3H-purine-2,6-dione. It is known as having CAS number 611-59-6 and molecular formula C7H8N4O2. Its molecular weight is 180.16 g/mol.

Paraxanthine has a white powder appearance when included in dietary supplement products and is generally soluble in organic solvents such as dimethylformamide, DMSO, and ethanol. It is only sparingly soluble in aqueous buffers.

Paraxanthine structure

What Are The Sources Of Paraxanthine Bulk Powder?

As a caffeine metabolite, Paraxanthine Powder is unknown in herbs or other plant sources. It is only produced after caffeine is broken down in the human body. It is, however, synthetically produced for dietary supplement formulations.

Paraxanthine bulk powder is a naturally occurring alkaloid found in tea and coffee. It’s a metabolite of caffeine, meaning the body produces it after ingesting caffeine. Paraxanthine powder stimulates the central nervous system, increasing energy and focus. It’s often used as a caffeine alternative due to its similar benefits but with fewer negative side effects. Paraxanthine has also been linked to potential weight loss and athletic performance benefits. Paraxanthine powder is widely used as an ingredient for pre-workout supplements like MuscleTech EuphoriQ.

4 Raw Ingredients Compare With Paraxanthine

Paraxanthine and Caffeine

While Caffeine and Paraxanthine are structurally related, they differ in certain aspects. Foremost, they differ in CAS number, molecular formula, and potency.

The CAS number of Paraxanthine is 611-59-6 and the molecular formula is C7H8N4O2. In contrast, the CAS number and molecular formula of Caffeine is 58-08-2 and C8H10N4O2, respectively. Also, while Paraxanthine is only sparingly soluble in aqueous buffers, Caffeine is readily soluble in water.

Also, while Caffeine and Paraxanthine are both central nervous system stimulants, Paraxanthine is believed to be advantageous for use in dietary supplement products as it is known to have lesser toxicity and lesser anxiogenic effects.

Theophylline, Theobromine, and Paraxanthine

Theophylline, Theobromine, and Paraxanthine are methylxanthine compounds that are all related to caffeine. It is believed that Caffeine is the parent compound of many methylxanthine compounds. While Theophylline and Theobromine may be obtained from other sources, such as food and plants, Paraxanthine is a metabolite of caffeine produced only from the latter’s breakdown.

Theophylline is known to have effects as a bronchial dilator and respiratory stimulant. Theobromine acts as a diuretic and a vasodilator, while Paraxanthine works primarily as a stimulant.

Ashwagandha vs. Paraxanthine

Several scientists have researched the effects of combined Ashwagandha and Paraxanthine on executive function or overall cognitive responses. Some studies suggest that combining the said products may boost executive functions. Nonetheless, further research is being conducted to verify the claims fully.

Paraxanthine Forms and Specifications

The most common form of Paraxanthine available in the market for purchase is Paraxanthine powder having 99% purity based on a high-performance liquid chromatography test. The product is available for purchase at our company, Nutriavenue.

We offer the product in bulk purchases or purchases in lesser quantities. When you buy Paraxanthine 99% powder in bulk or up to 25 kilograms, the same may be packed in paper drums with two layers of poly bags. However, if you want a different packaging material, you may request the same from our technical support staff.

Paraxanthine Metabolism

Essentially, Paraxanthine is among the results of the metabolism of caffeine through the hepatic cytochrome P45. It is then broken down into 7-methylxanthine. It is subsequently demethylated into xanthine or oxidized by CYP2A6 and CYP1A2 into 1,7-Dimethyluric acid. The compound may also be broken down into 5-acetylamino-6-Formylamino-3-Methyluracil through N-acetyl-transferase 2 in another pathway.

Paraxanthine benefits

How does Paraxanthine Work?

It is claimed that Paraxanthine works by stimulating the process known as lipolysis. Lipolysis refers to the breakdown of fat into glycerol and fatty acids. Aside from the breakdown of fats, lipolysis also results in the production of energy. Hence, Paraxanthine’s lipolysis-inducing effects may result in fat loss and energy production. This is why it is beneficial not only among athletes and bodybuilders but also among adults seeking to lose weight.

Paraxanthine Bulk Powder Healthy Benefits

  • Increased energy and alertness

Paraxanthine is known for giving great energy boosts and alertness by stimulating the central nervous system. When ingested, it’s metabolized by the liver and converted into a compound that can cross the blood-brain barrier, where it acts on the adenosine receptors in the brain. Paraxanthine helps to keep the brain alert and energized by blocking the action of Adenosine, a neurotransmitter promoting relaxation and sleep. This can increase mental and physical performance, making it a popular ingredient in pre-workout supplements and energy drinks.

  • Improved cognitive function

Paraxanthine has been shown to improve cognitive function by enhancing the brain’s ability to process information and maintain focus. By inhibiting Adenosine, Paraxanthine promotes wakefulness and helps to increase the brain’s capacity for attention and information processing. Additionally, some studies have suggested that Paraxanthine may have neuroprotective effects and could help prevent age-related cognitive decline. As a result, Paraxanthine is often included in supplements and nootropics designed to enhance cognitive performance.

Potential benefits for weight loss and athletic performance

Bulk Paraxanthine powder has been shown to have potential benefits for weight loss and athletic performance. Studies have found that Paraxanthine can increase the body’s metabolic rate, leading to greater calorie burn and potential weight loss. Paraxanthine has also been shown to increase lipolysis, which is the breakdown of fat cells, which may further aid in weight loss.

Regarding athletic performance, Paraxanthine can boost energy and improve focus, leading to better physical performance. Additionally, Paraxanthine has been shown to increase the release of calcium ions in skeletal muscle, which can enhance muscle contraction and improve endurance. However, additional research must be conducted to understand the full potential of Paraxanthine. It is important to note that Paraxanthine is never a substitute for a healthy lifestyle.

Are There Any Risks and Side Effects Of Paraxanthine?

  • Negative effects on heart health

There is limited research on the negative effects of Paraxanthine bulk powder on heart health. However, studies suggest that high doses of Paraxanthine may increase heart rate and blood pressure, which may be problematic for those with preexisting heart conditions. Additionally, Paraxanthine can cause vasoconstriction, which narrows blood vessels and may reduce blood flow to the heart. As a result, it’s recommended that individuals with heart conditions or high blood pressure avoid using Paraxanthine supplements or consult with their doctor before use.

  • Potential for addiction and dependence

Paraxanthine bulk powder has a lower potential for addiction and dependence than caffeine. However, like other stimulants, regular use of Paraxanthine may lead to tolerance, where the body becomes accustomed to the effects and requires higher doses to achieve the same results. This can potentially lead to dependence and withdrawal symptoms upon discontinuation. As a result, it’s important to use Paraxanthine in moderation and not exceed recommended dosages. Additionally, it’s recommended to cycle off Paraxanthine periodically to prevent the development of tolerance and dependence.

  • Other risks and side effects

Paraxanthine powder’s potential risks and side effects include gastrointestinal distress, insomnia, anxiety, and restlessness. High doses of Paraxanthine can also lead to tremors, irregular heartbeat, and seizures. Paraxanthine can also interact with certain medications, such as antidepressants and blood thinners, potentially causing adverse effects. As with any supplement or medication, it’s important to consult a healthcare professional before use, especially if you have preexisting medical conditions or are taking other medications.

What Ingredient is Paraxanthine Powder Alternative?

Various alternatives to Paraxanthine powder can offer similar benefits. One popular Paraxanthine Powder alternative is caffeine powder, a widely used stimulant that can increase energy and alertness. Other alternatives include green tea extract, which contains caffeine and other compounds that can boost metabolism and aid in weight loss, and Rhodiola Rosea extract, which can help reduce fatigue and improve cognitive function.

Paraxanthine Dosage

The recommended dosage of Paraxanthine Powder may vary depending on the individual’s weight, tolerance, and desired effects. As a general guideline, a 50-200mg daily dosage is considered safe and effective for most individuals.

Where To Buy Bulk Paraxanthine Powder?

Due to the uncertain FDA policy, we have decided not to sell this product for the time being. We are very sorry for the inconvenience caused to you.

However, you also can find many other same benefits ingredients in Nutri Avenue. For example:

Various ingredients at wholesale prices on Nutri Avenue are waiting for you to choose from.


In conclusion, bulk Paraxanthine powder is a stimulant that can offer a range of potential benefits, including increased energy and alertness, improved cognitive function, and weight loss. Due to its benefits, Paraxantine powder became a popular ingredient for workout products such as Muscletech Euphoria.

However, Paraxanthine still has potential risks and side effects associated with its use, such as negative effects on heart health and the potential for addiction and dependence. It’s important to use Paraxanthine in moderation and follow recommended dosages and usage guidelines. Individuals with preexisting medical conditions or taking other medications should consult a healthcare professional before using Paraxanthine supplements. Bulk Paraxanthine powder can be a useful supplement for those looking for an energy boost and increased athletic performance.

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