In 1957, American biochemist Dr. Frederick Crane extracted a quinone substance from bovine heart mitochondria. It is the first time humans have discovered the existence of Coenzyme Q10. Dr. Karl Folkers received the American Chemical Society’s highest honor, the Priestly Medal, in 1986 for his first determination of the structure of CoQ10. Frederick Crane continued to take CoQ10 for 40 years until his death at 91.
In 1961, Dr. Peter D. Mitchell, a famous University of Edinburgh chemist in the UK, discovered the working mechanism of coenzyme Q10 to produce energy at the human cell layer. This major discovery won him the 1978 Nobel Prize in Chemistry (Medicine).
Based on the importance of CoQ10 powder, the US FDA has approved the use of it as an over-the-counter drug and dietary supplement, and its related applications have been widely used. However, the FDA has not yet approved its use to treat cancer or any disease.
How Is Coenzyme Q10 Distributed In The Human Body?
Coenzyme Q10 is widely present in cell membranes, especially in mitochondrial membranes. It is mainly distributed in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands. Among them, the content in the heart, liver, and muscles is relatively high. Although the content of CoQ10 in the whole body is only 500~1500mg, it plays an important role.
As we age, the content of Coenzyme Q10 in the human body gradually decreases. Taking the age of 20 as the standard line, at the age of 80, the coenzyme Q10 in various human body parts naturally decays to:
- Liver: 83.0%
- Kidney: 65.3%
- Lungs: 51.7%
- Heart: 42.9%
Therefore, by default, the heart is the organ that most needs CoQ10 powder supplementation. In other words, the cause of many elderly heart discomforts is Coenzyme Q10.
What is more interesting is that a recent survey on Australians taking supplementary Coenzyme Q10 showed that the content of Coenzyme Q10 in the blood will increase with age without taking any health products and drugs that increase Coenzyme Q10. It may be due to the cell depletion of skeletal muscles due to aging, and the coenzyme Q in the cells is excreted into the blood as the cells die.
How CoQ10 Works In The Body?
Its main biochemical role is to serve as a cofactor in the electron transport chain to participate in redox reactions to synthesize adenosine triphosphate. Since most cellular functions depend on an adequate supply of adenosine triphosphate (ATP), it is thought to play an important role in all tissues and organs of the human body.
ATP: An unstable high-energy compound composed of 1 molecule of adenine, one molecule of ribose, and three molecules of phosphate groups. Also known as adenosine triphosphate, referred to as ATP. In cells, it can mutually convert with ADP to store and release energy, thus ensuring the energy supply for various life activities of cells.
Meanwhile, Coenzyme Q10 is one of the most important lipid antioxidants. It blocks the production of free radicals and changes in proteins, lipids, and DNA.
Are CoQ10 Powder And Ubiquinol The Same?
95% of Coenzyme Q10 in the human body exists in the form of Ubiquinol, also known as reduced Ubiquinol, except in the brain and lungs. It may be due to the greater oxidative stress in these two tissues, which oxidizes Ubiquinol to the oxidized form of Ubiquinone, oxidized Ubiquinone.
- Ubiquinol CoQ10 has the same effect as CoQ10. The difference is mainly in absorption rate and transport capacity.
- The body does not fully absorb Coenzyme Q10, and the absorption rate is lower than that of Ubiquinol CoQ10.
- Ubiquinol CoQ10 is the most important form of transport in human blood. In healthy adults, 95% of the total amount of CoQ10 in the blood is in the form of Ubiquinol CoQ10. When CoQ10 is ingested, some people’s bodies can quickly convert it into Ubiquinol CoQ10. And some people are unable to make this transition effectively.
The benefits of Ubiquinol CoQ10 powder are many.
- It can protect the heart and prevent the occurrence of heart disease.
- It supports skin protection such as wrinkle reduction and more.
- It has anti-fatigue properties. It can make us more energetic.
- It can also prevent and fight cancer.
CoQ10 powder Ubiquinol is also very safe. Panthenol is a deep-penetrating moisturizer that can stimulate the growth of epidermal cells when added to skin care products. This ingredient is very easy to absorb and penetrate, making the skin brighter. At the same time, it can also strengthen the skin barrier. If combined with nicotinamide, it can improve the skin’s ability to resist external stimulation. It can also condition the skin.
Furthermore, there are actually many studies related to Ubiquinol, and it has been proven to be effective. A trial called Q-SYMBIO on 420 patients with chronic heart failure in 9 countries confirmed that supplementing CoQ10 powder reduced the risk of serious cardiovascular problems by 42% compared to the placebo group. It also reduced cardiac-related death (43%) and all-cause mortality (42%). Likewise, similar experiments have been conducted in Europe. The risk of serious cardiovascular problems was reduced by 67%. Heart-related mortality was reduced by 53%. All-cause mortality was reduced by 55%. However, the opposite is true for left ventricular ejection fraction. It was significantly improved by 6%.
How Much CoQ10 Dosage Is Safe?
The human body well tolerates CoQ10 powder. The experiments found no serious side effects. Even if there are side effects, they are usually mild headache, diarrhea, bloating, and nausea.
Generally speaking, supplementary doses of 0 to 900mg are safe. The maximum supplementation dose currently tested is 1200mg/day. However, each person’s absorption capacity (bioavailability) may also vary. Therefore, it is recommended to start supplementing with 100mg~200mg. Then, increase or decrease the amount according to personal response.
Conclusion
The content of Coenzyme Q10 in the human body is not large, but it is distributed in various parts of the body, especially the heart. As we age, its content in the body gradually decreases. At this time, it is generally recommended to appropriately supplement this ingredient, especially panthenol (reduced Ubiquinol). The human body can better absorb this type of CoQ10 Powder. Thereby reducing mortality caused by cardiovascular, heart, and other related problems. Nutri Avenue, as an FDA-registered supplement ingredients supplier, offers high-quality, highly bioavailable CoQ10 Ubiquinol Powder.