Croscamellose Sodium:A reliable Partner for Better BioAvailability

Croscarmellose Sodium raw material

Croscamellose Sodium:A reliable Partner for Better BioAvailability

Croscarmellose Sodium is a common component of modern drugs and dietary supplement ingredients. It is primarily used as an emulsifier and a disintegrant for tablets and capsules to effectively increase bioavailability and enhance the therapeutic effects of various compounds.

What is Croscarmellose Sodium?

Croscarmellose Sodium is an FDA-registered disintegrant used in the manufacture of many pharmaceutical products. The compound essentially works to promote the breakdown of tablets in the small intestines for maximum absorption and effectiveness. Without Croscarmellose Sodium, many compounds are not sufficiently absorbed as the tablets easily dissolve while in the stomach or other parts of the gastrointestinal tract. The use of Croscarmellose Sodium is believed to increase not only the bioavailability of the primary component of the tablet but also the quantity of the said compound being absorbed by the body.

Croscarmellose Sodium is also referred to as Sodium carboxymethylcellulose and CSC. 

The CAS number of the compound is 74811-65-7. Its molecular formula is C8H16NaO8 and its molecular weight is 263.20 g/mol. Croscarmellose Sodium has a white, fibrous, free-flowing appearance. It is essentially hydrophilic but is made insoluble through cross-linking of sodium salt.

Croscarmellose Sodium forms and specifications

The compound which is a sodium salt of carboxymethylcellulose is often sold as Croscarmellose Sodium powder 99%. It may be purchased from various ingredient suppliers online in bulk or smaller quantities. When bought from legitimate ingredient suppliers like Nutriavenue, it may be packed in Export Worthy Fiber Drum at about 25 kilograms per drum. Packaging may also be customized as per the customer’s request.

Croscarmellose Sodium vs Sodium bicarbonate

Along with Croscarmellose Sodium, Sodium bicarbonate, which is classified as an antacid, is believed to have effects in increasing absorption of some drugs and compounds. The difference between the two compounds is in how they work to promote maximum compound absorption. 

As an antacid, Sodium bicarbonate works by reducing stomach acidity to protect drugs and compounds from being destroyed in the said organ. In contrast, Croscarmellose Sodium works by protecting pharmaceutical products and causing the disintegration of the same in the small intestines where drug absorption occurs.

Croscarmellose Sodium vs sodium chloride

Both Croscarmellose Sodium and Sodium chloride play vital roles in emulsification. However, while Croscarmellose Sodium acts as an emulsifier itself, Sodium chloride only works to support the action or enhance the effects of some emulsifiers. Hence, for purposes of emulsifying, the use of Croscarmellose Sodium is more advantageous and beneficial.

Croscarmellose Sodium and alpha-cyclodextrin

Cyclodextrins are common pharmaceutical compounds used to increase the water solubility of some compounds. The main forms of cyclodextrins are alpha and beta-cyclodextrin.

In enhancing bioavailability and improving stability, the use of Croscarmellose Sodium with alpha-cyclodextrin has become quite popular. The said compounds, when combined, help improve the overall absorption of active substances in drugs and pharmaceutical products.

Croscarmellose Sodium safety and regulation

Essentially, while Croscarmellose Sodium promotes the bioavailability of active compounds in tablets and capsules, it is generally unabsorbed in the body. Thus, based on the declaration of the FDA Select Committee on GRAS food substances, the compound is generally safe for use, provided that it is used within recommended doses.

In some studies, however, experts have found that the use of Croscarmellose Sodium may cause an increase in blood pressure among persons who experience allergic reactions to the compound. Hence, it is advisable for persons who commonly experience allergic reactions to consult physicians before using the compound.

What is Croscarmellose Sodium made from?

Croscarmellose Sodium is primarily derived from cellulose which is essentially a plant fiber. Cellulose is thereafter soaked in sodium hydroxide and with sodium monochloroacetate to eventually derive Croscarmellose Sodium. 

Croscarmellose Sodium Benefits

The use of Croscarmellose Sodium in pharmaceutical products and dietary supplements mainly provide the following benefits:

It acts as an emulsifier

As an emulsifier in both food and pharmaceutical products, Croscarmellose Sodium works as an active ingredient in the mixing of active substances. 

It works as a disintegrant

As a disintegration agent, Croscarmellose Sodium works to promote the breakdown of tablets and capsules in the small intestines. Experts say that the absence of disintegrants like Croscarmellose Sodium may cause tablets and capsules to not being broken down or being broken down in the wrong part of the gastrointestinal tract.

It enhances overall bioavailability

By acting as an emulsifier and a disintegrant, pharmaceutical product manufacturers believe that Croscarmellose Sodium may improve the overall bioavailability of active compounds in medicines and dietary products.

Croscarmellose Sodium side effects

Since the compound is essentially not absorbed, experts say that it may not cause side effects. However, hypersensitivity reactions may result, manifested initially by skin irritation or eye irritation. It is important for individual users to immediately discontinue the use of any medication containing Croscarmellose Sodium when hypersensitivity reactions occur. Individual users should also consult a physician immediately if severe allergic reactions like difficulty of breathing or changes in vital signs occur.

Croscarmellose Sodium dosage

In one study, experts have concluded that a safe dose for Croscarmellose Sodium is a maximum of 50,000 ppm or 3922 mg/kg/day for males and 4712 mg/kg/day for females. The said dose, however, may vary depending on a person’s age, weight, and overall physical condition.

Where to buy Croscarmellose Sodium in bulk?

Croscarmellose Sodium powder

Bulk Croscarmellose Sodium can be purchased from several ingredient suppliers offering services online. One of the best suppliers which have been long been providing very satisfactory services is Nutriavenue.

Nutriavenue is an FDA-registered ingredient supplier which has been in the market of ingredient sale for several years. We are confident in the quality of the products we offer as we are certified and recognized by FDA, Kosher, GMP, and Halal. We also offer our high-quality products at the most affordable prices.

For more information on Croscarmellose Sodium and the other ingredients we offer, you may visit our website at You may also get a free quote when you visit our website. If you have any queries, you may also contact our customer service representatives who are willing and able to provide information.

Our company also offers shipping services through sea, air, and couriers like FedEx and UPS.

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