Alpha Yohimbine Market Update: April 2025 Price Surge Explained

Alpha Yohimbine Market: Price Increase of $200/kg This Week

What Is Alpha Yohimbine? (Rauwolscine or α-Yohimbine)

Alpha Yohimbine, also referred to as Rauwolscine or α-Yohimbine, is a naturally occurring indole alkaloid primarily extracted from plants in the Rauwolfia genus, especially Rauwolfia serpentina (Indian snakeroot). Its CAS number is 146-48-5, with a molecular formula of C₂₁H₂₆N₂O₃ and a molecular weight of 354.44 g/mol.

Alpha Yohimbine typically appears as a white or off-white crystalline powder with high purity standards. It is sparingly soluble in water but readily dissolves in organic solvents such as ethanol, methanol, and chloroform. It has a melting point of approximately 284°C and remains relatively stable under normal conditions, though it should be stored away from direct sunlight and high temperatures.

Pharmacologically, Alpha Yohimbine functions as an α2-adrenergic receptor antagonist. Blocking these receptors increases norepinephrine activity, enhancing sympathetic nervous system function, fat metabolism, and energy expenditure. This mechanism makes it a popular ingredient in the sports nutrition sector—frequently included in fat-burning formulas, energy-boosting products, and appetite-control supplements.

Due to its receptor selectivity and milder side effects, Alpha Yohimbine is increasingly favored over traditional Yohimbine in premium nutritional formulations.

What Is Yohimbine Hydrochloride/Yohimbine HCl?

Yohimbine Hydrochloride is a salt derivative of traditional Yohimbine, typically sourced from the bark of the Pausinystalia yohimbe tree, which is native to Africa. It has a CAS number of 65-19-0, a molecular formula of C₂₁H₂₆N₂O₃·HCl, and a molecular weight of 390.90 g/mol. This compound appears white or off-white and is easily soluble in water and alcohols like ethanol. It melts at around 288°C and is photosensitive, requiring storage in a sealed, light-protected container.

Like Alpha Yohimbine, Yohimbine HCl acts as an α2-adrenergic receptor antagonist, though it has stronger pharmacological effects and a broader spectrum of activity. Beyond its role in fat loss and athletic performance, it has been extensively researched for its efficacy in treating erectile dysfunction, improving circulation, and enhancing mental alertness.

In some countries, Yohimbine HCl is included in prescription medications, with clinically verified therapeutic effects. However, its potent central nervous system stimulation can lead to side effects such as elevated heart rate and blood pressure. As a result, it is regulated or restricted in many regions and not approved for use in standard dietary supplements.

Alpha Yohimbine VS Yohimbine HCl: Key Differences, Uses, And More

• Chemical Structure & Molecular Weight

Though both belong to the Yohimbine class, they are structurally different. Alpha Yohimbine is an isomer, while Yohimbine HCl is a salt form of the standard compound. Their molecular weights reflect this difference—Alpha Yohimbine is 354.44 g/mol, while Yohimbine HCl weighs more due to the hydrochloride molecule (390.90 g/mol).

• Sources/Raw Material

Yohimbine HCl is primarily derived from Pausinystalia yohimbe, which is native to Africa. In contrast, Alpha Yohimbine is extracted from Rauwolfia species like Indian snakeroot. These sourcing differences influence their market positioning.

• Pharmacological Differences

While both compounds antagonize α2-adrenergic receptors, Alpha Yohimbine may exhibit greater receptor subtype selectivity and milder stimulatory effects. Some studies suggest its mechanism is more targeted, resulting in fewer side effects. This makes it more suitable for sports nutrition and over-the-counter fat-burning supplements.

• Product Applications & Uses

Alpha Yohimbine is mainly found in sports nutrition products, energy drinks, and weight management formulations—often used in synergy with caffeine. Yohimbine HCl, on the other hand, is frequently included in pharmaceutical-grade products targeting sexual function and circulatory health and is subject to regulatory restrictions in certain regions.

• Regulatory Status

Due to its potent effects, Yohimbine HCl is restricted or prohibited in dietary supplements across various countries. Alpha Yohimbine, being naturally sourced and milder, faces fewer regulatory hurdles but still requires careful dosage control.

As of this week, the market price for 90% pure Alpha Yohimbine powder is approximately $2,899/kg, while Yohimbine HCl tends to be slightly less expensive.

Ashwagandha: Extracted From Root or Whole Plant

Ashwagandha (scientific name: Sceletium tortuosum), also known as South African dream herb or “Kanna” in local languages, is a succulent plant native to South Africa. It has a rich ethnobotanical history and has been traditionally used by indigenous peoples, especially the Khoisan, for centuries. The term “Kanna” translates to “something that brings joy” or “something to chew.”

Traditionally, the plant’s leaves were dried and chewed during rituals, social gatherings, or as a healing remedy. They have also been ground into powder for use in teas, snuffs, or tinctures. Kanna has been valued for its ability to relieve anxiety, fear, and fatigue and restore energy after long treks or hunts.

Early Dutch settlers in South Africa documented its use and noted its calming and mood-lifting effects. In modern wellness markets, Ashwagandha powder is typically available as powders, capsules, or liquid extracts and is used to improve mood, enhance focus, and relieve stress.

Ashwagandha extracts are generally derived from the root or the whole herb. However, genuine root extracts are rare, and many on the market are counterfeit. Whole herb extracts offer similar effects at a lower cost and more reliable quality.

This week, Ashwagandha is priced at $42–$44/kg.

Ginkgo Biloba Leaf Extract: Proven Cardiovascular and Neuroprotective Benefits

The market’s most common and standardized specification for Ginkgo Biloba Leaf Extract is 24% flavone glycosides and 6% terpene lactones. This specification is widely recognized for its scientific backing, safety profile, regulatory approval, and clinical validation.

1. Based on the EGb 761 Standard from Germany

The global benchmark for standardized Ginkgo extract is the EGb 761 formula, developed by Dr. Willmar Schwabe Pharmaceuticals in Germany. EGb 761 requires:

• 24% Flavone Glycosides: Including quercetin, kaempferol, and isorhamnetin.
• 6% Terpene Lactones: Including ginkgolides A, B, C, and bilobalide.

This formula has been used in numerous large-scale, double-blind, placebo-controlled human trials, establishing its efficacy and safety.

2. Scientifically Optimized Ratio of Actives

The 24:6 ratio of flavonoids to terpene lactones is considered the gold standard for physiological efficacy and tolerability:

• Flavone Glycosides: Provide strong antioxidant activity, protecting neural tissue.
• Terpene Lactones: Improve circulation, reduce platelet aggregation, enhance oxygen delivery to the brain, and support memory.

Higher or lower ratios may impact stability, safety, or efficacy.

3. Globally Recognized Regulatory Status

Due to its extensive clinical foundation, the 24/6 Ginkgo extract is recognized in pharmacopeias around the world:

• European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) both define Ginkgo extract based on this standard.
• It is listed in the Pharmacopoeia and widely used in traditional Chinese medicines and health foods in China.
• In the U.S., it is a standard dietary supplement label specification and complies with FDA cGMP requirements.

4. Mature Production and Stable Supply Chain

With the development of the Ginkgo industry, the extraction process for the 24/6 specification is now highly mature and consistent across batches. For brand owners, using this standard simplifies formulation ensures compliance, and strengthens consumer trust.

This week, Ginkgo Biloba Leaf Extract 24% flavone glycosides & 6% terpene lactones is priced at $60–$65/kg. It holds clear clinical value in cardiovascular and neuroprotective health and is in high demand in countries like Germany, France, Japan, South Korea, and the United States.

U.S. – China Trade War: “Reciprocal Tariff” Policy Continues to Escalate

Earlier this month, President Trump announced a tariff hike on Chinese imports, raising duties to 145%. The new tariffs cover a wide range of goods, from baby products to high-tech equipment. This move aims to narrow the U.S. trade deficit with China but has triggered widespread concern. Prices on items like strollers, car seats, and baby furniture have risen sharply, leading many expectant parents to rush purchases ahead of further price hikes.

In response, China imposed a 125% tariff on U.S. goods, affecting agricultural products, energy resources, and high-tech equipment. Additionally, China implemented other countermeasures, including limiting imports of Hollywood films and suspending exports of critical rare earth elements.

Due to ongoing tariff impacts, pricing adjustments have been observed for the following products this week:

Monk Fruit Extract 10:1: $11–12/kg

Vitamin Market Update: NMN, NRC, NAD Prices Keep Climbing

Compared to last week, NMN saw the most significant price increase – over $10/kg.

• NMN: $115–120/kg
• NRC: $124–125/kg
• NAD: $178–180/kg

There have been no significant price changes for other vitamin products, which remain as follows:

• Vitamin B2: $38.5–40/kg
• Vitamin B5: $11–12/kg
• Vitamin B6: $30–32/kg
• Vitamin B7 (D-Biotin Powder): $178–180/kg
• Vitamin B8 (Inositol Powder): $12.5–14/kg
• Vitamin B9 (Folic Acid Powder): $60–63/kg
• Methylcobalamin Powder: $2,050–2,180/kg
• Cyanocobalamin Powder: $1,690–1,780/kg
• D-Chiro-Inositol Powder: $382–383/kg
• Vitamin C: $4–4.5/kg
• Calcium Ascorbate (Vitamin C): $8.8–9.5/kg
• Vitamin C DC 97%: $7–8/kg
• Vitamin D3 (100,000 IU): $16.5–17/kg
• Natural Vitamin E 700 IU: $16.8–17.5/kg
• Natural Vitamin E 1,185 IU: $80–82/kg
• Natural Vitamin E 1,210 IU: $80–82/kg
• Vitamin K2 MK4: $125–128/kg
• CoQ10 Powder: $175–178/kg
• Riboflavin Powder: $39–44/kg
• Pyridoxal 5-Phosphate Powder: $148–152/kg
• Riboflavin Sodium Phosphate Powder: $82–85/kg
• Benfotiamine Powder: $77–80/kg
• NADH (Cold Shipment Required): $622–625/kg
• Ubiquinol Powder: $664–666/kg

Popular Supplement Ingredient Price Trends

• L-Carnitine Base Powder: $28–30/kg
• L-Carnitine L-Tartrate Powder: $26.5–28/kg
• N-Acetyl L-Carnitine HCl Powder: $29–32/kg
• Creatine Monohydrate Powder: $6.8–8/kg
• Beta-Alanine Powder: $4–4.5/kg
• Arginine Alpha-Ketoglutarate (AAKG) 2:1: $14.5–16/kg
• GABA (Gamma-Aminobutyric Acid) Powder: $9.5–10/kg
• Alpha Lipoic Acid Powder/Granular: $45–49/kg
• R-Alpha Lipoic Acid Powder: $218–225/kg
• R-Alpha Lipoic Acid Sodium Powder: $228–236/kg
• Citicoline (CDP-Choline) Powder: $145–150/kg
• Wheat Germ Extract (1% Spermidine): $200–212/kg
• Monk Fruit Extract 25%: $210–214/kg
• Algae DHA 20%: $48–52/kg
• Sodium Hyaluronate Powder: $95–102/kg (market stabilizing)
• Xanthan Gum Powder 200/80 mesh: $7.5–8/kg
• Caffeine Anhydrous Powder: $12–13/kg
• Shilajit Extract (20% Fulvic Acid): $29–31/kg
• Turkesterone 10% (from Ajuga turkestanica): $33–35/kg
• Tribulus Terrestris Extract (90% Saponins): $12.8–14/kg

Weekly Promotional Ingredient Offers on Nutri Avenue

Valid from April 21 to April 27, 2025

To thank our loyal customers, Nutri Avenue releases weekly promotions on select raw ingredients—offering premium quality at below-market pricing. Ideal for supplement brands, functional beverage developers, and more, all our materials come directly from certified manufacturers with full documentation. Minimum order quantities generally start at 25kg, with larger orders enjoying greater discounts.

Highlight This Week: Saw Palmetto Extract Series

We’re offering saw palmetto extracts at approximately $2/kg below the current market rate. Our partnering factories have indicated upcoming price increases, so now is a great time for brands needing this ingredient to stock up.

For updated pricing, COAs, ISO certificates, and more, please contact our sales team.

• Saw Palmetto Extract (85% Oil): $48–50/kg
• Saw Palmetto Extract (45% Fatty Acids): $22–24/kg
• Saw Palmetto Extract (25% Fatty Acids): $12.5–14/kg
• Taurine Powder (Anti-caking): $4–4.5/kg
• NAC (N-Acetyl-L-Cysteine) Powder: $14.5–15.5/kg
• Citicoline Sodium Powder: $140–142/kg
• Citric Acid Anhydrous Powder (30–100 mesh): $1.7–1.9/lb
• Apigenin 98% Powder: $316–320/kg

Závěr

The U.S.-China trade war continues to escalate, significantly impacting global markets, especially in sectors like nutrition and supplements. Recently, President Trump announced an increase in tariffs on Chinese imports to 145%, which has raised concerns about price hikes across various consumer goods, including baby products and high-tech items. In retaliation, China has imposed a 125% tariff on U.S. goods, affecting everything from agricultural products to energy resources. This ongoing tariff war has led to price adjustments for several key ingredients, including Monk Fruit Extract, which has seen price shifts this week.

Meanwhile, the vitamin and supplement markets continue to experience price increases, particularly for NMN, NRC, and NAD, which have risen significantly in recent weeks. Other vitamins and supplements, however, have maintained stable prices, providing some relief to consumers. Popular ingredients like L-carnitine, Beta-Alanine, and alpha-lipoic acid remain in demand, with prices reflecting supply and demand trends.

To support customers during these volatile times, Nutri Avenue offers promotional discounts on select products, including Saw Palmetto Extract, with price reductions of approximately $2/kg below market value. With upcoming price hikes expected for some ingredients, it is an ideal time for businesses to stock up on essential raw materials.

Know more price updates of supplement ingredients market, please focus on Nutri Avenue.