Olivetol

What Is Olivetol?

Běžné zdroje

• Lichens: Olivetol is found in certain lichens as a secondary metabolite.
• Cannabis Plants: In Cannabis sativa L., olivetol serves as a key precursor in the biosynthesis of cannabinoids such as tetrahydrocannabinol (THC). Within the plant, olivetol combines with other compounds through enzymatic reactions to form cannabinoids.

• Grignard Reaction: It can be synthesized by reacting a six-carbon chain alkyl halide with resorcinol via a Grignard reagent.
• Hydroxylation Reactions: Directed hydroxylation on precursor compounds with an aromatic ring can also yield olivetol.

What Does Olivetol Do?

How To Produce Olivetol Powder?

1. Raw Material: Preparation High-purity hexanoyl chloride, resorcinol, and aluminium chloride catalysts are sourced as starting materials. All materials must meet pharmaceutical-grade specifications (>99% purity) and undergo quality testing.
2. Reaction Setup: A Friedel-Crafts acylation reaction is set up under anhydrous conditions. Resorcinol and aluminium chloride are combined in an appropriate solvent (typically dichloromethane) at 0-5°C under an inert atmosphere.
3. Reaction Process: Hexanoyl chloride is added dropwise while maintaining temperature. The reaction mixture is stirred for several hours under controlled conditions, with progress monitored via TLC/HPLC.
4. Hydrolysis: The reaction mixture undergoes careful hydrolysis with ice-cold water. The pH is adjusted, and an organic olivetol layer is separated.
5. Initial Purification: The organic layer is thoroughly washed with brine multiple times, then dried with sodium sulfate before being concentrated under vacuum at a controlled temperature.
6. Crystallization: The concentrated product is crystallized using an appropriate solvent system at a controlled temperature and cooling rate. Multiple recrystallization cycles may be performed.
7. Final Processing: Crystals are dried under vacuum at 40-45°C until constant weight. The product is milled if necessary to meet particle size specifications.
8. Quality Analysis: The final product undergoes comprehensive testing, including HPLC for purity (>98%), NMR/MS for structure confirmation, melting point determination, and stability studies.

Referenční list specifikace

Olivetol: Benefits, Side Effects, and More

1. Anti-inflammatory Properties: Studies in biochemistry have shown that it may possess anti-inflammatory properties. A research study published in the International Journal of Molecular Sciences (2019) suggested that olivetol-like compounds could modulate inflammatory responses through interaction with specific cellular receptors. However, most of these studies were conducted in vitro rather than human trials.
2. Antioxidant Activity: Laboratory studies have indicated the potential antioxidant properties of this ingredient. A Research study published in Free Radical Biology and Medicine suggested that compounds structurally similar to this compound demonstrated free radical scavenging abilities. However, the direct antioxidant capacity of pure olivetol in human systems needs further investigation.
3. Potential Neuroprotective Effects: Preliminary research in neuroscience journals has indicated that olivetol and related compounds might have neuroprotective properties. A study in the Journal of Neurochemistry examined the compound’s interaction with neural pathways, though these studies are primarily preclinical and require human trial validation.
4. Antimicrobial Properties: Some laboratory studies have shown that it may possess antimicrobial properties. Research in the Journal of Natural Products has demonstrated potential activity against certain bacterial strains, though clinical applications remain to be established.
5. Cellular Signaling Modulation: Biochemical studies have shown that it can influence cellular signalling pathways. Research published in cellular biology journals has examined these mechanisms, particularly endocannabinoid system interactions.

Nežádoucí účinky: Je to bezpečné?

• Trávicí problémy: High doses may cause mild gastrointestinal discomfort.
• Alergické reakce: Individuals with allergies to cannabis or related compounds should be cautious.

Je to legální?

1. United States (FDA): It is legal for use in dietary supplements and research purposes, though its association with cannabis may require regulatory oversight depending on the context of use.
2. European Union (EU): It is subject to EU regulations and may require safety assessments for specific product formulations, particularly those intended for human consumption.
3. Ostatní země

1. • Kanada: It is generally accepted for use in research and regulated products, but regulations may vary.
   • Austrálie: Depending on its intended use, it may require approval from the Therapeutic Goods Administration (TGA).

What is Olivetol used for?

1. Cannabis Industry: Olivetol is primarily used in the production of cannabinoids like THC, making it a valuable compound in the cannabis industry for both recreational and medicinal applications.
2. Doplňky stravy: Olivetol is explored for inclusion in supplements aimed at supporting brain health and reducing inflammation due to its potential neuroprotective and anti-inflammatory properties.
3. Research Applications: Olivetol is widely studied for its role in cannabinoid biosynthesis and its potential benefits in various therapeutic areas, including cancer treatment and neurological health.

Doporučené dávkování a použití

• For Supplements: The recommended dosage of Olivetol varies depending on the formulation and the intended benefit, but standard dosages are between 50 and 200 mg daily.
• For Functional Foods: Typically used at lower concentrations within a blended formula targeting inflammation and neuroprotection.

How to store olivetol powder?

Olivetol VS Olivetolic Acid

Závěr

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