Curcumin With Piperine is a common supplement ingredient. Why is this? First, we need to understand what these two ingredients are.
Curcumin is mainly derived from Turmeric’s rhizome (the rhizome’s content is about 2% to 5%). Research shows curcumin has antioxidant, anticancer, antithrombotic, and cardiovascular protective effects. Curcumin is approved by the FDA as a generally recognized safe substance. Clinical trials have shown that curcumin is safe for humans to consume up to 12 grams/day.
However, one of its biggest drawbacks is that it is poorly absorbed orally. After pure curcumin enters the human body, its absorption and utilization rate is less than 1%. The reason for this is that the liver almost eliminates most Turmeric. Regarding the potential adverse effects of curcumin, some studies have reported some mild side effects from using high doses of curcumin, including nausea, diarrhea, headache, rash, and yellow stools.
Piperine is the main active ingredient in black pepper extract. Black pepper contains 2.7%-4% piperine. Piperine has shown various pharmacological effects in in vitro and in vivo experiments, such as antioxidant, antibacterial, immune modulation, and cardiovascular protection.
Curcumin With Piperine: Anti-inflammatory, Anticancer, And More
As a polyphenol, curcumin has a variety of health benefits. However, its big disadvantage is that curcumin is not well absorbed in the body. As an alkaloid, Piperine inhibits a variety of metabolic enzymes, thereby improving the oral bioavailability of many drugs and nutrients. Studies have shown that Piperine can significantly increase the bioavailability of curcumin by up to 20 times.
How Does Curcumin With Piperine Work In The Body?
First, Piperine makes curcumin easier to pass through the intestinal wall. And then it enters the bloodstream.
Second, piperine slows down the breakdown of curcumin by the liver. It can increase blood levels.
Therefore, Curcumin With Piperine is a powerful combination to increase the potential health benefits.
Curcumin With Piperine: A Powerful Anti-Inflammatory
Curcumin powder extracted from Turmeric has strong anti-inflammatory properties. It relieves pain. Therefore, it has a great effect in preventing and treating arthritis.
Piperine has also been shown to have anti-inflammatory and anti-arthritic properties. It helps desensitize specific pain receptors in the body. It further reduces the feeling of discomfort.
Curcumin With Piperine: Cancer Preventation
Curcumin reduces cancer’s growth, development, and spread at a molecular level. It may also cause the death of cancer cells. Piperine also plays a role in the death of certain cancer cells. It reduces the risk of tumor formation and inhibits the growth of cancer cells.
One study showed that curcumin and piperine, either alone or in combination, disrupted the self-renewal process of breast stem cells. This process is the origin of breast cancer.
Curcumin With Piperine And COVID19
In May 2021, published in the journal “Frontiers in Pharmacology,” the first double-blind, randomized controlled trial was conducted to study the adjuvant treatment effect of Curcumin With Piperine on COVID-19. Its research results show that oral administration of curcumin plus Piperine can significantly improve patient symptoms. And it reduces the length of hospital stay for moderate and severe patients.
The study ultimately included 140 symptomatic, non-critically ill adult patients who tested positive for COVID-19 antigen between July and September 2020. Subjects were randomly assigned to experimental and control groups. There were 70 patients in each group (30, 25, and 15 mild, moderate, and severe patients, respectively). Both groups of patients received conventional COVID-19 drug treatment in the region. Take supplements on top of this. The experimental group took curcumin (525 mg) and Piperine (2.5 mg) capsules. 2 times a day. The control group took lactic acid bacteria and B vitamins. The intervention time is 14 days.
The results showed that patients taking curcumin and Piperine orally with mild, moderate, and severe symptoms, including fever, cough, sore throat, and dyspnea, recovered earlier than those in the control group. They had fewer deteriorations during their hospitalization. In addition, fewer patients in the Turmeric + piperine group required ventilator support and developed thromboembolism. There were also fewer deaths. There were no deaths among mild and moderate cases in the experimental group. In the control group, 1 and 5 patients died, respectively.
Conclusion
Since the blood does not easily absorb Turmeric, one study found that adding 2 grams of curcumin to 20 mg of Piperine at a ratio of 100:1 can increase the absorption rate of curcumin. After adding Piperine, the absorption rate of curcumin increased to 20 times (i.e. 2000%). In addition to Piperine, gamma-cyclodextrin, phospholipids, etc., have been studied to improve the bioavailability of Turmeric. Nutri Avenue offers turmeric extract powder curcumin and its accompanying ingredients. Welcome to contact our sales team for detailed product information and the latest quotations.