Daidzein is a plant metabolite that may promote various activated patterns in the human body. It is believed to work as an antioxidant for the prevention of oxidative stress and a phytoestrogen. The compound is also found to have certain osteoprotective effects which makes it ideal for use among elderly women and those who are at risk for osteoporosis.
What is Daidzein?
Daidzein is a naturally occurring compound that is a member of the class of 7-hydroxyisoflavones. It is an inactive analog of the tyrosine kinase inhibitor genistein and an EC 188.8.131.52 (alpha-glucosidase) inhibitor. In plants, the compound is used as a signal carrier. It is also used as a defense against pathogenic attacks from various microbial bodies. Essentially, Daidzein is used in humans as it is shown to possess antineoplastic, anticholesterolemic, antioxidant, and anti-inflammatory effects.
Daidzein is also known as Daidzeol, isoaurostatin, 4′,7-Dihydroxyisoflavone, 7-Hydroxy-3-(4-hydroxyphenyl) chromen-4-one, 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, and 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one. It is identified as having CAS number 486-66-8 and molecular formula C15H10O4. Its molecular weight is 254.24 g/mol.
In its powder form, the compound is described to have the appearance of a pale-yellow prism. It is generally insoluble in aqueous buffers but is soluble in organic solvents such as DMSO, ethanol, and dimethylformamide.
Genistein and Daidzein
Genistein and Daidzein are among the most prevalent isoflavones found in soybeans. Both Genistein and Daidzein are believed to have contributory effects in the inhibition of key enzymes in the steroid metabolism pathway. In effect, these compounds influence levels of active estrogen in the body and prevent problems and health conditions associated with estrogen deficiency.
Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein
Flavonoids are phytonutrients known to contribute to anti-inflammatory effects in the human body. They are also known to help prevent oxidative stress in body cells. The most common flavonoids found in soybeans are Genistein, Kaempferol, Quercetin, and Daidzein.
When taken orally through dietary supplement products, Daidzein is metabolized by the intestinal flora via dihydrodaidzein and tetra-hydrodaidzein into equol. Equol is a metabolite with potent estrogenic activity. Studies reveal that Equol may be more potent than its precursor compound.
Daidzein may also be metabolized extensively into O-desmethylangolensin.
Daidzein food sources
Soybeans are among the most prevalent sources of Daidzein. Aside from Daidzein, soybeans also contain other isoflavones such as genistein and glycitein. It also contains saponins and phytic acid which improves the absorption of zinc and iron. Soybeans also contain relevant amounts of vitamins and minerals like Manganese, Copper, Phosphorus, and Thiamine.
Soy contains about 40% Daidzein, 50% Genistein and 10% glycitein.
Daidzein forms and specifications
Daidzein in dietary supplement formulations is commonly in the form of natural powder with 98% purity assay or synthetic powder with 99% purity assay. You may purchase Daidzein powder from various ingredient suppliers offering services online including Nutriavenue.
When you buy the product in bulk from Nutriavenue, it is usually packed in paper drums with two layers of poly bags inside. Each paper drum has a net weight of about 25 kilograms. You may also choose to buy the product in lesser quantities or request a different packaging material.
How does Daidzein work?
Daidzein works by interfering with several activated pathways in the human body. For one, it is believed to work by regulating certain transcription factors that are involved in the proliferation of preadipocytes and fat accumulation. It is also found to decrease blood sugar levels and improve the ratio between blood sugar and insulin in the body. With this, it is believed that the compound may promote weight loss and improve the management of Diabetes Mellitus.
Also, as a phytoestrogen, the compound works by interacting with estrogen receptors to produce estrogenic effects. The molecular structure of Daidzein as a phytoestrogen containing a phenolic ring can contribute to its action as a weak estrogen agonist or an antagonist to endogenous estrogen. Hence, its action is primarily to work as an equivalent of estrogen itself or to block estrogen effects in certain cases.
Health benefits of using Daidzein
The following are among the health benefits of Daidzein:
It provides menopausal relief
Menopause among women may produce various effects such as mood changes, hot flashes, night sweats, and insomnia. Studies reveal that by improving estrogen levels through phytoestrogens like Daidzein, menopausal women may experience relief from menopausal symptoms.
It may help prevent osteoporosis
Osteoporosis is one of the most common serious side effects of changes in hormonal levels among women. Improving estrogen levels through Daidzein supplementation may help support bone density and prevent osteoporosis.
It may improve blood cholesterol
Daidzein is also found to have significant benefits in improving blood cholesterol levels among postmenopausal women. The effect of Daidzein in improving cholesterol levels is even better than Genistein as found in studies.
It may improve heart health
By regulating blood cholesterol and blood glucose levels, it is claimed that Daidzein may have contributory effects in improving overall cardiac health. This is because many lifestyle-associated heart illnesses are related to high cholesterol and glucose in the body.
It may prevent breast cancer
Although the primary cause of breast cancer and other cancer types is still unknown, it is found that abnormalities in hormone levels may contribute to the development of the condition. Hence, it is beneficial to use phytoestrogenic compounds like Daidzein to prevent breast cancer.
Daidzein side effects
Taking Daidzein supplements is not necessarily associated with any serious side effects. Nonetheless, side effects like stomach ache, irritation, and diarrhea may develop within the first few intakes of the dietary supplement. These symptoms are expected to disappear immediately. However, if symptoms persist, it is important to discontinue the use of the compound and seek medical attention.
The recommended dosage for Daidzein supplementation may vary depending on individual age, weight, and overall health condition. Pregnant and lactating women, as well as those who are suffering from certain medical conditions, are advised to consult their physician before using the compound.
Where to buy bulk Daidzein?
Bulk Daidzein powder may be purchased from Nutriavenue, an FDA-registered ingredient supplier which has been in the market for several years. Our company is also recognized by entities like Kosher, Halal, and GMP.
We also offer shipping services for your convenience. We ship through air, sea, or couriers like UPS and FedEx. The rates for shipping may vary depending on your location and the quantity of the ingredients you purchase.
For more details on our products and services, you may check out our website at Nutriavenue.com or contact our customer service representatives. You may also avail of a free quote when you visit our page.