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Berberine HCl

Produktname Berberine HCl
Andere Namen Natural Yellow 18, Berberina, Umbellatine, Berbine, Berbamine, Coptisine, Phellamurin, Oregonic acid
CAS-Nummer 2086-83-1
Molecular Formula C20H18ClNO4
Molekulargewicht 371.82 g/mol
Anwendungen Körperpflegemittel, Nahrungsergänzungsmittel, funktionelle Lebensmittel, Tiernahrung, usw.
Paket 1kg, 5kg/bag, 25kg/drum

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What Is Berberine?

It is a natural alkaloid found in some plants, such as Hydrastis canadensis, Berberis vulgaris, and Mahonia aquifolium. This ingredient has a variety of pharmacological effects. It is mainly derived from the roots and bark of Coptis chinensis, a plant of Coptis.

Berberine powder has the appearance of yellow needle-shaped crystals. Its density is 1.17g/cm³, melting point is 204-205℃, boiling point is 486.8℃, refractive index is 1.662, and vapor pressure is 3.41E-05mmHg at 25°C. It is soluble in hot water, slightly soluble in water or ethanol, and very slightly in chloroform. But it is insoluble in ether. Its molecular formula is C20H18NO4+, and its molecular weight is 336.36 g/mol. ,

It is mainly used as an antibiotic in medicine to treat intestinal infections. In addition, it has been found to have the effects of lowering blood lipids, treating diabetes, and regulating blood lipids. Pharmacological studies have shown that this natural compound has significant therapeutic effects in antibacterial and anti-inflammatory aspects and has high clinical application value for tumors, diabetes, and cardiovascular diseases.

As a dietary supplement ingredient, Berberine is available in various forms, including capsules, tablets, pills, etc. It is often used as an herbal remedy or incorporated into formulations targeting specific health concerns.

Sources from

  • Goldenseal (Hydrastis Canadensis)

It is a herbaceous perennial plant native to North America. The roots and rhizomes of goldenseal contain significant amounts of this ingredient.

  • Barberry (Berberis vulgaris)

It is a shrub native to Europe, Asia, and North Africa. The bark, roots, and stem of barberry contain the active ingredient we talked about here.

  • Oregon grape (Mahonia aquifolium)

It is an evergreen shrub native to western North America. The roots and rhizomes of Oregon grapes contain this natural compound.

  • Chinese goldthread (Coptis chinensis)

It is a perennial herb native to China and other parts of Asia. The rhizomes of Chinese goldthread are rich in it.

What Is Berberine HCl?

Berberine HCl (full name: Berberine hydrochloride) is a derivative of berberine. It has been combined with hydrochloric acid to enhance its stability and absorption in the body. It is commonly used as a medicine or supplement, especially in traditional Chinese medicine.

Berberine VS Berberine HCl

Berberine is a natural alkaloid found in various plants with a wide range of pharmacological effects, including antibacterial, anti-inflammatory, hypoglycemic, and hypolipidemic effects. It is often used as a drug or supplement, especially in traditional Chinese medicine. It is a quaternary ammonium salt with low solubility in water.

Berberine hcl is the hydrochloride form of berberine. It increases the solubility of berberine in water, which makes it more commonly used in pharmaceutical preparations. The hydrochloride form is often used as an antibiotic to treat intestinal infections and has shown potential benefits for metabolic diseases in some studies.

In summary, the main difference between the two forms is their solubility and pharmaceutical applications. Berberine hydrochloride is more popular in the pharmaceutical industry due to its improved water solubility. Berberine itself has a longer history of use in traditional medicine.

What Is Dihydroberberine?

It is a naturally occurring isoquinoline alkaloid, a hydrogenated berberine derivative. Its CAS number is 483-15-8, with the molecular formula of C20H19NO4, and the molecular weight between 337.37-337.40 g/mol.

Berberine VS Dihydroberberine

This form is one of the 17 active metabolites of berberine. It is produced naturally by gut microbes and undergoes a reduction process before being absorbed into the intestines. Supplementing with dihydroberberine may eliminate the limiting step of microbial reduction and alleviate the gastrointestinal discomfort some people experience when using berberine supplements. This gastrointestinal discomfort may be due to malabsorption or as a result of the microbial reduction process.

Its structure (containing multiple hydrogen bonds) allows for better bioavailability and absorption and easier binding at the cellular level. Dihydroberberine is absorbed five times more in the intestine than berberine. In addition, dihydroberberine also lasts longer in the body – eight hours compared to just four hours for berberine.

Regarding controlling blood sugar levels, berberine increases blood sugar breakdown and utilization, improves insulin sensitivity, promotes fat oxidation, and inhibits adipocyte growth by activating the AMP-activated protein kinase (AMPK) pathway. Research suggests that dihydroberberine is more effective at improving insulin sensitivity. In an animal study, the group given dihydro berberine had more significant improvements in improving fat, triglyceride accumulation, and insulin sensitivity than the berberine group.

Another simulation model study compared the inhibitory effects of these two ingredients on pancreatic lipase. The results showed that dihydroberberine had a stronger inhibitory effect than regular berberine, which may make it a more effective weight-loss aid than berberine.

In studies on improving atherosclerosis, dihydroberberine showed stronger anti-inflammatory effects than berberine and was more beneficial for cardiovascular health.

Although berberine is an effective agent for improving insulin and blood sugar emissions, dihydroberberine is more effective in managing blood sugar and insulin. And it may also have positive effects on weight and cholesterol. If considering switching from berberine to dihydroberberine supplementation, the recommended dose is 400 to 500 mg, divided into two 200 mg or 250 mg doses.

Specifications Sheet Reference

  • Berberine HCL powder 97%/98%

Typ

Plant extract

Erscheinungsbild

Yellow needle-like crystalline powder

Sources From

Hydrastis canadensis, Berberis vulgaris, Mahonia aquifolium, etc.

Reinheit

≥ 98%

Partikelgröße

80 mesh or as per customer requirement

Zertifizierungen

Please contact our Sales Team to get

Lösungsmittel

Water

Wassergehalt

≤ 5%

Prüfverfahren

HPLC, UV-VIS

MOQ (Mindestbestellmenge)

1kg

Muster

Verfügbar (10-20g/Beutel)

OEM-Dienst

Available, such as capsules, tablets, pills, etc.

ODM Service

Verfügbar

Eigenmarke

Verfügbar

Auftragsfertigung

Verfügbar

Berberine VS Metformin VS Ozempic VS Inositol VS Chromium Picolinate

Berberine is a natural compound in various plants, including witch hazel, barberry, and Oregon grape. It has been used for centuries in traditional Chinese medicine and is well known for its potential health benefits. This natural compound improves blood sugar control, promotes weight loss, and supports heart health. It regulates blood sugar levels by activating AMP-activated protein kinase (AMPK). It is often called a metabolic master switch.

Metformin is an oral antidiabetic drug. It is a first-line drug for the treatment of type 2 diabetes. Its mechanism of action includes reducing glucose production in the liver, increasing glucose absorption and utilization by muscle tissue, and possibly affecting the intestinal microbiota.

Compared with berberine, some studies have shown that berberine may be as effective as metformin in lowering blood sugar. However, metformin has been extensively clinically studied and used for a long time, and its safety and effectiveness are widely recognized. Berberine is generally considered a natural product. It is being investigated as a complementary and alternative therapy, but its long-term effects and safety still need more clinical studies to confirm.

Ozempic is a prescription medication. It is used to treat type 2 diabetes and, in some cases, for weight loss. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. Ozempic works by stimulating insulin secretion, inhibiting glucagon secretion, slowing stomach emptying, and promoting weight loss.

Although the two may have similar effects in lowering blood sugar and promoting weight loss, there are differences in their mechanisms. Ozempic acts as a GLP-1 agonist, which works in the brain to reduce hunger and increase satiety. Berberine works by improving insulin sensitivity and fat oxidation. In addition, Ozempic is administered as a prescription drug. Berberine, on the other hand, is more easily available as a dietary supplement.

Some people on social media have hailed Berberine as “nature’s Ozempic.” But it’s important to note that it is not a version of Ozempic. The mechanism of action of this natural compound does not include producing a sense of fullness in the brain as Ozempic does.

Inositol, also known as vitamin B8, is a natural compound that plays a key role in many cell functions. It is found in many foods, including fruits, legumes, and grains. Inositol has been shown to support mental health, improve insulin sensitivity, and promote healthy hair and skin.

When Berberine and Inositol are used together, they can synergize. It means that their combined benefits are greater than the sum of their individual effects. Here are the many uses this powerful combination can provide.

  • Both have been shown to help regulate blood sugar levels. When used together, they can provide greater support for individuals with diabetes or insulin resistance.
  • Berberine supports cardiovascular health by lowering cholesterol levels and improving blood flow. Inositol can help lower blood pressure and reduce the risk of heart disease. When used in combination, they can provide comprehensive support for heart health.
  • Berberine enhances weight loss by increasing metabolism and reducing appetite. Inositol can help regulate hormones involved in weight management. They can be a powerful tool for achieving and maintaining a healthy weight when used together.
  • Inositol has a positive impact on mental health. It can reduce symptoms of anxiety and depression. When combined these two ingredients together, they can provide even greater support for individuals struggling with mood disorders.

Chromium Picolinate is a nutritional supplement ingredient commonly used to support the regulation of blood sugar levels. It contains chromium, a trace element essential to metabolic processes. Chromium Picolinate is thought to enhance the effects of insulin and help cells use blood sugar more efficiently, thereby supporting healthy body composition and weight management.

Berberine Factory: How To Manufacture It?

Step 1: High-quality plant materials known to contain this natural compound, such as goldenseal, barberry, or Oregon grape, are selected as the raw materials for the extraction.

Step 2: The plant material, typically the roots, rhizomes, or bark, is processed to release it. Different extraction methods, such as solvent extraction or steam distillation, separate the active ingredient from the rest of the plant components.

Step 3: The resulting liquid extract is filtered to remove solid particles and impurities, ensuring a cleaner solution.

Step 4: The filtered extract undergoes a concentration process to remove excess moisture and increase its content. Techniques like evaporation or spray drying may be employed to achieve the desired concentration.

Step 5: The concentrated extract may undergo purification to remove impurities and obtain a higher purity level. Techniques such as chromatography or crystallization can further refine and isolate it.

Step 6: The purified extract is subjected to drying methods to remove any remaining moisture and convert it into a dry, powdered form. Techniques like spray drying or freeze drying are commonly employed to preserve the integrity of the compound during the drying process.

Step 7: The final powder undergoes rigorous testing to ensure its quality, purity, and potency. Various analytical techniques, including HPLC, may be used to verify the composition and the product’s specifications.

Step 8: The tested and approved powder is packaged in appropriate containers or materials.

berberine powder manfacturing process

Berberine: Benefits, Uses, And More

For Weight Loss

This natural ingredient lowers blood sugar levels and improves insulin sensitivity. It helps improve metabolic syndrome and reduce the accumulation of body fat.

It may help improve the structure of the intestinal flora, reduce the entry of endotoxins into the blood, and reduce chronic inflammation. It achieves the purpose of weight loss by regulating the energy balance in the organism.

Studies have shown that this natural compound can help genetically obese mice and mice eating a high-fat diet increase energy consumption and control weight gain.

It has the effect of blocking liver lipid changes and obesity caused by a high-calorie diet.

It activates AMP-activated protein kinase (AMPK), an enzyme that regulates the body’s energy levels, helps burn fatty acids in cells, stabilizes receptors for low-density lipoprotein cholesterol, and inhibits lipid production in the liver.

The active ingredient can reduce total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels. At the same time, it increases high-density lipoprotein (“good” cholesterol) levels. It may reduce the risk of heart disease and indirectly support the weight loss process.

Finally, some clinical studies have shown that taking this substance can lead to weight loss. At the same time, it improves multiple health indicators, such as BMI and abdominal fat.

Other Benefits

  • Lowers Blood Sugar Levels

It significantly reduces blood sugar levels in people with type 2 diabetes. The effects are comparable to some popular diabetes medications, such as Metformin. It works by reducing insulin resistance, increasing glycolysis, reducing sugar production in the liver, slowing the breakdown of carbohydrates in the intestines, and increasing the number of beneficial bacteria in the intestines.

  • Lowers Cholesterol

Studies show that this natural compound can reduce total and LDL cholesterol and triglyceride levels while increasing HDL, which is “good” cholesterol, potentially reducing the risk of heart disease.

  • Antioxidant and Anti-Inflammatory

Preliminary studies show that it may be good for depression, cancer, infections, fatty liver disease, and heart failure.

Safe Or Not

Many studies have used doses between 900 and 1,500 mg daily, usually taken before meals. Berberine has an excellent safety profile. Its main side effects are related to the digestive system, including cramping, diarrhea, gas, constipation, and stomach pain.

Used For Various Application Fields

  • Weight loss supplements
  • Cardiovascular disease field
  • Regulating blood sugar
  • usw.

FDA-Approved: Yes Or No?

Berberine hcl is a compound with multiple pharmacological effects, including antibacterial, antiviral, anti-inflammatory, analgesic, and anti-tumor. However, the US FDA has not approved the substance as a drug for treating specific diseases.

It is mainly available in the US market as a dietary supplement ingredient.

Globally Berberine HCl Supplier: Nutri Avenue

Nutri Avenue is a global supplier focused on providing high-quality Berberine HCl. As a leading nutritional ingredient supplier, Nutri Avenue is committed to meeting the needs of the health industry. Our extensive distribution network brings this important bioactive ingredient to customers worldwide, including North America, South America, Mexico, Poland, Hungary, France, the United Kingdom, and more.

Our mission is to provide reliable supply chain solutions to its partners while constantly exploring and innovating to meet the ever-changing market needs. Whether in raw material procurement, production process, or final product distribution, Nutri Avenue is committed to providing customers with excellent service and support.

By choosing Nutri Avenue as your supplement ingredients supplier, you will get high-quality products, professional technical support, and customized service experience to ensure that your business needs are met and stay ahead in the competitive market.

FAQs

Coptis chinensis is a traditional Chinese herb known to contain berberine, but it is not the same as berberine itself.

Coptis chinensis is a plant from which berberine, an isoquinoline alkaloid, is isolated. The herb has been used in traditional medicine for various purposes, and berberine is one of its main bioactive components with a wide range of pharmacological properties.

Therefore, while berberine is a significant constituent of Coptis chinensis, the two are not identical. Coptis chinensis is the source plant, and the natural compound is an active compound derived from it.

Yes. It is a natural compound found in plants like Coptis chinensis, has been studied for its potential effects on weight loss and metabolic health.

Some studies have shown that berberine may lose weight by lowering blood sugar and regulating pancreatic islets, reducing body fat, affecting fat and protein metabolism, activating AMPK, and improving intestinal microorganisms.

No. It does not appear harmful to the kidneys and may offer protective effects against kidney disease. Studies have shown that the compound has antioxidant, anti-inflammatory, and anti-fibrotic effects. It can effectively improve kidney damage in diabetic nephropathy (DKD). The specific mechanism of action may include:
– Improvement of glucose and lipid metabolism
– Reduction of oxidative stress
– Reduction of inflammatory response
– Improvement of renal fibrosis
– Regulating DNA methylation
– Improving mitochondrial function
– Regulating intestinal flora, improving intestinal metabolism and clearance function

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