English 
Arabic 
Bulgarian 
Czech 
Dutch 
Estonian 
Finnish 
French 
German 
Hungarian 
Italian 
Japanese 
Korean 
Norwegian 
Polish 
Portuguese 
Russian 
Slovak 
Slovenian 
Spanish 
Swedish 
branded ingredient ErgoYoung™
ErgoYoung™ is a branded ingredient of Nutri Avenue. Also known as L-Ergothioneine, mercaptohistidine trimethylintrinsic salt, or EGT, it is a powerful energy-boosting antioxidant and cell protector that offers anti-aging, immune-boosting, and skin-health-improving effects.
The Benefits for ErgoYoung™
DNA PROTECTION
ErgoYoung™ (L-Ergothioneine) Aging and Cancer Prevention
Skin Health
ErgoYoung™ (L-Ergothioneine) Skin Aging and Skin Quality
Immune Function Boost
ErgoYoung™ (L-Ergothioneine) Protect Health
Neuroprotection
ErgoYoung™ (L-Ergothioneine) Reduce Oxidative Damage to Nerve Cells
Antioxidant Effect
ErgoYoung™ (L-Ergothioneine) Powerful Antioxidant
Anti-fatigue
ErgoYoung™ (L-Ergothioneine) Promote Energy Metabolism
Branded ingredient
What Is ErgoYoung™?
ErgoYoung™ is a branded ingredient of Nutri Avenue. Also known as L-Ergothioneine, mercaptohistidine trimethylintrinsic salt, or EGT, ErgoYoung™ is a powerful energy-boosting antioxidant and cell protector that offers anti-aging, immune-boosting, and skin-health-improving effects.
ErgoYoung™ (L-Ergothioneine) may help reduce the signs of aging by protecting cells from damage and inflammation.
Ergothioneine was first isolated from the mushroom Claviceps Purpurea in 1909. Studies show that it is 3-30 times more effective than glutathione, vitamin C, and coenzyme Q10.
ErgoYoung™ (L-Ergothioneine) may have a protective effect on the brain and can reduce the risk of neurodegenerative diseases.
L-Ergothioneine Powder (ErgoYoung™)
Our Advantage
branded ingredient ErgoYoung™ from Nutri Avenue Inc
usa fresh stock
We have prepared sufficient inventory in both CA and FL warehouses in the US, which can provide you with stable supply demand.
Safer & Better
Ergothioneine is considered to be 6,000 times more effective than vitamin E in many cellular-level biochemical reactions.
3rd party test report
We will do HPLC test report on each batch of ErgoYoung™ to ensure that the purity of each batch can exceed 99%.
free samples
We can provide free samples from our warehouses in USA and China for your inspection before the order.
SCIENCE
ErgoYoung™ Overview
ErgoYoung™ is a branded ingredient of Nutri Avenue. Also known as L-Ergothioneine, mercaptohistidine trimethylintrinsic salt, or EGT, it is a powerful energy-boosting antioxidant and cell protector that offers anti-aging, immune-boosting, and skin-health-is.
| Chemical Name: | L- Ergothioneine |
| CAS Number: | 497-30-3 |
| Molecular Formula: | C9H15N3O2S |
| Molecular Weight: | 229.30 g/mol |
| Packaging: | In double sealed PP bag. Net Weight: 1KG/bag |
| Main Benefits: | Promotes cognitive health. Powerful antioxidant properties Protects cells against oxidative stress. Helps maintain cardiovascular health Supports healthy aging and immune function |
| Application: | Dietary supplements |
L-Ergothioneine Benefits
The cellular protective properties of L-ergothioneine are remarkable and multifaceted. As a potent scavenger of reactive oxygen species (ROS) and reactive nitrogen species (RNS), it provides comprehensive protection against oxidative stress at the cellular level. This protective action extends to various cellular components, including proteins, lipids, and DNA, helping to maintain cellular integrity and function even under challenging conditions[1].
One of the most significant benefits of L-ergothioneine lies in its tissue-specific accumulation patterns. The compound demonstrates a remarkable ability to concentrate in tissues that are particularly susceptible to oxidative stress. It shows notable presence in erythrocytes, bone marrow, liver, and ocular tissues, where its protective properties are most needed. Additionally, its ability to cross the blood-brain barrier suggests significant potential for neuroprotection, making it particularly valuable for maintaining cognitive health[2][3].
The longevity-promoting aspects of L-ergothioneine represent another crucial benefit. Research has shown a strong association between ERG levels and reduced risk of age-related diseases. The compound plays a vital role in maintaining cellular health throughout the aging process, potentially contributing to increased health span. This is particularly significant given the growing evidence linking oxidative stress to various age-related conditions. By maintaining optimal cellular function and protecting against oxidative damage, L-ergothioneine may help support healthy aging and longevity[4].
Immune support
ErgoYoung™ may enhance immunity and lower infection risk.
Anti-Fatigue
It can increase energy and reduce fatigue.
Anti-Aging
It may help reduce the signs of aging by protecting cells from damage and inflammation.
Brain Health
It may have a protective effect on the brain and can reduce the risk of neurodegenerative diseases.
The Mechanism of Action of ErgoYoung™
OCTN-1 – The exclusive transporter protein of ergotothioneine.
The Distribution of OCTN1 Protein in Different Tissues
Comparison of ErgoYoung™ with other antioxidants
Safer, more targeted, and more effective
Ergothioneine is considered to be 6,000 times more effective than vitamin E in many cellular-level biochemical reactions.
Odorless & Moisture-Resistant Secret
Stable Ingredient Quality
Stability test
Stability test
The production process is stable, with over 100 batches continuously produced without quality complaints. Even after being stored at room temperature for one year, the purity of the product remains at 99.9%!
Clinical Trial Insights: ErgoYoung™’s Oral Efficacy on Skin Enhancement
Oral ErgoYoung™ Capsules: Clinical Trial Exploratory on Skin Condition Improvement
Objective: To meticulously analyze and comprehensively discuss the impact of oral administration of ErgoYoung™ on the cutaneous condition of the subjects using the VISIA photography methodology.
Methodology: A total of nineteen healthy subjects were enlisted, possessing an average age of 34.1 ± 5.46 years. Their skin conditions were predominantly typified by a sparse presence of acne, mild to moderate freckles, and a lackluster complexion. The subjects were administered 25mg/per capsule of ErgoYoung™ capsules, with a daily dosage of one capsule, for 4 weeks. VISIA photography was conducted before the commencement of ingestion, as well as 2 weeks and 4 weeks after the initiation of consumption. Simultaneously, relevant data were meticulously recorded and subjected to comprehensive statistical analysis.
Results: Upon the completion of 4 weeks of consumption, a notable amelioration in the overall state of the facial skin among the subjects was observed. Marked enhancements were detected in specific parameters, namely pore size, wrinkle reduction, ultraviolet freckle diminution, brown spot fading, and porphyrin level modulation. Throughout the entirety of the trial and in the post-trial period, no adverse reactions were reported by any of the subjects.
Conclusion: The present study demonstrates that the oral intake of ErgoYoung™ exerts a substantial influence on the enhancement of skin conditions. Particularly, prominent improvements are manifested in aspects such as pore refinement, porphyrin regulation, ultraviolet freckle mitigation, and brown spot attenuation.
It is further suggested that ErgoYoung™ capsules, when administered orally, are capable of effectuating certain degrees of amelioration in wrinkle reduction, sebum secretion modulation, and pigmentation alleviation.
This finding is in congruence with the established mechanism of action of ergotothioneine, which is endowed with the capacity to permeate and stimulate the basal cells of the skin, thereby diminishing pigmentation and oxidative stress, and ultimately addressing skin issues at a fundamental level.
It is thus inferred that ErgoYoung™ represents a potentially outstanding active ingredient in the realm of oral cosmetics.
Pores
Pores reflect the expansion of the sebaceous gland orifice. Generally speaking, the more sebum is secreted, the larger the pores will be. The denser the purple dots in the VISIA photo, the more severe the large pores. In this experiment, after 2 weeks of taking by the subjects, the value on the right side of the face increased significantly by 26.08% (p< 0.05); after 4 weeks of taking, the VISIA values of the subjects’ entire face increased significantly (p < 0.05), and the data of the left, front, and right three sides of the face increased by 42.89%, 46.40%, and 54.84% respectively. It indicates that oral ErgoYoung™ capsules can improve the condition of large pores on the skin to a certain extent.
Porphyria
Porphyria, also known as porphyrin, is a metabolite of some bacteria that live in hair follicles, reflecting the sebum secretion of sebaceous glands, and is often related to the onset of acne. A low value indicates a higher sebum secretion. In this experiment, the values of the subjects’ entire faces increased.
After 2 weeks of taking, the value of the subject’s frontal face increased significantly by 10.01% (p < 0.05); after 4 weeks of taking, the VISIA values of the subject’s entire face increased significantly (p < 0.05), and the data of the left, frontal, and right sides of the face increased by 10.71%, 13.50%, and 13.22% respectively. It shows that oral ErgoYoung™ capsules can to some extent improve the deposition of skin bacterial metabolites and can improve the condition of sebum secretion.
Wrinkles
Wrinkles reflect static lines such as facial dry lines and fine lines. The higher the value, the better the facial wrinkles. In this experiment, the facial wrinkles of the subjects were significantly improved. Among them, after 2 weeks of taking, the VISIA value of the subject’s left side face increased significantly by 13.4%, which was extremely significantly different from that before taking (p < 0.01). After 4 weeks of taking, the value of the subject’s left side face also increased extremely significantly by 21.61% (p<0.01), and the VISIA values of the frontal and right side faces increased significantly by 13.74% and 9.3% (p<0.05), respectively. It shows that oral ErgoYoung™ capsules can improve the skin wrinkle condition to a certain extent.
Ultraviolet Freckles
Ultraviolet Freckles are the result of skin damage from sun exposure, which occurs due to the accumulation of melanin under the epidermis. Ultraviolet Freckles are normally not visible to the naked eye and require the use of an instrument with trace ultraviolet rays for detection and observation. In daily life, if sunscreen is not done properly, the data of this indicator will generally be relatively low. In this indicator test, the overall values of the subjects have increased, and after 4 weeks of taking, the value of the subject’s frontal face has an extremely significant difference compared with before taking (p < 0.01), and the value has increased by 18.44%. It indicates that oral ErgoYoung™ capsules can to some extent improve the accumulation of facial melanin.
Brown Spots
Brown spots, which are also invisible to the naked eye, are deeper than UV spots and are hidden latent spots under the dermis, such as freckles, melasma, and age spots. As people age or the skin barrier function is damaged, deep spots in the skin may rise to the surface. In this indicator, the value of the subject’s right side face increased significantly by 7.99% after 2 weeks of taking (p <0.05); after 4 weeks of taking, the value of the subject’s right side face also had an extremely significant difference compared with before taking (p<0.01), increasing by 16.57%. It indicates that oral ErgoYoung™ capsules can to some extent improve the situation of deep facial pigmentation.
What is Used for L-Ergothioneine
FAQ
- What are the best dietary sources of L-ergothioneine?
A: The richest sources are mushrooms, particularly oyster, king bolete, and shiitake varieties. Other sources include black and red beans, oat bran, and organ meats[5].
- How much L-ergothioneine should I consume daily?
A: While there is no official recommended daily intake, studies suggest that the average dietary intake ranges from 1-4 mg per day. Higher intakes of up to 5-10 mg daily have been studied and shown to be safe[6].
- Can L-ergothioneine be synthesized by humans?
A: No, humans cannot synthesize L-ergothioneine. We obtain it exclusively through dietary sources or supplements. Our bodies have evolved a specific transporter (OCTN1/ETT) to actively take up and retain this compound[7].
References
[1] Franzoni F, et al. (2006) An in vitro study on the free radical scavenging properties of ergothioneine. Biomed Pharmacother, 60(8):453-7.
[2] Gruber J, et al. (2013) Mitochondrial changes in ageing Caenorhabditis elegans–what do we learn from superoxide dismutase knockouts? PLoS One, 8(3):e19444.
[3] Halliwell B, et al. (2016) The metabolism of ergothioneine in the body. Antioxidants, 5(4):38.
[4] Beelman RB, et al. (2019) Is ergothioneine a ‘longevity vitamin’ limited in the American diet? J Nutr Sci, 8:e16.
[5] Kalaras MD, et al. (2017) Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Food Chem, 233:429-433.
[6] Cheah IK, Halliwell B. (2020) Could Ergothioneine Aid in the Treatment of Coronavirus Patients? Antioxidants, 9(7):595.
[7] Gründemann D. (2012) The ergothioneine transporter controls and indicates ergothioneine activity–a review. Prev Med, 54 Suppl:S71-4.
