Apigenin Extract (Apicalm™)

Apicalm™ Overview

Apicalm™ is a branded ingredient of Nutri Avenue. Celery contains an important component called apigenin, one of the plants’ most widely distributed flavonoids. It can effectively control blood pressure and has anti-inflammatory, anti-tumor, and antioxidant effects.

¿Qué es la Apigenin (Apicalm™)?

Apigenin（Apicalm™）, a naturally occurring plant flavone (4′, 5, 7,-trihydroxyflavone) abundantly present in common fruits and vegetables including parsley, onions, oranges, tea, chamomile, wheat sprouts, and some seasonings, has been shown to possess remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties【1】.

Apigenin (Apicalm™) Beneficios

【POSSIBILITY OF IMPROVING SKIN】

One of apigenin’s most significant benefits lies in its antioxidant properties, which help strengthen the skin’s natural defense mechanisms against environmental stressors. Studies have also indicated its potential role in preventing certain types of skin cancer, though more research is needed in this area. Scientists are currently working on developing improved delivery systems to enhance this compound’s oral and topical bioavailability, which could increase its effectiveness in skincare applications.

Despite these promising findings from preclinical studies, it’s important to note that clinical research in humans is still pending. While the compound demonstrates an acceptable safety profile, more comprehensive clinical trials are needed to validate its effectiveness and safety in skincare products fully. Given the positive results from existing research, apigenin shows potential as a natural ingredient for future dermatological treatments. However, further scientific validation through human studies is essential before making definitive claims about its benefits.

Much research has been conducted on the beneficial effects of apigenin on various skin conditions such as dermatitis, wrinkles, skin spots, UV-induced inflammation, and skin cancers【2】.

【POTENTIAL AGAINST CANCERS】

It is promising in preventing some cancers and is not limited to leukemia, gastrointestinal, and ovarian cancers. This is because of its ability to block and reduce excess estrogen. 【3】

Apigenin (Apicalm™) may have the potential for prevention and therapy for prostate cancer, apigenin treatment resulted in the induction of apoptosis as determined by DNA fragmentation, PARP cleavage, fluorescence microscopy, and flow cytometry, and also resulted in down-modulation of the constitutive expression of NF-kappaB/p65.【4】

Apigenin (Apicalm™) has anti-hepatoma activity and is as effective as 5-FU and its apoptotic mechanism might be mediated through the p53-dependent pathway and the induction of p21 expression.【5】

It possesses therapeutic potential against cancers, the combination of gemcitabine and apigenin enhances anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction【6】

【POWERFUL FLAVONOID】

A flavonoid commonly found in fruits and vegetables has emerged as a promising compound for various dermatological applications. Research has demonstrated its potential to protect against UV-induced skin damage, making it valuable for sun protection strategies. The compound’s remarkable anti-inflammatory properties work by suppressing pro-inflammatory cytokines and inflammatory mediators, showing particular promise in treating conditions like vitiligo and dermatitis.

It also can improve the immune system. The anti-inflammatory properties of apigenin are evident in studies showing suppression of LPS-induced cyclooxygenase-2 and nitric oxide synthase-2 activity and expression in mouse macrophages.【7】

【CALM YOUR NERVOUS SYSTEM】

Studies suggest that the natural components of Apigenin help reduce stress levels. Our Apigenin (Apicalm™) supplement incorporates potent natural ingredients, known for its potential stress-reducing properties, thereby helping to lower stress levels and indirectly promoting brain health and overall well-being.

【PROVIDES A RESTFUL SLEEP】

It can be found in many plants, including chamomile, parsley, and celery. It may support sleep, relaxation, immunity & brain health. It supports immune system health, normal sleep patterns, relaxation, skin & brain health, and cognition. It works by activating chloride ion channels, calming overall neuronal activity in the forebrain, and allowing the body to enter a more restful state.

Source of Apigenin (Apicalm™)

Apigenin (Apicalm™) is present principally as glycosylated in significant amounts in vegetables (parsley, celery, onions) fruits (oranges), herbs (chamomile, thyme, oregano, basil), and plant-based beverages (tea, beer, and wine).

Could commonly be prepared from its raw materials via solvent extraction with alcohol, and further purification steps.

Production Process of Apigenin (Apicalm™)

Clinical Trials Concerning Apigenin【8】

Natural Dietary Sources of Apigenin

The name apigenin derives from the Apiaceae genus Apium, also known as Umbelliferae and is a unique ingredient in chamomile (Matricaria chamomilla), an annual herb native to western Asia and Europe. Drinks prepared from chamomile contain from 0.8% to 1.2% of apigenin. Apigenin is abundant in a variety of other dietary sources [16], including fruits and vegetables (Figure 2), such as celery seeds (78.65 mg/100 g), spinach (62.0 mg/100 g), parsley (45.04 mg/100 g), marjoram (4.40 mg/100 g), Italian oregano (3.5 mg/100 g), sage (2.40 mg/100 g), chamomile (3 to 5 mg/100 g) and pistachio (0.03 mg/100 g), but the richest sources are the respective dried sources.【9】

Formula for a Dietary Supplement (Per Capsule or Serving):

Functionality: Antioxidant, Immunity enhancer

Application as Dietary supplements

Functionality: Effects on depression and insomnia.

Application as Hair Caring

Functionality: Hair Nutrition

Apigenin (Apicalm™) – HNMR

Apigenin (Apicalm™) – HPLC（Sample Information）

Certificate of Analysis

Apigenin (Apicalm™) MOA

Why Choose US?

• Natural appearance

Most apigenin on the market is usually gray due to low purity and impurities. Our apigenin has a light yellow appearance.

• Physical control

After strict physical control, our finished product achieves 5% NMT drying loss and 95% 80 mesh particle size.

• USP standard quality control

As a pioneer in biosynthesis technology, the international USP standard is adopted to strictly control the content of three heavy metals in the finished product, lead, arsenic, mercury, and three microorganisms.

We can provide apigenin of different specifications to meet customers’ various formulation requirements. The existing inventory ensures timely delivery, stable product quality, and sample testing is available.

The packaging of Apigenin (Apicalm™)

Packaging & Storage Packaging

– For 1 kilogram: packed in aluminum foil bags.

– For 25 kilograms: packed in paper drums (both round and square) or paper drums with iron rings.

Storage conditions

Store in a well-ventilated and dry environment, avoiding direct exposure to strong light and high-temperature conditions.

FAQ

Q： What are the precautions for taking products containing Apigenin (Apicalm™)?

A： Try to avoid alcohol, caffeine-containing foods, or beverages after taking it. Based on the principle of caution, pregnant women, teenagers, and children should avoid taking it. Based on the principle of caution, it should be avoided to be taken simultaneously with medications.

Q： What are the main functions of Apigenin (Apicalm™)?

A： This substance exhibits multiple beneficial effects, including anti-tumor and chemotherapy sensitization effects, antioxidant and anti-inflammatory effects, the ability to lower blood pressure, improvement in heart health, and relief of anxiety. 

Q: How is Apigenin (Apicalm™) consumed?

A: It can be obtained through the diet by consuming foods rich in apigenin, like the aforementioned parsley and celery. Some dietary supplements also contain apigenin in various forms, such as capsules or tablets. However, it’s important to note that taking supplements should be done under the guidance of a healthcare professional to ensure appropriate dosage and safety.

Referencias

【1】Patel D, Shukla S, Gupta S. Int J Oncol, 2007, 30(1):233-45.

【2】Bahadır Acıkara et al., 2019; Choi et al., 2016; Man et al., 2012; Zhao et al., 2017

【3】Mackey S. Promoting lifestyle modification for cancer prevention. Journal of the American Dietetic Association. 2004;104:1568–1569. doi: 10.1016/j.jada.2004.08.015. 

【4】Gupta S, Afaq F, Mukhtar H. Oncogene, 2002, 21(23):3727-38.

【5】Chiang, Lien-Chai, Ng, et al. Cancer Lett, 2006, 237(2):207-14.

【6】Lee S H, Ryu J K, Lee K Y, et al. Cancer Lett, 2008, 259(1):39-49.

【7】Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF, Lin JK. Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis. 1999;20:1945–1952. doi: 10.1093/carcin/20.10.1945.

【8】Bahare Salehi, etc., The Therapeutic Potential of Apigenin, Int. J. Mol. Sci. Int. J. Mol. Sci. 2019, 20, 1305 2019.

【9】McKay, D.L.; Blumberg, J.B. A review of chamomile tea’s bioactivity and potential health benefits (Matricaria recutita L.). Phytother. Res. 2006, 20, 519–530.