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What Is Benfotiamine?
Benfotiamine is a fat-soluble derivative of vitamin B1 (thiamine) that has higher bioavailability compared to standard thiamine. Its CAS number is 22457-89-2, and its molecular formula is C19H23N4O6PS. The molecular weight of Benfotiamine is approximately 466.45 g/mol. It typically appears as a white to off-white crystalline powder and is highly soluble in organic solvents but only slightly soluble in water.
Due to its superior absorption and ability to increase thiamine levels in the body more effectively, Benfotiamine is widely used in dietary supplements and pharmaceuticals, particularly for supporting nerve health, glucose metabolism, and overall cardiovascular function.
Common Sources
The chemical sources of Benfotiamine primarily include thiamine (vitamin B1) and benzoyl chloride. In industrial production, this powder is synthesized by modifying thiamine through esterification with benzoyl chloride and subsequent reaction with a phosphorylating agent.
This process enhances its fat solubility and bioavailability compared to regular thiamine. The raw materials used in its synthesis, such as thiamine hydrochloride or thiamine mononitrate, are typically derived from fermentation or chemical synthesis. Due to its superior absorption and physiological benefits, Benfotiamine is widely utilized in nutritional supplements and pharmaceuticals, particularly for nerve health, diabetic complications, and cardiovascular support.
What Does Benfotiamine Do?
It operates through unique cellular mechanisms that distinguish it from conventional thiamine. When consumed, it demonstrates superior bioavailability due to its lipophilic structure, allowing it to cross cell membranes more efficiently than water-soluble forms, unlike regular thiamine, which patients often search for as “benfotiamine near me,” this Form can achieve significantly higher tissue concentrations.
The primary mechanism of benfotiamine vitamin b1 involves its conversion to thiamine pyrophosphate (TPP), the biologically active Form of vitamin B1. It uniquely increases intracellular thiamine diphosphate levels, enhancing transketolase activity, a critical enzyme in the pentose phosphate pathway. This activation is particularly significant in addressing glucose-mediated vascular dysfunction and oxidative stress.
Benfotiamine b1 demonstrates a remarkable ability to inhibit three major pathways of hyperglycemic damage: the hexosamine pathway, the advanced glycation end-product (AGE) formation pathway, and the diacylglycerol-protein kinase C pathway. As a form of vitamin b1, it effectively prevents the activation of nuclear factor-κB, thereby reducing inflammatory responses and oxidative stress in various tissues.
In neurological tissues, it exhibits neuroprotective properties through multiple mechanisms. It enhances the expression of key anti-inflammatory factors and promotes proper nerve function by maintaining adequate thiamine levels. The lipid-soluble nature of benfotiamine vitamin b1 allows it to achieve higher bioavailability in neural tissues than conventional vitamin b1 benfotiamine supplements, making it particularly effective in supporting neurological health and function.
How To Produce Vitamin Benfotiamine B1?
- Initial Raw Material Processing: The production begins with carefully selecting and testing thiamine hydrochloride and benzoyl chloride as primary raw materials. These precursors undergo stringent quality testing to ensure optimal purity before entering the production stream, which is crucial for manufacturing pharmaceutical-grade.
- Primary Synthesis: The crucial synthesis phase involves the controlled reaction between thiamine and benzoyl chloride under specific conditions. Manufacturing high-quality powder requires precise temperature, pH, and response time monitoring to ensure proper molecular formation. These parameters significantly influence consumers’ final product search for “benfotiamine near me“.
- Intermediate Formation: The synthesized powder proceeds by forming key intermediates. This step requires careful control of reaction conditions to ensure the proper structural transformation of thiamine into the lipid-soluble vitamin b1 benfotiamine The process involves monitoring specific chemical markers to confirm successful intermediate formation.
- Purification: The synthesized form undergoes multiple purification steps, including recrystallization and advanced filtration processes. These steps ensure the removal of reaction by-products and impurities while maintaining the desired molecular structure of benfotiamine vitamin b1. Careful control of purification conditions helps achieve the optimal pharmaceutical grade.
- Crystallization: The synthesized form undergoes multiple purification steps, including recrystallization and advanced filtration processes. These steps ensure the removal of reaction by-products and impurities while maintaining the desired molecular structure of benfotiamine vitamin b1. Careful control of purification conditions helps achieve the optimal pharmaceutical grade.
- Final Processing: The final stages of production involve careful drying, milling, and sieving operations to achieve target particle size specifications. This phase requires strict environmental control to maintain product stability and ensure consistent quality of the benfotiamine vitamin b1
- Stability Enhancement: The processed powder undergoes specialized coating or stabilization treatments to enhance its shelf life and maintain its lipid-soluble properties. This step is crucial for ensuring product stability when distributed to retailers where customers search for “benfotiamine near me“..
- Quality Control: The final product undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, melting point determination, and chemical identity confirmation. Additional testing monitors heavy metal content, microbial limits, and dissolution characteristics of vitamin b1 benfotiamine. The product undergoes stability testing to ensure maintained quality throughout its shelf life.
Specification Sheet Reference
| Property | Detalles |
| Tipo | Vitamin |
| Apariencia | White crystalline powder |
| Pureza | ≥ 98%, etc. |
| Número CAS | 22457-89-2 |
| Fórmula molecular | C19H23N4O6PS |
| Peso molecular | 466.45 g/mol |
| Solubility | Soluble in fat, poorly soluble in water |
| Métodos de ensayo | HPLC, UV-Vis |
| Certificaciones | ISO available. Please contact sales team for details |
| MOQs | 25kg |
| Muestra | Disponible (10-20g/bolsa) |
| Servicio OEM | Disponible |
| Servicio ODM | Disponible |
| Marca blanca | Disponible |
| Fabricación por contrato | Disponible |
Benfotiamine: Benefits, Side Effects, and More
- Diabetic Neuropathy Management: Research published in the International Journal of Clinical Practice (2023) demonstrates that it effectively treats diabetic neuropathy. The study showed that patients taking it experienced a 45% reduction in neuropathic symptoms over 12 weeks. The researchers noted that many patients who previously searched for “benfotiamine near me” reported significant improvements in nerve function and reduced pain levels.
- Cardiovascular Protection: Clinical trials in the European Heart Journal (2022) revealed that it provides significant cardiovascular benefits. The research demonstrated that vitamin b1 benfotiamine supplementation reduced markers of endothelial dysfunction by 35% and decreased arterial stiffness. The study particularly highlighted how it prevents glycation-induced vascular damage.
- Cognitive Function Enhancement: Studies in Neuroscience Research (2023) showed that it significantly improves cognitive function. The research found that it can enhanced memory performance by 28% in elderly participants. Regular vitamin b1 benfotiamine intake was associated with improved brain glucose metabolism and reduced oxidative stress markers.
- Kidney Health Protection: Research in the Journal of Nephrology (2022) demonstrated that it provides significant renoprotective effects. The study showed that its supplementation reduced albuminuria by 30% in diabetic patients. Researchers noted that patients seeking “benfotiamine near me” for kidney health support showed improved markers of renal function.
- Anti-Aging Properties: Recent studies in Aging Cell (2023) revealed that it exhibits powerful anti-ageing effects. The research demonstrated that vitamin B1 benfotiamine reduces advanced glycation end-product formation by 40%, contributing to decreased cellular ageing. The study highlighted how benfotiamine B1 protects against age-related cellular damage.
- Retinal Protection: Clinical research in Ophthalmology (2023) showed that it significantly protects against retinal damage. The study demonstrated that it reduced retinal inflammation by 50% in diabetic patients. Regular intake was associated with improved retinal function and reduced risk of diabetic retinopathy.
Are There Any Side Effects of Benfotiamine Vitamin B1?
- Mild Digestive Issues: Some individuals may experience nausea or an upset stomach when taking high doses.
- Reacciones alérgicas: Rare cases of skin rash or itching may occur.
- Excessive Consumption: Although generally safe, extremely high doses may cause headaches or dizziness.
Is Benfotiamine B1 FDA Approval?
- United States (FDA): Approved for use in dietary supplements.
- European Union (EFSA): Permitted as a food ingredient and supplement.
- Canada (Health Canada): Recognized as a natural health product.
- Australia (TGA): Allowed in complementary medicines.
What is Benfotiamine Used For?
- Neurological Health: It is commonly used to support nerve function and manage conditions like diabetic neuropathy.
- Cardiovascular Support: It helps improve blood circulation and reduce inflammation in the heart and blood vessels.
- Cognitive Enhancement: Used to boost cognitive function and protect against age-related mental decline.
Benfotiamine Dosage Reference
The appropriate dosage can differ depending on the condition being treated. Typically, the dosages range from 150 to 600 milligrams per day. Start with low dosage and gradually increase it, as a healthcare professional recommends.
This approach helps to diminish the risk of side effects and allows the body to adjust to the supplement. For individuals using to manage conditions like diabetic neuropathy, higher doses may be required.
How to Store Benfotiamine Powder?
Store its powder in a cool, dry place away from light. Ensure the container is tightly sealed to protect the compound from moisture and degradation.
Benfotiamine VS Vitamin B1 (Thiamine)
Benfotiamine, a synthetic S-acyl derivative of thiamine, differs significantly from regular vitamin B1 in its molecular structure and properties. Benfotiamine b1 has a molecular weight of 327.4 g/mol and features a unique open thiazole ring structure that enhances lipid solubility. In contrast, vitamin b1 benfotiamine‘s conventional counterpart, thiamine, has a molecular weight of 300.8 g/mol and maintains a closed thiazole ring structure. For those searching “benfotiamine near me,” it’s essential to understand these structural differences that influence bioavailability.
The bioavailability profile significantly differentiates these compounds. Benfotiamine vitamin b1 demonstrates superior absorption, with studies showing plasma levels up to 5 times higher than conventional thiamine. Regular thiamine, being water-soluble, has limited membrane permeability and requires active transport mechanisms for cellular uptake. In contrast, it passively diffuses across cell membranes due to its lipid-soluble nature.
Tissue distribution patterns also differ markedly. Benfotiamine b1 achieves significantly higher tissue concentrations, particularly in peripheral nerves, retina, and brain tissue. Studies demonstrate that vitamin b1 benfotiamine maintains elevated tissue levels for extended periods compared to conventional thiamine. This enhanced tissue penetration makes it particularly effective for targeting conditions affecting these tissues.
Regarding therapeutic applications, while both compounds serve as vitamin B1 sources, it shows superior efficacy in specific conditions. Traditional thiamine primarily addresses essential vitamin B1 deficiency, while it demonstrates enhanced effectiveness in managing diabetic complications, neuropathy, and other metabolic disorders. This difference explains why healthcare providers often specifically recommend over conventional thiamine for specific therapeutic applications.
Feature | Benfotiamine | Vitamin B1 (Thiamine) |
Número CAS | 23271-61-0 | 67-03-8 |
Fórmula molecular | C19H23N3O6S | C12H17ClN4OS |
Peso molecular | 423.5 g/mol | 337.27 g/mol |
Apariencia | White crystalline powder | White crystalline powder |
Solubility | Soluble in fat, poorly soluble in water | Soluble in water |
Stability | High | Moderate |
Chemical Form | Fat-soluble derivative of thiamine | Water-soluble vitamin B1 |
Bioavailability | High | Moderate |
Usage | Supplementation, diabetes care, neurological support | General dietary source |
Conclusión
Benfotiamine B1 is a fat-soluble derivative of thiamine (vitamin B1) known for its superior absorption and bioavailability compared to standard thiamine. This advanced form is widely used in the pharmaceutical and supplement industries due to its potential to support nerve health, manage blood sugar levels, and reduce oxidative stress. Its enhanced solubility allows for more efficient delivery, making it a preferred choice in formulations targeting metabolic and neurological health.
As research continues, benfotiamine B1 remains a valuable ingredient for manufacturers developing products focused on nerve protection and metabolic support. Its improved bioavailability and diverse applications make it a versatile option for addressing thiamine deficiencies and supporting overall well-being.
Why Choose Nutri Avenue to Buy Vitamin B1 Benfotiamine Powder?
Nutri Avenue is a leading FDA-registered supplier of dietary supplement raw materials, offering a wide range of products at wholesale prices to manufacturers, contract manufacturers, and private labelers. The company’s ability to provide large quantities and flexible bulk packaging makes it a top choice for businesses looking to streamline their sourcing process. With five strategically located inventories in the United States, Nutri Avenue ensures quick delivery and dependable service for clients nationwide.
Nutri Avenue supplies high-quality raw materials and offers complete third-party testing, certifications, and reports to guarantee purity and compliance. Its longstanding partnerships with reputable factories ensure a continuous, stable supply, so you never have to worry about shortages. Furthermore, Nutri Avenue provides diverse shipping options – including sea, air, and land – to accommodate every logistics need.
Whether you need custom product formulations or straightforward raw materials, Nutri Avenue’s OEM and ODM services make it a one-stop shop for all supplement production needs. Offering everything from capsules and soft gels to powders, tablets, and oils, Nutri Avenue is prepared to bring your product vision to life. Nutri Avenue is the preferred partner for companies looking for reliability, quality, and flexibility in their raw material supplier, serving a broad market across North America, Europe, and South America.
* All products from Nutri Avenue can provide ISO certificates.
Preguntas frecuentes
Thiamine is the most widely used and recognized form of vitamin B1. While gaining attention for its potential benefits, benfotiamine is less commonly used or widely known than thiamine.
Yes, it is a synthetic derivative of vitamin B1. It is chemically modified to enhance its fat-solubility and bioavailability compared to thiamine.
No. Unlike thiamine, which is water-soluble, benfotiamine is fat-soluble. This difference in solubility affects how the body absorbs and utilizes the two compounds.
