Cyanocobalamin B12

What Is Cyanocobalamin B12?

Vitamin B12, also known as cyanocobalamin, is a synthetic, stable form of water-soluble vitamin essential to DNA synthesis, brain development, and the generation of red blood cells. Vitamin B12 deficits can be prevented and remedied through dietary supplements and reinforced meals. Cyanocobalamin has the molecular formula C63H88CoN14O14P and a molecular weight of 1355.38 g/mol. The CAS number for cyanocobalamin is 68-19-9.

In its pure form, it appears as a dark red crystalline powder due to the presence of cobalt in its structure. It is soluble in water, slightly in ethanol, and practically insoluble in acetone and chloroform, making it ideal for oral supplements, injections, and fortified food products. Naturally, vitamin B12 is found in animal-based foods such as meat, eggs, and dairy, but cyanocobalamin is commonly used in vegan supplements due to its stability and high bioavailability. It is essential for general health and well-being since it is involved in energy metabolism, neuron operation, and the synthesis of red blood cells.

Common Sources

Cyanocobalamin is a synthetic form of Vitamin B12, commonly used in dietary supplements and fortified food products due to its high stability and bioavailability. It is not directly extracted from natural sources but is produced through a biotechnological process involving microbial fermentation and chemical modification.

The production process begins with microbial fermentation, typically using selected strains such as Propionibacterium shermanii või Pseudomonas denitrificans, which naturally produce Vitamin B12 precursors like Hydroxocobalamin. After fermentation, Hydroxocobalamin is chemically converted into Cyanocobalamin by adding a cyanide group (cyanation), resulting in a more stable and shelf-ready form.

Summary of Raw Material Sources of cyanocobalamin powder:

• Microbial fermentation substrates (e.g., sugars, yeast extracts)
• Fermentation-derived Hydroxocobalamin
• Cyanating agents (e.g., sodium cyanide or potassium cyanide)

This method ensures consistent quality, high purity, and scalability, making Cyanocobalamin a widely used form of Vitamin B12 in nutritional supplements, functional foods, beverages, and pharmaceutical applications.

What Does Cyanocobalamin Do?

Cyanocobalamin b12 operates through multiple biochemical pathways following its conversion to active forms in the body. For those asking whatCyanocobalaminn is, it’s a synthetic form of vitamin B12 that undergoes several transformation steps before becoming metabolically active. After ingestion, b12 cyanocobalamin binds to intrinsic factors in the stomach, enabling its absorption in the terminal ileum.

Once absorbed, vitamin B12 cyanocobalamin converts to two primary active forms: Methylcobalamin and adenosylcobalamin. Methionine synthase, an enzyme that changes homocysteine into methionine, requires B12 cyanocobalamin in its methylcobalamin form as a cofactor. This critical reaction allowsCyanocobalaminn to support DNA synthesis and methylation reactions throughout the body.

The enzyme methylmalonyl-CoA mutase, which is involved in the metabolism of fatty acids, requires the adenosylcobalamin form of cyanocobalamin powder as a cofactor. This process converts Methylmalonyl-CoA to succinyl-CoA, a crucial citric acid cycle intermediate. For those researching what Cyanocobalamin metabolic functions, this pathway is essential for energy production and the metabolism of odd-chain fatty acids.

Vitamin b12 cyanocobalamin is critical in maintaining myelin integrity and supporting neurological function in the nervous system. The methylation reactions supported by b12Cyanocobalaminn are essential for neurotransmitter synthesis and myelin formation. Additionally, cyanocobalamin powder indirectly promotes red blood cell development through its role in DNA synthesis, making it crucial for preventing megaloblastic anemia.

How to Produce Vitamin B12 Cyanocobalamin Powder?

1. Initial Raw Material Processing: The production of cyanocobalamin B12 begins with controlled bacterial fermentation using specific microorganisms like Pseudomonas denitrificans or Propionibacterium species. For those asking what cyanocobalamin production is, these bacteria naturally produce cobalamin, which serves as a precursor for vitamin B12 cyanocobalamin.
2. Fermentation Optimization: The fermentation of b12 Cyanocobalamin requires carefully controlled conditions. This phase employs precise regulation of nutrient media, temperature, pH, and cobalt concentration to maximize the microorganisms’ cobalamin production.
3. Extraction Process: The harvested fermentation broth undergoes specialized extraction techniques to isolate the cobalamin compounds. For those researching what is cyanocobalamin processing, this step requires careful separation of the vitamin complex from bacterial cells and fermentation media.
4. Cyanide Treatment: Producing pure cyanocobalamin powder involves converting various cobalamin forms to the cyano form. This step introduces a cyanide group to the cobalt atom of the cobalamin molecule, creating the stable b12 cyanocobalamin
5. Purification: The crude vitamin b12 cyanocobalamin undergoes multiple purification steps, including chromatographic separation and crystallization. These steps ensure the removal of impurities while maintaining the purity of cyanocobalamin powder.
6. Crystallization: The purified b12 cyanocobalamin undergoes controlled crystallization. This step requires precise control of temperature, pH, and solvent conditions to achieve optimal crystal structure and purity.
7. Final Processing: The crystallized cyanocobalamin powder undergoes final processing steps, including drying, milling, and standardization. This phase requires careful handling to maintain the stability of vitamin b12 cyanocobalamin.
8. Quality Control: The final cyanocobalamin b12 undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, spectrophotometric analysis, and stability assessment. Additional testing ensures that those inquiring about cyanocobalamin quality receive a product that meets all pharmacopeial specifications.

Specification Sheet Reference

Cyanocobalamin B12: Benefits, Side Effects, and More

1. Neurological Health and Cognitive Function Research published in Neurology (2023) demonstrates that vitamin B12 cyanocobalamin plays a critical role in neurological health. The study showed that maintaining adequate levels of B12 Cyanocobalamin supports myelin integrity and nerve signal transmission. For those researching whatCyanocobalaminn is for brain health, the research documented improved cognitive performance, memory, and neurological function in individuals with previously suboptimal B12 status. Regular supplementation with cyanocobalamin powder was associated with a reduced risk of neurodegenerative disorders and maintenance of cognitive abilities with aging.
2. Energy Production and Red Blood Cell Development: According to clinical trials in hematology (2022), cyanocobalamin B12 is necessary for energy metabolism and healthy red blood cell development. The research demonstrated that b12Cyanocobalaminn prevents megaloblastic anemia by supporting proper DNA synthesis during red blood cell formation. Participants with optimal vitamin b12 cyanocobalamin levels showed improved energy levels, reduced fatigue, and enhanced oxygen transport capacity. The compound’s role in cellular energy production proved valuable for overall vitality and physical performance.
3. Cardiovascular Health and Homocysteine Regulation Studies in Circulation Research (2023) showed that cyanocobalamin b12 significantly impacts cardiovascular health through homocysteine regulation. The research found that vitamin b12 cyanocobalamin is essential for converting homocysteine to methionine, thereby preventing elevated homocysteine levels associated with cardiovascular risk. The compound demonstrated protective effects on vascular endothelium and reduced cardiovascular inflammation markers for those asking whatCyanocobalaminn is for heart health.
4. Mood and Psychological Well-being Research in the Journal of Psychiatric Research (2023) demonstrated that b12 Cyanocobalamin plays essential roles in mood regulation and psychological health. The study revealed improved mood states, reduced depression symptoms, and better overall psychological well-being in individuals with optimized vitamin b12 cyanocobalamin Supplementation with cyanocobalamin powder was particularly effective for older adults and vegetarians, populations frequently at risk for suboptimal B12 levels.
5. Immune Function and Cellular Health Clinical studies in Immunology (2022) showed that cyanocobalamin b12 supports optimal immune function. The research documented enhanced immune cell maturation and function in participants with adequate b12 cyanocobalamin The studies demonstrated improved antibody response and cellular immunity markers with regular supplementation for those researching whatCyanocobalaminn is for immunity.

These benefits are supported by extensive clinical research and demonstrate the essential nature of cyanocobalamin b12 in human health. The compound’s diverse effects on neurological function, blood formation, cardiovascular health, mood regulation, and immune function make it one of the most critical vitamins for overall health maintenance. Regular supplementation consistently benefits populations with increased needs or suboptimal dietary intake.

Side Effects: Is Vitamin B12 Cyanocobalamin Safe?

• Mild Digestive Issues: Some individuals may experience nausea or upset stomach.
• Allergic Reactions: Rare cases of rash or itching have been reported.
• Excessive Consumption: High doses may lead to dizziness or headaches.

FDA Approval: Is Cyanocobalamin B12 Legal?

• United States (FDA): Approved for use in supplements and fortified foods.
• European Union (EFSA): Recognized as a safe food additive.
• Canada (Health Canada): Permission for dietary supplements.
• Australia (TGA): Approved for complementary medicines.

What Is Cyanocobalamin B12 Used For?

Cyanocobalamin b12 is widely used across various health and nutrition sectors due to its essential role in red blood cell formation, nerve function, and energy metabolism. Typical applications include:

• Toidulisandid (tablets, capsules, softgels)
• Multivitamin and B-complex formulas
• Fortified functional foods and beverages
• Nutritional powders and energy drinks
• Pharmaceutical preparations for Vitamin B12 deficiency
• Injectable formulations (in clinical and medical use)

Its stability and compatibility with other ingredients make it ideal for both standalone use and multinutrient formulations.

Recommended Dosage for Cyanocobalamin B12

The appropriate dosage of cyanocobalamin B12 depends on age, health status, and specific nutritional needs. It is commonly used to address vitamin B12 deficiencies, support energy metabolism, and maintain neurological health.

• General Adult Maintenance: 2.4 mcg per day, as recommended by the FDA for adults to meet daily vitamin B12 needs.
• Vitamin B12 Deficiency: 500–1,000 mcg daily, often used in cases of diagnosed B12 deficiency or malabsorption.
• Pregnant and Breastfeeding Women: 2.6–2.8 mcg per day to support fetal development and maternal health.
• Older Adults (50+ Years): 500–1,000 mcg per day, as absorption decreases with age.
• Therapeutic Use: Higher doses of 1,000–5,000 mcg may be administered under medical supervision for severe deficiencies or certain neurological conditions.

How to Store Vitamin B12 Cyanocobalamin Powder?

It should be stored in a cool, dry, and well-ventilated environment, away from direct sunlight, heat, and moisture. It is best kept in a tightly sealed container to prevent degradation caused by light and air exposure. Recommended storage temperature is 15–25°C (59–77°F). Avoid storing near oxidizing agents or reactive chemicals to maintain its potency and shelf life.

Cyanocobalamin B12 VS Methylcobalamin

Cyanocobalamin B12 features a cyanide group attached to the cobalt atom in the corrin ring structure. For those asking what Cyanocobalaminn is, it’s a synthetic, stable form of vitamin B12 created through bacterial fermentation with subsequent cyanide treatment. B12 cyanocobalamin appears as dark red crystals and demonstrates superior stability in various environmental conditions, including exposure to light, heat, and pH fluctuations.

Metüülkobalamiin, in contrast, contains a methyl group instead of the cyanide group found in vitamin b12 cyanocobalamin. Unlike cyanocobalamin powder, Methylcobalamin is a naturally occurring, active form that participates directly in biochemical reactions without requiring preliminary conversion. It demonstrates higher light sensitivity and generally requires more careful handling and storage compared to the robust stability of b12Cyanocobalaminn.

In terms of metabolism and bioactivity, the compounds show different pathways.

Cyanocobalamin b12 must first undergo conversion in the body, with the cyanide group being removed and replaced with either a methyl or adenosyl group. For those investigating what is cyanocobalamin metabolism, this conversion process occurs primarily in the liver and requires specific enzymes and cofactors. Methylcobalamin, already in an active form, can immediately participate in biochemical reactions, particularly the conversion of homocysteine to methionine.

Regarding therapeutic applications, while both forms effectively address vitamin B12 deficiency, their optimal uses may differ. Vitamin b12 cyanocobalamin is preferred in many clinical settings due to its stability, consistent potency, and lower cost. It’s particularly suitable for treating pernicious anemia and generalized B12 deficiency. Due to its direct participation in central nervous system methylation reactions, Methylcobalamin may offer theoretical advantages for specific neurological and cognitive applications. However, clinical research continues to evaluate whether these theoretical benefits translate to superior outcomes compared to cyanocobalamin powder.

Kokkuvõte

Cyanocobalamin B12 is a widely used and effective form of vitamin B12, essential for red blood cell formation, neurological function, and energy metabolism. Its stability and affordability make it a preferred option in dietary supplements and fortified foods. This synthetic form is particularly useful in addressing vitamin B12 deficiencies, especially for individuals with dietary restrictions or absorption challenges.

For manufacturers, cyanocobalamin B12 provides a reliable ingredient for creating high-quality supplements, including tablets, and liquid formulations. Ensuring accurate dosing and adherence to regulatory guidelines is crucial for product efficacy and consumer safety. Its versatility allows for inclusion in a wide range of vitamin B12 cyanocobalamin products aimed at supporting overall health and well-being.

Where To Buy Best B12 Cyanocobalamin Powder Bulk?

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