Earthworm Extract

What Is Earthworm Extract?

Earthworm Extract is a biologically active substance derived from earthworms, commonly used in traditional medicine and modern health supplements for its potential anti-inflammatory, fibrinolytic, and immune-boosting properties.

Since it is a natural extract rather than a single chemical compound, it does not have a fixed CAS number, but specific active components within the extract, such as lumbrokinase (CAS 556743-18-1), may be individually classified. The primary bioactive components of Earthworm Extract include lumbrokinase, proteolytic enzymes, and various peptides, which contribute to its potential cardiovascular and circulatory benefits. The molecular formula and molecular weight vary depending on the specific bioactive compounds present.

In terms of appearance, Earthworm Extract is typically a light brown to yellowish-brown powder, with good water solubility due to its protein and enzyme content. It is widely used in dietary supplements and traditional medicine, particularly for supporting cardiovascular health, improving circulation, and reducing blood clot formation.

Earthworm Extract is not derived from plants, but from earthworms, which are the source material for the extract. The extract is obtained by processing and hydrolyzing earthworms to release their bioactive components.

Active Ingredients In Earthworms

1. Lumbrokinase: A group of proteolytic enzymes found in earthworms, known for their fibrinolytic activity, which can help break down fibrin, the protein involved in blood clotting.
2. Collagen: Present in earthworm tissues, collagen contributes to the extract’s potential benefits for joint health and tissue repair.
3. Peptides: These bioactive peptides are involved in various physiological processes, such as immune system modulation and anti-inflammatory effects.
4. Amino acids: Earthworm extract contains essential amino acids that support muscle repair and cell regeneration.

These active components make Earthworm Extract valuable in traditional medicine and modern supplements, especially for südame-veresoonkonna tervis, circulatory improvement, and wound healing.

What Does Earthworm Extract Do?

Lumbrokinase, derived from earthworms, demonstrates sophisticated fibrinolytic activity through multiple pathways. When entering the bloodstream, this complex of enzymes exhibits both direct and indirect fibrinolytic effects. The compound directly degrades fibrin while activating plasminogen to plasmin, creating a comprehensive approach to supporting healthy blood flow.

Earthworm extract powder operates through multiple mechanisms affecting blood viscosity and coagulation. The enzymes present in the extract demonstrate remarkable specificity for fibrin, showing minimal interaction with other blood proteins. This selective action allows for targeted effects on blood clots while maintaining normal coagulation parameters. Additionally, lumbrokinase supports the body’s natural fibrinolytic systems by enhancing endogenous enzyme activity.

The molecular activities extend beyond simple fibrinolysis to include anti-inflammatory and antioxidant effects. The compound influences various aspects of blood rheology while supporting vascular health through multiple pathways. This multi-target approach comprehensively affects circulatory health without disrupting standard hemostatic mechanisms.

How to Extract Earthworms?

1. Tooraine valik: The production of earthworm extract begins with carefully selected Lumbricus rubellus or Eisenia fetida species. Each batch of earthworms undergoes comprehensive authentication through DNA testing and microscopic analysis. Quality parameters include species verification, optimal growth conditions verification, and complete toxicological screening. The earthworms must be cultivated in controlled environments free from contaminants and fed organic materials to ensure lumbrokinase quality.
2. Initial Processing Phase: Fresh earthworms undergo careful cleaning and preparation under controlled conditions (temperature 4°C). This stage employs specialized washing systems with purified water to remove external contaminants. The process includes careful inspection and selection of healthy specimens. Multiple washing cycles ensure optimal cleanliness while maintaining the integrity of active enzymes in earthworm extract powder.
3. Enzyme Extraction Process: The extraction employs sophisticated multi-stage technologies optimized for maximum enzyme recovery. Initial extraction utilizes carefully selected buffer solutions under precisely controlled temperature and pH conditions. Multiple extraction cycles ensure optimal recovery of fibrinolytic enzymes while preserving their activity. Continuous monitoring through enzymatic assays guides the extraction process.
4. Purification and Concentration: The crude extract undergoes multiple purification stages utilizing advanced separation technologies. Initial separation employs membrane filtration and various chromatographic techniques to isolate active enzymes. Each stage employs specific parameters to ensure optimal separation while maintaining enzyme activity. The process includes careful monitoring of temperature and pH to preserve the biological activity of lumbrokinase.
5. Quality Control and Packaging: The final product undergoes comprehensive testing, including fibrinolytic activity assays, protein content analysis, heavy metal screening, and complete microbiological evaluation. Advanced analytical methods verify enzyme purity and activity levels. The finished earthworm extract powder receives specialized packaging in high-barrier, moisture-resistant containers under controlled temperature conditions. Storage specifications require temperatures below 8°C and humidity below 40% to ensure 24-month stability with maintained enzyme activity.

Specification Sheet Reference

Earthworm Extract: Benefits, Side Effects, and More

1. Cardiovascular Health Support: Earthworm extract, particularly its active component lumbrokinase, has shown promising effects on cardiovascular health. A 2013 study published in the Journal of Thrombosis and Thrombolysis found that lumbrokinase can effectively dissolve blood clots and improve blood circulation (Yan et al., 2013). This fibrinolytic activity makes earthworm extract powder a potential natural alternative for preventing and treating cardiovascular diseases.
2. Anti-inflammatory Properties: Research has demonstrated the anti-inflammatory effects of earthworm extract. A 2012 study in the Journal of Ethnopharmacology reported that earthworm extract reduced inflammation markers in animal models (Chang et al., 2012). This anti-inflammatory action may benefit various chronic conditions, including arthritis and inflammatory bowel diseases.
3. Neuroprotective Effects: Earthworm extract has shown potential neuroprotective properties. A 2015 study in Molecules found that earthworm extract neutralized a potential oxidative stress-induced neuronal cell death (Li et al., 2015). This suggests that earthworm extract powder might have applications in preventing or managing neurodegenerative diseases.
4. Antioxidant Activity: The antioxidant properties of earthworm extract have been well-documented. A 2018 study in the International Journal of Biological Macromolecules reported that earthworm extract exhibited vigorous free radical scavenging activity (Wang et al., 2018). These antioxidants can help protect cells from oxidation damage and may enhance overall health and longevity.
5. Liver Protection: Earthworm extract has shown hepatoprotective effects in several studies. A 2013 research article in the Journal of Ethnopharmacology demonstrated that earthworm extract protects liver cells against toxin-induced damage (Li et al., 2013). This suggests potential applications for earthworm extract powder in liver health supplements.
6. Immune System Modulation: Studies have indicated that earthworm extract can modulate immune system function. A 2011 study in Biological and Pharmaceutical Bulletin found that earthworm extract enhanced the activity and effect of the body’s natural killer cells and increased the production of immunoglobulins (Balamurugan et al., 2011). This immune-boosting effect could be beneficial for overall health and disease prevention.
7. Wound Healing Properties: Earthworm extract has demonstrated wound-healing properties. A 2014 Evidence-Based Complementary and Alternative Medicine study reported that earthworm extract accelerated wound healing in animal models (Goodarzi et al., 2014). This suggests potential applications in topical treatments for wounds and skin conditions like serums and creams.
8. Anti-cancer Potential: While more research is needed, some studies have suggested the anti-cancer potential of earthworm extract. A 2016 study in Scientific Reports found that lumbrokinase from earthworm extract inhibited the growth and metastasis of breast cancer cells in vitro (Fu et al., 2016). This opens up possibilities for further research into earthworm extract’s role in cancer prevention and treatment.

Side Effects: Is Earthworm Safe?

• It is generally well-tolerated but may cause mild digestive discomfort in some individuals.
• People taking blood-thinning medications should consult a healthcare provider before use.
• It is not recommended for individuals with bleeding disorders or upcoming surgical procedures.

FDA Approval: Is Earthworm Extract Legal?

• United States (FDA): Recognized as a dietary supplement ingredient.
• European Union (EFSA): Approved for use in food supplements.
• Canada (Health Canada): Permitted in natural health products.
• Australia (TGA): Allowed in complementary medicines.

What is Earthworm Extract Used For?

1. Dietary Supplements: Earthworm Extract is commonly added to cardiovascular health supplements due to its fibrinolytic properties, which help improve circulation and support heart health. It is also included in immune-boosting and anti-inflammatory supplements.
2. Joint Health Formulations: The extract is used in joint health products to promote tissue repair and support mobility, thanks to its collagen and amino acid content. It is often found in glucosamine or chondroitin-based supplements.
3. Wound Healing Products: Earthworm Extract is used in topical creams, gels, and ointments for wound healing, as it helps promote tissue regeneration and speed up recovery for cuts, bruises, and surgical wounds.
4. Skin Care Products: Due to its collagen and regenerative properties, Earthworm Extract is found in anti-aging and skin repair creams. It helps improve skin elasticity, reduce wrinkles, and support overall skin health.
5. Traditional Medicine Formulations: It is also used in various herbal remedies and traditional medicine products, especially for detoxification, reducing inflammation, and promoting vitality.

Overall, Earthworm Extract is versatile and can be added to supplements, skin care products, wound care formulations, and traditional medicine products, making it a valuable ingredient in various health and wellness industries.

How to Store Earthworm Extract Powder?

Store in a cool, dry place away from direct sunlight and moisture. Ensure airtight packaging to maintain enzyme stability and prevent oxidation.

Earthworm Extract VS Lumbrokinase

Earthworm extract represents a broader spectrum of compounds derived from earthworms. At the same time, lumbrokinase refers specifically to the purified fibrinolytic enzymes isolated from the extract. This fundamental difference influences their composition, potency, and applications. Earthworm extract powder contains various bioactive compounds, including peptides, enzymes, and other beneficial molecules. At the same time, lumbrokinase consists of specific isolated enzymes with focused fibrinolytic activity.

The potency and standardization of these compounds show marked differences. Pure lumbrokinase demonstrates higher specific activity and more predictable effects due to its isolated and standardized nature, typically measured in fibrinolytic units (FU). Lumbrokinase derived through isolation processes shows 15-20 times higher specific activity than crude earthworm extract. This difference in potency directly influences dosing requirements and therapeutic applications.

Manufacturing processes reveal substantial differences in complexity and sophistication. Earthworm extract powder production involves straightforward extraction procedures, while lumbrokinase requires advanced enzyme isolation and purification technologies. The additional processing steps for lumbrokinase, including multiple chromatographic separations and activity standardization, result in higher production costs but yield a more concentrated and specific product.

Stability and storage requirements also distinguish these forms. Pure lumbrokinase typically requires more stringent storage conditions to maintain enzyme activity, often needing refrigeration and protection from moisture. Earthworm extract, while still requiring careful storage, demonstrates better stability under various conditions due to the protective effects of its complex matrix. This difference in stability influences shelf life, storage requirements, and practical applications.

Clinical applications and effectiveness show distinct patterns between these forms. While both support cardiovascular health, lumbrokinase provides more targeted and potent fibrinolytic effects, making it preferred for specific therapeutic applications. Earthworm extract offers broader health benefits due to its diverse compound profile. However, it may require higher doses to achieve similar fibrinolytic effects. This difference in specificity and potency makes each form suitable for different applications and user needs.

Kokkuvõte

Earthworm extract is a unique bioactive substance known for its potential applications in health and wellness formulations. Rich in enzymes like lumbrokinase, it is primarily used in supplements aimed at supporting cardiovascular health, promoting circulation, and reducing inflammation. Its natural origin and enzyme-rich profile make it an innovative choice for manufacturers seeking to develop specialized products for these health benefits.

When sourcing earthworm extract, it is essential for manufacturers to prioritize high-purity formulations and standardized enzyme activity to ensure product consistency and efficacy. This extract’s diverse applications in the nutraceutical and pharmaceutical industries make it a valuable component in modern health supplements.

Why Choose Nutri Avenue To Buy Earthworm Extract?

Nutri Avenue leads the nutraceutical industry as a forward-thinking FDA-registered supplier dedicated exclusively to raw materials for dietary supplements, delivering innovative solutions to manufacturers, contract manufacturers, and private labelers worldwide. Our dynamic operational framework centers on five strategically positioned local inventories across the United States, enabling us to provide thousands of different raw materials in bulk quantities at competitive wholesale prices.

In today’s quality-conscious market, we maintain exceptional standards through comprehensive third-party testing, digital certificates, and detailed reports, supported by strategic partnerships with major factories that ensure resilient and responsive supply chains. Our expansive global reach extends throughout North America, Mexico, and key European territories, including Poland, Hungary, France, and the United Kingdom, alongside vital South American markets such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay.

We’ve optimized our distribution network with innovative transportation solutions, including sea, land, and air shipping options, ensuring agile delivery systems for modern supply chain requirements. Beyond raw material supply, Nutri Avenue offers advanced OEM and ODM services, providing integrated solutions from material procurement to product customization. Our contemporary manufacturing capabilities span multiple formats, including capsules, soft gels, tablets, powders, and oils, enabling us to deliver cutting-edge solutions while maintaining superior quality throughout production.

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