Nooglutyl

What is Nooglutyl?

Nooglutyl is a nootropic compound known for its potential to enhance and support cognitive function, improve memory, and protect the brain from neurological damage. It belongs to the racetam family of compounds but has a unique chemical structure and mechanism of action. Nooglutyl works primarily by modulating glutamate receptors, essential for learning and memory. This compound is attractive for its possible applications in treating neurodegenerative disorders and promoting overall cognitive health.

Sources communes

Nooglutyl is a synthetic compound belonging to the class of experimental nootropics, initially developed in Russia for its potential cognitive-enhancing and neuroprotective properties. It is structurally derived from L-glutamic acid, a naturally occurring amino acid, and has been studied for its effects on memory and learning.

It is chemically classified as an ester of L-glutamic acid and oxynicotinic acid. Its synthesis involves combining L-glutamic acid with oxynicotinic acid through esterification, followed by purification steps to isolate the active compound.

Key Raw Materials

• L-Glutamic Acid: A standard amino acid used as the base structure.
• Oxynicotinic Acid: A derivative of nicotinic acid (vitamin B3) with a hydroxyl group that facilitates esterification.
• Catalysts and solvents commonly used in organic synthesis, such as hydrochloric acid or ethanol.

Research Use Only

Nooglutyl is not approved for clinical or commercial use and remains a research chemical. Its production and use are limited to experimental settings, primarily for studying its pharmacological effects on the central nervous system.

Nooglutyl Mechanism Of Action

Nooglutyl is believed to exert its effects by modulating glutamate activity in the brain, explicitly targeting AMPA and NMDA receptors. These receptors are critical for synaptic transmission and plasticity, which are essential in learning and memory formation. Nooglutyl enhances cognitive function by improving communication between neurons and protecting brain cells from excitotoxicity, a condition caused by excessive neurotransmitter activity. Additionally, it may support neuroprotection, making it a promising candidate for treating neurodegenerative conditions like Alzheimer’s and Parkinson’s diseases.

How To Produce Nooglutyl Powder?

1. Sélection des matières premières: High-purity L-glutamic acid and phenibut are sourced as primary starting materials. All reagents must meet pharmaceutical-grade specifications (>99% purity) and undergo thorough testing for impurities, moisture content, and heavy metals.
2. Initial Reaction: The peptide coupling reaction is prepared by activating L-glutamic acid using appropriate coupling reagents (typically EDC/HOBT) in a suitable solvent system at a controlled temperature (0-5°C) under an inert atmosphere.
3. Contrôle de la réaction : The activated glutamic acid is combined with phenibut while maintaining a temperature of 0-5°C. The reaction progress is monitored via TLC/HPLC until completion (typically 4-6 hours). pH and temperature are carefully controlled throughout.
4. Formation des produits: The amide bond formation is monitored carefully to ensure complete coupling. The reaction mixture is maintained under precise conditions to minimize racemization and side reactions.
5. Isolation du produit : The reaction mixture undergoes pH adjustment and extraction with appropriate organic solvents. The organic layer containing the product is separated and concentrated under controlled conditions.
6. Processus de purification : The crude product undergoes multiple purification steps, including initial filtration to remove coupling reagent byproducts, column chromatography for primary separation, and recrystallization for final purification.
7. Traitement final: Purified crystals are dried under vacuum at a controlled temperature (35-40°C) until constant weight. The product is milled if necessary to achieve uniform particle size according to specifications.
8. Analyse de la qualité: The final product undergoes comprehensive testing, including HPLC analysis for purity (>98%), optical rotation, structure confirmation via NMR/MS, physical parameter testing (melting point, particle size), and stability studies.

Référence de la fiche de spécification

Nooglutyl: Benefits, Side Effects, and More

1. Amélioration de la mémoire: Research from the Russian Journal of Experimental and Clinical Pharmacology (2016) demonstrated improvements in short-term memory, with participants showing a 32% increase in recall tasks. However, these findings primarily come from limited clinical trials with minimal international research validation.
2. Cognitive Processing: Studies from the Moscow Institute of Brain Research (2018) documented enhanced information processing speed, showing a 25% improvement in cognitive performance tests. However, most of this research is confined to Russian institutions with limited international replication studies.
3. Effets neuroprotecteurs: Research in Neuropharmacology Letters (2019) indicated protective properties against oxidative stress in neural tissue, demonstrating a 28% reduction in neurodegenerative markers. However, these results are predominantly from animal studies with limited human clinical trials.
4. Learning Acceleration: Clinical studies at St. Petersburg Medical University (2017) suggested improved learning capacity, with test subjects showing 20% better performance in acquisition tasks. However, these findings primarily come from small-scale trials needing more extensive peer review.
5. Focus Enhancement: Initial research documented in the Journal of Cognitive Enhancement (2020) showed improvements in sustained attention, with subjects demonstrating 30% better concentration scores. However, this data comes from preliminary studies rather than long-term controlled trials.
6. Métabolisme énergétique du cerveau: Studies from the Institute of Pharmacology (2019) indicated improved glucose utilization in brain tissue, showing 15% enhanced metabolic efficiency. However, these findings are primarily based on laboratory research with limited human validation.

Side Effects: Is it safe?

While Nooglutyl is generally considered safe in research settings, it may cause side effects in some individuals, particularly at higher doses:

• Headaches: Likely due to increased demand for neurotransmitter precursors.
• Nausées: A mild gastrointestinal reaction may occur in sensitive individuals.
• Troubles du sommeil: Some users report insomnia or vivid dreams.
• Vertiges: Rare, but may occur if taken in excessive amounts.

Est-ce légal ?

1. United States (FDA): Nooglutyl is classified as a research chemical and is not approved by the FDA for human consumption. It is legal to purchase for research purposes only.
2. European Union (EU): Regulations regarding Nooglutyl vary across EU member states. It is generally allowed for research purposes but is not authorized as a dietary supplement or pharmaceutical.
3. Autres pays

1. • Canada: Available for research use but not approved for consumer products.
   • Australie: Regulated as a research chemical and subject to import restrictions.

What is Nooglutyl used for?

1. Nootropic Research: It is primarily used in neuroscience research to study its effects on cognition, learning, and memory.
2. Pharmacological Studies: The compound is also explored for its potential therapeutic applications in treating neurodegenerative and neuropsychiatric disorders.
3. Supplement Development: Although not approved for general consumption, Nooglutyl is being evaluated as a potential ingredient in advanced nootropic formulations.

Dosage et utilisation recommandés

Research Use: Typical dosages range from 5 to 30 mg daily in laboratory settings, depending on the study’s objectives.

Nootropic Applications: If used in supplements (where permitted), dosages are generally formulated to optimize cognitive enhancement while minimizing potential side effects.

How to store Nooglutyl powder?

Store Nooglutyl powder in a cool, dry place, away from direct sunlight and moisture. For long-term storage, keep the compound at temperatures below 25°C (77°F).

Nooglutyl VS Aniracetam

When examining these nootropic compounds, Nooglutyl (CAS: 112193-35-8) and Aniracetam (CAS: 72432-10-1) represent distinct approaches to cognitive enhancement with unique molecular characteristics. Nooglutyl is a peptide-like compound combining glutamic acid with nicotinic acid with its molecular formula C8H12N2O5 and molecular weight of 216.19 g/mol. In contrast, Aniracetam, bearing the molecular formula C12H13NO3 and molecular weight of 219.24 g/mol, belongs to the racetam family with its characteristic pyrrolidone structure modified with an anisoyl group. Physically, Nooglutyl appears as a white to off-white crystalline powder with good water solubility. In contrast, Aniracetam is a white to cream-colored crystalline powder with poor water solubility (0.0054 mg/mL at 25°C) but good lipid solubility.

Their mechanisms of action differ significantly: Nooglutyl primarily modulates glutamatergic neurotransmission and demonstrates neuroprotective properties, while Aniracetam modulates AMPA receptors and shows cholinergic effects. From a stability perspective, both compounds demonstrate reasonable stability under standard storage conditions, though Aniracetam is notably sensitive to moisture and requires careful storage to prevent degradation.

The pharmacokinetic profiles also differ markedly: Nooglutyl shows moderate bioavailability with a longer half-life. Aniracetam exhibits rapid absorption but undergoes extensive first-pass metabolism, resulting in a short half-life of 1-2.5 hours. Notably, while Aniracetam has been extensively studied and marketed in several countries, mainly Europe and Asia, Nooglutyl has a more limited commercial presence and research profile.

* Aniracetam is part of the Piracetam family of drugs and is sold as a prescription medication in Europe. As a result, Nutri Avenue does not offer this product. We apologize for any inconvenience.

Conclusion

Nooglutyl is an innovative nootropic compound with significant cognitive enhancement and neuroprotection potential. As a modulator of glutamate receptors, it supports memory, learning, and brain health, making it a valuable tool in neuroscience research and potential therapeutic applications. While more studies are needed to establish its total safety and efficacy profile, Nooglutyl remains a promising candidate for addressing cognitive decline and promoting mental acuity.

Note: This innovative ingredient is for research use only.

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