Genistein: A Phytoestrogen Isoflavone to Reduce Menopausal Symptoms and Support Bone Health for Women

Genistein reduces menopausal symptoms

Genistein: A Phytoestrogen Isoflavone to Reduce Menopausal Symptoms and Support Bone Health for Women

Genistein is an isoflavone compound known to help regulate estrogen levels and prevent degenerative conditions associated with estrogen decline among premenopausal and menopausal women. It also possesses antioxidant, anthelmintic, anti-inflammatory, and antihypertensive properties.

What is Genistein?

Genistein is an antineoplastic agent which is commonly obtained through natural dietary sources such as soybeans, tofu, and kudzu. It is also included in dietary supplement formulations along with other compounds to promote optimum health and wellness. The compound is especially beneficial to women who are experiencing various symptoms due to aging-associated hormonal imbalances. It may also be helpful in the prevention of osteoporosis due to abnormalities in estrogen levels.

When included in dietary supplement formulations, Genistein has a light yellow to yellowish powder appearance. It is identified through its molecular formula C15H10O5 and CAS number 446-72-0. The molecular weight of the compound is 270.241 g/mol and it is generally insoluble in water. Genistein is one of the most studied potential anti-cancer compounds used in modern-day health supplements.

Genistein food sources

Genistein in dietary supplements is primarily isolated from Sophora Japonica fruit or Soy extract. It is also found in several fruits and vegetables like strawberries, plums, mangoes, and cranberries. The compound may also be isolated from currants, figs, raisins, and various nuts.

Genistein soy complex

Soy phytoestrogens like Genistein and Daidzein are known to influence active estrogen levels and protect individuals from chronic debilitating diseases. Genistein aglycone which is the active form of genistein possesses anti-osteoporotic properties as established in health studies. Experts say that the Genistein soy complex may help improve overall health, especially among elderly women. Studies also show that the Genistein soy complex may especially work against breast cancer cell proliferation.

Aglycone form vs Glycoside form of Isoflavones

In one study, it was provided that in terms of bioavailability, both aglycone and glycoside forms of isoflavones have equal bioavailability rates. However, in another study, experts have found that aglycone forms of isoflavones are more readily absorbed than glycoside forms among humans. It is also found in the same study that aglycone forms are absorbed in higher quantities.

Genistein forms and specifications

Genistein powder 98% is generally sold as an ingredient in many dietary supplement formulations. It may be purchased in bulk or lesser quantities in legitimate ingredient suppliers online like Nutriavenue. Depending on the customer’s preference, the product is usually packed in paper drums with two layers of poly bags inside. 

Genistein manufacturing process

Genistein can be obtained from plant sources. Its glycoside from sophoricoside yields abundant Genistein for up-scale production in the industry. In one method, sophoricoside is hydrolyzed by a strain of Rhizopus oryzae. After biotransformation procedures are optimized, the said method produces Genistein. This is an alternative and more efficient manufacturing method for the compound.

How does Genistein work?

Genistein performs several vital functions in the human body. As an anti-neoplastic compound, experts say that it works by inhibiting protein-tyrosine kinase and topoisomerase-II activity. The compound also activates certain pathways and mechanisms in the body which results in apoptotic cell death. It also directly works as an antioxidant, making it effective in the reducing effects of circulating free radicals in the body cells. Genistein also modulates vascular inflammation which results in effective prevention of atherosclerosis.

Genistein health benefits

Genistein provides health benefits which include the following:

It reduces menopausal symptoms

Postmenopausal women often experience a variety of symptoms due to fluctuations in their hormone levels. Some of these symptoms include hot flushes, irritation, osteoporotic symptoms, and even depression. Several studies have suggested that Genistein supplementation may effectively reduce menopausal symptoms among elderly women and promote overall quality of life. This is because it may improve estrogen production through various active mechanisms.

Studies also show that women in the postmenopausal phase have higher risks to develop breast cancers. Research shows, however, that Genistein supplementation may effectively reduce breast cancer growth and proliferation.

It helps maintain normal cell growth

Interestingly, experts have found in a study that while Genistein inhibits the growth of rapidly proliferating cancer cells, it does not affect the growth and development of normal cells. Also, by acting as an antioxidant, Genistein may promote cell growth as it helps eliminate free radicals in the interstitial spaces of body cells which often interfere with normal cell development.

It supports immune system and bone marrow health

In one study, experts have found that Genistein effectively modulates immunity and increases disease resistance of individual users. This is because it increases cytotoxic T-cells activity and promotes phagocytic cell responses. 

Health experts also claim in studies that Genistein supplementation promotes bone marrow hemopoiesis and improves overall bone health.

Genistein side effects

The side effects of using takingGenistein supplements include the development of mild gastrointestinal symptoms such as stomach irritation and stomach cramps. However, most users do not experience symptoms. Upon the development of adverse reactions against Genistein supplementation such as severe headaches and changes in vital signs, individual users are advised to discontinue use of the compound and immediately consult their physicians.

Genistein dosage

The recommended dosage for Genistein supplementation is 30 to 60 mg per day. However, the recommended dose may change depending on the individual user’s age, weight, and overall physical condition.

Where to buy bulk Genistein?

You may purchase high-quality Genistein powder at very affordable prices from Nutriavenue, an FDA-registered company that is recognized by Halal, Kosher, and GMP. Our company offers a wide range of ingredients which you may check out when you visit our page at

We offer our products in bulk and small quantities. You may also get a free quote when you visit our website. As a company dedicated to serving its clients, we consider your suggestions and preferences when you make a purchase. Our technical support staff is also ready to answer your queries, should you have any.

Our company also offers shipping services through air, sea, and couriers like UPS and FedEx. Shipping fee rates depending on the quantity of your purchase and your location.

Share this post with your friends

Get a Free Quote

Stay In Touch

How can we help? Get free samples, pricing and stock list.

USA address
1641 W Main St, Ste 222, Alhambra, CA 91801
China address:
Room 209 , Huana Business Center , NO 1733 Lianhua Road , Minhang District , Shanghai , China 201103

Top Sellers

Nutri Avenue

how can we help ?

Bulk raw Ingredients Supplier

Nutri Avenue

Leave your details below, and let us help you get fresh, high-quality ingredients ASAP.