HMW Hyaluronic Acid Is About To Sell Out!

HMW Hyaluronic Acid Inventory Is Running Low.

The Hyaluronic Acid market trend remains stable. However, there is a shortage of Hyaluronic Acid, especially at the lower molecular levels, and LMW Hyaluronic Acid powder deliveries are already scheduled for August and September. Inventories of high molecular content are also about to be sold out.

This week, HMW Hyaluronic Acid 1.6 million Daltons in powder form is $178-188/kg.

What Is HMW Hyaluronic Acid?

HMW Hyaluronic Acid (HMW-HA) is a polysaccharide that occurs naturally in humans. It has a variety of biological functions. It is a long-chain sugar molecule that can bind large amounts of water to its molecules. Therefore, the ingredient has excellent moisturizing properties.

HMW-HA is mainly synthesized in the skin area by synoviocytes, keratinocytes, and endothelial cells. It is used to regulate a variety of biological processes.

High VS Low Molecular Weight Hyaluronic Acid

HMW-HA differs from low molecular weight hyaluronic acid (LMW-HA) because it is usually anti-inflammatory. LMW-HA, on the other hand, may exhibit pro-inflammatory effects.

Secondly, LMW-HA is less expensive to produce.

In addition, LMW-HA may have some deficiencies in biological functions compared to HMW Hyaluronic Acid. For example, LMW-HA may not be as strong as HMW Hyaluronic Acid regarding moisturizing ability.

What is Dalton in Hyaluronic Acid?

In Hyaluronic Acid or HA for short, “Dalton” is the unit of molecular weight. Hyaluronic acid is a high molecular weight polysaccharide. It consists of repeating units of N-acetyl-D-glucosamine and D-glucuronic acid alternately linked. The molecular weight of HA can vary from a few thousand to tens of millions of Dalton. This molecular weight size significantly impacts its biological function and application.

In particular, HMW Hyaluronic Acid usually refers to hyaluronic acid with a molecular weight greater than 2,000 kDa. This high molecular weight hyaluronic acid is structurally stable. It is commonly used in biomedical applications, such as a viscoelastic agent in ophthalmic surgery, a filler in joint surgery, and cosmetics for moisturizing and skin repair.

On the other hand, hyaluronic acid with low molecular weight usually refers to hyaluronic acid with a molecular weight of a few thousand to tens of thousands of daltons. Low molecular weight hyaluronic acid is more permeable. It can penetrate the skin’s stratum corneum and has a direct nourishing and refreshing effect on the skin’s stratum corneum. In addition, low molecular weight hyaluronic acid has strong moisturizing properties, which is 6-7 times more moisturizing than ordinary molecular HA.

Different molecular weight hyaluronic acids have different biological activities. How to apply hyaluronic acid, and how to choose different molecular weights? It is briefly described below.

• High molecular weight hyaluronic acid (>2000 kDa)

It is mainly used in biomedical fields, such as ophthalmic surgery, joint surgery, etc.

• Medium molecular weight hyaluronic acid (generally in the range of 200-2000 kDa)

It has some biological activity and can be used for specific applications.

• Low molecular weight hyaluronic acid (a few thousand to tens of thousands of daltons)

It has high permeability and good moisturizing properties, commonly used in cosmetics.

Vitamin B12 Is On A Price Increase Trend.

This week, Vitamin B12 is on a price increase in the US market. Its offer is as high as $2,420-2,600/kg.

Its forms include Adenosylcobalamin, Methylcobalamine Pure, etc. The price of Vitamin B12 in the US market is rising this week.

Popular Supplement Ingredients Prices Update 5/20-5/26

Creatine monohydrate powder 200 mesh is $8.5-10.8/kg. The market continues to maintain a stable trend.

Pea protein powder with 80% purity is $8.8-9.5/kg.

St. Johns Wort Extract 0.3% Total Hypericins is $28.5-31/kg.

Natural Piperine powder extracted from black pepper is $162-170/kg. Its purity is 95%.

Cissus Quadrangularis extract 10:1 is $13.5-15/kg.

The marigold extract has two great active ingredients, including Lutein and Zeaxanthin. The natural lutein powder is $16-60/kg with different purity levels, like 5%, 10%, 20%, etc. The natural zeaxanthin powder is $33-36/kg.

Vitamin B8 Inositol powder is 10.5-13/kg.

The market price of Benfotiamine, a derivative of Vitamin B1, is $68-72/kg.

Inositol Hexanicotinate powder is $48-53/kg.

Promotional Supplement Ingredients List On Nutri Avenue 5/20-5/26

There are a lot of ingredients to choose from on this week’s updated promotional list. In particular, look for L-carnosine, Bromelain, Vitamin K2 MK7, Vitamin D3, Pterostilbene, and more, as Nutri Avenue offers them well below market price.

Bromelain powder with 600 GDU is $35-38/kg. 

What is GDU in Bromelain, and How to choose different GDUs in it?

GDU (Gelatin Digestion Units) is a measure of bromelain activity. It specifically refers to the amount of bromelain required to hydrolyze gelatin under controlled conditions. This measurement evaluates the enzyme’s proteolytic activity by determining how much bromelain is required to liquefy a standardized gelatin solution in a specific time.

Typically, 1 GDU is defined as the amount of bromelain that hydrolyzes 1 gram of gelatin in 1 minute under standard conditions. The higher the GDU value, the higher the enzymatic activity of bromelain, indicating its effectiveness in breaking down proteins.

Therefore, the higher the GDU value, the higher the price of bromelain. And Nurti Avenue also offers 1,200 GDU bromelain powder form.

L-carnosine powder is $180-192/kg. The other form, Zinc L-Carnosine powder, is $242-256/kg with a steady market.

Natural Rutin powder-NF 95% purity extracted from Sephora japonica is around $35/kg. The market even quotes as high as $38/kg.

Vitamin K2 MK7 with 1% purity is one of the more bioavailable forms of K2. Studies have shown its beneficial effects in cardiovascular, inflammatory, and other areas, especially bone health. It is marketed at $355-382/kg.

Vitamin D3 100,00IU is 8.5-9.8/kg.

Pterostilbene powder with 98% purity is offered at $300/kg.

Uridine 5′-Monophosphate Disodium Salt in powder form is $80.5-88/kg, especially for larger orders.

Beta Alanine powder is $4-4.8/kg.

Gamma-aminobutyric acid powder (GABA) is $5.5-7/kg.

N-acetyl-l-cysteine (NAC) is $18-19/kg.

L-Glutamine powder is $9.8-11/kg.

Alpha Lipoic acid powder/granular form is $43-48/kg.

Chondroitin Sulfate is $40-43.5/kg.

Magnesium Glycinate powder is $13-28/kg.

Conclusion

This week, Nutri Avenue highlights that HMW and LMW Hyaluronic Acid are less available in the market. In particular, LMW-HA has been seen lined up for delivery, and Vitamin B12 has begun to see an increase in price quotes in the US market.

The vast majority of other supplement ingredients are still in a steady phase. All of the above updated market-priced ingredients are available to us. For more advice on different ingredients, contact the Nutri Avenue Sale Team.