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AAKG Powder 2:1

Product Name L-Arginine Alpha-Ketoglutarate AAKG
Other Names
CAS Number 16856-18-1
Molecular Formula C6H14N4O2·C5H6O5
Molecular Weight 320.2991 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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L-Arginine Alpha-Ketoglutarate AAKG powder is one of the most preferred dietary supplement ingredients when it comes to bodybuilding, weight loss, and weight-lifting activities as it effectively increases blood flow to muscle regions. It is also believed to boost overall heart health and prevent fatigue during workouts.

What Is L-Arginine Alpha-Ketoglutarate (AAKG)?

The term “AAKG” refers to the beneficial dietary supplement compound L arginine alpha-ketoglutarate. It is a combination of two popular chemicals in the body known as L-arginine and alpha-ketoglutarate that are necessary for the maintenance of blood flow and nitric oxide production. Arginine alpha-ketoglutarate is sometimes referred to as Arginine AKG.

L-arginine is classified as an amino acid. Hence, it serves as a building block to protein and a component of various enzymes and hormones necessary for metabolic processes. On the other hand, alpha-ketoglutarate is a chemical in the body that is naturally produced during the activation of the energy production process. Both being necessary for nitric oxide production, experts believe that the combination of L-arginine and alpha-ketoglutarate through the development of AAKG results in efficient synergistic effects.

L-Arginine Alpha-Ketoglutarate AAKG powder has a crystal formation that is colorless and prism-shaped. In terms of solubility, the compound is generally soluble in water and partly soluble in ethanol.

Source from: CN105036330A – Preparation method of crystalline L-arginine alpha-ketoglutarate (AAKG) – Google Patents

L-Arginine Alpha-Ketoglutarate VS L-Arginine

Several related studies have provided sufficient foundational evidence for the claim that Arginine Alpha-ketoglutarate (AAKG) is more beneficial for dietary supplementation purposes than plain L-arginine powder.

Research evidence reveals that in terms of use and effectiveness in increasing nitric oxide levels, L-Arginine Alpha-Ketoglutarate AAKG is more efficient in promoting nitric oxide production as it consists of two compounds necessary for the said process. Experts also believe that AAKG supplementation may extend benefits to individuals with hypertension or increased blood pressure, diabetes, and other metabolic conditions. L-arginine supplementation, on the other hand, supports treatment plans for congestive heart failure.

Certain studies reviewed by experts have also provided evidence that L-Arginine Alpha-Ketoglutarate AAKG may improve arginine absorption in the body. In effect, health practitioners believe that individual customers may use lesser doses of AAKG to increase arginine levels in the body instead of using high doses of arginine to supplement the arginine supply.

L-Arginine Alpha-Ketoglutarate VS Arginine Ethyl Ester

While AAKG is primarily used in workouts to improve athletic performance and increase energy levels, another arginine derivate that is popular in the market for its effects in improving sexual health is attracting the interests of medical experts. This compound is known as Arginine ethyl ester.

Arginine ethyl ester is commonly used to supplement arginine levels in the body. In this manner, it is similar to AAKG as the latter also works to enhance absorption of the amino acid arginine. It is believed that the effect of AAKG and Arginine ethyl ester in enhancing nitric oxide production is almost similar. However, arginine alpha-ketoglutarate (AAKG) is more commonly used in pre-workout dietary supplements to increase energy levels and improve overall exercise performance through vasodilatory effects. On the other hand, it is believed that Arginine ethyl ester is useful to improve sexual performance by increasing the blood supply in the blood vessels located in the genital area during a sexual engagement.

Customer review pages have also shown that arginine alpha-ketoglutarate is more suggested for muscle mass enhancement while Arginine ethyl ester is recommended for sexual health.

L-Arginine Alpha-Ketoglutarate VS Citrulline Malate

L-Citrulline Malate powder is another well-known dietary supplement ingredient for workouts and improved performance in exercise activities. Compared to the plain form of L-arginine, experts say that Citrulline Malate is so much better as the latter compound is quite effective in increasing arginine levels than arginine supplementation itself.

However, in a comparative review conducted by experts, answers on whether AAKG is better than Citrulline Malate have been provided. Researchers have found that while both L-Arginine Alpha-Ketoglutarate AAKG and Citrulline Malate effectively increase arginine levels, thereby providing support to the production of nitric oxide, L-arginine AKG is more helpful as it is found to increase short-term power performance among weight lifters. This health benefit is not necessarily supported by research on Citrulline Malate supplementation.

Bulk AAKG Powder Forms And Specifications

The chemical AAKG has two main specifications in the market, namely, L-Arginine Alpha-Ketoglutarate AAKG 1:1 and 2:1. The said ratio refers to the quantity of L-arginine as against alpha-ketoglutarate. Thus, in AAKG 2:1, the weight ratio between L-arginine and alpha-ketoglutarate is 70.45%:20.55%.

Both L-Arginine Alpha-Ketoglutarate AAKG 1:1 and AAKG 2:1 formulations are known to enhance nitric oxide production and provide biological effects such as an increase in muscle mass and vasorelaxation for improved blood flow. However, most health practitioners recommend AAKG 2:1 for dietary supplements as it provides more physiologic effects and health benefits than the 1:1 ratio. Among the distinctive differences between the said Arginine Alpha-ketoglutarate ratios is that the 2:1 ratio has more intense effects in liver detoxification than the 1:1 ratio. Nonetheless, the effects of the varying ratios on other biological functions such as regulation of neurotransmitter levels are yet to be verified.

How Does L-Arginine Alpha Ketoglutarate Work?

The mechanism of action of L-Arginine Alpha-Ketoglutarate AAKG is not yet fully verified by research. However, several related studies have been published to provide evidence suggestive of how the combination of arginine and alpha-ketoglutarate works.

One of the mechanisms of how L-arginine AKG is that it effectively supports the absorption of the compound arginine while, at the same time, increasing circulating arginine levels in the body. Hence, this mechanism effectively ensures that the body gets sufficient amounts of arginine through healthy supplementation.

An increase in arginine levels and AAKG in the human body is believed to increase nitric oxide production. This is the mechanism that gives foundation to many of the benefits associated with AAKG supplementation. Increased nitric oxide levels improve blood pump and circulation towards distal portions of the body. During workouts or engagement in extraneous exercises, the muscles need high amounts of nutrients and oxygen to prevent rapid wear and tear. By promoting blood circulation, experts say that AAKG can support musculoskeletal health.

It is also suggested in some research works that the L-Arginine Alpha-Ketoglutarate AAKG may boost cardiovascular health through dilatation of blood vessels and may be helpful among patients with elevated blood pressure.

L-Arginine-Alpha-Ketoglutarate Benefits

Arginine Alpha-Ketoglutarate powder supplements provide several health benefits not only to athletes and bodybuilders but also among other individual classifications. Some of the features of Arginine Alpha-Ketoglutarate dietary supplementation include the following:

  • It promotes body-building.

Among the factors affecting bodybuilding, as provided in reviews and quality research studies, is the use of an effective dietary supplement ingredient proven to increase muscle mass through healthy mechanisms. According to researchers, ketoglutarate alpha, combined with L-arginine, is a very potent substance that may promote the growth of muscle regions. This is because the compound effectively diverts nutrients and oxygen toward the muscles during workouts through nitric oxide patterns.

Some individual users in pre-workout dietary supplement reviews have also said that the compound helps prevent muscle fatigue which is a common hindrance to effective bodybuilding. Experts say that fatigue during a workout is common with poor oxygen supply. Hence, by increasing the oxygenation of the muscles, muscle fatigue is controlled.

  • It promotes energy production.

Arginine AKG is said to play a vital role in the energy production process of the human body. This is because it serves as an intermediate compound that supports metabolism. According to health practitioners, Arginine AKG may also further increase energy levels by preventing exhaustion and prolonging exercise endurance. It is believed that longer exercise or workout efforts lead to the breakdown of carbohydrates in the body, thereby increasing the overall nutrient and energy supply among body cells.

  • It enhances muscle recovery.

Muscle wear and tear is a normal response to workouts. However, the rate of recovery for worn-out muscle tissues depends on the extent of damage and the use of dietary supplements that are helpful in promoting muscle recovery.

Based on scientific studies, combined L-arginine and alpha-ketoglutarate supplementation may shorten recovery time for muscle healing as the compound effectively diverts blood flow, nutrients and oxygen towards the worn-out muscle fibers.

  • It may benefit patients with erectile dysfunction.

A recent medical study reviewed by health practitioners has suggested that supplementation of arginine alpha-keto-glutamate may address erectile dysfunction. This is attributed primarily to the effect of the compound in increasing nitric oxide production which, in turn, increases blood flow towards the genital tract during the sexual engagement. The effect of the compound on other sexual disorders is yet to be verified.

L-Arginine-Alpha-Ketoglutarate Side Effects

Taken in the oral form, individual users have reported mild side effects related to the use of L-Arginine Alpha-Ketoglutarate AAKG. These side effects include stomach upsets, nausea, and vomiting. The majority of the product users for muscle growth have claimed that the said side effects disappeared after the first few days of use.

Persons who are experiencing the difficulty of breathing, changes in breathing patterns and other adverse effects affecting the respiratory system are advised to immediately discontinue the use of the supplements and consult their physician. Persons who are pregnant or are suffering from certain medical diseases must also consult their physician prior to use of the compound.

L-Arginine-Alpha-Ketoglutarate Dosage

According to medical experts, a dosage of up to 30 grams per day is tolerable among adult users. However, individuals who are taking certain drugs or medications should consult their physicians prior to using the compound in order to prevent drug interactions.

Physicians may also recommend a different dose depending on a person’s weight, overall medical status, and age.

Buy L-Arginine Alpha-Ketoglutarate AAKG Bulk Powder In The USA

The price for bulk orders of the compound usually ranges from $11 to $16 per kilogram(Reference price). Prices may vary depending on the quantity of purchase and the distance between the supplier and the purchaser.

Bulk purchase of AAKG powder is available among reliable ingredient suppliers like Nutriavenue. Aside from being well-known for offering quality supplements ingredients at very affordable prices, many customers in product reviews recommend Nutriavenue as it is duly registered with the Food and Drug Administration as an ingredient supplier and is recognized and certified by Halal, GMP, and Kosher.

For more information on L-Arginine Alpha-Ketoglutarate AAKG and the other products we offer, you may contact our customer-oriented technical support staff at our website. You may also get a free quote when you visit our page.


L-Arginine Alpha-Ketoglutarate AAKG powder is very useful in increasing nitric oxide levels and promoting overall athletic performance during workouts. However, some of the claims related to the use of the supplement are still subject to evaluation by medical experts and the compound is not intended to diagnose, treat, cure or prevent any disease. Overall, the use of the compound in dietary supplements is recommended for the promotion of overall health and wellness.

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