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Albendazole

Product Name Albendazole
CAS Number 54965-21-8
Molecular Formula C12H15N3O2S
Molecular Weight 265.33 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum

 

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Albendazole

What is Albendazole?

Albendazole is a broad-spectrum anthelmintic compound derived from benzimidazole, commonly used to treat parasitic worm infestations in both humans and animals. First introduced in the 1970s, Albendazole has since become one of the primary drugs for combating gastrointestinal parasites, including roundworms, tapeworms, and flukes. It works by restricting the parasites’ ability to absorb glucose, leading to energy depletion and, ultimately, the death of the parasites. Albendazole is also increasingly used in the veterinary industry for its efficacy against various parasites in livestock, poultry, and companion animals.

Common Sources

Albendazole is synthesized chemically rather than being sourced from natural origins. It is a benzimidazole derivative produced through the reaction of various chemical precursors, including benzimidazole and thiophene. Due to its synthetic nature, Albendazole is manufactured on an industrial scale in pharmaceutical facilities under stringent quality control conditions. Albendazole is not naturally occurring, and its production relies on established chemical processes, making it a reliable and consistent source of antiparasitic medication.

How Does It Work?

Albendazole’s mechanism of action involves the inhibition of microtubule polymerization by binding to the β-tubulin subunit in parasitic cells. This disrupts cellular processes essential for survival, including glucose uptake and other metabolic functions. Without access to glucose, the parasite cannot maintain its energy levels, leading to immobilization and eventual death. Additionally, Albendazole’s secondary mechanism disrupts egg production and maturation in parasites, making it effective for both active infestations and preventing re-infestation.

Production Process

  1. Synthesis: Albendazole is synthesized from benzimidazole derivatives. The process involves the reaction of benzimidazole with a thiophene compound, followed by a series of chemical reactions, including alkylation and oxidation, to yield Albendazole as the final product.
  2. Purification: The crude Albendazole undergoes several purification steps, such as crystallization and recrystallization, to remove impurities and achieve the desired purity level. High-performance liquid chromatography (HPLC) is often used during this stage to ensure purity.
  3. Drying: The purified Albendazole is dried under controlled conditions to achieve the correct moisture content, which is crucial for maintaining the stability of the compound.
  4. Grinding: The dried Albendazole is finely ground to achieve a uniform particle size, essential for consistent dosing in pharmaceutical formulations.
  5. Quality Control and Testing: Extensive testing is conducted to confirm the Albendazole’s identity, purity, and potency. Standard test methods include HPLC and gas chromatography (GC).
  6. Packaging: The final product is packaged in moisture-resistant, airtight containers, typically in 1kg, 5kg, or 25kg quantities. The packaging is designed to shield the ingredient from environmental factors such as light, humidity, and air.

Bulk Albendazole Specifications

Type Supplement Ingredient
Appearance White to off-white crystalline powder
Purity 98%
Certifications Halal, Kosher, etc.
Test Methods HPLC, GC, etc.
MOQ (minimum order quantity) 1kg
Sample Available (10-20g/bag)
OEM Service Available, such as capsules, tablets, pills, etc.
ODM Service Available
Private Label Available
Contract Manufacturing Available

Albendazole: Benefits, Side Effects, And More

Treatment of Parasitic Infections

Albendazole is highly effective in treating many parasitic infections, including those caused by roundworms, tapeworms, and flukes. It is commonly prescribed for conditions like ascariasis, trichuriasis, and neurocysticercosis.

Veterinary Applications

In the veterinary industry, Albendazole is used to deworm livestock, poultry, and companion animals, ensuring healthier and more productive animals. It is particularly effective in controlling gastrointestinal parasites in cattle, sheep, and goats.

Preventive Treatment

Albendazole is used as a prophylactic measure in areas with high incidences of parasitic infections, especially in developing countries where hygiene and sanitation standards are lower.

Anti-Cancer Research

Emerging research suggests that Albendazole may have potential as an anti-cancer agent. Preliminary studies indicate that its ability to inhibit microtubule formation could help target cancer cells, though this application is still in the experimental stages.

Industry Applications and Uses

Pharmaceuticals

Albendazole is a crucial ingredient in medications for treating parasitic infections in humans and animals. It is formulated into tablets, suspensions, and chewables for easy administration.

Veterinary Medicine

Albendazole is widely used in the animal nutrition and health industry. It is formulated into deworming solutions, boluses, and feed additives to maintain the health of livestock and pets.

Dietary Supplements

While less common, Albendazole has been formulated into dietary supplements in some regions for its deworming properties, particularly in combination with other antiparasitic ingredients.

Functional Foods

Albendazole may be included in some functional food formulations to improve gut health, particularly in communities where parasitic infections are endemic.

Standard Dosage and Usage

For human use, Albendazole is typically prescribed in doses of 400 mg, taken either as a single dose or over several days, depending on the type and severity of the parasitic infection. In pediatric cases, the dosage may be adjusted based on body weight. In veterinary applications, the dosage varies significantly depending on the species, weight, and type of infection being treated. For example, in cattle and sheep, Albendazole is administered as an oral drench or feed additive, with dosages typically ranging from 7.5 to 10 mg/kg body weight.

Safety and Side Effects

Albendazole is generally well-tolerated, with side effects being mild and infrequent. These include digestive system discomfort, such as nausea, vomiting, and abdominal pain. In some cases, headache and dizziness may occur. Though rare, more severe side effects such as liver enzyme elevations or blood disorders like leukopenia may be observed, particularly in long-term use or high dosages. Pregnant women are typically advised against using Albendazole due to potential teratogenic effects. Monitoring liver function and blood counts during prolonged treatment courses is also essential.

Albendazole vs. Mebendazole

Both Albendazole and Mebendazole are benzimidazole derivatives with similar antiparasitic properties. However, Albendazole has broader efficacy and is used against a more comprehensive range of parasites, including tissue parasites like cystic echinococcosis and neurocysticercosis, where Mebendazole is less effective.

Albendazole vs. Ivermectin

While both drugs treat parasitic infections, Ivermectin is more commonly prescribed for external parasites like scabies and lice and certain nematodes like Strongyloides. Albendazole, on the other hand, is preferred for treating tapeworms and liver flukes.

Albendazole vs. Praziquantel

Praziquantel is primarily used to treat schistosomiasis and tapeworm infections, while Albendazole is more versatile in treating a broader spectrum of helminths, including nematodes and cestodes. In some cases, these drugs are used in combination for enhanced efficacy.

How Should This Ingredient Be Stored?

Like many raw materials, this ingredient must be stashed in a cool and dry place. It must also be kept out from direct sunlight, heat, and moisture. The storage area should be free from chemicals and strong odors that might contaminate the product. Keeping Albendazole in airtight, opaque containers is recommended to protect it from environmental factors that could compromise its potency. For extended storage, refrigeration is advisable, particularly for bulk quantities, to ensure maximum shelf life and stability. Always follow manufacturer-specific storage guidelines and maintain proper labeling to avoid cross-contamination and provide traceability.

Where Can I Find Wholesale Albendazole Supplier?

Nutri Avenue is a trusted global supplier of Albendazole, offering high-quality bulk Albendazole for pharmaceutical, veterinary, and dietary supplement applications. With rigorous testing protocols and a commitment to quality, Nutri Avenue ensures that their Albendazole meets international standards, including cGMP, Halal, and Kosher certifications. They provide competitive pricing, flexible packaging options, and robust customer support. Nutri Avenue also offers customization options, including OEM and ODM services, catering to diverse business needs. For more information, visit their official website or contact their sales team directly.

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