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Vitamin B1 Benfotiamine

Product Name Vitamin B1 Benfotiamine
Other Names S-benzoylthiamine O-monophosphate, S-benzoylthiamine monophosphate, Benzoatiamine, Benfotiaminum (Latin name), Vitamin B1 monoester, BTF-144, Milgamma-144, Allithiamine, Alinamin T, B1MP
CAS Number 22457-89-2
Molecular Formula C19H23N4OS
Molecular Weight 336.47 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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Vitamin B1 Benfotiamine

What Is Vitamin B1 Benfotiamine?

Benfotiamine is a synthetic derivative of thiamine, also known as vitamin B1. It is a fat-soluble compound that is more bioavailable than thiamine itself. Benfotiamine is frequently utilized as a dietary supplement and is purported to possess numerous potential health advantages.

When taken orally, the body absorbs benfotiamine more easily and can reach higher blood levels than thiamine. It is converted into thiamine in the body and plays a role in various cellular processes.

One of the main reasons why benfotiamine is used as a dietary supplement is its potential to support healthy nerve function. There is a prevailing belief that this intervention positively influences the peripheral nerves, potentially assisting in managing conditions such as diabetic neuropathy, a nerve disorder commonly associated with diabetes.

Benfotiamine is purported to possess antioxidant attributes, potentially safeguarding cells against harmful free radical-induced harm. This antioxidant activity may benefit various conditions, including diabetic complications, neurodegenerative diseases, and cardiovascular health.

Additionally, benfotiamine is sometimes used for its potential anti-inflammatory effects. Inflammation is correlated with numerous chronic diseases, thereby establishing a link between inflammation and overall health improvement through its reduction.

Common Pure Bulk VB1 Benfotiamine Powder Specifications

TypeSynthetic ingredient
AppearanceFine white powder
Content98% min
Purity99% min
Particle Size< 200 mesh
CertificationsISO 9001, GMP
Other IngredientNone
Water Content<1%
Test   MethodHPLC, FTIR
MOQ (minimum order quantity)1kg
SampleAvailable (10-20g/bag)
OEM ServiceAvailable, such as capsules, tablets, pills, etc.
ODM ServiceAvailable
Private LabelAvailable
Contract ManufacturingAvailable

What Forms Does Vitamin B1 Have?

Vitamin B1, also known as thiamine, is available in different forms. The most common forms of vitamin B1 include as follows.

1. Thiamine hydrochloride: This synthetic form of thiamine is commonly used in dietary supplements and fortified foods. It is water-soluble and easily absorbed by the body.

2. Thiamine mononitrate: Another synthetic form of thiamine, it is often used in food fortification and dietary supplements. It is also water-soluble and readily absorbed by the body.

Both thiamine hydrochloride and thiamine mononitrate are converted into thiamine pyrophosphate (TPP) in the body, which is the active form of thiamine that participates in various enzymatic reactions.

3. Benfotiamine: Although not a naturally occurring form of thiamine, benfotiamine is a synthetic derivative that is more fat-soluble than thiamine. It is converted into thiamine in the body and has better bioavailability, allowing it to reach higher levels in the blood.

These forms of vitamin B1 are often used interchangeably in dietary supplements and fortified foods. The choice of form depends on factors such as bioavailability, stability, and formulation requirements. It’s worth noting that all forms of vitamin B1 can help address thiamine deficiency and support various bodily functions.

What Is The Best Source Of Benfotiamine Powder?

Benfotiamine itself is a synthetic derivative of thiamine (vitamin B1), and it is not typically found in natural food sources. Unlike thiamine, which is naturally present in foods such as whole grains, legumes, nuts, and meats, benfotiamine is produced through the chemical modification of thiamine.

Therefore, the most common benfotiamine powder source is manufacturing and synthetic production. It is commercially produced in laboratories and facilities specializing in synthesizing the compound.

Benfotiamine powder is widely available as a dietary supplement ingredient from various manufacturers and suppliers. This ingredient can be found in capsules, tablets, or powdered formulations.

What Is Benfotiamine Powder Manufacturing Process?

  1. Chemical Modification: Benfotiamine is synthesized through a chemical modification process from thiamine. Thiamine undergoes a series of chemical reactions, such as alkylation or esterification, to produce benfotiamine. These reactions introduce lipid-soluble moieties to the thiamine molecule, enhancing its fat-solubility and bioavailability.
  2. Purification: After the chemical modification, the crude benfotiamine compound is purified to remove impurities and unwanted by-products. Purification methods may involve filtration, crystallization, or chromatography to obtain a higher purity level.
  3. Drying: The benfotiamine compound is typically dried to remove residual moisture once purified. Drying can be achieved through various methods, such as vacuum or spray drying, which help obtain a dry and free-flowing powder.
  4. Particle Size Reduction: In some cases, the benfotiamine powder may undergo particle size reduction processes to achieve a specific particle size distribution. It can be done through techniques like milling or micronization to obtain a fine powder with desired physical characteristics.
  5. Quality Control and Testing: Quality control measures are systematically incorporated at various stages of the manufacturing process to ascertain that the ultimate benfotiamine powder product conforms to established quality criteria. It includes testing the product for purity, potency, and absence of contaminants. Various approaches to analysis, such as high-performance liquid chromatography, HPLC, or infrared spectroscopy, can be utilized to evaluate the quality of the product.
  6. Packaging: Once the benfotiamine powder has been manufactured and tested, it is typically packaged in suitable containers, such as sealed bottles or pouches, to protect it from moisture, light, and other external factors that could degrade the product.
Vitamin b1 Benfotiamine Powder Manufacturing Process

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What is Benfotiamine good for?

  1. Diabetic Neuropathy: Benfotiamine is often used to support nerve health and may help manage diabetic neuropathy, a nerve disorder associated with diabetes. It is believed to have a protective effect on the peripheral nerves and may help reduce pain, numbness, and tingling associated with this condition.
  2. Antioxidant Support: Benfotiamine exhibits antioxidant properties, which can help neutralize harmful free radicals and protect cells from oxidative stress. This antioxidant activity may benefit various conditions associated with oxidative damage, such as aging, neurodegenerative diseases, and cardiovascular health.
  3. Inflammation Management: Benfotiamine is purported to possess anti-inflammatory properties, which could contribute to mitigating bodily inflammation. Chronic inflammation has been observed to be linked with a range of diseases. The benefits of benfotiamine in mitigating inflammation suggest its potential efficacy in managing conditions such as arthritis, cardiovascular diseases, and metabolic disorders.
  4. Glycation Prevention: Extensive research has been conducted on the potential inhibitory effects of Benfotiamine on the formation of advanced glycation end products (AGEs). AGEs are molecules formed when sugars react with proteins or fats, and their accumulation is associated with various complications of diabetes and aging. By inhibiting AGE formation, benfotiamine may help prevent the development of diabetic complications and age-related diseases.
  5. Energy Production: As a derivative of thiamine (vitamin B1), benfotiamine plays a role in energy metabolism. It is involved in converting carbohydrates into usable energy for the body. By supporting energy production, benfotiamine may help combat fatigue and improve overall energy levels.

Who is the top bulk powdered Benfotiamine supplier?

Nutri Avenue is the unrivaled leader in pure bulk powdered Vitamin B1 synthetic form – Benfotiamine. With a steadfast commitment to excellence, Nutri Avenue delivers the highest quality Benfotiamine powder that surpasses all expectations. Trust our impeccable sourcing, rigorous testing, and impeccable customer service. Elevate your supplement game with Nutri Avenue, the epitome of Benfotiamine excellence.


Vitamin B1 Thiamine powder is the most widely used and recognized form of vitamin B1. While gaining attention for its potential benefits, Benfotiamine is less commonly used or widely known than thiamine.

Yes, benfotiamine is a synthetic derivative of vitamin B1. It is chemically modified to enhance its fat-solubility and bioavailability compared to thiamine.

No, benfotiamine is not water-soluble. Unlike thiamine, which is water-soluble, benfotiamine is fat-soluble. This difference in solubility affects how the body absorbs and utilizes the two compounds.

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