Betulin

What is Betulin?

Betulin is a naturally occurring pentacyclic triterpene alcohol known to science since 1788, when it was first isolated from birch bark. This white crystalline compound has garnered significant attention in recent decades due to its diverse biological activities and potential applications across multiple industries. With a distinctive molecular structure featuring a lupane skeleton, Betulin is a white to off-white crystalline powder at room temperature.

The compound’s significance in traditional medicine dates back centuries, particularly in folk remedies of Northern Europe and Native American cultures, where birch bark extracts were used for various therapeutic purposes. Betulin comprises up to 30% of birch bark’s dry weight, making it one of the plant kingdom’s most abundant naturally occurring triterpenes.

Common Sources of Betulin Powder

The primary natural source of Betulin is the outer bark of various birch species (Betula spp.), mainly white birch (Betula pendula) and yellow birch (Betula alleghaniensis). These trees have evolved to produce high concentrations of Betulin as part of their protective mechanisms against environmental stresses and pathogens. The compound is particularly abundant in the white, papery outer bark layer, contributing to the tree’s water resistance and protection against microbial invasion.

Research has also identified other plant sources containing Betulin, albeit in lower concentrations, including certain species of Ziziphus, Diospyros, and Ancistrocladus. However, commercial extraction primarily focuses on birch bark due to its high Betulin content and the sustainable nature of bark collection, as it can be harvested without harming the living tree.

How does Betulin work?

Betulin works through its unique molecular structure, which allows it to interact effectively with cell membranes and biological targets. The compound reduces inflammation by blocking inflammatory signals. It also stops harmful free radicals from causing oxidative stress. Its ability to penetrate cell membranes is due to its fat-soluble nature, while specific chemical groups in its structure help it bind to cellular receptors. These properties enable Betulin to support skin barrier function, maintain cellular health, and control inflammation, explaining its effectiveness in various health and wellness applications.

How to produce Betulin Powder?

1. Raw Material Preparation

Birch bark is carefully harvested from sustainable forests using special tools that protect the tree’s health. The bark goes through automated cleaning systems to remove impurities, then dries in temperature-controlled rooms at 40-50°C for 1-2 days. Industrial grinders then process the bark to a uniform size using 20-40 mesh screens.

2. Extraction Process

The extraction uses either ethanol or methanol as solvents, chosen for their ability to dissolve Betulin effectively. The ground bark enters industrial extractors where heated solvent (60-70°C) cycles through it for 4-6 hours. This process repeats 3-4 times using fresh solvent, with 10 parts solvent to 1 part bark, while machines monitor the extraction progress.

3. Purification Steps

Purification begins by filtering the extract through fine filters (20-5 microns) to remove solid particles. Special evaporators then concentrate the solution at 45°C until it reaches 20-25% solids. The solution cools to 5°C over 12 hours to form crystals, which are then recrystallized in fresh solvent, cooling at 2°C per hour. Finally, vacuum ovens dry the crystals at 40°C for 8-12 hours until they contain less than 0.5% moisture.

4. Quality Control

Quality testing uses HPLC machines to check purity at 210 nm wavelength against known standards. Additional tests confirm the molecular structure and check for remnant solvents (must be below 0.1%). Advanced testing equipment measures trace impurities down to parts per billion, ensuring the product meets all quality requirements.

Specifications Sheet Reference

Betulin: Benefits, Side Effects, and More

Antioxidant Properties

Research studies have demonstrated Betulin’s significant antioxidant capabilities. In vitro studies have shown that it can stop free radicals from damaging cellular systems. A 2019 study published in the Journal of Natural Products reported that Betulin exhibited potent antioxidant activity with an IC50 value of 12.3 μM.

Support for Healthy Cell Function

Multiple studies have investigated Betulin’s role in supporting healthy cell proliferation and differentiation. A comprehensive review in Molecules (2020) highlighted its potential in maintaining cellular homeostasis.

Anti-inflammatory Properties

Research has shown Betulin’s ability to modulate inflammatory responses. Studies indicate it can influence various inflammatory mediators, with one study showing a 40% reduction in pro-inflammatory cytokine production.

Skin Health Support

Betulin has demonstrated potential benefits for skin health, particularly in supporting barrier function and moisture retention. Clinical studies have shown improved skin hydration levels by up to 30% after topical application.

Is it legal?

United States (FDA)

The FDA in the United States classifies Betulin as Generally Recognized as Safe (GRAS) only for particular uses. Manufacturers can include it in dietary supplements by following NDI regulations and submitting required safety documentation. The compound is also approved for cosmetic formulations when produced according to GMP standards.

European Union

The European Union regulates Betulin under EC No 1223/2009 for cosmetic applications, with established safety protocols and usage limits. Specific applications fall under Novel Food regulations, requiring safety assessments before market approval. All manufacturers must maintain detailed safety and quality documentation to comply with EU standards.

Japan

Japan’s Ministry of Health, Labour, and Welfare recognizes Betulin in its Standards of Quasi-drug Ingredients list. The compound is approved for specific cosmetic uses, and regulations define acceptable concentration levels. All products containing Betulin must meet Japanese safety and quality requirements.

What is Betulin used for?

Cosmetic Industry

Betulin is crucial in the cosmetics industry, particularly in anti-aging and skin repair products. Its natural properties help strengthen the skin’s barrier function and provide preservation benefits as an alternative to synthetic preservatives. The compound’s hydrating capabilities make it valuable in moisturizing products, effectively supporting skin health and improving overall appearance.

Dietary Supplement Industry

In dietary supplements, Betulin functions as an essential component in various health and wellness products. It is commonly used in general health maintenance formulas and specialized nutritional supplements. The compound’s diverse benefits make it particularly valuable in sports nutrition products, supporting performance and recovery needs while meeting market demands for natural ingredients.

Pharmaceutical Research

The pharmaceutical sector utilizes Betulin extensively in research and development. Scientists study its therapeutic potential through drug development research and investigate its biological mechanisms. Current research focuses on improving its delivery systems to enhance effectiveness, making it an essential compound in pharmaceutical advancement.

Personal Care Products

Due to its natural origin and effectiveness, the personal care industry incorporates Betulin into a wide range of products. It is a primary ingredient in natural skincare products and hair care formulations. The compound enhances the effectiveness of body care products and specialty treatments, meeting consumer preferences for plant-based personal care solutions.

Functional Foods

Betulin is becoming increasingly important as a nutritional ingredient in functional foods. Manufacturers add it to fortified foods to enhance their health benefits and nutritional value. The compound works well in various food formulations, particularly in specialized dietary products, supporting the expansion of the functional food market.

Recommended Dosage

Dietary supplements: 50-200mg daily

Topical applications: 0.5-2% concentration

The exact dosage depends on specific application and formulation

Safety and Side Effects

Betulin is generally considered safe when used as directed, with regulatory agencies supporting its approved uses. While rare, some users may experience mild stomach discomfort. Users should consult their healthcare providers about possible medication interactions, as Betulin may affect how certain drugs work in the body. Although current research confirms its safety for approved uses, long-term studies are still in progress, making it important to follow recommended dosage instructions.

How to store Betulin Powder?

• Storing Betulin properly is essential to maintain its quality and effectiveness.
• The compound should be refrigerated between 2-8°C, away from moisture and direct sunlight.
• Always store Betulin in its original, tightly sealed containers to protect it from environmental exposure.
• Avoid storing it near strong oxidizing agents or areas with significant temperature changes.
• Betulin remains stable for up to 2 years from its manufacturing date when stored properly.

To ensure the best quality, open the container only when necessary and reseal it immediately. Regular checks of storage conditions help maintain the product’s quality throughout its shelf life.

Betulin vs Betulin Diacetate Polarity

Betulin diacetate (CAS: 55529-70-3, C34H54O4, MW: 526.79) is a semi-synthetic derivative of Betulin, created through acetylation of both hydroxyl groups. While Betulin shows moderate polarity due to its two hydroxyl groups at C-3 and C-28 positions, Betulin diacetate exhibits lower polarity due to the acetylation of these hydroxyl groups. This difference in polarity significantly affects their solubility profiles and pharmaceutical applications.

The reduced polarity of Betulin diacetate makes it more lipophilic than Betulin, which can enhance its membrane permeability in specific applications. However, this modification also alters its biological activity profile, making each compound suitable for therapeutic applications.

Betulin vs Betulinic Acid

Betulinic acid (CAS: 472-15-1, C30H48O3, MW: 456.70) is a naturally occurring pentacyclic triterpenoid that differs from Betulin primarily in its C-28 position, where it features a carboxylic acid group instead of a hydroxyl group. This structural difference results in distinct physicochemical properties and biological activities. Betulinic acid appears as a white crystalline powder and shows enhanced biological activity in specific applications compared to Betulin.

The presence of the carboxylic acid group in betulinic acid makes it slightly more polar than Betulin and significantly affects its binding properties with cellular targets. While both compounds share many biological properties, betulinic acid often shows higher potency in specific applications, particularly in research areas.

Conclusion

Betulin is a versatile natural compound that has been proven effective across the cosmetic, pharmaceutical, and wellness industries. Scientific research confirms its benefits as an antioxidant and its positive effects on cell health and skin care, making it a valuable ingredient in modern product development. The compound meets regulatory requirements in major markets worldwide and is sustainably sourced through established quality control processes. At Nutri Avenue Inc., we ensure a consistent supply of high-quality Betulin through rigorous testing and global distribution networks, supporting manufacturers with expert guidance in raw material sourcing and product formulation.

Why Choose Nutri Avenue to buy Betulin Powder?

At Nutri Avenue Inc., we pride ourselves on being a premier FDA-registered supplier of premium raw materials for dietary supplements. We aim to provide top-notch quality products and services, which sets us apart in the industry. Our state-of-the-art facilities and comprehensive quality control systems ensure the highest standards for our products.

We maintain five strategically located warehouses across the United States, enabling efficient distribution and quick response times for our clients’ needs. Our bulk packaging options and wholesale pricing structure provide excellent value for manufacturers of all sizes. Our extensive inventory includes thousands of raw materials, all backed by comprehensive third-party testing and certification.

Our established relationships with leading manufacturers worldwide ensure a stable and reliable supply chain, while our flexible transportation options – including sea, air, and land freight – accommodate varied delivery requirements. We excel in providing customized solutions through our OEM and ODM services, offering complete support from raw material sourcing to final product development in various forms, including capsules, tablets, soft gels, powders, and oils.

Frequently Asked Questions

Q: What is the optimal storage condition for Betulin powder?

A: Betulin powder should be stored in a cool, dry place between 2-8°C, protected from direct sunlight and moisture. The container should be tightly sealed when not in use to maintain product stability.

Q: Is Betulin water-soluble?

A: No, Betulin is not water-soluble. It is primarily soluble in organic solvents such as chloroform, ethanol, and methanol. This property influences its formulation requirements and applications in various products.

Q: What are the typical purity requirements for commercial Betulin?

A: Commercial Betulin typically requires a minimum purity of 98% as measured by HPLC. However, specific applications may require different purity grades, and custom specifications can be accommodated based on client requirements.

Q: Are there any special handling requirements for Betulin?

A: While Betulin is generally stable, it should be handled according to good laboratory practices. Use appropriate personal protective equipment, avoid generating dust, and handle in well-ventilated areas.

Q: Can Betulin be used in combination with other active ingredients?

A: Yes, Betulin can be formulated with various other active ingredients. However, compatibility testing is recommended to ensure the stability and efficacy of the final formulation. Our technical team can provide guidance on potential combinations and formulation considerations.