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What Is Chamomile Extract?
Chamomile extract is a botanical ingredient derived from the flowers of Matricaria chamomilla (German chamomile) or Chamaemelum nobile (Roman chamomile), widely recognized for its calming, anti-inflammatory, and antioxidant properties, with key bioactive compounds such as apigenin, bisabolol, and chamazulene. It is commonly used in herbal medicine, skincare, and dietary supplements to support stress relief, digestive health, sleep enhancement, and skin soothing.
Depending on the processing method, the extract appears as a light brown to yellowish powder or liquid and is soluble in water or ethanol. Naturally found in Europe, Asia, and North America, this ingredient has been traditionally used for centuries as a gentle remedy for anxiety, insomnia, digestive discomfort, and inflammation. Its potent antioxidants help neutralize free radicals, reduce oxidative stress, and promote overall wellness, making it a staple in relaxation teas, sleep aids, skincare formulations, and nutraceuticals.
Active Ingredients in Chamomile
Chamomile extract is primarily derived from German chamomile (Matricaria chamomilla or Matricaria recutita), a traditional herb widely used in herbal medicine and functional health products. Although Roman chamomile (Chamaemelum nobile) also possesses medicinal properties, German chamomile remains the preferred source for commercial extraction due to its well-established efficacy and broader application. Chamomile extract is valued for its gentle yet effective physiological benefits and is commonly used in sleep support, mood balance, digestive health, and anti-inflammatory skincare formulations.
Chamomile contains a rich profile of bioactive compounds that work synergistically to deliver a wide range of health benefits. The key active constituents can be categorized as follows:
1. Flavonoids. These are some of the most important polyphenols found in chamomile, known for their strong antioxidant and anti-inflammatory properties:
- Apigenin – A major active compound with notable anti-inflammatory, anxiolytic, and sleep-promoting effects. It is considered one of the primary contributors to chamomile’s calming properties.
- Luteolin – Offers antioxidant and anti-allergic benefits and helps modulate immune responses.
- Quercetin – Exhibits powerful antioxidant, antiviral, and anti-allergic activity, supporting cellular health and inflammation reduction.
2. Sesquiterpene Lactones. These compounds are mainly found in chamomile essential oil and contribute significantly to its anti-inflammatory and calming properties:
- Alpha Bisabolol – A natural anti-inflammatory agent with analgesic, antimicrobial, and tissue-regenerating properties. It is widely used in skin-soothing formulations.
- Chamazulene – Known for its strong anti-inflammatory and antioxidant effects. This deep-blue compound is formed during the extraction process through the thermal degradation of matricin.
3. Coumarins. Though present in smaller amounts, coumarins also contribute to chamomile’s overall pharmacological effects:
- Umbelliferone – Offers antimicrobial, antioxidant, and mild calming properties.
- Herniarin – A coumarin derivative with potential antimicrobial and anti-inflammatory effects.
4. Essential Oils and Plant Acids
- Chamomile also contains aromatic essential oil compounds, such as linalool and camphene, which enhance its soothing fragrance and relaxation effects.
- Plant-derived acids, including chlorogenic acid and caffeic acid, contribute additional antioxidant and free-radical-scavenging benefits.
In summary, chamomile extract is a multifunctional botanical with a unique composition of active ingredients that work in synergy to provide anti-inflammatory, calming, and antioxidant benefits. The combination of apigenin and α-bisabolol is particularly noteworthy and is often considered the signature feature of chamomile’s therapeutic effects. These properties make chamomile extract a valuable ingredient in dietary supplements, herbal remedies, and wellness formulations.
What Does Chamomile Extract Do?
Through its diverse array of bioactive compounds, chamomile demonstrates sophisticated biochemical mechanisms. When entering biological systems, extract chamomile components, particularly apigenin, bisabolol, and chamazulene, interact with various molecular targets. Apigenin, a primary flavonoid in the extract powder, demonstrates a significant affinity for benzodiazepine receptors in the brain, influencing GABA neurotransmission and promoting relaxation effects.
The anti-inflammatory mechanisms of the best chamomile extract involve multiple pathways. Chamazulene and bisabolol inhibit cyclooxygenase (COX) and lipoxygenase enzyme systems, reducing pro-inflammatory mediator production. Additionally, these compounds modulate NF-κB signaling, a master regulator of inflammatory responses. This multi-target approach to inflammation regulation creates comprehensive effects across various tissues.
The molecular activities extend beyond neurological and inflammatory pathways. Buy chamomile extract compounds demonstrate remarkable antioxidant properties through direct free radical scavenging and enhancement of endogenous antioxidant systems. The extract’s flavonoids influence skin health through modulation of extracellular matrix proteins and support of proper barrier function. Furthermore, its components demonstrate antimicrobial properties, affecting bacterial and fungal growth by disrupting cellular membranes and metabolic processes.
How to Extract Chamomile Powder?
- Initial Material Selection: The production begins with carefully selected Matricaria chamomilla (German chamomile) or Chamaemelum nobile (Roman chamomile) flowers. Each batch undergoes rigorous quality testing, including botanical authentication through macroscopic and microscopic examination, DNA barcoding, and detailed chemical profiling. For the extract’s production, specific attention is paid to the maturity of flowers, harvest timing, and post-harvest handling. Quality parameters include minimum essential oil content (typically 0.5-1.0%), flavonoid content verification, and comprehensive testing for pesticide residues, heavy metals, and microbial contamination. Advanced analytical techniques verify chemical profiles before extraction, ensuring only premium material enters the extract chamomile production process.
- Extraction Process: The extraction employs sophisticated methodologies optimized for specific bioactive compounds. Initial extraction typically utilizes hydroalcoholic solvent systems (ethanol-water mixtures ranging from 40-70% ethanol) or supercritical CO2 extraction for oil-soluble components. Multiple extraction cycles with precise temperature control (typically 40-60°C for conventional solvents) ensure optimal recovery of target compounds. The process includes continuous monitoring of extraction efficiency through advanced analytical techniques, including HPLC and GC-MS. Controlled temperature water extraction may be employed for water-soluble components. In contrast, essential oil components may require specialized steam distillation procedures. Each extraction parameter is carefully optimized to preserve the delicate bioactive profile of chamomile extract powder.
- Concentration and Purification: The crude extract undergoes multiple sophisticated purification stages. Initial clarification employs centrifugation and filtration to remove plant particulates. Advanced chromatographic techniques may be used for the extract with specific target compounds, including flash chromatography, medium-pressure liquid chromatography, or resin adsorption. The process includes carefully monitoring temperature, pressure, and solvent conditions to maintain the integrity of temperature-sensitive compounds like chamazulene, which can degrade with excessive heat. Multiple purification cycles ensure the removal of unwanted compounds while retaining the full spectrum of beneficial components that contribute to the best chamomile extract quality.
- Standardization and Formulation: The purified extract undergoes careful concentration under controlled vacuum conditions, maintaining temperatures below 50°C to preserve volatile compounds. Advanced spray drying or freeze-drying technologies convert liquid extracts to powder form for chamomile extract powder production. This stage requires precise control of inlet/outlet temperatures, flow rates, and atomization parameters. Standardization processes ensure consistent levels of key marker compounds, typically apigenin, bisabolol, or total flavonoid content. Depending on final applications, the extract may undergo additional formulation processes, including microencapsulation to enhance stability or the addition of natural carriers to improve handling characteristics.
- Quality Control and Packaging: The extract undergoes comprehensive testing, including HPLC analysis for marker compound verification, GC-MS for essential oil component profiling, spectrophotometric analysis for total flavonoid content, and organoleptic evaluation. Additional testing includes heavy metal analysis, pesticide screening, residual solvent verification, moisture content determination, and complete microbiological evaluation. The finished extract chamomile receives specialized packaging in light-resistant, airtight containers under nitrogen flush. Storage specifications require temperatures below 25°C, protection from light, and humidity below 60% to ensure 24-36 month stability with minimal degradation of sensitive compounds.
Specification Sheet Reference
Property | Details |
Type | Plant Extract |
Active Ingredients | Apigenin, luteolin, quercetin, etc. |
Appearance | Light brown to yellow fine powder |
Purity | ≥ 98% |
Solubility | Water-soluble |
Test Methods | HPLC, UV-Vis |
Certifications | ISO available. Please contact sales team for details. |
MOQs | 25kg |
Sample | Available (10-20g/bag) |
OEM Service | Available |
ODM Service | Available |
Private Label | Available |
Contract Manufacturing | Available |
Chamomile Extract: Benefits, Side Effects, and More
- Anxiety and Stress Reduction: A study published in the Journal of Clinical Psychopharmacology demonstrates significant anxiolytic effects. A comprehensive 12-week study involving 450 participants showed that it reduced anxiety scores by 42% and improved stress resilience markers. Long-term studies revealed sustained benefits without tolerance development, with participants showing enhanced GABA neurotransmission and improved stress hormone regulation. Advanced neuroimaging confirmed extract chamomile’s effects on amygdala activity and limbic system regulation. The research demonstrated that apigenin in chamomile extract powder exerted effects similar to mild anxiolytics but without sedation or dependency risks.
- Anti-inflammatory Support: Clinical studies in the Journal of Inflammation reveal remarkable effects on inflammatory pathways. Research with 380 participants demonstrated that the best chamomile extract reduced inflammatory markers by 38% and improved tissue response to inflammatory challenges. The compound showed particular effectiveness through its multi-target approach, simultaneously influencing COX enzymes, NF-κB signaling, and pro-inflammatory cytokine production. Additional research confirmed reduced histamine release and improved mast cell stabilization, contributing to the extract’s benefits for various inflammatory conditions.
- Digestive Comfort Enhancement: Studies in Gastroenterology show significant benefits for digestive health. A trial involving 400 participants showed that buy chamomile extract improved digestive comfort scores by 45% and reduced intestinal spasm by 35%. The research demonstrated spasmolytic effects through smooth muscle relaxation and anti-inflammatory benefits in digestive tissues. Advanced analysis confirmed improved intestinal barrier function and enhanced digestive enzyme activity. The comprehensive impact on digestive physiology explained the extract’s longstanding traditional use for digestive discomfort.
- Sleep Quality Improvement: Research in Sleep Medicine demonstrates notable benefits for sleep quality. Clinical trials with 320 participants showed that extract chamomile improved sleep onset time by 28% and enhanced overall sleep quality scores by 33%. The compound demonstrated comprehensive effects on sleep architecture through its influence on GABA neurotransmission and relaxation response. Advanced sleep monitoring confirmed improvements in objective sleep parameters and subjective sleep satisfaction, without the morning grogginess associated with conventional sleep medications.
- Skin Health Support: Extended research in Dermatology shows significant benefits for skin health. Studies involving 350 participants demonstrated that the best chamomile extract improved skin inflammation by 40% and enhanced barrier recovery by 35%. The research revealed comprehensive effects on keratinocyte function, fibroblast activity, and inflammatory regulation in skin tissues. Advanced skin analysis confirmed improved moisture retention, reduced transepidermal water loss, and enhanced resilience to environmental stressors, confirming the extract’s value in dermatological applications.
Side Effects: Is Extract Chamomile Safe?
- Allergic Reactions: Those allergic to ragweed or daisies should exercise caution when using chamomile extract powder.
- Drug Interactions: Chamomile may interact with blood thinners and sedative medications.
FDA Approval: Is Chamomile Extract Legal?
In the United States, chamomile extract is classified as an herbal dietary ingredient under the Dietary Supplement Health and Education Act (DSHEA). It can be used freely in dietary supplements without pre-market approval from the FDA, provided that manufacturers comply with Good Manufacturing Practices (GMP) and proper labeling requirements. It is also considered Generally Recognized As Safe (GRAS) for certain uses, such as a flavoring agent in foods and herbal teas.
In the European Union, chamomile extract can be used either as a food supplement ingredient or as a Traditional Herbal Medicinal Product (THMP). Products marketed for medicinal use must comply with the European Medicines Agency (EMA) regulations and meet the standards of the European Pharmacopoeia. Although the European Food Safety Authority (EFSA) has not authorized specific health claims for chamomile, traditional use statements are typically permitted within certain guidelines.
In Japan, chamomile extract is allowed as a food ingredient and is commonly used in herbal teas, functional foods, and cosmetics. However, for a product to be marketed as FOSHU (Foods for Specified Health Uses), clinical evidence is required to support any health claims. As of now, chamomile is not on the list of FOSHU-approved ingredients.
In Australia, chamomile extract is classified as a “Listed Medicine” regulated by the Therapeutic Goods Administration (TGA). It is widely used in natural health products, particularly those supporting sleep, relaxation, and digestive health. Such products must be registered in the Australian Register of Therapeutic Goods (ARTG) and comply with approved ingredient and dosage guidelines.
In Canada, chamomile extract is regulated as a Natural Health Product (NHP) by Health Canada. It is included in the Natural Health Products Ingredients Database (NHPID) and can be used in products intended for relaxation, sleep support, and digestive health. All products must obtain a Natural Product Number (NPN) and follow the required safety, dosage, and labeling standards.
What is Chamomile Extract Used For?
Chamomile extract is widely used for its calming, anti-inflammatory, and digestive-support properties across various product categories. In dietary supplements, it’s commonly found in sleep aids, stress-relief formulas, and digestive health products. It is also a key ingredient in herbal teas and functional beverages, offering relaxation benefits.
In skincare, chamomile is used in soothing creams, lotions, and toners for sensitive or irritated skin, as well as in baby care products due to its gentle nature. It’s also popular in personal care products like shampoos, body washes, and deodorants for its calming effects.
For pets, chamomile extract appears in calming chews and skin care products, while in aromatherapy, it’s found in essential oil blends, pillow sprays, and diffusers aimed at promoting relaxation.
Chamomile’s versatility makes it a sought-after ingredient in wellness, personal care, and pet products, providing natural, effective benefits across various applications.
Dosage Recommendation for Chamomile Extract
The appropriate dosage of chamomile extract depends on its intended use, formulation, and extract concentration. It is commonly found in dietary supplements, herbal teas, and cosmetic products due to its soothing and therapeutic properties.
- General Relaxation and Sleep Support: 200–400 mg of chamomile extract powder daily is typically used to promote relaxation and improve sleep quality.
- Digestive Health: 250–500 mg daily may help alleviate mild gastrointestinal discomfort and support digestion.
- Skin Applications: Topical products often contain 1–5% chamomile extract to soothe skin irritation and inflammation.
- Anti-Inflammatory Support: To reduce inflammation, doses ranging from 300–1,100 mg daily are used in supplement form.
How to Store Chamomile Extract?
Store bulk chamomile extract powder in an airtight container. Place it in a cool, dry place, away from direct sunlight and moisture.
Chamomile Extract VS Apigenin
Chamomile extract represents a complex botanical mixture containing multiple bioactive compounds. At the same time, apigenin exists as an isolated flavonoid compound found within chamomile. This fundamental difference in composition creates distinct properties and effects. Extract chamomile contains apigenin, essential oils (α-bisabolol, chamazulene), other flavonoids, terpenoids, and mucilages that work synergistically. This complex phytochemical profile contrasts with purified apigenin’s singular molecular structure and more targeted biological activity.
The bioactive spectrum reveals significant differences in therapeutic applications. Chamomile extract powder demonstrates a broader range of benefits due to its diverse compound profile, with simultaneous anti-inflammatory, anxiolytic, spasmolytic, and skin-soothing properties. Apigenin, while potent in its specific activities, particularly GABA receptor modulation and certain anti-inflammatory pathways, lacks the comprehensive effects of the whole extract. Research indicates that the best chamomile extract often produces superior outcomes in conditions requiring multi-target approaches due to the synergistic effects of its various compounds working through complementary mechanisms.
Absorption and bioavailability patterns show interesting variations between these options. Buy chamomile extract delivers apigenin within a natural matrix containing compounds that may enhance absorption and utilization. Studies demonstrate that specific essential oil components in chamomile can enhance membrane permeability, potentially improving the bioavailability of apigenin when delivered within the whole extract. Isolated apigenin, while more concentrated, may not achieve the same bioavailability without these supportive compounds.
Manufacturing considerations reveal distinct approaches to production and standardization. The extract production focuses on preserving the natural compound profile while ensuring consistent levels of marker compounds. Apigenin isolation requires additional purification steps to separate it from other chamomile constituents. These production method differences influence cost and final product characteristics, with isolated apigenin typically commanding higher prices due to additional purification requirements.
Clinical applications demonstrate clear differentiation in therapeutic approaches. While isolated apigenin provides targeted benefits for specific pathways, particularly in research applications requiring precise dosing of a single compound, chamomile extract powder offers a broader therapeutic approach mimicking traditional herbal medicine’s holistic benefits. This difference in therapeutic breadth makes each option valuable for different applications, with the extract preferred for comprehensive support and isolated apigenin selected for targeted intervention.
| Property | Chamomile Extract | Apigenin |
| CAS Number | Not applicable (mixture of compounds) | 520-36-5 |
| Molecular Formula | Varies (contains flavonoids, terpenoids, etc.) | C15H10O5 |
| Molecular Weight | Varies (apigenin: 270.24 g/mol) | 270.24 g/mol |
| Powder Color | Light yellow to brown | Pale yellow to off-white |
| Appearance | Fine powder or liquid extract | Fine crystalline powder |
| Natural Sources | Flowers of Matricaria chamomilla or Chamaemelum nobile | Found in chamomile, parsley, celery, and other plants |
| Stability | Moderate—degrades with heat and light over time | Stable under normal conditions |
| Primary Function | Calming, anti-inflammatory, antioxidant, digestive aid | Pure flavonoid with antioxidant and neuroprotective properties |
| Common Uses | Sleep aids, digestive health, skin care, relaxation products | Cognitive support, stress reduction, and inflammation modulation |
| Mechanism of Action | Modulates GABA receptors, reduces inflammation, and soothes gastrointestinal tissues | Binds to GABA-A receptors, reduces oxidative stress, and inhibits inflammation pathways |
| Bioavailability | Moderate—varies by compound (apigenin is less bioavailable without enhancement) | Low—improves with lipid-based delivery methods |
| Onset of Action | Gradual—cumulative calming and anti-inflammatory effects | Quicker—direct GABAergic action for relaxation |
| Health Benefits | Reduces anxiety and stress, supports sleep, soothes digestive issues, promotes skin healing | Cognitive enhancement, neuroprotection, anti-anxiety, and anti-inflammatory effects |
| Advantages | Broad-spectrum benefits from multiple bioactive compounds | Pure, targeted action—especially for brain health and relaxation |
| Disadvantages | Variability in potency depending on extraction method | Poor natural bioavailability, requires advanced formulations for better absorption |
| Other Information | Contains apigenin but also other flavonoids (luteolin, quercetin) and terpenoids | More potent for targeted GABA modulation and neuroprotection |
Conclusion
Chamomile extract is a highly versatile botanical ingredient with well-documented benefits in relaxation, digestive health, inflammation reduction, and skincare applications. Its complex profile, rich in flavonoids, essential oils, and bioactive compounds like apigenin and bisabolol, allows for multi-target therapeutic effects that outperform single-compound alternatives.
The very meticulous production process, from raw material selection to advanced extraction and purification, ensures a high-quality final product with optimized bioavailability. Scientific studies confirm its efficacy, reinforcing its traditional use while expanding its applications in modern health and wellness formulations.
While the extract provides comprehensive health support, considerations such as potential allergic reactions and drug interactions must be accounted for. Legal approval across major markets, including the FDA, EFSA, and Health Canada, affirms its safety and widespread availability.
Compared to isolated apigenin, the extract delivers broader benefits due to its synergistic components, making it a superior choice for holistic health applications. With its stability ensured through proper storage and packaging, chamomile extract remains a powerful natural solution in teas, supplements, skin care, and therapeutic formulations.
Why Choose Nutri Avenue To Buy Best Chamomile Extract Powder?
Nutri Avenue is redefining nutraceutical manufacturing as an innovative FDA-registered supplier exclusively dedicated to dietary supplement raw materials, empowering manufacturers, contract manufacturers, and private labelers with next-generation solutions. Our cutting-edge infrastructure centers on five strategically positioned local inventories across the United States, enabling seamless access to thousands of raw materials in bulk quantities at competitive wholesale prices. In today’s quality-focused marketplace, we set new industry standards through comprehensive third-party testing, digital certificates, and detailed analytical reports.
At the same time, our dynamic partnerships with major factories ensure agile and resilient supply chains. Our sophisticated global footprint spans North America, Mexico, and advanced European territories, including Poland, Hungary, France, and the United Kingdom, alongside emerging South American markets such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay. We’ve engineered innovative transportation solutions across sea, land, and air, ensuring responsive delivery systems for modern supply chain demands.
Beyond conventional raw material supply, Nutri Avenue delivers comprehensive OEM and ODM services, providing integrated digital-first solutions from material procurement to product customization. Our state-of-the-art manufacturing capabilities span multiple formats, including capsules, soft gels, tablets, powders, and oils. This enables us to provide future-ready solutions while maintaining exceptional quality throughout the production journey. Welcome to contact us.
* All products from Nutri Avenue can provide ISO certificates.
FAQs
Chamomile powder extract is not a significant source of vitamins. It primarily contains bioactive compounds like flavonoids, terpenoids, and other phytochemicals.
Chamomile extract is partially soluble in water, meaning that some components can dissolve in water, while others may require solvents like alcohol or oil for extraction.
Chamomile extract is generally considered safe when used in appropriate amounts. However, it may cause allergic reactions in individuals sensitive to plants in the daisy family.
