Chelidonine

What is Chelidonin?

Chelidonin is a naturally occurring alkaloid found primarily in the plant Chelidonium majus (greater celandine). Known for its complex chemical structure and potent biological effects, Chelidonin has garnered interest in traditional and modern medicine. This bioactive compound has been used for centuries in herbal medicine practices and has shown promising potential in studies related to pain relief, anti-inflammatory properties, and antispasmodic effects.

Chelidonin is a white to yellowish crystalline powder soluble in water and organic solvents. It is typically found in greater celandine leaves, stems, and roots, and various extraction methods allow for its use in dietary supplements and potential therapeutic formulations.

Common Sources

Plant-Based Sources

Greater Celandine: The primary source of Chelidonin is the Chelidonium majus plant, particularly concentrated in its roots.

Other Related Plants: While less common, Chelidonin may also be found in trace amounts in other members of the Papaveraceae family.

What Does Chelidonin Do?

Chelidonin powder primarily disrupts cellular microtubules, affecting cell division and growth. This compound exhibits multiple therapeutic properties: it reduces inflammation, blocks cell division, fights microbes, and protects liver tissue. In cancer research, Chelidonin has demonstrated the ability to trigger apoptosis in cancer cells by activating specific protein pathways. The substance also interacts with the nervous system by binding to GABA and opioid receptors, resulting in pain-relieving effects. While these biological activities make Chelidonin valuable for medical research, its use requires careful monitoring due to possible toxic effects on the liver and nervous system at higher doses.

How to Produce Chelidonin Powder?

Extraction: Chelidonin is typically extracted from the roots and aerial parts of Chelidonium majus using solvents like ethanol or methanol.

Purification: The extract is then purified using techniques such as chromatography to achieve high-purity Chelidonin.

Drying and Powdering: Once purified, the Chelidonin is dried and processed into a fine powder suitable for supplement formulations.

Specification Sheet Reference

Chelidonin: Benefits, Side Effects, and More

Anti-Cancer Properties

Chelidonin demonstrates remarkable antineoplastic potential through its ability to disrupt cancer cell division. It accomplishes this by interfering with microtubule formation during mitosis, preventing cancer cells from completing their division cycle. Additionally, it triggers programmed cell death (apoptosis), specifically in cancer cells, through complex protein pathways, making it a compound of interest in oncology research.

Anti-Inflammatory Effects

As an anti-inflammatory agent, Chelidonin helps reduce inflammation in body tissues. This property makes it potentially valuable for treating various inflammatory conditions. The compound achieves this by modulating inflammatory mediators and reducing the production of pro-inflammatory substances in the body, contributing to its therapeutic potential in inflammatory diseases.

Antimicrobial Activity

Chelidonin exhibits notable antimicrobial properties, effectively combating various pathogens. This characteristic suggests potential applications in treating infections and developing new antimicrobial therapies. Its ability to inhibit microbial growth adds versatility as a therapeutic compound.

Pain Management Properties

Through its interaction with opioid receptors in the nervous system, Chelidonin demonstrates significant analgesic (pain-relieving) effects. This property suggests potential applications in pain management therapies, particularly in cases where alternative pain relief options are needed. The compound’s ability to modulate pain perception through multiple neural pathways makes it an exciting candidate for pain management research.

Hepatoprotective Effects

One of Chelidonin’s most intriguing benefits is its potential liver-protective properties. While the exact mechanisms remain under investigation, research suggests it may help protect liver cells from damage and support liver function. This hepatoprotective effect could be valuable in developing treatments for various liver conditions, though careful dosing is essential due to its paradoxical potential for hepatotoxicity at higher concentrations.

Neurological Interactions

The compound’s interaction with GABA receptors and neurotransmitter systems indicates potential benefits for neurological applications. These interactions affect neural signaling and may have implications for treating various neurological conditions.

Side Effects

Chelidonin is generally considered safe when used as directed, but potential side effects include:

Gastrointestinal Issues: This compound may induce digestive discomfort to some individuals.

Neurological Symptoms: In rare cases, dizziness or light-headedness may occur, especially at higher doses.

Precautions

Individuals with liver conditions or sensitivities should consult with a healthcare provider before using Chelidonin. It is advised to start with a low dose to assess individual tolerance.

Is It Legal?

United States Legal Status

The FDA allows Chelidonin in dietary supplements and herbal products but has not approved it as a medication. This means manufacturers can include it in supplements but cannot market these products with specific medical claims or treatments.

European Union Legal Status

Under EU herbal medicine regulations, Chelidonin is permitted for use in supplements. To legally produce and distribute Chelidonin-containing supplements, manufacturers must follow the European Medicines Agency’s safety protocols and guidelines for herbal products.

Canadian Legal Status

Health Canada classifies Chelidonin as legal for use in natural health products. Before selling Chelidonin-containing products, manufacturers must meet specific quality standards and obtain proper licensing under the Natural Health Products Regulations.

International Legal Framework

The legal status of Chelidonin varies by country, with each nation enforcing its regulations and restrictions. Verification of local laws is essential to ensure compliance with regional requirements before any production, sale, or use of Chelidonin products.

Industry Applications and Uses

Supplements: Chelidonin is often included in herbal formulations for its pain-relieving and anti-inflammatory benefits.

Pharmaceuticals: Investigated for its therapeutic potential, particularly in pain relief and inflammation reduction.

Cosmetics: Occasionally added to skincare products for its potential antioxidant benefits.

Recommended Dosage and Usage

For Supplements: Typical dosage ranges from 100 mg to 500 mg per day, based on intended health benefits.

For Skincare: Chelidonin concentrations in skincare products typically range between 0.1% and 1%.

How to Store Chelidonin Powder?

Chelidonin powder requires specific storage conditions to preserve its chemical stability. Store the powder in an airtight, amber glass container to prevent light and moisture exposure. Keep it refrigerated at 2-8°C (35.6-46.4°F), though brief storage at room temperature up to 25°C (77°F) is acceptable. Place the container away from heat and direct sunlight in a dark, dry area. Use clean, dry instruments when handling the powder, and seal the container immediately after use. Label the container with the opening date and regularly check for quality changes such as color alterations, clumping, or odd smells. These storage practices help maintain the powder’s integrity and effectiveness.

Chelidonin VS Berberine

Chelidonin and Berberine share natural therapeutic properties, but Chelidonin demonstrates superior medical applications. Through its cell division disruption mechanism, Chelidonin shows enhanced effectiveness against cancer cells compared to Berberine. While Berberine focuses on metabolic functions, Chelidonin delivers three key advantages: inflammation reduction, antimicrobial action, and pain relief through receptor interaction. Chelidonin’s specialized ability to target cancer cells through multiple pathways highlights its advanced therapeutic potential over Berberine’s general metabolic benefits, particularly in cancer research applications.

Conclusion

Chelidonin is especially promising for pain management and reducing inflammation. Traditionally valued for its antispasmodic properties, it now draws attention to its antioxidant effects and potential therapeutic uses. With its varied biological activities, Chelidonin is an attractive ingredient for supplements and therapeutic formulations.

Why Choose Nutri Avenue Supplier to Buy Chelidonin Powder?

At Nutri Avenue, we maintain superior quality standards for our Chelidonin powder through strict quality control and independent testing. Our GMP-certified facilities ensure product consistency and purity while comprehensive laboratory testing verifies the absence of contaminants and confirms chemical composition. We provide detailed Certificates of Analysis with each product, demonstrating our commitment to quality. Our professional storage and handling protocols preserve the compound’s integrity throughout the supply chain.

We provide expert customer support with in-depth knowledge of Chelidonin applications, backed by our flexible manufacturing capabilities. Nutri Avenue offers market-competitive pricing, reliable stock availability, and adaptable purchase options. Our business practices include complete transparency in documentation, from product specifications to safety information. Through consistent delivery performance, professional quality assurance, and customizable production solutions, we have established ourselves as a versatile supplier for your Chelidonin powder requirements. Whether you need standard products or specialized formulations, our comprehensive OEM/ODM services ensure we can meet your unique business needs while maintaining our high-quality standards.

FAQs

What is Chelidonin used for?

Chelidonin is primarily used for pain relief, inflammation reduction, and gastrointestinal support.

Is Chelidonin safe?

Yes, Chelidonin is generally safe when used within recommended doses.

Can Chelidonin help with muscle spasms?

Yes, Chelidonin has effectively relieved muscle spasms, especially those in the digestive tract.

Is Chelidonin legal in my country?

Chelidonin is legal in most countries but may be subject to local regulations.