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Product Name D-Mannose
Other Name D-Mannitol
CAS Number 69-65-8
Molecular Formula C6H12O6
Molecular Weight 180.156 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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D-Mannose is the most popular beneficial Sugar Compound and Effective in Control of Bacterial Growth, get the best dietary supplement ingredients

What Is D-Mannose?

Mannose is a vital sugar that belongs to the aldohexose series of carbohydrates. It is not only found in fruits but also occurs naturally in the human body. Mannose plays a crucial role in human metabolism, especially in the glycosylation of certain proteins. It is worth mentioning that various congenital disorders of glycosylation are associated with mutations in enzymes involved in mannose metabolism. Therefore, it is essential to maintain a healthy intake of mannose in our daily diet.

Physical and Chemical Properties

Unless otherwise specified, all data are for standard state materials at 25 °C [77 °F] and 100 kPa.

Molecular Formula 


Molecular Weight

180.16 g/mol

Physical Form

Solid white crystalline powder



Bulk D-Mannose Powder Specification Sheet




white powder




Kosher, Halal, GMP, etc.


Slightly sweet

Assay of D-mannitol (dry basis)


Loss on drying




Residue on ignition


Reducing sugar


Nichel (Ni)


Lead (Pb)


Test Methods


MOQ (minimum order quantity)



Available (10-20g/bag)

OEM Service

Available, such as capsules, tablets, pills, etc.

ODM Service


Private Label


Contract Manufacturing


D-Mannose Powder Health Benefits?

D-mannose is a type of sugar that is like glucose and has incredible benefits like:

  1. Reduce Bleeding

Dietary supplementation with D-mannose can help prevent blood clotting disorders.

  1. Protects Liver

The study examined how D-mannose could protect against hepatic steatosis in experimental alcoholic liver disease.

  1. Lowers Blood Sugar

Mannose must convert to fructose, then glucose, which reduces the insulin response and lowers blood sugar levels.

  1. Prevents UTI

D-Mannose reduces recurrent UTIs and extends UTI-free periods.

Applications and Uses

D-Mannose is a key component of polysaccharides and glycoproteins, and it has widespread usage in:

MEDICAL: Mannitol is a diuretic that reduces swelling and pressure in the body. It is used to treat cerebral edema, kidney failure, and glaucoma.

FOOD AND BEVERAGE: D-Mannitol powder is a low-calorie sugar substitute that is used in a variety of food and beverage products, including candies, chewing gum, desserts, and baked goods.

COSMETICS: Mannitol is a common ingredient in cosmetics and personal care products. It helps retain moisture.

PHARMACEUTICAL: Mannitol is a widely used excipient in pharmaceuticals to improve drug stability, solubility, and absorption. 

INDUSTRIAL: Mannitol is used in various industrial applications, such as producing resins, adhesives, and coatings, as well as a blowing agent for foam products and a dust suppressant in coal mining.

Dose D-Mannose Have Side Effect?

Studies suggest that D-mannose is well-tolerated in most individuals. It is important to note that D-mannose may cause side effect such as:

  • Nausea
  • Diarrhea

It is important to note that consuming high doses of D-mannose may cause harm to the kidneys.

Special Precautions and Warnings

D-mannose is safe in normal dietary doses but can be toxic in higher amounts. The long-term safety of daily or any dose of D-mannose is unknown.

Diabetes: Some studies indicate that consumption of D-mannose may negatively impact blood sugar regulation in individuals with diabetes.

Breast Feeding and Pregnancy: Insufficient evidence exists on the safety of using D-mannose during pregnancy and breastfeeding. It is recommended to avoid its use as a precautionary measure.

Is D-Mannitol FDA-Approved?

FDA approved Mannitol on October 30, 2020, as add-on maintenance therapy for controlling pulmonary symptoms in adult patients with cystic fibrosis.

How Long is the Shell Life of D-Mannitol?

Adding potassium and sodium chloride to mannitol can cause precipitation. Unopened 100- and 250-ml containers last for 2 years. 

How to Store D-Mannitol Powder?

Storage Instructions: Store between 2°C and 30°C in original container.

Where to Source Bulk D-Mannitol Powder?

Nutri Avenue is a supplier of plant active ingredients. They offer high-quality D-Mannitol Powder at a competitive price, which can be used in various industries including food and dietary supplements. Nutri Avenue has multiple warehouses located in California (2), Florida (1), and a public warehouse in NY/NJ. Along with the warehouse information, it is important to note key supplier information such as pricing, shipping, services, certificates, and a stable supply chain capability. Contact us to get a quote now. 


Mannitol is a type of sugar that can be used both as a sweetener and as a medication. D-mannitol is the D enantiomer of mannitol.

Overeating certain sugar alcohols, like mannitol and sorbitol, can lead to digestive problems, such as bloating, gas, and diarrhea.

Mannitol is commonly produced through catalytic hydrogenation, but this process is suboptimal. 

Suvchem is a manufacturer and exporter of D (-) MANNITOL LR.


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