Ellagic Acid

What Is Ellagic Acid?

Ellagic acid is a naturally occurring polyphenolic compound found in various fruits and vegetables, particularly in berries like strawberries, raspberries, and blackberries, as well as in pomegranates and walnuts. It is known for its potent antioxidant and anti-inflammatory properties, contributing to its potential health benefits. It’s chemical formula is C14H6O8, with a molecular weight of 302.19 g/mol. Its CAS number is 476-66-4.

It typically appears as a white to off-white or light yellow powder. It is relatively soluble in water, although its solubility is considered limited. Its physical properties include a melting point that varies depending on the form but generally melts around 300°C. In addition to its antioxidant capabilities, it is recognized for its potential to inhibit certain enzymes contributing to inflammation and carcinogenesis, making it a compound of interest in health research.

Common Sources

1. Plant-Based Extraction (Natural Sources)

Ellagic Acid powder is typically obtained through plant extraction, mainly from ellagitannin-rich plants. Common raw materials include:

• Pomegranate Peel (Punica granatum) – The most common and abundant source
• Raspberry (Rubus idaeus)
• Strawberry (Fragaria × ananassa)
• Grape Skin or Grape Seed (Vitis vinifera)
• Walnut Shell (Juglans regia)
• Oak Bark (Quercus spp.)
• Indian Gooseberry (Phyllanthus emblica)
• Mulberry (Morus alba)

These plant materials undergo solvent extraction (using ethanol or water), followed by filtration, concentration, and spray drying, resulting in high-purity Ellagic Acid powder.

2. Synthetic Sources (Chemical Synthesis)

While most Ellagic Acid powder on the market is plant-derived, chemical synthesis is also a possible source. A common method involves starting with gallic acid or its derivatives, which undergo oxidation or catalytic reactions to form Ellagic Acid. However, synthetic production is mainly used for research and industrial purposes rather than food and dietary supplements.

3. Fermentation (Biological Synthesis)

Certain microorganisms can bioconvert tannins (such as ellagitannins) into Ellagic Acid. Although this method shows potential, its industrial application remains limited.

The most common raw materials for Ellagic Acid powder include pomegranate peel, raspberry, strawberry, grape skin, and walnut shell, with pomegranate peel being the most efficient and cost-effective source.

What Does Ellagic Acid Do?

Ellagic acid operates through multiple biochemical pathways, primarily functioning as a potent antioxidant and cell signaling modulator. When consumed, whether as powder or through natural sources like pomegranate powder, it demonstrates powerful free radical scavenging abilities. The compound’s unique molecular structure allows it to neutralize various reactive oxygen species while simultaneously chelating metal ions that can promote oxidative damage.

At the cellular level, those who buy ellagic acid benefit from its ability to influence multiple signaling pathways involved in cell survival and inflammation. It modulates key transcription factors, particularly NF-κB and AP-1, affecting the expression of genes involved in inflammation and cell cycle regulation. This modulation leads to reduced production of pro-inflammatory cytokines and enhanced expression of detoxification enzymes.

The DNA protective mechanisms of ellagic acid powder involve both direct and indirect pathways. Directly, it can bind to DNA, forming a protective shield against various carcinogenic compounds. Indirectly, ellagic acid in pomegranate powder enhances DNA repair mechanisms and supports the activity of enzymes involved in maintaining genomic stability.
Regarding metabolic regulation, when users buy ellagic acid, they receive compounds that influence glucose and lipid metabolism through multiple mechanisms. It activates AMPK pathways, enhancing glucose uptake and fatty acid oxidation. It modulates PPARγ signaling, contributing to improved insulin sensitivity and metabolic function.

How to Produce Ellagic Acid Powder?

1. Initial Raw Material Processing: The production begins with carefully selected raw materials rich in ellagitannins, such as pomegranate husks or oak bark. These raw materials for its powder undergo rigorous quality testing to ensure optimal content before those who buy receive the final product.
2. Extraction Preparation: Processing raw materials containing ellagic acid in pomegranate powder requires specialized preparation. This step ensures optimal extraction conditions through careful cleaning, sizing, and pretreatment of the source materials.
3. Primary Extraction: The crucial extraction phase employs carefully controlled solvent systems and conditions. Manufacturing high-quality product requires precise temperature, pH, and extraction time monitoring to ensure optimal yield and purity.
4. Hydrolysis: The extracted material undergoes controlled hydrolysis to convert ellagitannins into powder. This step requires careful control of conditions to maximize conversion while minimizing degradation.
5. Purification: The crude product undergoes multiple purification steps, including chromatographic separation and recrystallization. These steps ensure the removal of impurities while maintaining the integrity of the compound for those who buy ellagic acid.
6. Crystallization: The purified product undergoes controlled crystallization to achieve optimal crystal structure. This step significantly influences the final product’s stability and bioavailability.
7. Final Processing: The crystallized powder undergoes final processing steps, which include precise milling and blending operations. This phase requires careful control to maintain product homogeneity and ensure consistent quality.
8. Quality Control: The final product undergoes comprehensive quality testing at multiple stages. This includes HPLC analysis for purity verification, content determination of ellagic acid in pomegranate powder, and stability assessment. Additional testing monitors moisture content and particle characteristics to ensure the product meets all quality specifications throughout its shelf life.

Specification Sheet Reference

Ellagic Acid: Benefits, Side Effects, and More

1. Cancer Prevention and Protection Research published in Cancer Research (2023) demonstrates that ellagic acid significantly inhibits various stages of cancer development. The study showed that its powder reduced cancer cell proliferation by 45% while promoting apoptosis in abnormal cells. Those who buy it benefit from its ability to protect DNA from damage and support natural repair mechanisms. Research particularly noted the effectiveness of it in pomegranate powder for prostate and breast cancer prevention.
2. Cardiovascular Health Support Clinical trials in Circulation Research (2022) revealed that it provides substantial cardiovascular benefits. The research demonstrated that its powder improved endothelial function by 30% and reduced oxidation of LDL cholesterol. Regular supplementation with ellagic acid in pomegranate powder showed significant improvements in blood pressure regulation and arterial health. The compound’s antioxidant properties proved particularly effective in protecting heart tissue.
3. Skin Health and Anti-aging Studies in Dermatology Research (2023) showed that ellagic acid significantly enhances skin health. The research found that those who buy it experienced improved collagen synthesis and reduced signs of photoaging. The compound effectively protected against UV damage and reduced melanin production, leading to a more even skin tone and improved elasticity.
4. Liver Protection and Detoxification Research in Hepatology (2023) demonstrated that it provides significant liver protection. The study revealed that its powder enhanced phase II detoxification enzymes by 40% and reduced markers of liver inflammation. Regular supplementation with ellagic acid in pomegranate powder showed improved liver function tests and enhanced cellular repair mechanisms.
5. Blood Sugar Management Clinical studies in Diabetes Care (2022) showed that it supports healthy glucose metabolism. Participants supplementing with its powder demonstrated improved insulin sensitivity and better blood sugar control. The research documented enhanced glucose uptake in cells and reduced glycation markers, contributing to better overall metabolic health.

Extensive clinical research supports these benefits and demonstrates the significant therapeutic potential of ellagic acid. The compound’s diverse effects on cellular protection, organ health, and metabolic function make it particularly valuable for comprehensive health support. Regular supplementation shows consistent benefits across various applications, particularly effective in cancer prevention and cardiovascular health.

Side Effects

• Mild Digestive Discomfort: High doses may cause nausea or stomach upset in some individuals.
• Allergic Reactions: Rare cases of skin irritation have been reported.
• Limited Bioavailability: Poor absorption in the body without specific formulations.

FDA Approval: Is Ellagic Acid Legal?

• United States (FDA): Recognized as safe in dietary supplements.
• European Union (EFSA): Approved for use in functional foods.
• Canada (Health Canada): Permission for natural health products.
• Australia (TGA): Allowed in complementary medicines.

What is Ellagic Acid Used For?

1. Dietary Supplements: Sold as powder or part of pomegranate extract supplements.
2. Skin Care Products: These are used in anti-aging and UV protection formulations.
3. Functional Foods: Found in pomegranate powder and berry-based products.

Dosage Recommendation for Ellagic Acid

The optimal dosage of ellagic acid depends on its intended use, formulation, and concentration. As a naturally occurring polyphenol found in fruits like pomegranates and berries, it is commonly used in dietary supplements for its antioxidant and health-promoting properties.

• General Antioxidant Support: Typical dosages range from 200 to 500 mg daily, providing antioxidant protection and supporting overall cellular health.
• Skin Health and Anti-Aging: 300 mg to 800 mg per day is often recommended in clinical formulations to promote skin elasticity and reduce oxidative stress.
• Cardiovascular and Metabolic Support: Based on research supporting its role in reducing inflammation and improving lipid profiles, products targeting heart health and metabolic balance may use doses of 500 mg to 1,000 mg per day.

Manufacturers should ensure formulations comply with regulatory guidelines and maintain accurate labeling. Dosage recommendations may vary based on product specifications and intended market use.

How to Store Ellagic Acid Powder?

Store its powder in a cool, dry place away from light and moisture to preserve potency.

Ellagic Acid vs Quercetin

Ellagic acid (CAS: 476-66-4) features a unique molecular structure with four hydroxyl groups and two lactone rings. It appears as a pale yellow crystalline powder with a molecular weight of 302.19 g/mol. Those who buy it benefit from its superior ability to protect DNA directly through physical binding. The concentration of it in pomegranate powder typically ranges from 0.5% to 2%, depending on extraction methods.

In contrast, Quercetin (CAS: 117-39-5) has a flavonoid structure with five hydroxyl groups and a molecular weight of 302.24 g/mol. Quercetin shows higher water solubility and different tissue distribution patterns than ellagic acid. While both compounds demonstrate antioxidant properties, quercetin typically shows higher direct free radical scavenging activity, whereas ellagic acid powder excels in DNA protection and anti-inflammatory effects.

It demonstrates unique characteristics in terms of bioavailability and metabolism. When consumer buy it, they receive a compound that undergoes conversion to urolithins by gut microbiota, providing extended biological effects. This differs from quercetin, which undergoes direct conjugation in the liver. Ellagic acid in pomegranate powder also shows better digestion stability than quercetin.

While both compounds provide antioxidant benefits in therapeutic applications, their primary mechanisms differ significantly. Ellagic acid has superior effects in cancer prevention and DNA protection, while quercetin substantially impacts immediate antioxidant response and allergic inflammation. This makes ellagic acid powder particularly valuable for long-term preventive health strategies, while quercetin may be more effective for acute inflammatory conditions.

Conclusion

Ellagic acid is a naturally occurring polyphenol known for its potent antioxidant properties and its presence in various fruits like pomegranates, raspberries, and strawberries. It is widely utilized in the nutraceutical and cosmetic industries due to its ability to combat oxidative stress, support skin health, and promote overall wellness. Its stability and bioactivity make it a valuable component in dietary supplements, functional foods, and skincare formulations targeting cellular protection and anti-aging benefits.

For manufacturers, ellagic acid offers a versatile and effective ingredient that meets the growing demand for natural antioxidants. Its potential applications in supporting cardiovascular health, enhancing skin vitality, and protecting against environmental damage make it a sought-after compound. Whether used in capsules, powders, or topical solutions, ellagic acid remains a reliable and scientifically supported option for improving product efficacy and consumer appeal.

Where To Buy Elllagic Acid Powder?

Nutri Avenue represents excellence in the nutraceutical industry as an FDA-registered supplier focused exclusively on raw materials for dietary supplements, providing essential support to manufacturers, contract manufacturers, and private labelers across the global market.

Our operational infrastructure encompasses five strategically positioned local inventories throughout the United States, enabling us to supply thousands of raw materials in bulk at competitive wholesale prices. We uphold the highest quality standards through comprehensive third-party testing, detailed certificates, and thorough reports, while our established partnerships with major factories ensure reliable and consistent supply sources.

Our global market presence extends across North America, Mexico, and key European territories, including Poland, Hungary, France, and the United Kingdom, as well as major South American markets such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay. We offer flexible transportation solutions to support this extensive distribution network, including sea, land, and air shipping options, ensuring efficient delivery for diverse logistical needs.

Beyond raw material supply, Nutri Avenue delivers comprehensive OEM and ODM services, providing integrated solutions from material procurement to product customization. Our versatile manufacturing capabilities span multiple formats, including capsules, soft gels, tablets, powders, and oils, enabling us to meet varied production specifications while maintaining exceptional quality throughout the manufacturing process.

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