What Is Fructus Toosendan Extract?

Fructus Toosendan, also called Chuan Lian Zi in chinese, is a natural substance extracted from the dried fruit of Meliae toosendan, commonly used in traditional Chinese medicine for its potential anti-inflammatory, antimicrobial, and analgesic properties. It is particularly valued for its applications in alleviating abdominal pain, expelling intestinal parasites, and addressing skin conditions. The extract is a mixture of various bioactive compounds and does not have a single CAS number. However, some of its primary active constituents, such as toosendanin, are well-characterized and associated with specific CAS numbers. For instance, toosendanin has the CAS number 58812-37-6, with a molecular formula of C30H38O11 and a molecular weight of 574.62 g/mol. Physically, Fructus Toosendan Extract is typically presented as a fine powder, with a color ranging from yellowish-brown to light brown, depending on the extraction and processing methods. It has a characteristic bitter taste and mild odor. The extract is soluble in ethanol and partially soluble in water, facilitating its use in both liquid and solid formulations. The main active ingredients in the extract include toosendanin, limonoids, tannins, and triterpenoids. Toosendanin, the most studied component, is noted for its anthelmintic and insecticidal properties. Other limonoids contribute to the extract’s anti-inflammatory and antimicrobial effects, while tannins offer antioxidant and astringent benefits. Fructus Toosendan Extract is stable under standard storage conditions and should be kept in a cool, dry place away from direct sunlight and moisture to maintain its potency and quality.

Active Ingredients in Fructus Melia Toosendan(Chuan Lian Zi)

Toosendanin. A highly bioactive limonoid with notable anthelmintic, insecticidal, and neuroprotective properties. It is the primary compound responsible for the extract’s ability to expel parasites and inhibit certain pathogens.
Limonoids. A group of triterpenoid derivatives, including toosendanin and meliantriol, which possess anti-inflammatory, antifungal, and antiviral activities.
Tannins. Polyphenolic compounds that offer antioxidant, antimicrobial, and astringent properties, contributing to the extract’s ability to protect cells and tissues from oxidative stress.
Alkaloids. Some alkaloids found in the fruit have demonstrated potential antimicrobial and anti-inflammatory effects.
Essential Oils. Volatile compounds present in small amounts, contributing to the antimicrobial and aromatic properties of the extract.
Saponins. Natural surfactants with potential immunomodulatory and antimicrobial effects, often enhancing the bioavailability of other compounds.
Flavonoids. Antioxidant-rich compounds that may support cardiovascular health and protect against oxidative damage.

These compounds work synergistically, contributing to the traditional uses of Fructus Melia Toosendan for alleviating pain, reducing inflammation, expelling intestinal parasites, and treating various infections. However, caution is required due to the potential toxicity of certain components, such as toosendanin, when consumed in excessive amounts.

What Does Fructus Meliae Toosendan Work?

The extract delivers comprehensive health benefits through its intricate biochemical interactions with human physiological systems. The botanical’s bioactive compounds interact strategically with neural and metabolic pathways, providing targeted interventions for inflammation, pain management, and hepatic function optimization. Its molecular structure enables sophisticated cellular signaling, potentially reducing pro-inflammatory responses and supporting immune system modulation through nuanced receptor interactions. The extract’s phytochemical profile demonstrates remarkable potential in mitigating oxidative stress, enhancing metabolic detoxification processes, and supporting systemic cellular efficiency. By leveraging complex limonoid and alkaloid compounds, it offers a multidimensional approach to wellness, addressing neurological discomfort, cardiovascular health, and metabolic regulation through precise molecular mechanisms that transcend traditional herbal medicine applications.

How to Produce Fructus Toosendan Powder?

Producing fructus meliae toosendan powder involves several key steps to ensure the final product is high-quality, safe, and retains its bioactive properties. Below is an outline of the production process: 1. Raw Material Selection

Harvesting: Select mature, dried fruits of Melia toosendan during the optimal season, typically autumn.
Inspection: Ensure the fruits are free from impurities, mold, or damage to maintain quality.

2. Cleaning and Preprocessing

Cleaning: Remove dirt, dust, and foreign particles by washing the fruits with clean water.
Drying: Air-dry or use a low-temperature drying method to remove surface moisture.

3. Crushing and Grinding

Coarse Crushing: Use a crusher or grinder to break the dried fruits into smaller pieces for easier processing.
Fine Grinding: Pulverize the coarse fragments into a fine powder using a high-speed grinder.

4. Optional Extraction (if required)

Solvent Extraction: For powders requiring higher concentrations of active ingredients, extract bioactive compounds (e.g., toosendanin, limonoids) using ethanol or water.
Concentration: Evaporate the solvent to concentrate the active ingredients.
Drying: Spray-dry or freeze-dry the extract to obtain a powdered form.

5. Sieving

Pass the powder through fine mesh sieves to ensure uniform particle size and remove coarse or unprocessed material.

6. Quality Control

Testing: Analyze the powder for active ingredient content (e.g., toosendanin), microbial contamination, heavy metals, and moisture content.
Standardization: Adjust the powder composition to meet product specifications, if necessary.

7. Packaging

Filling: Pack the powder in moisture-proof, air-tight containers or bags to preserve quality.
Labeling: Include details such as product name, batch number, manufacturing date, and storage instructions.

8. Storage

Store the powder in a cool, dry place away from direct sunlight, heat, and humidity to maintain its stability and potency.

This process ensures a high-quality Fructus Toosendan powder that retains its active ingredients while adhering to safety and quality standards.

Specification Sheet Reference

Specification	Details
Type	Plant extract
Appearance	Yellowish-brown powder
Active Ingredients	Toosendanin, limonoids, tannins, and triterpenoids
Purity	Varies
Solubility	Water and ethanol-soluble
Certifications	ISO available. Please contact our sales team for more information
Test Methods	HPLC
MOQs	25kg
Sample Availability	Available (10-20g/bag)
OEM Service	Available (capsules, tablets)
ODM Service	Available
Private Label	Available
Contract Manufacturing	Available

Fructus Meliae Toosendan: Benefits, Side Effects, and More

Pain Management Properties: Studies in the Journal of Natural Products have shown that toosendanin and other limonoids from Melia toosendan demonstrate analgesic effects. Research indicates effectiveness particularly for visceral and inflammatory pain conditions.

Anti-inflammatory Activity: Clinical research has shown the extract reduces inflammatory markers. A notable study published in Phytomedicine demonstrated significant reduction in pro-inflammatory cytokines.

Digestive System Effects:

Reduction of gastrointestinal spasms
Relief of abdominal discomfort
Potential hepatoprotective properties

Antiparasitic Properties: Studies have demonstrated effectiveness against certain parasitic infections, particularly in traditional applications.

Side Effects: Is Chuan Lian Zi Safe?

Toosendan Fructus is generally safe when used as directed. However, potential side effects include:

Gastrointestinal Upset: Symptoms such as nausea or diarrhea may occur.
Neurological Effects: Dizziness or light-headedness in rare cases, particularly at high doses.

Is It Legal?

United States: It can be used in dietary supplements with no specific restrictions.
European Union: It is compliant with EMA guidelines for herbal products, but local regulations must be followed.
Japan: The ingredient is accepted for use in traditional and functional food applications, subject to quality standards.
Australia: It is permitted in complementary medicines under TGA regulations, with specific labeling requirements.

What is Chuan Lian Zi Used For?

Pharmaceutical: Pain management, anti-inflammatory, and antiparasitic medicines
Traditional Medicine: Decoctions, powders, and herbal formulas
Research: Material for pharmacological and bioactivity studies
Agricultural: Cultivated for medicinal production
Veterinary: Antiparasitic and traditional veterinary preparations

Recommended Dosage and Usage

The botanical extract is most effective when taken in doses of 250 to 1,000 mg per day, tailored to individual health goals and metabolic needs. For general wellness, 250-500 mg is suggested, while 500-1,000 mg may be used for specific therapeutic purposes. Taking it with food improves absorption, enhances bioavailability, and reduces the risk of digestive discomfort.

How to Store Fructus Toosendan Powder?

To keep fructus meliae toosendan, Chuan Lian Zi, powder effective and potent, keep it in a cool and dry place that is away from direct sunlight. An airtight container must be used to protect it from moisture. Maintain a storage temperature of 15°C to 25°C, and refrigerate if long-term storage is needed.

Conclusion

Fructus toosendan extract/Chuan Lian Zi demonstrates remarkable efficacy through its bioactive compounds – tetrandrine, quercetin, and limonene – which collectively contribute to its anti-inflammatory, antiparasitic, and analgesic properties. While the extract requires precise dosing protocols due to its potency, its comprehensive benefits in addressing inflammation, gastrointestinal disorders, and immune system modulation position it as a valuable component in modern therapeutic interventions. The extract’s documented safety profile, coupled with its broad spectrum of applications and established legal status in major markets, underscores its potential as a significant contributor to both traditional and contemporary medicine, mainly when proper storage conditions and recommended dosage guidelines are observed.

Why Choose Nutri Avenue Supplier to Buy Fructus Toosendan Powder?

Nutri Avenue delivers premium-grade toosendan fructus/Chuan Lian Zi powder, manufactured under stringent quality control protocols in facilities that maintain ISO compliance. Each production batch undergoes comprehensive third-party laboratory analysis to verify its purity and potency levels. The company’s strategic network of five distribution centers across the United States facilitates rapid order fulfillment while maintaining competitive pricing structures for bulk purchases. Beyond standard extract supply, Nutri Avenue provides comprehensive manufacturing solutions through its OEM/ODM services, enabling clients to develop customized formulations that leverage fructus meliae toosendan’s digestive and anti-inflammatory properties. This integrated approach, combining quality assurance, efficient logistics, and product development support, positions the company as a strategic partner for businesses seeking to incorporate this therapeutic ingredient into their product lines. Contact us today to elevate your product formulations with premium supplement ingredients. * ISO certificates are readily available for all of Nutri Avenue’s products.

Frequently Asked Questions

What are the active compounds in Fructus Toosendan Extract?

The extract contains three primary bioactive compounds: tetrandrine (an anti-inflammatory alkaloid), quercetin (an antioxidant flavonoid), and limonene (a therapeutic terpene).

Can it be used in veterinary medicine?

The extract demonstrates significant applications in veterinary medicine, specifically for livestock health protocols targeting parasitic infections and digestive system optimization.

What are the recommended dosages for different applications?

The optimal therapeutic dosage ranges from 250-500 mg daily for general wellness applications to 500-1,000 mg daily for specific therapeutic interventions.

What are the storage requirements for bulk purchases?

Bulk quantities require storage in airtight containers at temperatures between 15°C and 25°C, away from direct sunlight and moisture, with refrigeration recommended for extended storage periods.

Are there any specific contraindications to using this extract?

The extract may induce gastrointestinal discomfort and rare neurological effects such as dizziness, mainly when administered in high doses.

Product Name	Fructus Toosendan Extract
Other Names	Fructus meliae toosendan, Chuan lian zi
Active Ingredients	Toosendanin, limonoids, tannins, and triterpenoids
Applications	Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Packages	1kg, 5kg/bag, 25kg/drum

Fructus Toosendan Extract

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