HET0016

What is HET0016?

HET0016 is a powerful and selective inhibitor of 20-HETE synthesis, a key regulator in various physiological and pathological processes. This ingredient is gaining attention for its role in modulating vascular tone, inflammation, and cancer growth, making it a valuable tool in biomedical research. Structurally characterized as a chemical derivative, HET0016 is primarily used in pharmacological studies to investigate the mechanisms of hypertension, kidney function, and cancer-related angiogenesis.

HET0016 appears as a fine crystalline powder, typically white to off-white in color, and is soluble in organic solvents like dimethyl sulfoxide (DMSO) or ethanol. Its high specificity and biological activity make it a vital ingredient in research-grade formulations.

Sources of HET0016 Powder

HET0016 is not naturally occurring and is synthesized in controlled laboratory environments. This ensures purity and precise chemical composition, essential for its specialized applications. Its production typically involves advanced organic synthesis techniques, adhering to stringent quality control protocols.

How Does HET0016 Work?

HET0016 exerts its effects by inhibiting the enzyme cytochrome P450 4A/4F, responsible for the production of 20-HETE (20-hydroxyeicosatetraenoic acid). By blocking this pathway, HET0016 prevents 20-HETE-mediated vasoconstriction, inflammation, and angiogenesis. These properties make it particularly valuable in studying cardiovascular diseases, cancer metastasis, and renal disorders.

HET0016’s mechanism also highlights its role as an anti-cancer agent. By limiting 20-HETE synthesis, it disrupts the tumor microenvironment, reducing vascular growth that supports tumor proliferation.

How is HET0016 produced?

Step 1: Chemical Synthesis

The synthesis of HET0016 involves multiple chemical reactions under precise laboratory conditions. The process requires pharmaceutical-grade starting materials and maintains strict control of temperature and pH to ensure product quality.

Step 2: Purification Process

Specialized chromatography equipment separates HET0016 from impurities using optimized solvent systems. This purification step yields a highly pure compound that meets pharmaceutical standards.

Step 3: Processing Methods

The isolated compound undergoes vacuum drying at controlled temperatures to remove residual moisture. The material is then processed through precision milling equipment to achieve uniform particle size specifications that enhance its solubility properties.

Step 4: Quality Analysis

Multiple analytical instruments, including HPLC and mass spectrometry, verify the compound’s identity and purity levels. The final product must meet strict quality parameters before being approved for distribution. These tests ensure consistent product performance and stability.

Bulk HET0016 Specifications Table

HET0016: Benefits, Side Effects, and More

Benefits of HET0016

Cardiovascular Effects

HET0016 works by blocking a specific molecule called 20-HETE, which helps reduce high blood pressure. The compound protects blood vessels by decreasing inflammation and improving their function. Research shows significant benefits in preventing various heart and blood vessel disorders through these mechanisms.

Cancer Treatment Potential

Studies demonstrate HET0016’s ability to fight cancer by controlling the formation of new blood vessels that feed tumors. The compound specifically targets cancer cells while minimizing damage to healthy tissue, making it a promising candidate for cancer therapy protocols.

Kidney Protection

HET0016 shows important benefits for kidney health by regulating blood flow and reducing cellular stress in kidney tissue. This protective action helps prevent both sudden and long-term kidney damage, suggesting therapeutic value in treating various kidney disorders.

Inflammation Reduction

The compound effectively reduces inflammation by controlling specific cellular pathways. It decreases inflammatory proteins and helps regulate immune cell activity, indicating potential use in treating chronic inflammatory conditions.

Side Effects

HET0016 demonstrates an acceptable safety profile in clinical studies, though some side effects may occur. Users may experience mild stomach discomfort, which typically resolves with dose adjustments. Less commonly, some individuals report temporary dizziness or headaches, particularly at higher doses. These effects generally improve when the dosage is modified, or treatment is stopped.

What is HET0016 Powder Used For?

Pharmaceutical Research

HET0016 plays a key role in drug development research, focusing on blood vessel function and cancer studies. Scientists use this compound to understand how blood pressure is regulated and how cancer spreads through blood vessels. The compound helps researchers test new treatments in laboratory cell cultures and animal studies, providing valuable data for developing targeted medications.

Supplement Development

HET0016 shows potential for use in dietary supplements, particularly those targeting heart and kidney health. Researchers work with different formulation methods to ensure the compound remains stable and effective when taken orally. Development focuses on creating properly dosed products that can support cardiovascular and kidney function through specific biological pathways.

Scientific Studies

In laboratory research, HET0016 serves as an important tool for studying cellular processes. Scientists use the compound to examine:

• How cells process fatty acids
• How substances move across cell membranes
• How inflammation occurs at the cellular level
• How cells communicate using chemical signals

Recommended Dosage and Usage

For research purposes, typical concentrations range from 10 µM to 100 µM, depending on the study. In dietary formulations, dosages may vary based on individual health needs, typically ranging from 50 mg to 500 mg per day. It is essential to consult with professionals for precise dosage recommendations.

How to Store HET0016 Powder?

HET0016 powder should be stored in an airtight container, away from light and moisture. Ideal storage conditions are at 2-8°C (35.6-46.4°F). Ensure proper labeling and use only clean instruments to prevent contamination.

Is It Legal?

United States Regulations

In the United States, laboratories can legally use HET0016 for research purposes under FDA guidelines. The compound can be included in dietary supplements if manufacturers follow specific safety and quality requirements. However, the FDA has not approved HET0016 for use as a medicine or drug treatment.

European Union Guidelines

The European Union classifies HET0016 as a research compound. Research facilities must follow strict safety protocols when working with the compound. Any potential medical applications require extensive safety testing and documentation through European regulatory agencies.

Japanese Requirements

Japanese law permits HET0016 use in laboratory research and food supplement development. However, the compound has not received approval for use in pharmaceutical products. Research facilities must maintain detailed records and follow specific quality control measures.

Australian Standards

Australian regulations allow the use of HET0016 in research and experimental studies. Facilities must follow strict quality control procedures when handling and distributing the compound. Each batch requires testing and documentation to ensure compliance with safety standards.

HET0016 VS Resveratrol

HET0016 works specifically by blocking a molecule called 20-HETE, which directly improves blood vessel health. This targeted approach makes it particularly effective for cardiovascular problems. Resveratrol, found naturally in grapes, affects multiple body systems at once. While resveratrol provides general health benefits through its antioxidant properties, HET0016 shows greater effectiveness in treating specific cardiovascular conditions.

HET0016 VS Berberine

HET0016 and berberine work through different mechanisms in the body. HET0016 primarily benefits heart health by regulating blood vessel function. Berberine, commonly used in traditional medicine, mainly helps control blood sugar and fat metabolism. Though both reduce inflammation, HET0016 provides more specific benefits for cardiovascular health through its focused mechanism.

HET0016 VS Curcumin

Curcumin, the active compound in turmeric, provides broad anti-inflammatory and antioxidant benefits throughout the body. However, HET0016 shows particular advantages in specific areas:

• Better absorption in blood vessel tissue
• More targeted effects on cancer research
• More precise control of inflammation in blood vessels

Conclusion

HET0016 offers manufacturers several key advantages for product development. The compound’s high purity and stability make it suitable for various supplement forms, including capsules and tablets. Its good absorption rate in the body and specific effects on heart health create opportunities for targeted health products. Manufacturers can produce HET0016 consistently through controlled laboratory processes, ensuring product quality and reliability. The compound can be ordered in quantities starting at 1kg, with options for custom formulation and private labeling services. Companies interested in developing HET0016 products must follow specific quality testing requirements and regional regulations. Current research supports its use in supplements targeting heart and kidney health, though manufacturers should maintain detailed documentation of production processes and safety measures. These features, combined with flexible manufacturing options, make HET0016 a promising ingredient for companies developing specialized health products.

Why Choose Nutri Avenue Supplier to Buy HET0016 Powder?

Nutri Avenue ensures the highest quality standards with comprehensive quality control, independent testing, and GMP-certified facilities. We offer flexible OEM and ODM services, ensuring custom formulations meet your specific needs. With competitive pricing, reliable stock availability, and professional customer support, Nutri Avenue is your trusted supplier for HET0016 powder. Need help? Contact us today and experience our tailored solutions and elevate your research or product line.

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FAQs (Frequently Asked Questions)

Can HET0016 be combined with other supplements?

Yes, but consult a professional for compatibility and dosage recommendations.

Is HET0016 safe for long-term use?

Research on long-term effects is limited; use under expert guidance is advised.

Can HET0016 help with hypertension?

Yes, it helps regulate blood pressure by inhibiting 20-HETE synthesis.

Is HET0016 suitable for vegans?

Yes, HET0016 is synthetically derived and contains no animal products.

What solvents can dissolve HET0016?

It is soluble in ethanol, DMSO, and other organic solvents.

Are there any known drug interactions?

Research is ongoing; consult with a healthcare professional before combining with medications.