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What Is Inositol Powder?
Inositol is a naturally occurring cyclic polyol compound that belongs to the vitamin B family, although it is not strictly classified as a vitamin. It is widely found in plant and animal tissues and plays a critical role in cell signaling, lipid metabolism, and the formation of cell membranes. Inositol powder is commonly used in dietary supplements due to its potential benefits for brain health, metabolic regulation, and hormonal balance.
The chemical properties can be described as follows: its CAS number is 87-89-8, its molecular formula is C6H12O6, and its molecular weight is 180.16 g/mol. Physically, inositol appears as a white crystalline powder with a sweet taste and is highly soluble in water. It has a melting point range of 224-227°C and remains stable under normal temperature and pressure, making it suitable for various food and pharmaceutical applications.
Additionally, its polyol structure gives it excellent hygroscopic properties, and it forms a neutral solution when dissolved in water. As a bioactive compound, it is frequently studied for its applications in cognitive health, mood management, and endocrine-related areas, offering researchers and pharmaceutical companies a wealth of opportunities for exploration.
Common Sources
1. Chemical Sources
Inositol powder can be chemically synthesized through processes like cyclization reactions from cyclohexanol or other chemical precursors. The synthetic methods make it widely available for industrial production, commonly used in dietary supplements and pharmaceuticals.
2. Plant Sources
This compound is naturally present in many plants, especially in seeds, nuts, whole grains, and legumes. The form of inositol found in plants is primarily Myo-Inositol. Common plant sources include:
- Legumes: such as soybeans, peas, and lentils.
- Nuts: such as almonds, peanuts, and walnuts.
- Whole Grains: like oats, brown rice, and wheat.
- Fruits: such as citrus fruits and apples.
3. Food Sources
Inositol in foods primarily comes from plant-based sources. In addition to the nuts, legumes, and whole grains mentioned, foods rich in dietary fiber also contain it. While animal-based foods also contain small amounts, especially in brain tissue, plant-based sources are typically richer. Common food sources include:
- Whole Wheat Bread and Pasta: Whole grains contain higher amounts.
- Fruits and Vegetables: such as oranges, grapefruits, grapes, and cabbage.
- Nuts and Seeds: like peanuts, almonds, sesame seeds, and sunflower seeds.
The abundant plant sources make it a popular ingredient in modern dietary supplements, particularly for its applications in supporting metabolism, brain health, and hormonal balance.
Is D-Inositol The Same As Inositol?
Both are not exactly the same. While both belong to the same class of chemical compounds—cyclic alcohols—there are differences, mainly in their isomeric structures.
1. Inositol
The term “Inositol” typically refers to Myo-Inositol, the most common form and the one predominantly found in the human body. Myo form is a six-membered cyclic molecule with six hydroxyl (OH) groups, distributed across different carbon atoms.
2. D-Inositol
It refers to the D-isomer of Inositol. It is one of the stereoisomers. While the chemical composition is the same, the arrangement of atoms in space differs, which can result in different biological activities or effects. D-Inositol is relatively rare and may have different biological functions compared to Myo-Inositol.
While D-Inositol and Myo-Inositol (often referred to simply as Inositol) share similar chemical components, they are distinct isomers, which may lead to differences in their biological roles and applications. Myo-Inositol is the most common form and is widely used in supplements and research, whereas D form is less common and has fewer known applications.
What Does Inositol Do?
This ingredient plays a crucial role in several bodily functions, particularly in cellular signaling, brain health, metabolism, and overall well-being. It is a key component of phosphoinositides, which are involved in transmitting signals within cells, helping regulate growth, survival, and communication.
In the brain, it supports the production of neurotransmitters like serotonin and dopamine, which are essential for mood regulation, making it beneficial for managing anxiety, depression, and mood disorders.
Additionally, it helps improve insulin sensitivity, particularly in individuals with conditions like polycystic ovary syndrome (PCOS), and plays a role in balancing hormones, supporting menstrual regularity and fertility in women with PCOS.
Beyond its effects on metabolism and hormones, it aids in fat metabolism, supporting liver health by preventing fat accumulation and reducing the risk of fatty liver disease. It may also help improve skin health, particularly by balancing hormones that influence conditions like acne.
Moreover, vitamin b8 has been shown to help reduce LDL cholesterol levels and improve lipid profiles, contributing to cardiovascular health.
Overall, the ingredient is an essential compound with wide-ranging benefits for mental, metabolic, hormonal, and skin health, making it a popular supplement for improving various aspects of health.
How To Produce Inositol Powder?
1. Source and Extraction
The powder is typically sourced from natural plant materials, such as corn steep liquor (a byproduct of corn processing), soybean oil, or other plant-based sources rich in inositol. Some methods also use chemical synthesis or fermentation processes for production. Here’s how it can be done:
- Fermentation Process: Microorganisms, such as yeast, are used to ferment sugar substrates (like glucose or sucrose) into inositol. This method is often used for producing high-purity powder.
- Extraction from Plant Materials: This compound is extracted from plant-based sources like corn or soybeans through a series of solvent extraction steps. Typically, water or alcohol is used to extract it from these materials.
2. Purification
After extraction, the ingredient needs to be purified to remove any unwanted compounds, such as residual solvents, fats, and other byproducts. The purification process may involve:
- Filtration: To remove larger impurities.
- Chromatography: A more refined process that helps separate this ingredient from other substances based on its chemical properties.
- Crystallization: It is often crystallized from an aqueous solution, as it has a high solubility in water. Crystallization helps isolate pure form from the mixture.
3. Drying
Once purified, the ingredient is converted into a powder by removing excess moisture. This is typically done through spray drying or freeze-drying techniques:
- Spray Drying: The purified solution is sprayed into hot air, which evaporates the water, leaving behind fine powder.
- Freeze Drying: This method involves freezing the powder solution and then removing water through sublimation. This process results in a more delicate powder, retaining a higher level of its purity.
4. Quality Control and Packaging
The final powder is rigorously tested for purity, particle size, and other quality parameters to ensure it meets industry standards. Once approved, the powder is packaged in airtight containers to maintain its stability and prevent moisture absorption.
5. Optional Steps
In some cases, this compound may be further processed into other forms, such as capsules or tablets, depending on its intended use. It may also be blended with other ingredients if used in supplements or fortified foods.
Overall, the production involves sourcing, extraction, purification, drying, and quality control steps to ensure the final product is high-quality and suitable for use in supplements, pharmaceuticals, and food products.
Specifications sheet reference
Type | Supplement ingredient |
Appearance | White crystalline powder |
Purity | 99%, etc. |
Particle Size | 20-80 Mesh |
Certifications | ISO available. Please contact sales team for details. |
Solvent | None |
Water Content | Maximum 1% |
Test Method | HPLC, FTIR, GC |
MOQs | 25kg |
Sample | Available (10-20g/bag) |
OEM Service | Available, such as capsules, tablets, pills, etc. |
ODM Service | Available |
Private Label | Available |
Contract Manufacturing | Available |
Inositol: Benefits, Side Effects, and More
Inositol, particularly Myo-Inositol, has garnered significant attention for its potential health benefits, supported by a variety of clinical studies and research trials. These benefits span across areas like mental health, metabolic function, hormone regulation, and more.
1. Mental Health and Cognitive Function
- Anxiety and Depression: Several studies suggest that inositol, particularly Myo-Inositol, may help reduce symptoms of anxiety, depression, and other mood disorders. In one study, Myo form supplementation was shown to be effective in reducing symptoms of panic disorder and obsessive-compulsive disorder (OCD). A randomized controlled trial (RCT) published in the American Journal of Psychiatry found that 18 grams of inositol per day was as effective as fluvoxamine, an SSRI, in treating OCD.
- Bipolar Disorder: Its role in supporting brain neurotransmitter function, particularly serotonin, has led to research examining its effects on bipolar disorder. A trial published in Bipolar Disorders indicated that inositol supplementation may help stabilize mood in patients with bipolar disorder, although results vary between individuals.
2. Polycystic Ovary Syndrome (PCOS)
- Insulin Sensitivity and Fertility: It has been extensively studied for its role in PCOS, a condition associated with insulin resistance, hormonal imbalances, and infertility. Studies have shown that Myo-Inositol and D-Chiro Inositol (another form of inositol) can improve insulin sensitivity, regulate menstrual cycles, and enhance ovulation rates. In one large study, women with PCOS who took a combination of Myo form and D-Chiro form had improved ovulation and pregnancy rates compared to those who did not take inositol.
- Clinical Trials: A study published in Fertility and Sterility found that Myo-Inositol supplementation improved insulin sensitivity and reduced androgen levels in women with PCOS, leading to more regular menstrual cycles and better fertility outcomes. Another study found that it alone improved ovulation and hormone levels in women with PCOS.
3. Metabolic Health
- Insulin Sensitivity and Blood Sugar Regulation: This ingredient is known to play a role in insulin signaling, which is beneficial for improving insulin sensitivity, particularly in individuals with metabolic disorders like PCOS and type 2 diabetes. Several studies have shown that the supplementation helps improve insulin sensitivity, reduce blood glucose levels, and enhance fat metabolism.
- Weight Loss: It has been investigated for its effects on weight management, especially in individuals with PCOS, where insulin resistance can contribute to obesity. A clinical trial published in The Journal of Clinical Endocrinology & Metabolism showed that inositol supplementation helped reduce waist circumference and body fat percentage in women with PCOS.
4. Fertility and Hormonal Balance
- Improved Ovulation: It plays a role in balancing hormones, particularly in women with PCOS, where hormonal imbalances like elevated testosterone levels can interfere with ovulation. Research shows that the compound helps lower testosterone levels, promoting more regular ovulation and enhancing fertility.
- Sperm Quality: Some studies have also explored the effects on male fertility. A study in Human Reproduction found that Myo-form supplementation improved sperm quality and motility in men with fertility issues.
5. Cholesterol and Heart Health
- Reducing Cholesterol Levels: It has been shown to help reduce LDL (bad) cholesterol and triglyceride levels. A study published in The Journal of Clinical Investigation demonstrated that the compound helps improve lipid profiles, contributing to better cardiovascular health.
- Fatty Liver Disease: It has been suggested to help prevent non-alcoholic fatty liver disease (NAFLD) by improving fat metabolism. One study published in Hepatology found that Myo-form reduced liver fat content and improved liver function in people with fatty liver disease.
6. Skin Health
- Acne and Hormonal Imbalances: Its ability to balance hormones also extends to its benefits for skin health. Women with PCOS often suffer from acne due to hormonal imbalances, but supplementation has shown promise in improving skin appearance by regulating hormones like androgens. A study in the Journal of Clinical Endocrinology & Metabolism demonstrated that supplementation improved acne symptoms in women with PCOS.
7. Chronic Conditions and Other Benefits
- Fatigue and Sleep: Some studies have shown that the ingredient helps reduce fatigue and improves sleep quality, especially in people with conditions like fibromyalgia or chronic fatigue syndrome. The exact mechanism is still being explored, but it may relate to inositol’s effects on neurotransmitter function and insulin regulation.
- Neuroprotective Effects: Emerging research suggests that inositol may have neuroprotective properties, potentially benefiting people with neurodegenerative diseases like Alzheimer’s or Parkinson’s disease. However, more research is needed in this area.
Side Effects
Yes, the powder is generally considered safe when used in appropriate amounts, both as a dietary supplement and in food. It has been widely used in research and as a supplement for various health conditions, with relatively few reported side effects.
- Gastrointestinal issues: such as nausea, bloating, or diarrhea.
- Headaches: Some people may experience headaches, particularly when starting supplementation.
These side effects are typically mild and resolve with time or by adjusting the dosage.
Is It Legal?
- United States: Regulated as a dietary supplement by the FDA, with no pre-market approval required. Health claims must be substantiated.
- European Union: Regulated as a food supplement. Health claims must be approved by EFSA and supported by scientific evidence.
- Japan: Regulated as a food ingredient or supplement by MHLW. Health claims require scientific substantiation.
- Canada: Regulated as a natural health product, requiring evidence for health claims.
- Australia: Regulated as complementary medicine by the TGA, with approval required for therapeutic claims.
What is Inositol Used For?
Its diverse applications span across healthcare, nutrition, cosmetics, pharmaceutical research, and even agriculture.
It is primarily known for its benefits in managing conditions like PCOS, mental health disorders, insulin resistance, and fertility. It is also emerging as an important ingredient in skincare and functional foods.
Research is ongoing to uncover more of its potential therapeutic uses, particularly in neurodegenerative diseases and cancer treatment.
Recommended Dosage and Usage
Typical dosages for inositol supplements range from 500 mg to 2,000 mg per day, though higher doses (up to 12 grams per day) have been used in clinical studies for conditions like PCOS and anxiety.
Studies have shown that even higher doses are generally well-tolerated in the short term, though individuals should always start with the lowest effective dose.
How to Store Inositol Powder?
Store the powder in a cool, dry place, away from direct sunlight and moisture. Keep tightly sealed to maintain stability and potency.
Berberine VS Inositol
Both are compounds with significant health benefits, but they differ in their chemical structure, applications, and mechanisms of action. Here’s a comparison between the two, including an introduction to berberine.
Berberine is an alkaloid compound that occurs naturally in several plants, including Goldenseal, Berberis, and Phellodendron. It has a wide range of uses, particularly in managing metabolic health and various chronic conditions.
- CAS Number: 2086-83-1
- Molecular Formula: C20H18NO4
- Molecular Weight: 336.37 g/mol
- Appearance: Berberine typically appears as a yellow powder or crystals. It is known for its distinct yellow color, which is a characteristic of berberine alkaloids.
- Physical Properties:
- Berberine is sparingly soluble in water but dissolves well in ethanol, methanol, and other organic solvents.
- It has a bitter taste and is stable under normal conditions but can degrade when exposed to extreme temperatures and light.
Berberine is a potent bioactive compound that has been extensively researched for its various health benefits:
- Insulin Sensitivity: Berberine is known to improve insulin sensitivity, making it beneficial for those with type 2 diabetes or metabolic syndrome. It works by activating an enzyme called AMP-activated protein kinase (AMPK), which regulates glucose and lipid metabolism.
- Cholesterol and Lipid Profile: It helps lower total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. This makes it useful for improving cardiovascular health.
- Weight Loss: Berberine has been shown to help with weight loss by improving metabolism and regulating fat storage.
- Gut Health: It may support gut health by inhibiting the growth of harmful bacteria and promoting a healthy gut microbiome.
- Anti-inflammatory: Berberine has anti-inflammatory properties that can help manage chronic inflammation, a key factor in many diseases like heart disease and cancer.
Comparison between Berberine VS Inositol
Mechanism of Action:
- Berberine works primarily by activating AMPK, improving insulin sensitivity, and regulating lipid metabolism. It has a broader effect on metabolic health and is used in conditions like type 2 diabetes and high cholesterol.
- Inositol primarily affects insulin sensitivity and hormonal regulation, particularly in conditions like PCOS and fertility. It also helps in managing mental health conditions like anxiety and depression.
Uses:
- Berberine is often used for metabolic health, including managing diabetes, improving cholesterol levels, and supporting weight loss. It has broader use in the management of cardiovascular and gut health.
- Inositol powder is more commonly used for hormonal health, particularly PCOS, and as a supplement for improving mental health, such as anxiety, depression, and OCD. It is also used to support fertility and regulate blood sugar.
Side Effects and Safety:
- Berberine can cause gastrointestinal issues such as diarrhea, constipation, or cramping, especially at higher doses. It may also interact with other medications, particularly those related to blood sugar regulation.
- Inositol is generally well-tolerated, though high doses can cause mild gastrointestinal discomfort such as bloating or diarrhea.
Conclusion
Inositol powder is a versatile and essential compound with numerous applications in health and wellness. From supporting mental health to regulating hormones and improving metabolic functions, this natural carbohydrate is a valuable addition to dietary supplements and functional foods.
Why Choose Nutri Avenue Supplier to Buy Inositol Powder?
Nutri Avenue, an FDA-registered supplier of raw materials for dietary supplements, specializes in providing high-quality ingredients to supplement product manufacturers of all sizes, contract manufacturers, and private labelers. Distinguished by our extensive capabilities in bulk packaging and wholesale pricing, we maintain five local inventories across the United States, offering thousands of raw material products to meet diverse manufacturing needs.
Our commitment to quality is evidenced through complete third-party testing, certificates, and reports, while our long-term cooperative relationships with significant factories ensure stable and sufficient supply sources. We offer flexible transportation solutions, including sea, land, and air shipping, to serve our global markets, spanning North America, Mexico, European countries including Poland, Hungary, France, and the United Kingdom, as well as South American nations such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay.
Beyond raw material supply, Nutri Avenue provides comprehensive OEM and ODM services, offering one-stop solutions from raw material procurement to product customization. To meet our customers’ diverse needs, Nutri Avenue offers versatile manufacturing options, including capsules, soft gels, tablets, powders, and oils.
For more information on ordering and about our products, contact us here.
* All products from Nutri Avenue can provide ISO certificates.
FAQs
It is not a recognized vitamin, despite being occasionally labeled as vitamin B8.
Yes, it is sometimes referred to as vitamin B8, although some authorities do not officially recognize it as a vitamin.
While this compound is sometimes associated with promoting hair growth, more research is needed to establish its effectiveness.
