Magnesium L-Threonate

Magnesium L-Threonate: Benefits, Side Effects, and More

1. Cognitive Enhancement: Magnesium L Threonate has shown promising results in improving cognitive function, particularly in learning and memory. A landmark study published in the journal Neuron (2010) demonstrated that magnesium L-threonate enhanced both short-term and long-term memory in rats. The researchers found that increasing brain magnesium using L Threonate Magnesium significantly improved working memory, recall, and spatial memory.
2. Neuroprotection and Potential Alzheimer’s Management: Research suggests Magnesium L Threonate may have neuroprotective properties, potentially slowing age-related cognitive decline. A study in the Journal of Alzheimer’s Disease (2016) found that magnesium L-threonate could prevent and restore memory deficits in animal models of Alzheimer’s disease. The study showed that the supplement increased synaptic plasticity and reduced inflammation in the brain, suggesting its potential as a therapeutic remedy or agent for Alzheimer’s.
3. Improved Synaptic Plasticity: One of the most significant benefits of L threonate magnesium is its ability to enhance synaptic plasticity, which is crucial for learning and memory formation. A study published in PLOS One (2014) demonstrated that magnesium L-threonate could increase synaptic density and plasticity in the hippocampus, a region of the brain critical for memory. This increased plasticity was associated with improved cognitive performance in aging rats.
4. Sleep Quality Enhancement: While more human studies are needed, preliminary research indicates that Magnesium L Threonate may improve sleep quality. A study in the Journal of Sleep Research (2018) found that magnesium supplementation helped improve subjective insomnia and sleep efficiency measures. Although this study didn’t specifically use the L-threonate form, the ability of this form to cross the blood-brain barrier more effectively suggests it could have even more pronounced effects on sleep quality.
5. Mood Regulation and Anxiety Reduction: Emerging research suggests that Magnesium L Threonate may benefit mood and anxiety. A preclinical study published in Neuropharmacology (2017) found that magnesium L-threonate supplementation produced rapid and long-lasting antidepressant-like effects in mice. The researchers observed changes in brain chemistry similar to those made by conventional antidepressant medications, suggesting potential applications for mood disorders.

Side Effects: Is L-Threonate Magnesium Safe?

• Mild: Some users may experience gastrointestinal discomforts, such as nausea or diarrhoea, especially at higher doses.
• Rare: Magnesium toxicity is possible in individuals with kidney issues, though this is extremely rare when used within recommended dosages.

FDA Approval: Is Magnesium L Threonate Legal?

Magnesium L-Threonate is a magnesium salt of L-threonic acid, known for its potential cognitive benefits due to its ability to cross the blood-brain barrier. Its regulatory status and patent considerations vary across different regions:

• United States

In the U.S., Magnesium L-Threonate is marketed as a dietary supplement. Dietary supplements are regulated by the Food and Drug Administration (FDA) under the Dietary Supplement Health and Education Act of 1994 (DSHEA). Under DSHEA, dietary supplements do not require FDA approval before they are marketed, provided they do not contain new dietary ingredients introduced after October 15, 1994, without notification. Manufacturers are responsible for ensuring the safety and labeling of their products. As of now, there is no specific FDA approval for Magnesium L-Threonate as a drug.

• European Union

In the EU, Magnesium L-Threonate has been evaluated as a novel food. On January 30, 2024, the European Food Safety Authority (EFSA) published a scientific opinion concluding that Magnesium L-Threonate is safe under the proposed conditions of use as a novel food. Subsequently, on October 17, 2024, the European Commission authorized its placement on the market as a novel food, amending Implementing Regulation (EU) 2017/2470 to include Magnesium L-Threonate in the Union list of authorized novel foods. citeturn0search2turn0search4

• Japan

Information regarding the regulatory status of Magnesium L-Threonate in Japan is limited based on the provided sources. Typically, dietary supplements in Japan are regulated under the Food Sanitation Act and the Health Promotion Act. For specific details, it is advisable to consult Japan’s Consumer Affairs Agency or the Ministry of Health, Labour and Welfare.

• Australia

In Australia, dietary supplements are regulated by the Therapeutic Goods Administration (TGA). Magnesium supplements are generally listed as complementary medicines. However, specific information on Magnesium L-Threonate’s approval or listing was not found in the provided sources. Manufacturers intending to market such products in Australia should consult the TGA for guidance.

• Canada

Health Canada oversees dietary supplements under the Natural Health Products Regulations. Magnesium L-Threonate would likely be classified as a natural health product (NHP). Manufacturers must obtain a product license by providing evidence of safety and efficacy. Specific information on products containing Magnesium L-Threonate approved by Health Canada was not available in the provided sources.

Patent Considerations

Magtein® is a branded form of Magnesium L-Threonate developed by a team led by Professor Guosong Liu. The compound has been patented in various jurisdictions. Recently, Wuxi Magtein Biotechnology Co., Ltd., which holds rights to Magtein®, successfully defended its patent rights against infringement in China, reinforcing the patent’s validity.

In summary, while Magnesium L-Threonate is available as a dietary supplement in several regions, its regulatory status varies. In the U.S., it is marketed without specific FDA approval as a drug. The EU has authorized its use as a novel food. Information for Japan, Australia, and Canada is limited, and manufacturers should consult local regulatory bodies. Patent protections, such as those for Magtein®, are in place, and companies should be mindful of existing intellectual property when developing and marketing products containing Magnesium L-Threonate.

What Is Magnesium L-Threonate Used For?

Magnesium L-Threonate is widely used in the health and wellness industry due to its superior ability to increase magnesium levels in the brain. This makes it a popular ingredient in various dietary supplements and functional products. Some of its key applications include:

1. Brain Health Supplements. It is commonly found in nootropic supplements designed to enhance cognitive function, memory, and learning ability. It is particularly marketed for its potential to support neuroplasticity, improve focus, and help with age-related cognitive decline.
2. Sleep Aid Formulations. Due to its role in calming the nervous system and supporting neurotransmitter balance, Magnesium L-Threonate is used in sleep support supplements. It may help improve sleep quality, relaxation, and reduce symptoms of insomnia.
3. Stress and Anxiety Management. As magnesium plays a critical role in regulating the stress response, Magnesium L-Threonate is often included in stress-relief and anti-anxiety formulations. It may aid in reducing anxiety, promoting relaxation, and supporting emotional well-being.
4. Sports Nutrition and Recovery. Magnesium is essential for muscle relaxation, nerve function, and reducing muscle cramps. Some sports recovery supplements include Magnesium L Threonate powder to enhance muscle recovery, reduce fatigue, and support overall physical performance.
5. Anti-Aging and Longevity Products. Because Magnesium L-Threonate has been studied for its potential in reducing brain aging and supporting neural regeneration, it is included in longevity-focused formulations aimed at preventing cognitive decline and maintaining mental clarity in aging populations.
6. Functional Foods and Beverages. Some companies incorporate Magnesium L-Threonate into functional drinks, powders, and fortified foods designed to support brain health and relaxation. It may be found in products like nootropic coffee, cognitive-enhancing beverages, and magnesium-fortified snack bars.
7. Pharmaceutical and Medical Applications (Research-Based). Although primarily used as a dietary supplement, some research is exploring the potential of Magnesium L-Threonate in neurological and psychiatric treatments. It is being studied for its effects on Alzheimer’s disease, ADHD, and depression, though more clinical trials are needed.

In summary, Magnesium L Threonate is a versatile ingredient primarily found in nootropic, sleep aid, stress relief, sports recovery, anti-aging, and functional nutrition products. Its ability to cross the blood-brain barrier and boost brain magnesium levels makes it especially valuable in formulations targeting cognitive health and mental performance.

Recommended Dosage and Usage

• Cognitive Support: 1,000–2,000 mg per day, typically divided into two doses.
• Neuroprotection: 2,000 mg daily for enhanced brain health and aging-related cognitive support.
• General Magnesium Supplementation: 1,000 mg daily, based on individual magnesium needs.

How to Store Magnesium L Threonate Powder?

Store in a cool location with little to no humidity, away from direct sunlight and moisture. Use an airtight container to maintain potency and avoid degradation of the compound.

Magnesium L-Threonate VS Magnesium Citrate Anhydrous

When comparing these magnesium compounds, Magnesium L-Threonate (CAS: 778571-57-6) and Magnesium Citrate Anhydrous (CAS: 7779-18-9) represent distinctly different approaches to magnesium supplementation. Magnesium L-Threonate, with its molecular formula C8H14MgO10 and molecular weight of 294.50 g/mol, combines magnesium with L-chronic acid, a metabolite of vitamin C. Magnesium Citrate Anhydrous, bearing the molecular formula C12H10Mg3O14 and molecular weight of 214.41 g/mol, pairs magnesium with citric acid in a water-free form.

Magnesium L-Threonate appears as a white to off-white crystalline powder with good water solubility and contains approximately 8% elemental magnesium by weight. Its unique feature is its documented ability to bypass the blood-brain barrier more effectively than other magnesium forms, leading to significant increases in brain magnesium levels. This property makes it particularly valuable for cognitive applications and neurological support.

Magnesium Citrate Anhydrous is a fine white powder with excellent water solubility that provides about 16% elemental magnesium by weight. Its anhydrous form makes it more concentrated than its hydrated counterpart, offering a higher magnesium content per gram. The citrate component provides additional benefits through its mild osmotic effects and potential role in energy metabolism through the citric acid cycle.

Their mechanisms of absorption show notable differences. Magnesium L-Threonate utilizes specific transport mechanisms that enhance its delivery to neural tissues while maintaining good systemic absorption. Magnesium Citrate Anhydrous relies on both passive diffusion and the enhancing effects of citrate on mineral absorption, showing excellent general bioavailability but without the specific neural targeting of the threonate form.

From a stability perspective, Magnesium L-Threonate shows good stability but requires protection from moisture. At the same time, Magnesium Citrate Anhydrous demonstrates excellent stability but is hygroscopic, requiring appropriate packaging to prevent moisture absorption and maintain its anhydrous state.

Conclusion

Magnesium L-Threonate is a specialized magnesium form known for its superior ability to bypass blood-brain restrictions, making it a valuable ingredient in cognitive health formulations. It supports brain function by enhancing synaptic density and improving memory, focus, and overall mental performance. This unique magnesium compound is also utilized in dietary supplements to promote neurological health and address magnesium deficiencies.

For manufacturers, Magnesium L-Threonate offers a scientifically backed solution for cognitive enhancement and brain health support. Its bioavailability and targeted delivery to the brain make it ideal for formulations focused on memory improvement and neuroprotection. Regulatory compliance is crucial for maintaining product efficacy and safety in the supplement market.

Why Choose Nutri Avenue to Buy Best Magnesium L Threonate?

Nutri Avenue is a leading FDA-registered supplier in the dietary supplement industry, specializing exclusively in raw materials rather than finished products. Our extensive network of five local inventories across the United States enables us to serve a diverse global clientele, from supplement product manufacturers and contract manufacturers to private labourers of all sizes.

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