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VB12 Methylcobalamin

Product Name Vitamin B12 Methylcobalamin
Other Names Mecobalamin, Methyl-B12, MeCbl, Methyl vitamin B12, Methyl-5,6-dimethylbenzimidazolylcobamide, Methylcob(III)alamin
CAS Number 13422-55-4
Molecular Formula C63H91CoN13O14P
Molecular Weight 1344.39 g/mol
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg,5kg/bag, 25kg/drum


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VB12 Methylcobalamin

What Is Vitamin B12 Methylcobalamin?

Vitamin B12, frequently referred to as cobalamin, is an essential component required for various body activities. One of the active variants of vitamin B12 is Methylcobalamin. It is a naturally occurring coenzyme form of vitamin B12 that the body rapidly utilizes.

Methylcobalamin is engaged in various critical activities in the body, including red blood cell creation, DNA synthesis, and nervous system function. It is essential for the health of nerve cells and aids in producing myelin, a protective coating surrounding neurons.

One of the notable features of Methylcobalamin is its involvement in methylation reactions. Methylation is a biochemical process throughout the body essential for many physiological functions. Methylcobalamin acts as a cofactor in methylation reactions, contributing to converting homocysteine to methionine, which is necessary for synthesizing proteins and other compounds.

Supplementation with Methylcobalamin is often recommended for individuals with vitamin B12 deficiency, particularly those with certain health conditions that affect the absorption or utilization of vitamin B12. It is available as an oral supplement, sublingual tablet, or injectable form.

While Methylcobalamin is considered an active and bioavailable form of vitamin B12, it’s worth noting that other forms of vitamin B12, such as cyanocobalamin, are also commonly used in supplements. Cyanocobalamin is converted to Methylcobalamin and other active forms in the body.

Common Bulk Pure Methylcobalamin Powder Specifications

The possible purities of bulk pure Methylcobalamin powder can range depending on the specific supplier or manufacturer. Here are some standard purity specifications seen in the market.

  1. VB12 as Methylcobalamin 98% pure powder
  2. Vitamin B12 pure powder 1,000,000IU Methylcobalamin
  3. Methylcobalamin 1% powder
Type Vitamin
Appearance Off-white or pinkish crystalline powder
Content ≥ 98%
Purity ≥ 99%
Particle Size < 50 microns
Certifications GMP, ISO, or other relevant certifications
Other Ingredient None
Solvent None
Water Content ≤ 5%
Test Method HPLC, GC, or other validated methods
MOQ (minimum order quantity) 1kg
Sample Available (10-20g/bag)
OEM Service Available, such as capsules, tablets, pills, etc.
ODM Service Available
Private Label Available
Contract Manufacturing Available

What Types Does Vitamin B12 Have?

Vitamin B12, also known as cobalamin, exists in several different forms, including:

  1. Cyanocobalamin: Cyanocobalamin is a synthetic vitamin B12 widely used in supplements and fortified meals. It is converted into active forms of vitamin B12 (Methylcobalamin and adenosylcobalamin) in the body. The “cyano” part of the name refers to the presence of a cyanide molecule tightly bound to the cobalamin molecule. However, the amount of cyanide released during metabolism is negligible and poses no significant health risk.
  2. Methylcobalamin: Methylcobalamin is one of the active forms of vitamin B12. The body quickly absorbs it and participates in various metabolic activities, including methylation reactions. Methylcobalamin supports nerve health, red blood cell production, and DNA synthesis.
  3. Hydroxocobalamin: Hydroxocobalamin is another natural form of vitamin B12. The body converts it into active formats (Methylcobalamin and adenosylcobalamin). Hydroxocobalamin has a longer half-life in the body than other forms of B12, making it suitable for specific therapeutic uses, such as treating vitamin B12 deficiency.
  4. Adenosylcobalamin: Adenosylcobalamin is the other active form of vitamin B12. It is involved in the energy metabolism of cells, particularly in the mitochondria. Adenosylcobalamin helps in the breakdown of specific amino acids and fatty acids.

What Is The Best Source Of Methylcobalamin Powder?

Methylcobalamin powder is derived from microbial fermentation processes. Bacteria, such as certain strains of Propionibacterium freudenreichii or Pseudomonas denitrificans, are commonly used to produce Methylcobalamin through fermentation.

These bacteria are grown under controlled conditions during fermentation in a nutrient-rich medium. The bacteria naturally synthesize Methylcobalamin as part of their metabolic processes. After fermentation, the Methylcobalamin is isolated, purified, and processed into a powdered form as a dietary supplement.

While microbial fermentation is the most common source of methylcobalamin powder, it’s worth noting that some brands may use different techniques or sources for production. It’s always recommended to carefully read product labels or consult with the manufacturer to determine the specific source and production methods employed for a particular methylcobalamin powder.

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What is the use of Methylcobalamin powder?

Methylcobalamin powder, as a vitamin B12 supplement, is used to address vitamin B12 deficiency or support overall health and well-being. Here are some common uses and benefits of methylcobalamin powder.

  1. Treating Vitamin B12 Deficiency: Methylcobalamin is an active form of vitamin B12 readily utilized by the body. It is often prescribed or recommended to individuals with vitamin B12 deficiency, which can occur due to inadequate dietary intake, malabsorption issues, certain health conditions, or certain medications. Methylcobalamin supplementation helps restore adequate levels of vitamin B12 in the body, supporting proper red blood cell formation, nerve health, and other vital functions.
  2. Supporting Nervous System Health: Methylcobalamin plays a crucial role in the maintenance and function of the nervous system. It promotes the health of nerve cells and assists in producing myelin, a protective coating that wraps around neurons. Adequate levels of Methylcobalamin are necessary for optimal nerve function and the transmission of nerve impulses.
  3. Boosting Energy Levels: Vitamin B12, including Methylcobalamin, is involved in energy metabolism. It helps to transform meals into helpful energy, and a lack of it can cause exhaustion and low energy levels. Supplementing with Methylcobalamin may help boost energy levels and combat feelings of tiredness or weakness.
  4. Supporting Cognitive Function: Adequate levels of Methylcobalamin are essential for healthy brain function and cognition. Vitamin B12 plays a role in neurotransmitter synthesis and overall brain health. Some research suggests that vitamin B12 supplementation, including Methylcobalamin, may help support cognitive function and memory.
  5. Supporting Mood and Emotional Well-being: Vitamin B12 is required to produce neurotransmitters like serotonin, which controls mood. Methylcobalamin supplementation may aid in the maintenance of good attitudes and emotional well-being.

Who is the top Vitamin B12 Methylcobalamin Supplier?

Nutri Avenue is the unrivaled champion in providing pure powdered Methylcobalamin! With our commitment to excellence, Nutri Avenue is the top supplier, delivering unparalleled quality and potency. Our rigorous manufacturing process ensures food-grade Methylcobalamin, guaranteeing maximum effectiveness. Trust Nutri Avenue for your health and wellness needs. Elevate your B12 experience with the superior choice – Nutri Avenue!

What Is VB12 Methylcobalamin Powder Manufacturing Process?

Vitamin B12 (Methylcobalamin) powder manufacturing process typically involves the following steps.

VB12 Methylcobalamin Powder Manufacturing Process


Yes, Methylcobalamin is water-soluble. Being water-soluble means, it can dissolve in water and be readily absorbed by the body.

Methylcobalamin is a naturally found vitamin B12 form. It is in various food sources, such as animal products, including meat, fish, eggs, and dairy. It can also be produced through microbial fermentation processes.

Methylcobalamin is not banned in India. It is commonly available and prescribed as a vitamin B12 supplement in India and many other countries. However, regulations and restrictions on specific products or formulations can vary, so it’s essential to refer to current and accurate information from relevant authorities for the most up-to-date details.

The active components of vitamin B12, Methylcobalamin, and adenosylcobalamin, are often considered the most effective supplement alternatives.

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