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Nicotinamide Riboside Chloride

Product Name Nicotinamide Riboside
Other names Vitamin B3 Niacin, NR
CAS number 1341-23-7
Molecular Formula C11H15N2O5
Molecular Weight 255.3 g/mol
Appearance/color White powder
Applications Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.
Package 1kg, 5kg/bag, 25kg/drum


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Nicotinamide Riboside is abbreviated as NR. But in fact, the market’s mainstream is selling NRC powder, the full name called nicotinamide riboside chloride. NRC is a chloride form of NR. There is almost no such product as NR powder on the market. Why? Here is the answer.

Nicotinamide Riboside VS Nicotinamide Riboside Chloride

NRC is more stable than NR. NR is very easily oxidized. After bulk nicotinamide riboside powder is opened, if it is not sealed in time, it will be oxidized soon and even change color. It can easily affect ingredient powder quality.

So, chloride is added to Nicotinamide Riboside, but the function of the ingredient is the same. The aim just makes the product more stable. It is also more conducive to processing.

About NR Patent Problem

The patent was solved. So, Nutri Avenue can sell nicotinamide riboside chloride powder to all parts of the world, including the United States. Welcome to get a free quote.

What Is Nicotinamide Riboside?

Known as an alternative form of Vitamin B3 or Niacin, Nicotinamide riboside is a popular compound believed to increase nicotinamide adenine dinucleotide (NAD+) levels in the human body. This is because the compound, once introduced into the body through supplementation, is converted into NAD+. As a helper molecule, NAD+ maintains certain processes of vital organ systems, thereby preventing their damage and rapid wear and tear.

While experts say that NAD+ can be increased to promote health and wellness by consuming its natural food sources such as dairy products, fish, and mushrooms, taking supplement products with compounds such as nicotinamide riboside can boost healthy aging and support the normal function of the human body.

Nicotinamide Riboside Form And Specifications

Because NR powder is easy to oxidize, factories and manufacturers will add Chloride to NR to increase its stability. This is also convenient and ensures customers will not be troubled and lost due to quality problems when purchasing and applying this ingredient powder. Bulk Nicotinamide Riboside Chloride is the mainstream form of NR powder sold in the market. The most famous market specifications and their basic information are as follows.

  • 99% Pure Bulk Nicotinamide Riboside Chloride Powder
  1. CAS number: 23111-00-4
  2. Chemical formula: C11H15ClN2O5
  3. Molecular weight: 290.70 g/mol
  4. Main benefits:

Nicotinamide Riboside Chloride is a form of chloride salt. Aside from increasing NAD levels, the compound is believed to activate certain pathways which help promote weight loss and address conditions associated with a high-fat diet. The compound is a potent synergized form of Nicotinamide Riboside, also sold in the market for optimal body function.

Nicotinamide Riboside Chloride C11H15ClN2O5

Nicotinamide Riboside Tablets VS Capsules

Pure Nicotinamide Riboside supplements come in either tablet or capsule forms. It is helpful for those who consume Nicotinamide Riboside to understand the pros and cons of using capsules and tablets to understand better what is more beneficial, depending on their preferences.

Tablet forms of Nicotinamide Riboside supplements can work in extended-release mechanisms. It is also widely accepted as it may come in chewable forms and is often more affordable. However, the disadvantage of using tablets is that it disintegrates lowly in the gastrointestinal tract.

On the other hand, capsule forms of Nicotinamide Riboside are advantageous as it helps protect the ingredient and do not often damage the gastrointestinal tract. However, capsules are usually more expensive.

Nicotinamide Riboside is often sold in capsule forms as they are normally more comfortable to swallow. Hence, leading product reviews promote capsule forms more than tablets.


Nicotinamide Riboside vs. Niacin

Although both Nicotinamide Riboside and Niacin are known to increase NAD levels, studies show their effects on the human body may vary. At the outset, Nicotinamide Riboside is a derivative of Nicotinamide. One study supports the claim that Nicotinamide is more similar to NAD than Niacin and is associated with lesser risks when used to treat skin conditions.

In leading health studies, it is observed that Niacin supplementation causes skin flushing among patients with Pellagra, otherwise known as Vitamin B3 deficiency. Although experts say skin flushing is not alarming and is not associated with inflammation, it is still a side effect. On the other hand, Nicotinamide Riboside supplementation for Vitamin B3 deficiency does not cause any associated side effects. Health experts also prefer Nicotinamide Riboside as it has longer bioavailability than niacin.

One research also shows that Nicotinamide Riboside may prevent acne. This benefit is not necessarily found in Niacin supplementation.

Nicotinamide Riboside vs. Nicotinamide Mononucleotide

Experts consider efficiency-wise, Nicotinamide Riboside as supreme over Nicotinamide Mononucleotide, otherwise referred to as NMN. While both compounds act as precursors for NAD+, studies have observed that Nicotinamide Riboside is smaller than Nicotinamide Mononucleotide. This means that the delivery of Nicotinamide Riboside to body cells is more efficient, especially in supporting mitochondrial processes for cellular energy. As a result, Nicotinamide Riboside powder promotes longevity in cells and muscles more than NMN.

Nicotinamide Mononucleotide C₁₁H₁₅N₂O₈P

The CAS number of Nicotinamide Riboside is 1341-23-7, and its molecular formula is C11H15N2O5. On the other hand, the CAS number of Nicotinamide Mononucleotide is 1094-61-7, and its molecular formula is C₁₁H₁₅N₂O₈P.

The latest news about NMN, the FDA banned NMN from being sold as a dietary supplement in 2022/11.

The price per kilogram of Nicotinamide Riboside Chloride powder is usually $532 to $545, while the price for Nicotinamide Mononucleotide is $695 to $700 per kilo. The prices may vary depending on the quantity of purchase and the location of the buyer.

Nicotinamide Riboside vs. Pterostilbene

One of the key compound combinations for the body’s effective muscle and DNA repair is Nicotinamide Riboside plus Pterostilbene. Among athletes and bodybuilders who often engage in energy-boosting exercises, muscle wear, and tear is always a problem. Studies on animal subjects suggest that Nicotinamide Riboside supplementation combined with Pterostilbene is the key to muscle cell repair and regeneration. Pterostilbene also augments the intended effect of Nicotinamide Riboside supplementation, primarily for healthy aging.

Action Mechanism Of Nicotinamide Riboside

Health supplement products with Nicotinamide Riboside are usually indicated to prevent rapid aging, which is one of the factors affecting the onset of disease processes. It is believed that Nicotinamide Riboside provides the said benefit by serving as a precursor to NAD+. NAD+ supports many processes in the body, including repairing damaged DNA and maintaining the body’s immune system. It is also established in health studies that the compound is necessary for converting food into energy. NAD+, however, reduces in quantity with age.

The gradual decrease of NAD+ in the body is a natural phenomenon. Thus, supplementation through Nicotinamide Riboside is necessary to prevent deterioration and compromise of bodily processes.

Nicotinamide Riboside Benefits

The increase of NAD+ through Nicotinamide Riboside powder supplementation produces natural benefits, as revealed in studies and confirmed by product reviews.

One study found that increasing NAD+ prevents various neurologic conditions linked with the degeneration of brain cells. Hence, it is said that Nicotinamide Riboside may be helpful for patients searching for a preventive measure for Alzheimer’s disease and Dementia.

Nicotinamide Riboside is also among the enzymes that fuel energy delivery to various parts of the human body. Thus, it may help promote weight loss among individuals who engage in healthy exercises as it boosts energy and prevents related rapid deterioration of cells.

Animal studies also show that when combined with Resveratrol, Nicotinamide Riboside can help prevent cardiac cell damage and improve the powder’s brain-protective effects. This also promotes blood circulation and enhances DNA repair.

Nicotinamide Riboside Research

The increasing interest in Nicotinamide Riboside has become the subject of many research studies conducted on humans and animals. Among the subjects of today’s research are NAD and nicotinamide adenine dinucleotide + hydrogen or NADH and their effects on maintaining the body’s energy production rate through the ATP mechanism. One research established that higher NAD to NADH ratio is more beneficial to humans than the other way around. Thus, it is recommended by health experts for persons to take Nicotinamide Riboside supplements for better health, as it is a so-called NAD precursor.

Nicotinamide Riboside Dosage

The daily dose for adults for Nicotinamide Riboside powder supplement is 1000-2000mg. When taken within this range, no side effect relative to the product is expected, except among individuals suffering from certain conditions.

Understanding that various related factors must be considered in developing the proper dosage for Nicotinamide Riboside powder supplementation is essential. These factors include the person’s age, current vitamins and medications being taken, weight, and current health condition.

Nicotinamide Riboside Side Effects

Other than mild gastric effects like nausea and indigestion, Nicotinamide Riboside supplementation has no known side effects when taken within recommended doses. However, when the product causes difficulty breathing or other symptoms affecting the respiratory tract, especially among persons of advanced age, it should be discontinued, and the patient must be brought to a physician.

Nicotinamide Riboside Transportation And Storage

Depending on the shop and supplier, bulk Nicotinamide Riboside can be available with free shipping services. The powder is usually packed in a double-sealed PP bag for transport protection.

The compound is not shelf-stable at high temperatures. Thus, it must be stored in cool and dark places after purchase, especially among individuals who live in humid environments.

Who Is The Best Nicotinamide Riboside Supplier?

If you are looking for a one-stop shop for supplement ingredients like Nicotinamide Riboside, the best source for bulk purchase is Nutri Avenue. Our company offers a wide variety of products at an affordable price. It is also a registered ingredient supplier with the FDA and is a well-known product distributor.

For more information about Nutriavenue, you may visit our website at Technical support is also available when checking our page.


The ingredient Nicotinamide Riboside Chloride is FDA-approved, with the status of GRAS. Hence, it may be used regularly for its claimed benefits within the recommended dosages.


Nicotinamide riboside chloride is a form in which chloride is added to nicotinamide riboside. Because nicotinamide riboside powder is easy to oxidize and even change color. It greatly affects its quality. So, nicotinamide riboside chloride is the more stable form of NR. Nicotinamide riboside chloride and nicotinamide riboside are not the same ingredients, but their functions are the same. In the market, the mainstream products named nicotinamide riboside are actually nicotinamide riboside chloride.

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