Nobiletin

What Is Nobiletin?

Nobiletin is a natural polymethoxyflavonoid found mainly in the peel of citrus fruits, especially in orange peel. It has attracted much attention from scientific research due to its multiple biological activities, including anti-inflammatory, antioxidant, anti-cancer, and protective effects on metabolic syndrome and the nervous system. The CAS number of Nobiletin is 478-01-3, the molecular formula is C21H22O8, and the molecular weight is 402.39 g/mol. As a compound, it usually appears as a light yellow to orange powder.

Due to the multiple methoxy groups in its structure, Nobiletin has very poor solubility in water and is almost insoluble in water, but it can be dissolved in some organic solvents such as ethanol and dichloromethane. This property makes Nobiletin have low bioavailability, but its absorption and efficacy can be improved through the development of certain preparations or derivatives. In modern research, Nobiletin is widely used in research related to anti-inflammatory, anti-cancer, neuroprotection and improvement of metabolic function.

Food With Nobiletin

Nobiletin is abundant in citrus fruits, particularly in the peels of oranges, tangerines, lemons, and grapefruits. Often discarded, citrus peels contain significantly higher concentrations of Nobiletin than the fruit’s pulp.

As a result, consuming zest or using citrus peel extracts in cooking or supplements can boost its intake. It is also present in smaller amounts in other fruits and vegetables, but citrus remains its primary and most potent source.

Sources from

The most common source of nobiletin is citrus fruits, mainly oranges (Citrus sinensis), tangerines (Citrus reticulata), and lemons (Citrus limon). These citrus fruits contain this compound in their peels and are the primary natural sources for extracting.

The peels of these citrus fruits are rich in nobiletin and other poly methoxylated flavonoids. The extraction process involves isolating and concentrating this active ingredient from the peels to obtain the powder.

Notably, the concentration can vary depending on the specific citrus fruit variety, growing conditions, and the extraction method. Furthermore, it can also be found in some other citrus fruits, such as grapefruits (Citrus paradisi) and limes (Citrus aurantifolia), although to a lesser extent compared to oranges, tangerines, and lemons.

When purchasing nobiletin powder, choosing a reputable supplier that ensures the extract’s quality, purity, and standardized content is essential.

Active Ingredients In Citrus Fruits

The active ingredient in citrus fruits is primarily Nobiletin itself. 

Apart from this main active ingredient, the extract may also contain other flavonoids and compounds in the citrus fruits from which it is derived. These extra components might differ depending on the extraction procedure and the source of the extract. Some potential compounds include tangerine, sinensetin, and other poly methoxylated flavonoids.

Common Specification sheet reference

Nobiletin 20%/25%/60%/80%/90%/98%/ extracted from Citrus Aurantium in Powder & Granular forms

Nobiletin: Benefits, Side Effects, And More

1. Antioxidant Activity: Nobiletin exhibits strong antioxidant properties, helping to neutralize harmful free radicals and protect cells from oxidative stress. This antioxidant activity may contribute to overall health and well-being.
2. Anti-inflammatory Effects: Nobiletin has been discovered to have anti-inflammatory characteristics, which may aid in the reduction of inflammation in the body. Chronic inflammation has been associated with several illnesses, and Nobiletin’s anti-inflammatory properties may be beneficial.
3. Cardiovascular Health: Studies suggest that Nobiletin may benefit cardiovascular health. It has been shown to help lower cholesterol levels, reduce plaque formation in blood vessels, and improve blood flow, potentially reducing the risk of cardiovascular diseases.
4. Neuroprotective Potential: Nobiletin has been investigated for its potential neuroprotective effects. It may aid in protecting brain cells and preventing neurodegenerative disorders such as Alzheimer’s and Parkinson’s.
5. Anti-cancer Properties: Preliminary studies have suggested that Nobiletin may have anti-cancer effects by inhibiting the growth and spread of cancer cells. However, further research is needed to understand its potential in cancer prevention and treatment fully.
6. Metabolic Benefits: Nobiletin has been studied for its potential effects on metabolism and weight management. It may aid in blood sugar regulation, insulin sensitivity, and the reduction of obesity-related problems.

Nobiletin Side Effects: Is It Safe?

It is considered safe when consumed through dietary sources or as a supplement at recommended doses.

However, some individuals may experience side effects which are quite mild, such as stomach discomforts or allergic reactions, particularly when consuming large amounts.

Long-term safety data is still limited, so cautious use is advised.

Dosage: How Much To Take?

As a dietary supplement, typical dosages range from 50 to 500 milligrams per day. It is crucial to follow advised dosage guidelines to avoid potential side effects.

There is no established upper limit for individuals consuming Nobiletin through natural food sources, as citrus fruits are generally considered safe in moderate amounts.

However, higher doses may require medical supervision when taken as a concentrated supplement.

Nobiletin Structure You Need To Know

Chemically, Nobiletin is classified as a polymethoxylated flavone, characterized by multiple methoxy groups attached to its flavonoid backbone. This unique structure enhances its fat solubility, allowing it to penetrate biological membranes more quickly than other flavonoids. This increased bioavailability contributes to its effectiveness in exerting anti-inflammatory, antioxidant, and lipid-lowering effects in the body. Its chemical structure also enables Nobiletin to interact with various cellular pathways, promoting overall health and preventing disease development.

Buy Nobiletin Powder From Nutri Avenue Supplier

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What Is Nobiletin Powder Manufacturing Process?

The manufacturing process of Nobiletin powder typically involves the following steps.