Radix Adenophorae Extract

What is Adenophorae Radix?

Adenophorae Radix, commonly known as Ladybell root, is a traditional herbal ingredient derived from the roots of Adenophora stricta or related species. Other Radix Adenophorae common names include Balloon flower root or Chang Sha Shen. It has been used for centuries in East Asian medicine for its purported Radix Adenophorae benefits, including respiratory support, immune system enhancement, and overall vitality. The herb is particularly valued in dietary supplements and personal care products for its bioactive compounds, which exhibit antioxidant, anti-inflammatory, and immunomodulatory properties.

Active ingredients in radix adenophorae

The phytochemical profile of this extract reveals a complex matrix of bioactive compounds, with triterpenoid saponins serving as the primary active constituents. The major triterpenoids identified include adenophorasides A, B, and C, which are unique to this genus. These compounds exhibit molecular weights ranging from 800 to 1200 daltons, with complex sugar moieties attached to their triterpene backbones. The saponin content typically ranges from 2.5% to 4.5% in high-quality extracts.

Beyond saponins, it also contains significant quantities of polysaccharides, particularly beta-D-fructans and adenophoran A, B, and C. These polysaccharides, with molecular weights of 472.71 g/mol, contribute substantially to the herb’s therapeutic properties. Additional bioactive compounds include flavonoids (primarily luteolin and apigenin derivatives), phenolic acids, and trace amounts of essential oils rich in monoterpenes and sesquiterpenes.

Common Sources

Plant-Based Sources: The roots of Adenophora stricta, Adenophora triphylla, and other Adenophora species.

Geographical Origins: Predominantly grown in East Asia, including China, Korea, and Japan.

How Does It Work?

Through its bioactive compounds, it interacts with the body’s biological systems. Saponins and polysaccharides modulate immune responses, reduce inflammation, and enhance antioxidant defenses. Additionally, inulin fosters a healthy gut environment, which indirectly supports overall health by improving digestion and nutrient absorption.

How To Produced Adenophorae Radix Powder?

Harvesting: The roots of Adenophora species are collected during the late growth phase when bioactive compounds are at their peak.

Drying: The roots are thoroughly cleaned and dried under controlled conditions to preserve their nutritional integrity.

Extraction: Bioactive compounds are extracted using water or ethanol solvents.

Purification: Extracts are refined through filtration and chromatography techniques to ensure high purity.

Drying and Milling: The purified Radix Adenophorae extract is dried and processed into a fine powder suitable for various applications.

Bulk Adenophorae Radix Specifications Sheet

Radix Adenophorae: Benefits, Side Effects, and More

The chemical composition of Adenophorae Radix extract is remarkably complex, featuring an array of bioactive compounds that contribute to its medicinal properties. Research has identified numerous active constituents, including triterpenoid saponins, polysaccharides, flavonoids, and essential oils. These compounds work synergistically to produce various therapeutic effects that have been documented in both traditional medical texts and contemporary scientific literature.

One of the most thoroughly researched aspects of radix adenophorae is its potent anti-inflammatory properties. Multiple studies published in respected journals, including the Journal of Ethnopharmacology, have demonstrated its ability to modulate inflammatory responses at the cellular level. Research has shown that Adenophorae Radix extract significantly reduces the production of pro-inflammatory cytokines, particularly TNF-α and IL-6, in laboratory studies using lipopolysaccharide-stimulated macrophages. This anti-inflammatory action appears to be mediated through multiple pathways, suggesting a comprehensive approach to inflammation regulation.

In the realm of respiratory health, radix adenophorae extract has shown remarkable potential in both traditional applications and modern research settings. Scientific investigations have revealed its ability to reduce excessive mucus production in respiratory tract tissues while simultaneously demonstrating bronchodilating effects. These properties make it particularly valuable in the treatment of various respiratory conditions, including chronic bronchitis and asthma. The extract’s ability to modulate respiratory function appears to be related to its impact on bronchial smooth muscle tissue and inflammatory mediators.

The immunomodulatory effects of radix adenophorae extract represent another significant area of scientific interest. Research has demonstrated its capacity to enhance natural killer cell activity, promote T-cell proliferation, and regulate cytokine production. These effects suggest potential applications in supporting immune system function and managing various immune-related disorders. Studies have shown that the polysaccharide components of Adenophorae Radix extract play a crucial role in these immunomodulatory properties, potentially offering new therapeutic approaches for immune system regulation.

The antioxidant properties of Adenophorae Radix extract have been well-documented through various research methodologies. Scientific studies have demonstrated its ability to effectively scavenge free radicals and reduce oxidative stress markers in cellular systems. This antioxidant activity appears to be particularly potent in protecting cellular structures from oxidative damage, suggesting potential applications in preventing age-related cellular deterioration and various oxidative stress-related conditions.

Clinical applications have shown promising results in several areas, particularly in the treatment of respiratory disorders. Studies have documented its effectiveness in managing chronic bronchitis, asthma, and upper respiratory tract infections. The extract’s combined anti-inflammatory and immunomodulatory properties appear to provide a comprehensive approach to treating these conditions, offering both symptomatic relief and potential long-term therapeutic benefits.

Research has also explored the potential of Adenophorae Radix extract in treating systemic inflammatory conditions and chronic inflammatory disorders. The extract’s ability to modulate inflammatory responses while supporting immune system function suggests possible applications in managing various inflammatory conditions. However, more extensive clinical trials are needed to fully establish its efficacy in these applications.

Side Effects: Is radix adenophorae sfe?

• Gastrointestinal Upset: Mild bloating or stomach discomfort may occur in rare cases.
• Allergic Reactions: Individuals with sensitivities to herbal compounds should exercise caution.

Is It Legal?

United States: The FDA recognizes it as a dietary supplement ingredient through DSHEA compliance parameters, with established manufacturing and labeling protocols in place. Current regulations do not extend to pharmaceutical applications, limiting its use to the supplement category within U.S. markets.

European Union: EMA guidelines govern its usage in herbal medicinal products, requiring manufacturers to implement standardized quality controls and GMP protocols. These regulations establish uniform production standards across all EU member states, ensuring consistent product quality and safety.

Japan: The Japanese regulatory framework incorporates the compound as an approved Kampo medicine component, subject to standardized quality specifications. Manufacturers must demonstrate compliance with Japanese Pharmacopoeia requirements for all approved formulations containing this ingredient.

Australia: TGA’s oversight of this ingredient encompasses its use in complementary medicines, with mandatory ARTG listing requirements. Quality control measures include specified testing protocols and daily intake limits, establishing clear parameters for commercial applications.

What is adenophorae radix powder used for?

1. Health Supplements
   • Usage: Included in capsules, tablets, or powders targeting respiratory health, immune support, and digestive wellness.
   • Benefit: Soothes cough, reduces inflammation, and nourishes the body.
2. Functional Foods and Beverages
   • Usage: Added to teas, herbal drinks, and fortified foods.
   • Benefit: Improves hydration, promotes digestion, and boosts energy.
3. Cosmetics and Skincare Products
   • Usage: Used in moisturizers, serums, and masks.
   • Benefit: Enhances skin hydration, reduces dryness, and supports anti-aging.
4. Traditional Herbal Medicine
   • Usage: Mixed into decoctions or powders for respiratory and gastrointestinal conditions.
   • Benefit: Supports lung function, alleviates dry throat, and strengthens the body.
5. Animal Health Products
   • Usage: Integrated into veterinary supplements.
   • Benefit: Boosts immunity and supports respiratory health in livestock or pets.

Recommended Dosage and Usage

• Dietary Supplements: 250–500 mg per day, depending on the specific formulation.
• Personal Care Products: 0.5%–2% concentration in creams or serums.

How to store adenophorae radix powder?

Preserving this powder requires strict adherence to environmental control parameters, specifically maintaining storage temperatures between 2-8°C in hermetically sealed containers with relative humidity below 60%. Implementing these storage conditions, combined with protection from direct light exposure and temperature fluctuations, ensures the stability of bioactive compounds for up to 36 months, as verified through periodic quality control testing of key chemical markers.

Adenophorae Radix VS Astragalus Root

The pharmacological comparison between Adenophorae Radix and Astragalus Root (Astragalus membranaceus) reveals distinct mechanistic differences despite overlapping therapeutic applications. Adenophorae Radix demonstrates superior mucolytic properties through its unique triterpenoid saponins, particularly adenophorasides A, B, and C. These compounds show a specific affinity for respiratory epithelial tissues, promoting mucus clearance and bronchial function.

Astragalus Root, containing astragalosides and polysaccharides, exhibits stronger cardiovascular tropism. Its bioactive compounds, especially astragaloside IV, demonstrate pronounced effects on endothelial function and cardiac muscle tissue. Both extracts show comparable bioavailability profiles (40-60% absorption rates) when administered orally, though their distribution patterns differ significantly. Adenophorae Radix shows higher concentration in pulmonary tissues, while Astragalus demonstrates preferential accumulation in cardiovascular tissues.

Adenophorae Radix VS Licorice Root

The comparison between Adenophorae Radix and Licorice Root (Glycyrrhiza glabra) reveals essential distinctions in their safety profiles and therapeutic mechanisms. While both botanicals demonstrate effectiveness in respiratory health, their risk-benefit profiles differ significantly. Licorice Root contains glycyrrhizin, a compound with potent mineralocorticoid effects that can impact blood pressure and electrolyte balance, particularly with prolonged use.

Adenophorae Radix presents a more favorable safety profile due to its lack of mineralocorticoid activity. Both extracts show comparable bioavailability (40-60%), but their therapeutic windows differ substantially. Adenophorae Radix demonstrates a wider therapeutic window, allowing for more flexible dosing strategies without significant risk of adverse effects. The immunomodulatory effects of Adenophorae Radix are achieved through mechanisms that do not involve hormonal modulation, making it a preferred choice for long-term respiratory support.

Conclusion

Radix Adenophorae is a versatile herbal ingredient celebrated for its respiratory, immune, and digestive health benefits. With its rich profile of bioactive compounds and centuries of use in traditional medicine, it continues to be a vital component in dietary supplements and personal care products.

Why Choose Nutri Avenue To Buy Radix Adenophorae Extract Powder?

Nutri Avenue provides premium-quality Adenophorae Radix powder, which has been rigorously tested for purity and potency. Our ISO-certified facilities ensure the highest production standards, while our flexible OEM/ODM services cater to customized formulations. With competitive pricing, reliable stock availability, and professional customer support, Nutri Avenue is your trusted partner for high-quality herbal ingredients.

Contact Nutri Avenue today to explore our Adenophorae Radix offerings and elevate your product line.

* ISO certificates are readily available for all of Nutri Avenue’s products.

FAQs (Frequently Asked Questions)