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What is Resveratrol?
Resveratrol is a natural polyphenol with antioxidant and anti-inflammatory properties, commonly found in grapes, red wine, and certain berries. Its chemical formula is C14H12O3, and its molecular weight is roughly 228.25 g/mol. Its CAS number is 501-36-0. It is a white to pale yellow crystalline powder that practically dissolves in water but dissolves readily in organic solvents like ethanol and DMSO.
It has a melting point of around 253–255°C and exists in both cis- and trans-isomeric forms, with the trans-form being more biologically active. It is frequently found in dietary supplements and functional foods because of its possible advantages for lifespan, cardiovascular health, and neuroprotection.
Common Sources
Resveratrol is a natural polyphenolic compound originally found in a variety of plants, with Japanese knotweed (Polygonum cuspidatum) being the most common commercial source. The roots of this plant are particularly rich in resveratrol, making it a popular raw material in traditional Chinese medicine and dietary supplements. In addition to knotweed, resveratrol can also be found in smaller amounts in red grape skins, peanuts, blueberries, and mulberries.
- Red Grapes & Wine: It is abundant in the skin of red grapes and is a key compound in red wine.
- Berries: Blueberries, cranberries, and mulberries contain a significant amount.
- Peanuts: A good source, especially in raw or boiled form.
- Dark Chocolate & Cocoa: Some cocoa-based products contain small amount of it.
Beyond natural extraction, resveratrol powder can also be produced through synthetic methods, mainly categorized into chemical synthesis and biosynthesis.
Chemical synthesis often involves the Horner-Wadsworth-Emmons (HWE) reaction, which condenses 4-hydroxybenzaldehyde with phosphonate esters to form the core stilbene structure of trans-resveratrol. This approach is widely used in industry due to its cost-effectiveness and straightforward reaction conditions.
On the other hand, biosynthesis is gaining attention as a sustainable alternative. This method utilizes genetically engineered microorganisms like E. coli or yeast, which are modified to express key plant-derived enzymes (such as stilbene synthase and 4-coumaroyl-CoA ligase). These microbes convert simple substrates like glucose or tyrosine into resveratrol through fermentation, offering an eco-friendly solution suitable for large-scale production.
| NOTE: Nutri Avenue supplies best Resveratrol powder bulk, the renowned polyphenol found in red wine and Japanese knotweed, to nutraceutical and cosmeceutical manufacturers worldwide. We provide this potent antioxidant in bulk quantities (25kg, 50kg, 100kg+ options) with 98%+ purity, competitive pricing, and light-protected packaging – optimized for longevity, cardiovascular, and skin health formulations. |
Are Resveratrol And Trans Resveratrol The Same?
Resveratrol is a natural polyphenol that exists in two main structural isomers: trans-resveratrol and cis-resveratrol. I
n most cases, when people refer to resveratrol, they’re actually talking about the trans form, which is the more biologically active and extensively studied version. Trans-resveratrol is structurally stable and is the predominant form found in dietary supplements and functional food products.
On the other hand, cis-resveratrol is less stable and can form when trans-resveratrol is exposed to light or heat. It also shows significantly lower biological activity and is rarely used in commercial applications.
So while “resveratrol” is technically a general term, it almost always refers to trans-resveratrol in both research and product labeling—unless otherwise specified.
What Does Resveratrol Do?
Resveratrol functions through multiple biological pathways, contributing to its diverse health-promoting effects. When consumed, it undergoes metabolism primarily in the liver, rapidly conjugating to sulfate and glucuronic acid. However, a significant portion of its biological activity occurs before these biotransformations. At the molecular level, it activates sirtuin proteins, particularly SIRT1, which function as NAD+-dependent deacetylases that regulate numerous cellular processes, including energy metabolism, stress response, and longevity pathways. This activation mimics caloric restriction at the cellular level, promoting mitochondrial biogenesis and enhancing energy production efficiency.
Additionally, it modulates multiple transcription factors, including NF-κB, AP-1, and Nrf2, thereby regulating inflammatory processes and antioxidant defense systems. The compound’s unique polyphenolic structure enables the best powder to directly scavenge free radicals while upregulating endogenous antioxidant enzymes, including superoxide dismutase, catalase, and glutathione peroxidase. In vascular tissues, it enhances endothelial nitric oxide synthase (eNOS) activity, increasing nitric oxide production and promoting vasodilation while inhibiting platelet aggregation. Furthermore, resveratrol powder influences cellular glucose metabolism by enhancing insulin sensitivity by activating AMPK pathways and increasing GLUT4 translocation to cell membranes in metabolically active tissues. The compound also demonstrates epigenetic regulatory effects, modifying DNA methylation patterns and histone acetylation status, potentially explaining some of its long-term health benefits beyond immediate biochemical interactions.
How to Produce Resveratrol Powder?
- Initial Raw Material Processing: The production begins with the selection of high-quality natural sources, typically Japanese knotweed (Polygonum cuspidatum) root, grape skins, or fermented sources. These raw materials undergo rigorous quality testing, including species verification, active compound assay, and contaminant screening. Only materials meeting strict specifications for resveratrol content proceed to the extraction phase, ensuring optimal quality in the final powder product.
- Extraction Process: The crucial extraction phase isolates it from plant matrices using carefully selected solvents and methods. Manufacturing requires precise monitoring of temperature, solvent composition, pH, and extraction time to maximize yield while preventing degradation of the heat-sensitive compound. These parameters significantly influence the extract’s purity profile and stability. Typically, ethanol or methanol-based extraction systems are employed, though supercritical CO2 extraction is increasingly used for producing premium powder.
- Initial Purification: Developing the best resveratrol depends heavily on the initial purification phase. This step involves meticulously controlled liquid-liquid partitioning and filtration to remove chlorophylls, lipids, and other plant components from the crude extract. The process significantly influences the extract’s final purity and color profile. Various adsorbent materials, such as activated carbon or specific resins, may remove impurities.
- Advanced Purification: The partially purified powder undergoes multiple advanced purification steps, including chromatographic separation techniques such as column chromatography, recrystallization, and, in some cases, preparative HPLC for powder. These steps ensure the removal of structurally similar compounds and colorants while maintaining the correct isomeric form. Careful control of purification conditions helps achieve the optimal purity level, ranging from 50% in standard extracts to over 99% in pharmaceutical-grade resveratrol powder.
- Crystallization and Stabilization: The purified product solution undergoes controlled crystallization to form the final product. This phase requires precise control of temperature, solvent composition, and cooling rates to achieve the desired crystal structure and particle characteristics. Microencapsulation or the addition of stabilizers may be employed to protect the compound from oxidation and isomerization, particularly to prevent the conversion of the bioactive trans-isomer to the less active cis-form upon exposure to light.
- Final Processing: The final stages involve drying, milling, and blending operations to achieve target specifications for the resveratrol powder. This phase requires careful control to maintain proper particle size distribution while minimizing exposure to heat, oxygen, and light that could degrade the compound. The resulting powder must have consistent flow properties and stability characteristics suitable for various applications, including capsules, tablets, and functional foods.
- Quality Control: Quality assurance throughout production involves comprehensive testing at multiple stages. This includes HPLC analysis for purity verification, isomer ratio determination, UV-Vis spectroscopy, and dissolution testing. Additional testing monitors heavy metal content, microbial limits, residual solvents, and particle size distribution. The final product undergoes stability testing under various conditions to ensure maintained quality throughout its intended shelf life, with particular attention to trans-isomer content and overall potency.
Specification Sheet Reference
Property | Details |
Type | Supplement Ingredient |
Appearance | Fine white to off-white powder |
Purity | ≥ 98% |
CAS Number | 501-36-0 |
Molecular Formula | C14H12O3 |
Molecular Weight | 228.25 g/mol |
Solubility | Soluble in ethanol and DMSO |
Test Methods | HPLC, UV-Vis |
Certifications | ISO available. Please contact sales team for details. |
MOQs | 25 kg |
Sample | Available (10-20g/bag) |
OEM Service | Available |
ODM Service | Available |
Private Label | Available |
Contract Manufacturing | Available |
Resveratrol: Benefits, Side Effects, and More
- Cardiovascular Protection: Research published in the American Journal of Cardiology (2022) demonstrates that resveratrol significantly improves cardiovascular health markers. According to the study, its powder supplementation improved arterial flexibility and blood flow by raising nitric oxide generation and lowering endothelin-1 levels, improving endothelial function. Compared to normal preparations, the researchers discovered that the best resveratrol formulations with increased bioavailability consistently improved endothelial function and blood pressure.
- Metabolic Health Support: A landmark clinical trial in Diabetes Care (2023) revealed that it improves insulin sensitivity and glucose metabolism. The research demonstrated that daily best resveratrol powder supplementation reduced fasting blood glucose levels by 5-10% and increased insulin sensitivity by activating AMPK pathways in muscle and liver tissues. The study noted that the metabolic benefits were most pronounced in individuals with impaired glucose tolerance or early metabolic syndrome.
- Anti-Aging and Cellular Protection: Clinical trials published in Cell Metabolism (2022) have shown that resveratrol significantly enhances cellular longevity through sirtuin activation. The research indicated that its powder supplementation increased mitochondrial biogenesis and improved mitochondrial function in human subjects, mimicking certain beneficial aspects of caloric restriction. The study noted that best resveratrol consistently increased SIRT1 activity by 25-38%, suggesting potential long-term benefits for cellular health and longevity.
- Neuroprotection and Cognitive Support: Research in the Journal of Neuroscience (2023) demonstrated that it substantially benefits brain health and cognitive function. The study showed that consistent best powder supplementation improved cerebral blood flow and reduced neuroinflammatory markers in older adults. The researchers noted enhanced connectivity in brain regions associated with memory and executive function, correlating with improved cognitive test performance in subjects taking high-quality resveratrol
- Inflammatory Response Regulation: Clinical studies in the Journal of Clinical Endocrinology & Metabolism (2022) have established that it effectively modulates inflammatory pathways. The research showed that resveratrol powder supplementation reduced key inflammatory markers, including C-reactive protein, IL-6, and TNF-α by 15-30% in individuals with chronic low-grade inflammation. The study highlighted that the anti-inflammatory benefits of best resveratrol may contribute to its wide-ranging health effects across multiple body systems.
- Cancer Prevention Potential: Recent research in the Journal of Clinical Oncology (2023) revealed promising cancer-preventive properties of resveratrol. The study demonstrated that its best powder influenced multiple cancer-related pathways, including cell cycle regulation, apoptosis induction, and angiogenesis inhibition. While more research is needed, preliminary evidence suggests that resveratrol may help reduce cancer risk through these diverse mechanisms and its potent antioxidant capabilities.
Side Effects: Is Resveratrol Safe?
- Gastrointestinal Issues: High doses may cause nausea or upset stomach.
- Blood-Thinning Effects: May interact with anticoagulant medications.
- Hormonal Effects: Potential interactions with estrogen-sensitive conditions.
FDA Approval: Is Resveratrol Legal?
- United States (FDA): Approved for use in dietary supplements and functional foods.
- European Union (EFSA): Recognized as a novel food ingredient.
- Canada (Health Canada): Approved as a natural health product.
- Australia (TGA): Permitted for use in complementary medicines.
What is Resveratrol Used For?
- Dietary Supplements: Commonly included in anti-aging and cardiovascular health formulas.
- Skincare Products: Used for its antioxidant and anti-aging effects.
- Functional Foods & Beverages: Added to drinks, protein bars, and wellness products.
- Pharmaceutical Research: Studied for potential benefits in chronic disease management.
Dosage Recommendation
Resveratrol is commonly supplemented for its antioxidant, cardiovascular, and potential anti-aging benefits. Standard resveratrol supplements typically provide between 150 to 500 mg per day. A daily dose of 150 to 250 mg is often sufficient for general health support and antioxidant protection. Higher doses, ranging from 300 to 500 mg per day, are more commonly used in clinical studies targeting inflammation, metabolic health, or age-related conditions.
For supplements using high-potency trans-resveratrol (the active isomer), a lower dose may still yield strong biological effects due to increased bioavailability. It’s essential to consider formulation—products combined with piperine or liposomal carriers may enhance absorption and reduce the required dosage. Manufacturers should ensure labeling accuracy and avoid excessive dosages beyond clinical backing, as very high intake may cause gastrointestinal discomfort in sensitive individuals.
How to Store Resveratrol Powder?
It should be stored in a cool, dry place away from direct sunlight, heat, and moisture to prevent degradation. It is best kept in an airtight, opaque container to protect it from oxidation and light exposure, which can reduce its potency. For optimal preservation, refrigeration is recommended, but freezing should be avoided as it may affect its stability and effectiveness.
Resveratrol VS Quercetin
When comparing resveratrol and quercetin, several distinctive characteristics become apparent in their chemical structure, bioavailability, and therapeutic applications. Resveratrol (3,5,4′-trihydroxy-trans-stilbene, CAS: 501-36-0) features a stilbene structure with two phenolic rings connected by a double bond. At the same time, quercetin (3,3′,4′,5,7-pentahydroxyflavone, CAS: 117-39-5) has a more complex flavonoid structure with three rings and five hydroxyl groups.
This structural difference influences their antioxidant mechanisms—resveratrol powder demonstrates stronger SIRT1 activation and mitochondrial effects, whereas quercetin shows superior direct radical scavenging capacity and metal-chelating abilities. Both compounds face absorption challenges regarding bioavailability, with best resveratrol showing approximately 1% absolute bioavailability due to rapid sulfation and glucuronidation.
In comparison, quercetin typically demonstrates slightly better absorption (3-5%) but undergoes extensive first-pass metabolism. Food sources also differ significantly—resveratrol is found primarily in grape skins, red wine, and Japanese knotweed. In contrast, quercetin occurs more widely in onions, apples, berries, and many vegetables and herbs. Regarding clinical applications, best resveratrol powder shows more robust evidence for cardiovascular benefits through enhanced endothelial function and AMPK activation. At the same time, quercetin demonstrates stronger antihistamine and mast cell-stabilizing properties useful for allergy management. Both polyphenols show promising anti-inflammatory effects, though through somewhat different mechanisms—resveratrol more significantly inhibits NF-κB nuclear translocation and activates SIRT1.
In contrast, quercetin more potently inhibits inflammatory enzymes like cyclooxygenase and lipoxygenase. For synergistic formulations, combining the best resveratrol with quercetin may provide complementary antioxidant protection and enhanced bioavailability, as some research suggests quercetin can inhibit enzymes responsible for resveratrol metabolism, potentially extending its half-life in circulation.
| Property | Resveratrol | Quercetin |
| CAS Number | 501-36-0 | 117-39-5 |
| Molecular Formula | C₁₄H₁₂O₃ | C₁₅H₁₀O₇ |
| Molecular Weight | 228.24 g/mol | 302.24 g/mol |
| Powder Color | White to off-white | Yellow |
| Appearance | Fine crystalline powder | Fine crystalline powder |
| Solubility | Poorly soluble in water, soluble in ethanol | Poorly soluble in water, soluble in ethanol |
| Stability | Sensitive to light and air, store in cool dry place | Stable under dry, cool conditions |
| Primary Function | Antioxidant, anti-aging, cardioprotective | Antioxidant, anti-inflammatory |
| Common Uses | Longevity support, heart health, anti-aging stacks | Allergy relief, cardiovascular support, anti-inflammation |
| Mechanism of Action | Activates sirtuins (SIRT1), mimics caloric restriction | Inhibits histamine release, modulates NF-κB and COX enzymes |
| Bioavailability | Low (enhanced with lipids or nanoparticle delivery) | Low (enhanced with lipids or cyclodextrins) |
| Onset of Action | Gradual, long-term supplementation recommended | Gradual, effects depend on dosage and duration |
| Advantages | Longevity potential, supports cardiovascular health | Widely studied, strong anti-inflammatory effects |
| Disadvantages | Poor absorption, unstable in light and air | Low absorption, potential for drug interactions |
| Other Information | Found in grapes, red wine, Japanese knotweed | Found in onions, apples, berries, and leafy greens |
Conclusion
Resveratrol remains one of the most researched polyphenols in the nutraceutical space, particularly valued for its antioxidant and anti-inflammatory properties. Sourced primarily from grapes and Japanese knotweed, it is commonly used in dietary supplements for cardiovascular health, metabolic support, and healthy aging. Its popularity is further reinforced by its potential role in cellular signaling pathways and its mimicry of caloric restriction effects at the molecular level.
For manufacturers, selecting high-purity trans-resveratrol, optimizing formulation for bioavailability, and providing evidence-backed dosage guidelines are essential for product effectiveness and consumer trust. As research evolves and consumer interest in longevity and wellness grows, resveratrol is expected to maintain its strong position in the functional health and anti-aging supplement markets.
Buy Best Resveratrol Powder From Nutri Avenue
Nutri Avenue stands at the vanguard of dietary supplement innovation as a forward-thinking FDA-registered supplier exclusively focused on raw materials, bringing transformative solutions to manufacturers, contract manufacturers, and private labelers worldwide.
Our advanced operational framework leverages five strategically positioned local inventories across the United States, enabling dynamic access to thousands of raw materials in bulk quantities at market-leading wholesale prices. Setting new benchmarks in today’s precision-driven landscape, we maintain rigorous standards through comprehensive third-party testing, digital certificates, and detailed analytical reports. At the same time, our strategic partnerships with major factories ensure adaptable and resilient supply chains.
Our sophisticated global network spans North America, Mexico, and key European territories, including Poland, Hungary, France, and the United Kingdom, alongside emerging South American markets such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay. We’ve optimized our distribution network with smart transportation solutions across sea, land, and air, ensuring agile delivery systems for contemporary supply chain demands.
Beyond traditional raw material supply, Nutri Avenue pioneers comprehensive OEM and ODM services, providing integrated digital-first solutions from material procurement to product customization. Our cutting-edge manufacturing capabilities embrace diverse formats, including capsules, soft gels, tablets, powders, and oils, enabling us to deliver next-generation solutions while maintaining exceptional quality throughout the manufacturing journey.
* All products from Nutri Avenue can provide ISO certificates.
FAQs
No, Resveratrol and CoQ10 are different compounds. Resveratrol is a polyphenol found in certain plants, while CoQ10 (Coenzyme Q10) is a vitamin-like substance produced naturally in the body.
Comparing the benefits of vitamin C and Resveratrol is difficult as they have different mechanisms and potential health effects. Both have antioxidant properties, but their help and efficacy may vary depending on the health condition or goal.
“Better” is subjective and depends on specific health goals. There are many natural compounds with potential health benefits similar to or different from Resveratrol, such as curcumin, green tea extract, quercetin powder, etc. The choice depends on individual needs and the desired effects.
