S-Allyl-l-Cysteine (SAC)

What is S-Allyl-l-Cysteine?

S-Allyl-l-Cysteine (SAC) is a sulfur-containing amino acid derived from garlic. It is an active compound in aged garlic extract (AGE), widely recognized for its antioxidant, anti-inflammatory, and cardioprotective properties. SAC has gained attention for its role in improving metabolic health, promoting liver protection, and supporting immune functions. Unlike raw garlic, this odorless compound offers potent therapeutic benefits without the pungent smell.

Sources of S-Allyl-l-Cysteine Powder

S-Allyl-l-Cysteine is primarily sourced from aged garlic extract. The aging process of garlic enhances the stability and concentration of SAC while reducing harsh compounds like allicin. This aging ensures that garlic-derived supplements offer higher therapeutic potential.

Other sources may include enzymatically processed garlic or chemically synthesized SAC for pharmaceutical applications.

How Does S-Allyl-l-Cysteine Work?

It works through several important mechanisms in the body. As an antioxidant, it protects cells by neutralizing harmful molecules called free radicals that can damage cellular structures. In the cardiovascular system, SAC helps produce nitric oxide, a compound that relaxes blood vessels and improves blood flow, which helps lower blood pressure. The compound reduces inflammation by blocking specific proteins that cause inflammatory responses, particularly beneficial for conditions like arthritis. In the brain, SAC works in two ways: it helps regulate brain chemicals and protects brain cells from damage, which may help prevent memory problems and other brain disorders. SAC also strengthens the immune system by increasing the activity of immune cells, allowing the body to fight off infections more effectively. These combined effects make SAC valuable for supporting overall health through multiple biological pathways.

How is S-Allyl-l-Cysteine Powder Produced?

Raw Material Selection

The production of SAC begins with a rigorous selection of premium garlic bulbs (Allium sativum L.). Quality control specialists evaluate each batch for optimal maturity, physical integrity, and absence of microbial contamination. The garlic must meet specific criteria for sulfur compound content and moisture levels. Testing protocols include microbiological screening, heavy metal analysis, and pesticide residue evaluation to ensure compliance with pharmaceutical-grade standards. Only garlic meeting these stringent requirements proceeds to the aging process.

Aging Process

The selected garlic undergoes a carefully controlled aging process lasting approximately 20 months under precisely monitored conditions. Temperature is maintained between 18-22°C with relative humidity at 60-70%. During this period, natural enzymatic processes convert allicin and other compounds into more stable and bioavailable forms, particularly SAC. Regular testing throughout the aging process monitors the conversion rates and compound stability. This extended aging significantly increases SAC concentration while reducing volatile sulfur compounds responsible for garlic’s characteristic odor.

Extraction Methodology

Following aging, the material undergoes specialized extraction using either purified water or food-grade ethanol as solvents. The extraction process typically operates at controlled temperatures between 40 °C and 60°C to optimize yield while preserving compound stability. Multiple extraction cycles ensure maximum recovery of SAC and other beneficial compounds. The process employs automated systems to maintain consistent extraction parameters and product quality.

Purification Process

The extracted material undergoes multi-stage purification using advanced filtration systems and chromatographic techniques. Initial mechanical filtration removes physical impurities, followed by more refined separation methods, including ion exchange chromatography and molecular sieving. These steps systematically eliminate unwanted compounds while concentrating SAC. Each purification stage includes quality checkpoints to verify purity levels and compound integrity.

Final Processing

The purified SAC extract enters the final processing phase, where it undergoes carefully controlled drying using vacuum technology at temperatures below 40°C to preserve molecular stability. The dried material is then processed through precision milling equipment to achieve a uniform particle size distribution, typically ranging from 60 to 80 mesh. This final powder form is virtually odorless and demonstrates excellent stability and solubility characteristics, making it ideal for various formulation applications.

Bulk S-Allyl-l-Cysteine Specifications Table

S-Allyl-l-Cysteine: Benefits, Side Effects, and More

Benefits of S-Allyl-l-Cysteine

Antioxidant Properties

SAC combats oxidative stress by scavenging free radicals and enhancing cellular defenses, reducing the risks of chronic diseases.

Heart Health

It helps lower blood pressure, improves endothelial function, and reduces arterial stiffness, contributing to overall cardiovascular wellness.

Neuroprotection

SAC’s ability to cross the blood-brain barrier makes it an ingredient for brain health effective in protecting against neurodegenerative conditions like Alzheimer’s and Parkinson’s disease.

Liver Protection

SAC supports detoxification pathways and protects against hepatotoxic substances.

Immune Boosting

SAC enhances the function of immune cells, helping to fight infections and reduce the severity of autoimmune diseases.

Anti-Inflammatory Effects

By downregulating inflammatory mediators, SAC helps manage inflammatory conditions, including joint disorders.

Side Effects

SAC is generally well-tolerated when consumed within recommended doses. However, excessive intake may lead to slight problems like gastrointestinal discomfort (e.g., bloating, mild nausea) or allergic reactions in sensitive individuals.

What is S-Allyl-l-Cysteine Powder Used For?

Dietary Supplements

Manufacturers add SAC to health supplements, mainly in pills and liquids targeting heart health. They often combine it with other beneficial ingredients like CoQ10. Products typically contain 100-500mg of SAC per dose, using special coatings to mask the garlic taste while maintaining effectiveness. Regular testing ensures product quality and consistency.

Functional Foods

Food companies incorporate SAC into health drinks, bars, and baked goods. They use special processing methods to protect SAC during manufacturing and digestion. Most products contain 50-200mg per serving. Careful production controls help maintain SAC’s benefits throughout the product’s shelf life.

Pharmaceutical Products

Drug companies use pure SAC in medications for brain health and inflammation treatment. Research focuses on improving how the body absorbs SAC through advanced delivery systems. Ongoing studies help develop standardized medications with exact dosing. All products must meet strict safety regulations.

Recommended Dosage and Usage

For dietary supplementation, typical dosages range from 100 mg to 500 mg daily, depending on the intended health benefits.

How to Store S-Allyl-l-Cysteine Powder?

For optimal stability and potency, store S-Allyl-l-Cysteine (SAC) powder in airtight, dark amber containers at temperatures between 2-8°C. Protect from moisture by maintaining relative humidity below 60% and using desiccant packets when necessary. Keep containers away from direct sunlight and heat sources, ensuring proper sealing after each use. Regular monitoring of storage conditions and adequate inventory rotation helps maintain the compound’s chemical integrity throughout its shelf life.

Is It Legal?

United States Regulations

The FDA recognizes SAC as a legal ingredient for dietary supplements under DSHEA guidelines. While manufacturers can include SAC in supplement formulations, they must follow Good Manufacturing Practice (GMP) standards and proper labeling requirements. The compound has yet to receive FDA approval for use as a pharmaceutical drug.

European Union Framework

EU regulations permit SAC use in dietary supplements under established herbal product directives. Manufacturers must comply with European Food Safety Authority (EFSA) guidelines regarding purity standards and labeling requirements. Each member state may have additional specific requirements for SAC-containing products.

Japanese Market Status

Japan’s regulatory bodies approve SAC for use in functional foods and dietary supplements. When used in functional foods, the compound falls under FOSHU (Foods for Specified Health Uses) regulations. Japanese manufacturers regularly incorporate SAC into various health products due to its established safety profile.

Australian Guidelines

The Therapeutic Goods Administration (TGA) allows SAC in supplement formulations following proper registration and approval processes. Manufacturers must provide safety data and meet quality standards before marketing SAC-containing products. Regular compliance audits ensure ongoing adherence to TGA requirements.

S Allyl L Cysteine VS Chelidonium Majus

S-allyl L-cysteine (SAC) and Chelidonium majus have different therapeutic applications and safety profiles. SAC, derived from aged garlic, is a safe compound that helps protect the heart and reduce inflammation through its antioxidant properties. In contrast, Chelidonium majus (greater celandine) is a medicinal plant containing compounds that fight inflammation and microbes. However, it must be used carefully as it may cause liver problems in some cases.

S-allyl Cysteine VS Allicin

S-allyl cysteine and allicin are both beneficial garlic compounds but work differently in the body. SAC dissolves in water and remains stable, allowing it to consistently support heart health and brain function over time. Allicin, while more powerful in the short term for fighting microbes and oxidative stress, breaks down quickly in the body, making SAC more reliable for ongoing health benefits.

S Allyl L Cysteine VS S-Allyl-L-Cysteine Sulfoxide

S-allyl L-cysteine and S-allyl-L-cysteine sulfoxide (alliin) represent different stages of garlic’s beneficial compounds. SAC directly provides benefits like improved heart health and antioxidant protection. Alliin, however, starts as an inactive form in whole garlic and only becomes active when converted to allicin through crushing or cutting. This makes SAC more immediately useful for health benefits compared to alliin, which requires activation.

Conclusion

S-Allyl-l-Cysteine is a versatile ingredient with broad health benefits, including antioxidant, anti-inflammatory, and neuroprotective effects. Its bioavailability and stability make it an essential component in dietary supplements and functional foods.

Why choose Nutri Avenue?

Nutri Avenue produces S-Allyl-l-Cysteine (SAC) powder following strict quality guidelines and GMP standards. Independent labs test each product batch to confirm purity and strength. The company provides manufacturing services for different product forms, including capsules and tablets, with options for custom branding. All products come with complete quality documentation and testing certificates. Nutri Avenue maintains reliable product availability through efficient supply management, offering competitive prices and flexible solutions like OEM/ODM services for different customer needs. Their quality team oversees production and shipping to ensure product quality at every stage.

Choose Nutri Avenue for superior product quality, exceptional customer support, and unmatched expertise. Contact us today to elevate your supplement line with our premium SAC powder.

*ISO certificates are readily available for all of Nutri Avenue’s products.

FAQs

What are the primary health benefits of SAC?
SAC supports cardiovascular health, reduces inflammation, and boosts antioxidant defenses.

Can SAC help with neurodegenerative diseases?
Yes, studies suggest SAC may delay the progression of Alzheimer’s and Parkinson’s diseases.

Is SAC safe for daily consumption?
Yes, when consumed within recommended doses.

Does SAC have a strong garlic odor?
No, SAC is odorless, making it suitable for supplements.

Can SAC improve liver function?
SAC supports detoxification pathways and protects liver cells.

Is SAC vegan-friendly?
Yes, SAC is derived from plant sources and is suitable for vegans.

What makes Nutri Avenue’s SAC powder stand out?
Nutri Avenue offers high-purity SAC with customizable solutions and rigorous quality assurance.