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Tetrahydroisoquinolone

Chemical Name Tetrahydroisoquinolone
CAS Number 118864-75-8
Molecular Formula C15H15N
Molecular Weight 209.29 g/mol
Packaging 1kg,5kg/bag, 25kg/drum
Main Benefits Tetrahydroisoquinolone may control tumor growth and may as well provide support for bodily processes.
Application Dietary Supplement for Personal Care, Dietary Supplements, Functional Foods, Animal Nutrition, etc.

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Tetrahydroisoquinolone

About Tetrahydroisoquinolone

Tetrahydroisoquinolone may control tumor growth and may as well provide support for bodily processes.

What Is Tetrahydroisoquinoline?

Tetrahydroisoquinoline is a chemical compound in the class of organic compounds known as isoquinolines. This compound features a structure where a six-membered benzene ring is joined with a five-membered ring that includes nitrogen. Tetrahydroisoquinoline has various uses, including as a building block in organic synthesis and as a precursor in synthesizing pharmaceuticals and other biologically active compounds. It exhibits pharmacological properties and is studied for its potential therapeutic applications.

Reactions

  1. Nucleophilic Addition – Tetrahydroisoquinoline’s nitrogen atom can act as a nucleophile, reacting with electrophiles such as alkyl halides or acyl halides to form N-substituted or N-acylated derivatives.
  2. Ring-Opening Reactions – Tetrahydroisoquinoline can undergo ring-opening reactions to yield open-chain amine compounds under acidic conditions.
  3. Oxidation – Tetrahydroisoquinoline can be oxidized to form the corresponding isoquinoline derivative using oxidizing agents such as potassium permanganate (KMnO4) or chromic acid (H2CrO4).
  4. Reduction – Reduction of tetrahydroisoquinoline can yield 1,2,3,4-tetrahydro-1,2-dihydroisoquinoline derivatives using reducing agents like lithium aluminum hydride (LiAlH4).
  5. Cyclization Reactions – Tetrahydroisoquinoline can undergo intramolecular cyclization reactions under certain conditions, forming heterocyclic compounds with different ring sizes.
  6. Functional Group Transformations – Tetrahydroisoquinoline derivatives can undergo functional group transformations, such as hydroxylation, alkylation, and acylation, to introduce different substituents onto the molecule.

Toxicology

  1. Neurotoxicity – Studies suggest that some TIQs, formed from the metabolism of THIQ, may exhibit neurotoxic effects, potentially contributing to the development or progression of Parkinson’s disease. These effects may involve inhibiting mitochondrial function, oxidative stress, and the formation of neurotoxic metabolites.
  2. Metabolism – THIQ can undergo metabolism by enzymes such as monoamine oxidase (MAO) and aldehyde dehydrogenase (ALDH) to form TIQs. These metabolites may have varying degrees of toxicity and may contribute to neurodegenerative processes.
  3. Reactive Intermediates – THIQ can undergo oxidation to form reactive intermediates, such as quinone imines, which interact with cellular macromolecules and induce oxidative stress and damage.
  4. Acute Toxicity – Limited data are available on the acute toxicity of THIQ in humans. However, animal studies suggest that high doses of THIQ may cause central nervous system depression, respiratory depression, and convulsions.
  5. Genotoxicity – Some studies suggest that TIQs derived from THIQ metabolism may exhibit genotoxic effects, potentially leading to DNA damage and mutagenesis.
  6. Carcinogenicity – The carcinogenic potential of THIQ and its metabolites has yet to be extensively studied. However, certain TIQs have been implicated as potential carcinogens based on their structural similarity to known carcinogens and their ability to induce DNA damage in vitro.

Application of Tetrahydroisoquinolines

  1. Pharmaceuticals – THIQ derivatives are essential intermediates in synthesizing pharmaceutical compounds, including antipsychotics, antidepressants, antihistamines, and analgesics. They may also exhibit pharmacological activity, making them potential drug candidates for various therapeutic applications.
  2. Agrochemicals – THIQ derivatives are utilized in synthesizing agrochemicals, such as insecticides, herbicides, and fungicides, due to their pesticide properties and ability to target specific biological pathways in pests and pathogens.
  3. Flavors and Fragrances – Certain THIQ derivatives possess aromatic properties. They are used as flavoring agents and fragrance ingredients in the food, beverage, and cosmetic industries to impart desirable scents and tastes to consumer products.
  4. Polymer Chemistry – THIQ derivatives are employed as monomers or crosslinking agents in polymer chemistry to synthesize various polymers and copolymers with tailored properties for coatings, adhesives, and materials science applications.
  5. Organic Synthesis – THIQ and its derivatives serve as versatile building blocks in organic synthesis, enabling the construction of complex organic molecules through a wide range of chemical transformations, such as cyclization reactions, functional group manipulations, and stereochemical control.
  6. Research and Development – THIQ derivatives are valuable tools in chemical research and drug discovery efforts, serving as probes for investigating biological pathways, drug-receptor interactions, and structure-activity relationships to develop novel therapeutic agents and understand disease mechanisms.

How to Store Tetrahydroisoquinoline?

The storage method as follows:

  1. Keep in a cool, dry place.
  2. Store away from sunlight.
  3. Use an airtight container.
  4. Maintain a stable temperature (2°C to 8°C).
  5. Label the container clearly.
  6. Keep away from reactive substances.

Key Concerns of Tetrahydroisoquinoline Supplier

Nutir Avenue, as a FDA- registered supplier, focuses on the following key concerns:

  1. Quality Control: Ensuring product purity and consistency through rigorous testing and inspections.
  2. Safety: Adhering to strict safety protocols to protect employees and customers.
  3. Regulatory Compliance: Meeting all relevant laws and industry standards, with regular compliance audits.
  4. Supply Chain Management: Ensuring reliable supply of raw materials and timely delivery of products.
  5. Customer Service: Providing excellent support and responsiveness to customer needs.
  6. Market Demand: Monitoring market trends and adjusting strategies to meet changing demands.

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