Inositol hexanicotinate: A Niacin Supplement for Healthy Lipid Levels

Hexanicotinate support protein metabolism

Inositol hexanicotinate is a common dietary supplement ingredient used in the treatment of Vitamin B3 deficiency. The compound is believed to improve overall blood circulation and lower blood cholesterol levels by helping the body meet normal Niacin levels.

What is Inositol Hexanicotinate?

Also known as inositol hexaniacinate and inositol nicotinate, Inositol hexanicotinate is a lipid-regulating agent derived from the combination of Niacin and Inositol. Its structure is described as consisting of six molecules of niacin and one molecule of inositol. It is preferred in oral administration for Niacin supplementation as it is absorbed intact in the gastrointestinal tract and has an almost 70% absorption rate in the bloodstream. The use of the compound in dietary supplement formulations is said to help promote weight loss and prevent certain mood disorders.

The CAS number identifier for Inositol Hexanicotinate is 6556-11-2. Its molecular formula is C42H30N6O12 and its molecular weight is 810.7 g/mol. The compound in its powder form has a whitish crystalline appearance and is soluble in both water and organic solvents. 

Hexanicotinate provides steady niacin levels

Inositol hexanicotinate forms and specifications

The compound is included in dietary supplements in powder forms with a 99% purity assay based on high-performance liquid chromatography. Inositol hexanicotinate powder 99% is available for purchase in various ingredient suppliers online in bulk or lesser quantities.

When purchasing the compound in bulk, it is usually packed in paper drums with two layers of poly bags inside. Each paper drum has a net weight of 25 kilograms. Nonetheless, packaging options may vary depending on the quantity of purchase and the preferences of the customer.

Inositol Hexanicotinate vs Niacin

While both Inositol Hexanicotinate and plain Niacin supplementation help resolve Vitamin B3 deficiency, the majority of health practitioners recommend the use of Inositol Hexanicotinate as it does not cause flushing. Flushing is a symptom characterized by reddening of the epidermal tissues due to irritation. It is commonly observed among individuals taking plain Niacin supplementation. Hence, to avoid the symptom, Inositol Hexanicotinate is preferred.

Inositol Hexanicotinate vs Niacinamide

Otherwise known as Nicotinic acid amide, Niacinamide is a known derivative of Niacin. Along with Inositol Hexanicotinate, Niacinamide is used in the treatment of pellagra or Vitamin B3 deficiency. Both Inositol Hexanicotinate and Niacinamide are widely used in the field of dietary supplement formulation as they both do not flush which is a common side effect in Niacin supplementation. 

However, in terms of specific effects on the human body, experts say that Inositol Hexanicotinate and Niacinamide differ. Inositol hexanicotinate primarily works to interfere with lipid and cholesterol metabolism. Hence, it may be useful in controlling obesity and other health conditions associated with lipid issues. In contrast, Niacinamide is converted into NAD when it enters the human body. NAD is necessary for energy production, hence, Niacinamide is useful in increasing energy levels.

Inositol Hexanicotinate vs Nicotinic acid

Nicotinic acid or Niacin is a form of Vitamin B3. Using plain Nicotinic acid is less preferred for treatment of pellagra or Vitamin B3 supplementation as it causes skin flushing which, in some cases, maybe severe. Hence, as between Inositol Hexanicotinate and Nicotinic acid, health practitioners recommend the use of the former.

How does Inositol Hexanicotinate work?

When taken through oral administrations, Inositol Hexanicotinate is hydrolyzed in the body into two compounds. These compounds are inositol and free nicotinic acid or niacin. The said mechanism helps provide the body with a steady niacin supply within the blood plasma as the compound has a slow-release action. 

Based on clinical researches, Inositol Hexanicotinate helps promote healthy circulation by causing vasodilation. Thus, the compound may be helpful among patients with diagnosed intermittent claudication.

Inositol Hexanicotinate benefits

The following are among the health benefits associated with Inositol Hexanicotinate supplementation:

It provides steady niacin levels without flushing

Many users of Inositol Hexanicotinate have reported that, unlike plain niacin supplements, Inositol Hexanicotinatesupplementation helps treat pellagra without associated flushing. This is ideal as flushing can be severe in some patients and may interfere with the performance of activities of daily living.

It promotes healthy cholesterol and triglyceride levels

In some studies, it was observed that the experimental subjects subjected to Inositol Hexanicotinate supplementation have lower cholesterol and triglyceride levels as compared to the control group. Hence, it is believed that supplementation of the compound may improve lipid profiles, especially among high-risk individuals.

Hexanicotinate supports energy production

It may support carbohydrate and protein metabolism

Lack of inositol in the body has been associated with various metabolic conditions. The inositol molecule in Inositol Hexanicotinate is believed to help prevent the development of metabolic conditions by improving carbohydrate and protein metabolism.

It supports energy production

Inositol is also known to aid in food conversion into energy. In effect, Inositol Hexanicotinate supplementation may be useful in supporting energy levels among individual users.

It helps control anxiety and depression

Studies reveal that Inositol in Inositol Hexanicotinate also helps stimulate the production of serotonin. This neurotransmitter is useful in improving overall mood and preventing anxiety and depression.

Other health benefits

By promoting healthy metabolism, Inositol Hexanicotinate is also known to promote weight loss. The compound also possesses anti-inflammatory effects which may be useful among persons with acne. Inositol hexanicotinate is said to aid in promoting healthy sleep.

Inositol Hexanicotinate side effects

No serious side effects have been associated with Inositol Hexanicotinate supplementation within recommended doses. Nonetheless, some users have reported having experienced mild side effects such as stomach irritation and nausea. Since the compound causes vasodilation, health practitioners warn users against possible dizziness which may result from Inositol Hexanicotinate supplementation.

Inositol Hexanicotinate dosage

The typical dosage for Inositol Hexanicotinate supplementation usually ranges from 1500 to 4000 mg per day. However, the said dosage may vary depending on the individual user’s age, overall physical condition, and weight. Persons with diagnosed medical conditions, as well as pregnant and lactating women, are advised to consult their physicians before Inositol Hexanicotinate supplementation for the determination of appropriate dosage.

Where to buy bulk Inositol Hexanicotinate?

Inositol hexanicotinate can be purchased in bulk from legitimate ingredient suppliers like Nutriavenue. Buying the product from our company is ideal as we are among the registered ingredient suppliers with the Food and Drug Association. Our company is also recognized and certified by entities like Halal, Kosher, and GMP. 

Aside from Inositol Hexanicotinate, we also offer several other ingredients on our website. We also offer shipping services through the sea, air, and couriers like UPS and FedEx.

For a complete list of the products we offer, we recommend you to visit our website. You may also contact our technical support staff should you have any questions about our products and services. You may also get a free quote when you visit our page. 

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