Ipriflavone: A Daidzein Derivative for Bone Health

Ipriflavone is a Daidzein Derivative for Bone Health

Ipriflavone is a Daidzein-derived dietary supplement ingredient primarily used among early post-menopausal women to help prevent bone loss associated with irregularities in hormone levels. The compound is also used by athletes and bodybuilders as it is claimed to increase metabolism and prevent bone pain associated with engagement to extraneous exercises.

What is Ipriflavone?

Ipriflavone is a synthetic flavone compound developed under laboratory procedures that are primarily used to inhibit bone resorption. It is described as an isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. Currently, the compound is being studied to fully understand its claimed potential cytoprotective effects suggestive of its benefits among cancer patients.

Other names for the compound include Ostivone, 7-Isopropoxyisoflavone, FLI13, 7-Isopropoxy-Isoflavone, Ipriflavona, and TC-80. The most well-known brand name for the compound is Yambolap. The compound is identified as having CAS number 35212-22-7. Its molecular formula is C18H16O3 and its molecular weight is 280.323 g/mol.

Ipriflavone powder used in dietary supplement formulations has a white crystalline powder appearance and is generally soluble in DMSO. The compound has very poor solubility in water.

Ipriflavone and Estrogen

While the compound was originally considered a phytoestrogen or an agent that mimics the action of estrogen in the body, it was later discovered not to have effects in increasing or decreasing estrogen or any other uterine hormones.

A recent study conducted in 2011 has found that there are no significant estrogenic effects among participants who took the Ipriflavone and those in the control group. It is undeniable, however, that despite its non-estrogenic activities, the compound has effectively improved bone mass and manifested bone production activity in early post-menopausal and menopausal women. Hence, it was concluded that the effect of Ipriflavone in inhibiting bone resorption is independent of the estrogenic effects of its precursor compound.

Ipriflavone and Daidzein

Daidzein is a phytoestrogen compound primarily derived from soy. It is known to improve estrogen production and regulate hormone levels among women, making it beneficial in the treatment and prevention of various illnesses associated with hormone irregularities.

Essentially, Ipriflavone is developed from Daidzein through advanced procedures conducted in laboratories. While both Ipriflavone and Daidzein are believed to help post-menopausal women find relief from osteoporosis or bone demineralization, they are found to work through varying mechanisms of action.

Ipriflavone sources

The majority of Ipriflavone used in dietary supplement formulations are sourced out from those derived from Daidzein through laboratory procedures. However, the compound may also be found in trace quantities from natural herbal sources such as Alfalfa or Lucerne. Studies show that trace amounts of the compound may also be found in tree buds resin known as Propolis.

Ipriflavone forms and specifications

Ipriflavone powder is usually sold in the market at a 99% purity assay based on a high-performance liquid chromatography test. Ipriflavone powder 99% is available at several ingredient suppliers offering services online such as Nutriavenue. It is best to purchase products from legitimate companies like Nutriavenue to ensure product purity and quality. Our company also offers products at very affordable prices.

When bought from Nutriavenue in bulk, Ipriflavone powder is usually packed in paper drums with two layers of poly bags inside. Each drum for bulk purchase usually contains a net weight of about 25 kilograms. Depending on the customer’s preference and other factors, the said packaging may vary. The product may also be bought from Nutriavenue in lesser quantities.

How do Ipriflavone works?

Bone resorption is one of the most common manifestations of osteoporosis. This results in several complications as the minerals in the bones are being abnormally brought to the bones. Studies reveal that among the mechanisms of action of Ipriflavone is that it prevents bone resorption. Hence, it helps bone retain minerals and prevent them from becoming brittle due to demineralization.

The compound is also found to promote osteogenesis or bone formation. It is claimed that the benefit of using Ipriflavone is associated with its effects in preventing bone demineralization.

Overall, Ipriflavone is believed to help prevent osteoporosis-associated complications as well as prevent fractures.

Ipriflavone manufacturing process

A method to manufacture Ipriflavone begins with the reaction of 2,4-dihydroxy-phenyl-benzyl-ketone with ethyl orthoformate. The solvent to be used in the said process is dimethylformamide. A catalyst consisting of morpholine is likewise included to yield 7-hydroxyisoflavone. The product residue is thereafter separated, then the product is subjected to alkylation with isopropyl halide. Ipriflavone is then finally obtained.

Ipriflavone benefits

The following are among the health benefits of using Ipriflavone:

It supports bone health

The compound is claimed to effectively prevent bone resorption and demineralization which are often the root causes of osteoporosis and other bone conditions. Hence, supplementation of the compound is beneficial for elderly women as it supports bone health.

It promotes bodybuilding

Certain studies also show that the compound may have contributory effects in bodybuilding as it helps maintain sufficient mineral supply in the bones. Hence, it prevents bones from becoming brittle and effectively supports muscles attached to bones.

It is effective for tinnitus

One of the manifestations of otosclerosis is tinnitus. It has been found that the intake of Ipriflavone may also contribute to the effective management of tinnitus among otosclerosis patients.

It supports calcium absorption

Calcium is important for overall bone health. It was established in researches that Ipriflavone prevents calcium from escaping from the bones to the blood. It also supports the absorption of the said mineral in the bones.

Ipriflavone supplement

One of the most popular supplements for optimum bone health is Amway Nutrilite Bone Health with Ipriflavone. Another product that contains Ipriflavone is Ostivone. These products are essential and recommended for use among adult men and women.

Ipriflavone side effects

Many persons who use supplements with Ipriflavone do not experience untoward side effects. However, some reported side effects of using the compound include vomiting, muscle pain, and stomach discomfort. Long-term use of the compound at high doses is not ideal as it may alter some bodily processes and cause dangerous adverse effects.

Ipriflavone dosage

In most cases, intake of 400 to 600 mg per day of Ipriflavone supplements is beneficial for bone health. However, the dosing may increase among patients taking the compound as a treatment for Paget’s disease. The dosing may also vary depending on the individual user’s age, weight, and overall physical condition.

Where to buy bulk Ipriflavone powder?

Bulk Ipriflavone powder is available for purchase at Nutriavenue.com. Nutriavenue is a duly registered ingredient supplier with the Food and Drug Administration. It is likewise recognized by entities like Kosher, Halal, and GMP. Hence, it is the best source of Ipriflavone, along with other supplement ingredients.

Our company also offers shipping services for our customer’s convenience. Shipping rates may vary depending on your location and the number of products you purchase.

For more details on our products and services, or to get a free quote, you may visit our website and contact our technical support staff.  

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