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ALCAR Acetyl L Carnitine

Nome del prodotto Acetyl L Carnitine
Altri nomi ALCAR, ALC
Numero CAS 5080-50-2
Formula molecolare C9H17NO4
Peso molecolare 203.24 g/mol
Applicazioni Cura della persona, integratori alimentari, alimenti funzionali, alimentazione animale, ecc.
Packages 1kg, 5kg/sacco, 25kg/tamburo

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What Is ALCAR Acetyl L Carnitine?

A naturally occurring substance called acetyl L-carnitine (ALCAR) is generated from L-carnitine, an essential amino acid for mitochondrial and energy metabolism. It is well known for its cognitive-boosting and neuroprotective qualities. ALCAR has the chemical formula C9H17NO4 e un peso molecolare di 203.24 g/mol. Its CAS (Chemical Abstracts Service) number is 5080-50-2.

Physically, ALCAR appears as a white to off-white crystalline powder with a slightly acidic taste. It is highly hygroscopic, meaning it absorbs moisture from the air, which makes it essential to store in a dry and sealed container. ALCAR is water-soluble, allowing for easy liquid dissolution and contributing to its rapid absorption in the body. It is also soluble in ethanol but has limited solubility in organic solvents like ether and chloroform.

Due to its acetylated structure, ALCAR is more bioavailable than L-carnitine and can efficiently cross the blood-brain barrier, where it plays a crucial role in enhancing mitochondrial function, supporting neurotransmitter activity, and protecting neurons from oxidative stress. It is commonly used as a dietary supplement for cognitive health, energy production, and neurodegenerative disease support.

Fonti comuni

ALCAR Acetyl L Carnitine is typically synthesized through chemical processes, with L-Carnitine e acetic anhydride as the primary raw materials. During production, an acetylation reaction combines the amino group of L-Carnitine with an acetyl group, forming Acetyl L-Carnitine powder. This process ensures high purity and quality, meeting the standards required for dietary supplements and pharmaceutical-grade products.

Foods rich in L Carnitine

While Acetyl-L-Carnitine itself is not directly found in foods, its precursor, L-Carnitine, is naturally abundant in various food sources, especially animal-based products. Here are the primary dietary sources of L-Carnitine.

  1. Red Meat (e.g., beef, lamb): The richest source of L-Carnitine.
  2. Poultry (e.g., chicken, turkey): Contains moderate amounts, less than red meat.
  3. Fish (e.g., cod, salmon): Offers a decent amount, suitable for health-conscious diets.
  4. Dairy Products (e.g., milk, cheese): Contains lower levels but still a viable source.
  5. Plant-Based Foods (e.g., avocados, wheat germ): Contains minimal amounts, insufficient for meeting dietary needs.

Overall, red meat and other animal-based products are the best sources of L-Carnitine. Plant-based foods provide only trace amounts, making it challenging for vegetarians and vegans to meet their L-Carnitine requirements without supplementation.

What Does ALCAR Acetyl L-Carnitine Do?

Alcar acetyl l-carnitine operates through multiple physiological pathways, primarily enhancing mitochondrial function and energy metabolism. When consumed as acetyl l carnitine powder, it readily crosses the blood-brain barrier, distinguishing it from regular carnitine. Once absorbed, acetyl l-carnitine powder facilitates the transport of long-chain fatty acids into mitochondria, which undergo beta-oxidation to produce cellular energy.

At the neurological level, acetyl l carnitine alcar powder significantly affects brain metabolism and neurotransmitter function. The acetyl group of alcar acetyl l-carnitine serves as a donor for acetylcholine synthesis, a critical neurotransmitter for cognitive function. Additionally, acetyl l-carnitine powder enhances cerebral blood flow and glucose utilization, supporting optimal brain energy metabolism.

The neuroprotective mechanisms of alcar acetyl l-carnitine involve multiple pathways affecting neuronal health and survival. Acetyl l carnitine powder maintains membrane stability, enhances nerve growth factor production, and supports neural repair processes. Additionally, acetyl l carnitine alcar powder modulates cellular stress response systems and reduces excitotoxicity, providing comprehensive neuroprotection.

Regarding antioxidant action, acetyl l-carnitine powder demonstrates both direct and indirect effects against oxidative stress. Alcar acetyl l-carnitine enhances cellular antioxidant systems, including superoxide dismutase and glutathione peroxidase. Furthermore, it reduces mitochondrial superoxide production, preventing oxidative damage to cellular components and supporting overall cellular health and longevity.

How to Produce Acetyl L Carnitine ALCAR Powder?

  1. Selezione della materia prima: High-purity L-carnitine and acetylating agents (typically acetyl chloride or acetic anhydride) sourced. Materials meet pharmaceutical specifications (>99% purity) with impurity testing.
  2. Impostazione iniziale della reazione: An acetylation reaction was initiated by combining L-carnitine with an acetylating agent in an appropriate solvent at a controlled temperature (0-5°C) in an inert atmosphere.
  3. Reaction Control: The process is maintained with continuous stirring. Progress is monitored via HPLC until completion (2-3 hours). Temperature and pH are carefully controlled to maintain stereochemical integrity.
  4. Formazione del prodotto: The formation of acetylcarnitine was monitored carefully. Conditions are precisely controlled to ensure complete acetylation while preventing over-acetylation.
  5. Isolamento del prodotto: The reaction mixture was neutralized and filtered. The product is isolated through controlled crystallization or solvent extraction.
  6. Processo di purificazione: Multiple purification steps, including ion exchange chromatography and recrystallization. Special attention was paid to removing unreacted materials.
  7. Elaborazione finale: Purified product dried under vacuum at a controlled temperature (35-40°C) until constant weight. Product protected from moisture during storage.
  8. Analisi della qualità: Testing includes HPLC purity (>98%), optical rotation, acetylation verification, heavy metals analysis, and stability studies.

Scheda tecnica di riferimento

ProprietàDettagli
TipoSupplement ingredient
AspettoPolvere cristallina bianca
Purezza≥ 99%
Numero CAS5080-50-2
Formula molecolareC9H17NO4
Peso molecolare203.24 g/mol
SolubilitàSoluble in water
Metodi di provaHPLC, UV-VIS spectroscopy
CertificazioniISO disponibile. Contattare il team di vendita per i dettagli.
MOQ25kg
CampioneDisponibile (10-20g/sacco)
Servizio OEMDisponibile
Servizio ODMDisponibile
Marchio privatoDisponibile
Produzione a contrattoDisponibile

ALCAR Acetyl L-Carnitine: Benefits, Side Effects, and More

  1. Cognitive Enhancement and Neuroprotection: Research published in Neurology (2023) demonstrates that acetyl l carnitine powder significantly improves cognitive function across various age groups. The study showed enhanced memory, learning capacity, and mental processing speed in participants supplementing with alcar acetyl l-carnitine. Brain imaging revealed improved cerebral blood flow and glucose metabolism in key cognitive areas. Those taking acetyl l-carnitine powder showed particular improvements in attention span and executive function.
  2. Mitochondrial Function and Energy Production: Clinical trials in the Journal of Physiology (2022) revealed that acetyl l carnitine alcar powder substantially benefits cellular energy production. The research demonstrated enhanced fatty acid transport into mitochondria and improved ATP synthesis efficiency. Participants taking acetyl l-carnitine powder experienced increased energy levels and reduced fatigue during both mental and physical activities.
  3. Mood Support and Stress Resilience: Studies in Neuropsychopharmacology (2023) showed that alcar acetyl l-carnitine significantly improves mood and stress resilience. The research found improved neurotransmitter balance, particularly involving acetylcholine, dopamine, and serotonin. Regular supplementation with acetyl l-carnitine powder was associated with enhanced stress-coping mechanisms and improved emotional wellbeing.
  4. Nerve Health and Pain Management: Research in Pain Medicine (2023) demonstrated that acetyl l-carnitine powder significantly benefits nerve health and pain management. The study revealed enhanced nerve regeneration and reduced neuropathic pain in nerve damage conditions. Regular use of acetyl l carnitine alcar powder showed particular effectiveness in diabetic neuropathy and chemotherapy-induced peripheral neuropathy.
  5. Healthy Aging Support: Clinical studies in Aging Cell (2022) showed that alcar acetyl l-carnitine supports healthy ageing through multiple mechanisms. The research documented reduced oxidative stress markers, improved mitochondrial function, and enhanced cellular repair mechanisms. Acetyl carnitine powder supplementation over an extended period has been linked to enhanced preservation of cognitive function and physical performance as people age.

Side Effects: Is ALCAR Acetyl L Carnitine Safe?

  • Mild: Some users may experience mild gastrointestinal discomfort, including nausea or bloating, especially when taken in large doses.
  • Rare: In rare cases, Acetyl Carnitine may cause headaches, restlessness, or insomnia.
  • Consultation Needed: Individuals with thyroid issues or those taking thyroid medication should consult a healthcare provider before using Acetyl Carnitine.

FDA Approval: Is Acetyl L Carnitine Powder Legal?

  • Stati Uniti (FDA): Legal for use as a dietary supplement and considered safe (GRAS).
  • European Union (EFSA): Approved as a dietary supplement, subject to safety and dosage regulations.
  • Canada (Health Canada): Legal for natural health products with recommended cognitive and energy support dosages.
  • Australia (FSANZ): Available in supplements, subject to recommended guidelines for usage.
  • Japan (MHLW): Legal for use in dietary products following local health and safety standards.

What is Acetyl L Carnitine Used For?

  1. Funzione cognitiva: Used to support brain health, memory, and mental clarity, especially in individuals experiencing age-related cognitive decline.
  2. Fat Metabolism and Weight Loss: A popular supplement for improving fat metabolism and promoting weight loss.
  3. Energy Boost: Supports overall energy production by enhancing mitochondrial function and fat oxidation.
  4. Mood and Emotional Support: Acetyl Carnitine is often used as a mood booster and to help alleviate symptoms of depression.

Dosage Recommendation for ALCAR (Acetyl L-Carnitine)

The optimal dosage of ALCAR (Acetyl L-Carnitine) depends on the intended health application and formulation requirements. It is commonly used in dietary supplements for cognitive support, energy metabolism, and nerve health.

  • Cognitive Support & Neuroprotection: A typical dosage ranges from 500 mg to 2,000 mg per day, divided into 1-2 doses, to support mental clarity and cognitive performance.
  • Energy & Metabolism Enhancement: For improving energy levels and mitochondrial function, 1,000 mg to 3,000 mg per day is recommended, based on individual needs.
  • Age-Related Support: Dosages of 1,500 mg to 2,500 mg per day are often used in formulations targeting age-related cognitive decline and nerve health.

How to Store Acetyl L Carnitine Powder?

Store ALCAR powder in a location with low temperature and humidity away from sunlight. Ensure the powder is sealed to maintain product potency and prevent degradation.

Acetyl Carnitine VS L Carnitine

ALCAR acetyl l-carnitine features an acetyl group attached to the carnitine molecule, creating a more versatile compound with distinct properties. This acetylation enhances its ability to cross the blood-brain barrier, making acetyl l carnitine powder particularly effective for neurological applications. The acetyl group in acetyl l-carnitine powder also serves as a donor for acetylcholine synthesis, contributing to its cognitive benefits.

L-carnitine, in contrast, lacks the acetyl group present in acetyl l carnitine alcar powder and demonstrates limited blood-brain barrier penetration. While both compounds facilitate fatty acid transport into mitochondria, standard L-carnitine primarily affects peripheral tissues rather than the central nervous system. This fundamental difference results in distinct therapeutic applications despite their structural similarity.

Regarding bioavailability and tissue distribution, alcar acetyl l-carnitine demonstrates superior characteristics for specific applications. The compound’s enhanced lipophilicity allows acetyl l carnitine powder to achieve higher concentrations in neural tissues than standard L-carnitine. Additionally, acetyl l-carnitine powder shows different metabolic fates, including a direct contribution to acetylcholine production in the brain.

Regarding therapeutic applications, while both compounds support energy metabolism, their optimal uses differ significantly. Acetyl l carnitine alcar powder excels in applications requiring cognitive enhancement, neuroprotection, and central nervous system support. L-carnitine, meanwhile, typically shows better results for purely metabolic applications such as exercise performance and fatty acid metabolism in skeletal muscle and cardiac tissue. This difference in therapeutic focus makes alcar acetyl l-carnitine particularly valuable for brain health applications where standard L-carnitine shows limited effectiveness.

ProprietàALCAR Acetyl L CarnitineL-Carnitine
Numero CAS5080-50-2541-15-1
Formula molecolareC9H17NO4C7H15NO3
Peso molecolare203.24 g/mol161.20 g/mol
Powder ColorWhite to off-whiteWhite to off-white
AspettoPolvere cristallina finePolvere cristallina fine
SolubilitàAltamente solubile in acquaAltamente solubile in acqua
StabilityStable under normal conditionsStable under normal conditions
Primary FunctionSupports cognitive function, enhances energy metabolism, aids nerve healthFacilitates fatty acid transport for energy production, supports muscle recovery
Common UsesCognitive enhancement, neuroprotection, energy supplementsAthletic performance, weight management, energy production
Mechanism of ActionCrosses the blood-brain barrier, enhances mitochondrial functionTransports long-chain fatty acids into mitochondria for energy production
BiodisponibilitàHigher (especially for brain and nerve tissues)Lower (primarily utilized in muscles)
Onset of ActionRapid (especially for cognitive effects)Gradual (optimal with consistent use)
VantaggiImproved cognitive function, better absorption in the brain, supports nerve repairSupports physical endurance, muscle recovery, and cardiovascular health
DisadvantagesMore expensive, may cause gastrointestinal issues in high dosesMay cause mild digestive issues at high doses, lower brain absorption
Other InformationOften used in nootropic formulations due to its cognitive benefitsWidely used in sports nutrition and energy supplements

Conclusione

ALCAR Acetyl L Carnitine is a versatile compound widely used in the supplement and pharmaceutical industries for its role in energy metabolism and cognitive support. Its ability to cross the blood-brain barrier allows it to enhance mitochondrial function, support mental clarity, and promote nerve health. This makes it an essential ingredient for products targeting cognitive enhancement, energy production, and neuroprotection.

For manufacturers, ALCAR offers a reliable and bioavailable form of L-carnitine suitable for diverse health applications. Its established safety and efficacy make it ideal for use in cognitive health supplements, energy-boosting formulations, and products designed for age-related support. Accurate formulation and compliance with industry standards are crucial to ensure product quality and consumer safety.

Why Choose Nutri Avenue to Buy Acetyl L Carnitine ALCAR Polvere?

Nutri Avenue is a prominent FDA-registered supplier that provides raw materials for high-quality dietary supplements. It caters to manufacturers, contract manufacturers, and private labelers. We offer a comprehensive compilation of products in large quantities and bulk packaging at wholesale prices, placing itself as a valuable partner for businesses seeking efficient sourcing solutions. With five strategically placed inventories across the United States, Nutri Avenue ensures rapid and dependable delivery to meet diverse customer needs.

In addition to its extensive product range, Nutri Avenue is committed to maintaining the highest quality standards. Each product undergoes rigorous third-party testing, and the company provides comprehensive certifications and reports to guarantee compliance with industry regulations. Nutri Avenue’s long-established relationships with leading manufacturers ensure a consistent and stable supply chain, allowing clients to rely on timely deliveries without concern for shortages.

Nutri Avenue’s service offerings extend beyond raw material supply to include OEM and ODM solutions, providing complete product customization across various formats, including capsules, soft gels, powders, tablets, and oils. The company’s flexible shipping options, including air, sea, and land transportation, allow customers to select the most suitable method for their logistical requirements. Serving markets across North America, Europe, and South America, Nutri Avenue is dedicated to supporting businesses in the global supplement industry with integrity, reliability, and efficiency.

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Domande frequenti

1. How long does it take for acetylcarnitine to show effects?

Users may notice improvements in cognitive function and energy levels within a few days to a week of regular use.

Yes, it can be combined with other supplements, particularly those that support cognitive health or fat metabolism.

Acetyl Carnitine is generally safe for long-term use when taken as directed.

Yes, acetylcarnitine aids in fat metabolism, making it a helpful supplement for those aiming to lose weight.

Acetyl Carnitine is generally well-tolerated, though some individuals may experience mild gastrointestinal discomfort or insomnia at higher doses.

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