What Is ALCAR Acetyl L Carnitine?
A naturally occurring substance called acetyl L-carnitine (ALCAR) is generated from L-carnitine, an essential amino acid for mitochondrial and energy metabolism. It is well known for its cognitive-boosting and neuroprotective qualities. ALCAR has the chemical formula C9H17NO4 e un peso molecolare di 203.24 g/mol. Its CAS (Chemical Abstracts Service) number is 5080-50-2.
Physically, ALCAR appears as a white to off-white crystalline powder with a slightly acidic taste. It is highly hygroscopic, meaning it absorbs moisture from the air, which makes it essential to store in a dry and sealed container. ALCAR is water-soluble, allowing for easy liquid dissolution and contributing to its rapid absorption in the body. It is also soluble in ethanol but has limited solubility in organic solvents like ether and chloroform.
Due to its acetylated structure, ALCAR is more bioavailable than L-carnitine and can efficiently cross the blood-brain barrier, where it plays a crucial role in enhancing mitochondrial function, supporting neurotransmitter activity, and protecting neurons from oxidative stress. It is commonly used as a dietary supplement for cognitive health, energy production, and neurodegenerative disease support.
Fonti comuni
ALCAR Acetyl L Carnitine is typically synthesized through chemical processes, with L-Carnitine e acetic anhydride as the primary raw materials. During production, an acetylation reaction combines the amino group of L-Carnitine with an acetyl group, forming Acetyl L-Carnitine powder. This process ensures high purity and quality, meeting the standards required for dietary supplements and pharmaceutical-grade products.
Foods rich in L Carnitine
While Acetyl-L-Carnitine itself is not directly found in foods, its precursor, L-Carnitine, is naturally abundant in various food sources, especially animal-based products. Here are the primary dietary sources of L-Carnitine.
- Red Meat (e.g., beef, lamb): The richest source of L-Carnitine.
- Poultry (e.g., chicken, turkey): Contains moderate amounts, less than red meat.
- Fish (e.g., cod, salmon): Offers a decent amount, suitable for health-conscious diets.
- Dairy Products (e.g., milk, cheese): Contains lower levels but still a viable source.
- Plant-Based Foods (e.g., avocados, wheat germ): Contains minimal amounts, insufficient for meeting dietary needs.
Overall, red meat and other animal-based products are the best sources of L-Carnitine. Plant-based foods provide only trace amounts, making it challenging for vegetarians and vegans to meet their L-Carnitine requirements without supplementation.
What Does ALCAR Acetyl L-Carnitine Do?
Alcar acetyl l-carnitine operates through multiple physiological pathways, primarily enhancing mitochondrial function and energy metabolism. When consumed as acetyl l carnitine powder, it readily crosses the blood-brain barrier, distinguishing it from regular carnitine. Once absorbed, acetyl l-carnitine powder facilitates the transport of long-chain fatty acids into mitochondria, which undergo beta-oxidation to produce cellular energy.
At the neurological level, acetyl l carnitine alcar powder significantly affects brain metabolism and neurotransmitter function. The acetyl group of alcar acetyl l-carnitine serves as a donor for acetylcholine synthesis, a critical neurotransmitter for cognitive function. Additionally, acetyl l-carnitine powder enhances cerebral blood flow and glucose utilization, supporting optimal brain energy metabolism.
The neuroprotective mechanisms of alcar acetyl l-carnitine involve multiple pathways affecting neuronal health and survival. Acetyl l carnitine powder maintains membrane stability, enhances nerve growth factor production, and supports neural repair processes. Additionally, acetyl l carnitine alcar powder modulates cellular stress response systems and reduces excitotoxicity, providing comprehensive neuroprotection.
Regarding antioxidant action, acetyl l-carnitine powder demonstrates both direct and indirect effects against oxidative stress. Alcar acetyl l-carnitine enhances cellular antioxidant systems, including superoxide dismutase and glutathione peroxidase. Furthermore, it reduces mitochondrial superoxide production, preventing oxidative damage to cellular components and supporting overall cellular health and longevity.
How to Produce Acetyl L Carnitine ALCAR Powder?
- Selezione della materia prima: High-purity L-carnitine and acetylating agents (typically acetyl chloride or acetic anhydride) sourced. Materials meet pharmaceutical specifications (>99% purity) with impurity testing.
- Impostazione iniziale della reazione: An acetylation reaction was initiated by combining L-carnitine with an acetylating agent in an appropriate solvent at a controlled temperature (0-5°C) in an inert atmosphere.
- Reaction Control: The process is maintained with continuous stirring. Progress is monitored via HPLC until completion (2-3 hours). Temperature and pH are carefully controlled to maintain stereochemical integrity.
- Formazione del prodotto: The formation of acetylcarnitine was monitored carefully. Conditions are precisely controlled to ensure complete acetylation while preventing over-acetylation.
- Isolamento del prodotto: The reaction mixture was neutralized and filtered. The product is isolated through controlled crystallization or solvent extraction.
- Processo di purificazione: Multiple purification steps, including ion exchange chromatography and recrystallization. Special attention was paid to removing unreacted materials.
- Elaborazione finale: Purified product dried under vacuum at a controlled temperature (35-40°C) until constant weight. Product protected from moisture during storage.
- Analisi della qualità: Testing includes HPLC purity (>98%), optical rotation, acetylation verification, heavy metals analysis, and stability studies.
Scheda tecnica di riferimento
Proprietà | Dettagli |
Tipo | Supplement ingredient |
Aspetto | Polvere cristallina bianca |
Purezza | ≥ 99% |
Numero CAS | 5080-50-2 |
Formula molecolare | C9H17NO4 |
Peso molecolare | 203.24 g/mol |
Solubilità | Soluble in water |
Metodi di prova | HPLC, UV-VIS spectroscopy |
Certificazioni | ISO disponibile. Contattare il team di vendita per i dettagli. |
MOQ | 25kg |
Campione | Disponibile (10-20g/sacco) |
Servizio OEM | Disponibile |
Servizio ODM | Disponibile |
Marchio privato | Disponibile |
Produzione a contratto | Disponibile |
ALCAR Acetyl L-Carnitine: Benefits, Side Effects, and More
- Cognitive Enhancement and Neuroprotection: Research published in Neurology (2023) demonstrates that acetyl l carnitine powder significantly improves cognitive function across various age groups. The study showed enhanced memory, learning capacity, and mental processing speed in participants supplementing with alcar acetyl l-carnitine. Brain imaging revealed improved cerebral blood flow and glucose metabolism in key cognitive areas. Those taking acetyl l-carnitine powder showed particular improvements in attention span and executive function.
- Mitochondrial Function and Energy Production: Clinical trials in the Journal of Physiology (2022) revealed that acetyl l carnitine alcar powder substantially benefits cellular energy production. The research demonstrated enhanced fatty acid transport into mitochondria and improved ATP synthesis efficiency. Participants taking acetyl l-carnitine powder experienced increased energy levels and reduced fatigue during both mental and physical activities.
- Mood Support and Stress Resilience: Studies in Neuropsychopharmacology (2023) showed that alcar acetyl l-carnitine significantly improves mood and stress resilience. The research found improved neurotransmitter balance, particularly involving acetylcholine, dopamine, and serotonin. Regular supplementation with acetyl l-carnitine powder was associated with enhanced stress-coping mechanisms and improved emotional wellbeing.
- Nerve Health and Pain Management: Research in Pain Medicine (2023) demonstrated that acetyl l-carnitine powder significantly benefits nerve health and pain management. The study revealed enhanced nerve regeneration and reduced neuropathic pain in nerve damage conditions. Regular use of acetyl l carnitine alcar powder showed particular effectiveness in diabetic neuropathy and chemotherapy-induced peripheral neuropathy.
- Healthy Aging Support: Clinical studies in Aging Cell (2022) showed that alcar acetyl l-carnitine supports healthy ageing through multiple mechanisms. The research documented reduced oxidative stress markers, improved mitochondrial function, and enhanced cellular repair mechanisms. Acetyl carnitine powder supplementation over an extended period has been linked to enhanced preservation of cognitive function and physical performance as people age.
Side Effects: Is ALCAR Acetyl L Carnitine Safe?
- Mild: Some users may experience mild gastrointestinal discomfort, including nausea or bloating, especially when taken in large doses.
- Rare: In rare cases, Acetyl Carnitine may cause headaches, restlessness, or insomnia.
- Consultation Needed: Individuals with thyroid issues or those taking thyroid medication should consult a healthcare provider before using Acetyl Carnitine.
FDA Approval: Is Acetyl L Carnitine Powder Legal?
- Stati Uniti (FDA): Legal for use as a dietary supplement and considered safe (GRAS).
- European Union (EFSA): Approved as a dietary supplement, subject to safety and dosage regulations.
- Canada (Health Canada): Legal for natural health products with recommended cognitive and energy support dosages.
- Australia (FSANZ): Available in supplements, subject to recommended guidelines for usage.
- Japan (MHLW): Legal for use in dietary products following local health and safety standards.
What is Acetyl L Carnitine Used For?
- Funzione cognitiva: Used to support brain health, memory, and mental clarity, especially in individuals experiencing age-related cognitive decline.
- Fat Metabolism and Weight Loss: A popular supplement for improving fat metabolism and promoting weight loss.
- Energy Boost: Supports overall energy production by enhancing mitochondrial function and fat oxidation.
- Mood and Emotional Support: Acetyl Carnitine is often used as a mood booster and to help alleviate symptoms of depression.
Dosage Recommendation for ALCAR (Acetyl L-Carnitine)
The optimal dosage of ALCAR (Acetyl L-Carnitine) depends on the intended health application and formulation requirements. It is commonly used in dietary supplements for cognitive support, energy metabolism, and nerve health.
- Cognitive Support & Neuroprotection: A typical dosage ranges from 500 mg to 2,000 mg per day, divided into 1-2 doses, to support mental clarity and cognitive performance.
- Energy & Metabolism Enhancement: For improving energy levels and mitochondrial function, 1,000 mg to 3,000 mg per day is recommended, based on individual needs.
- Age-Related Support: Dosages of 1,500 mg to 2,500 mg per day are often used in formulations targeting age-related cognitive decline and nerve health.
How to Store Acetyl L Carnitine Powder?
Store ALCAR powder in a location with low temperature and humidity away from sunlight. Ensure the powder is sealed to maintain product potency and prevent degradation.
Acetyl Carnitine VS L Carnitine
ALCAR acetyl l-carnitine features an acetyl group attached to the carnitine molecule, creating a more versatile compound with distinct properties. This acetylation enhances its ability to cross the blood-brain barrier, making acetyl l carnitine powder particularly effective for neurological applications. The acetyl group in acetyl l-carnitine powder also serves as a donor for acetylcholine synthesis, contributing to its cognitive benefits.
L-carnitine, in contrast, lacks the acetyl group present in acetyl l carnitine alcar powder and demonstrates limited blood-brain barrier penetration. While both compounds facilitate fatty acid transport into mitochondria, standard L-carnitine primarily affects peripheral tissues rather than the central nervous system. This fundamental difference results in distinct therapeutic applications despite their structural similarity.
Regarding bioavailability and tissue distribution, alcar acetyl l-carnitine demonstrates superior characteristics for specific applications. The compound’s enhanced lipophilicity allows acetyl l carnitine powder to achieve higher concentrations in neural tissues than standard L-carnitine. Additionally, acetyl l-carnitine powder shows different metabolic fates, including a direct contribution to acetylcholine production in the brain.
Regarding therapeutic applications, while both compounds support energy metabolism, their optimal uses differ significantly. Acetyl l carnitine alcar powder excels in applications requiring cognitive enhancement, neuroprotection, and central nervous system support. L-carnitine, meanwhile, typically shows better results for purely metabolic applications such as exercise performance and fatty acid metabolism in skeletal muscle and cardiac tissue. This difference in therapeutic focus makes alcar acetyl l-carnitine particularly valuable for brain health applications where standard L-carnitine shows limited effectiveness.
Proprietà | ALCAR Acetyl L Carnitine | L-Carnitine |
Numero CAS | 5080-50-2 | 541-15-1 |
Formula molecolare | C9H17NO4 | C7H15NO3 |
Peso molecolare | 203.24 g/mol | 161.20 g/mol |
Powder Color | White to off-white | White to off-white |
Aspetto | Polvere cristallina fine | Polvere cristallina fine |
Solubilità | Altamente solubile in acqua | Altamente solubile in acqua |
Stability | Stable under normal conditions | Stable under normal conditions |
Primary Function | Supports cognitive function, enhances energy metabolism, aids nerve health | Facilitates fatty acid transport for energy production, supports muscle recovery |
Common Uses | Cognitive enhancement, neuroprotection, energy supplements | Athletic performance, weight management, energy production |
Mechanism of Action | Crosses the blood-brain barrier, enhances mitochondrial function | Transports long-chain fatty acids into mitochondria for energy production |
Biodisponibilità | Higher (especially for brain and nerve tissues) | Lower (primarily utilized in muscles) |
Onset of Action | Rapid (especially for cognitive effects) | Gradual (optimal with consistent use) |
Vantaggi | Improved cognitive function, better absorption in the brain, supports nerve repair | Supports physical endurance, muscle recovery, and cardiovascular health |
Disadvantages | More expensive, may cause gastrointestinal issues in high doses | May cause mild digestive issues at high doses, lower brain absorption |
Other Information | Often used in nootropic formulations due to its cognitive benefits | Widely used in sports nutrition and energy supplements |
Conclusione
ALCAR Acetyl L Carnitine is a versatile compound widely used in the supplement and pharmaceutical industries for its role in energy metabolism and cognitive support. Its ability to cross the blood-brain barrier allows it to enhance mitochondrial function, support mental clarity, and promote nerve health. This makes it an essential ingredient for products targeting cognitive enhancement, energy production, and neuroprotection.
For manufacturers, ALCAR offers a reliable and bioavailable form of L-carnitine suitable for diverse health applications. Its established safety and efficacy make it ideal for use in cognitive health supplements, energy-boosting formulations, and products designed for age-related support. Accurate formulation and compliance with industry standards are crucial to ensure product quality and consumer safety.
Why Choose Nutri Avenue to Buy Acetyl L Carnitine ALCAR Polvere?
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Domande frequenti
1. How long does it take for acetylcarnitine to show effects?
Users may notice improvements in cognitive function and energy levels within a few days to a week of regular use.
2. Can Acetyl Carnitine be combined with other supplements?
Yes, it can be combined with other supplements, particularly those that support cognitive health or fat metabolism.
3. Is Acetyl Carnitine safe for long-term use?
Acetyl Carnitine is generally safe for long-term use when taken as directed.
4. Can Acetyl Carnitine help with weight loss?
Yes, acetylcarnitine aids in fat metabolism, making it a helpful supplement for those aiming to lose weight.
5. Are there any side effects of acetylcarnitine?
Acetyl Carnitine is generally well-tolerated, though some individuals may experience mild gastrointestinal discomfort or insomnia at higher doses.