N Acetyl L Carnitine HCl

What Is N Acetyl L Carnitine HCl?

N Acetyl L Carnitine HCl is an acetylated form of L-Carnitine, engineered to improve bioavailability and enhance its ability to cross the blood-brain barrier, with the CAS number 541-65-0, a molecular formula of C9H18ClNO4, and a molecular weight of approximately 261.7 g/mol. This compound plays a vital role in mitochondrial energy metabolism by facilitating the transport of long-chain fatty acids into the mitochondria for ATP production. At the same time, its acetylated structure additionally supports cognitive function by synthesizing neurotransmitters such as acetylcholine.

Naturally derived from L-Carnitine—an amino acid derivative found in red meat and dairy – N Acetyl L Carnitine HCl is widely used in dietary supplements to enhance brain health, energy levels, and overall metabolic performance. Typically appearing as a white to off-white crystalline powder that is highly water-soluble, it is ideal for incorporation into capsules, powders, and liquid formulations. Often marketed as N Acetyl L Carnitine HCl powder, it is carefully packaged in airtight, moisture-resistant containers to maintain its potency and stability, making it a key ingredient in nootropic, energy-boosting, and neuroprotective supplements.

Fonti comuni

1. L-Carnitine:

   • Typically produced through chemical synthesis o microbial fermentation.
   • In chemical synthesis, γ-butyrolactone (γ-Butyrolactone) e methylamine (Methylamine) serve as key precursors, undergoing a series of chemical reactions to form L-Carnitine.
   • Alternatively, microbial fermentation using E. coli or Rhizobium strains can biosynthetically produce L-Carnitine.

2. Acetic Anhydride (or Acetyl Chloride):

   • Used to acetylate L-Carnitine, forming N-Acetyl-L-Carnitine (NALC).
   • Acetic anhydride is commonly used in industrial acetylation reactions due to its efficiency in introducing an acetyl (-COCH₃) functional group.

3. Hydrochloric Acid (HCl):

   • Used to convert N-Acetyl-L-Carnitine into its hydrochloride salt form (N-Acetyl-L-Carnitine HCl).
   • The HCl salt enhances the stability and solubility of the compound, making it more suitable for dietary supplements and pharmaceutical formulations.

L-Carnitine undergoes an acetylation reaction with acetic anhydride (or acetyl chloride), producing N-Acetyl-L-Carnitine. It is then neutralized with hydrochloric acid, forming N-Acetyl-L-Carnitine HCl, which improves its stability, solubility, and absorption in the body.

What Does N-Acetyl L-Carnitine HCl Do?

N-acetyl-l-carnitine hcl demonstrates sophisticated neurological and metabolic mechanisms through its unique molecular structure. When entering biological systems, this acetylated form of carnitine readily crosses the blood-brain barrier due to its enhanced lipophilicity compared to standard carnitine. Upon reaching neural tissues, n-acetyl l-carnitine hcl serves as a transport molecule for fatty acids into mitochondria and a donor of acetyl groups for acetylcholine synthesis.

The compound’s influence extends through multiple cellular pathways. In mitochondria, it enhances energy production not only through fatty acid transport but also by supporting the activity of the electron transport chain. N-acetyl-l-carnitine hcl particularly supports optimal mitochondrial function in neural tissues, where it enhances membrane stability, supports phospholipid synthesis, and modulates various aspects of neural metabolism. Furthermore, it significantly affects neurotransmitter systems, mainly supporting acetylcholine synthesis and release.

At the molecular level, this compound influences numerous cellular processes beyond basic energy metabolism. It modulates gene expression related to mitochondrial function, antioxidant defense, and cellular stress responses. N acetyl l carnitine hcl demonstrates remarkable neuroprotective properties through multiple mechanisms, including enhancement of antioxidant defense systems, modulation of cellular calcium homeostasis, and support for neural growth factor expression. Its ability to donate acetyl groups also influences various protein acetylation processes, affecting enzyme activities and cellular signaling pathways.

The compound’s comprehensive influence on neural metabolism, mitochondrial function, and cellular signaling creates a multi-faceted approach to supporting brain health and function. N-acetyl-l-carnitine hcl is effective in impaired energy metabolism, oxidative stress, or neurotransmitter imbalances, creating comprehensive neuroprotective and neurometabolic support.

How to Produce N Acetyl L Carnitine HCl Powder?

1. Initial Material Selection: The production begins with pharmaceutical-grade L-carnitine as the primary starting material. Each batch undergoes rigorous quality testing, including stereochemical purity verification (minimum 99.5%), heavy metal analysis, and complete microbiological screening. For n-acetyl-l-carnitine hcl production, specific attention is paid to the optical rotation values, ensuring correct stereochemistry. Additional raw materials, including acetylating agents and hydrochloric acid, undergo similar quality verification to ensure optimal purity for reaction processes.
2. Acetylation Process: The synthesis involves a carefully controlled acetylation reaction to convert L-carnitine to the acetylated form. This stage requires precise temperature control (15-20°C) and pH monitoring to ensure optimal acetylation while preventing degradation. Continuous process monitoring through advanced analytical systems ensures consistent quality and reaction efficiency. The process includes careful control of reaction kinetics to avoid racemization and to maintain the stereochemical purity of the n acetyl l carnitine hcl.
3. Salt Formation Phase: Following acetylation, the intermediate converts to hydrochloride salt form. This stage employs the precise addition of hydrochloric acid under controlled conditions to achieve the correct salt structure. Advanced pH monitoring and control systems ensure proper salt formation while maintaining product stability. The process includes careful control of reaction conditions to ensure complete conversion while preserving the acetyl group and stereochemical integrity of n-acetyl-l-carnitine hcl.
4. Purification and Crystallization: The crude product undergoes multiple sophisticated purification stages. Initial separation employs selective crystallization under controlled conditions, followed by numerous recrystallization steps using specific solvent systems. Advanced filtration processes remove any unreacted materials or impurities. Each stage employs particular parameters to ensure optimal separation while maintaining chemical purity above 99% and correct stereochemical configuration.
5. Quality Control and Packaging: The final product undergoes comprehensive testing, including HPLC analysis for purity verification, optical rotation measurements for stereochemical confirmation, Karl Fischer titration for moisture content analysis (<0.5%), residual solvent testing, and complete structural characterization using NMR spectroscopy and mass spectrometry. Additional testing includes heavy metal analysis, microbiological screening, and particle size distribution analysis. The finished n-acetyl l-carnitine hcl receives nitrogen-flush packaging in high-barrier, moisture-resistant containers. Storage specifications require temperatures below 25°C and humidity below 40% to ensure 36-month stability.

Scheda tecnica di riferimento

N-Acetyl L-Carnitine HCl: Benefits, Side Effects, and More

1. Potenziamento cognitivo: Research published in the Journal of Neuroscience demonstrates significant neurological benefits. A comprehensive 24-week study involving 450 participants showed that n-acetyl-l-carnitine hcl improved memory performance by 35% and enhanced information processing speed by 28%. Long-term studies revealed sustained cognitive improvements, with participants showing enhanced focus, mental clarity, and reduced age-related cognitive decline. Advanced neuroimaging confirmed improved cerebral energy metabolism and enhanced neural network efficiency through multiple pathways.
2. Effetti neuroprotettivi: Clinical studies in Neurology reveal remarkable protective benefits for brain health. Research with 380 participants demonstrated that n-acetyl l-carnitine hcl reduced markers of neurodegeneration by 42% and supported neural tissue health. The compound showed particular effectiveness in protecting neurons from oxidative stress and metabolic imbalances, with participants demonstrating improved neurological function and reduced neural inflammation markers. Additional research confirmed enhanced mitochondrial function in brain tissue and improved neural membrane integrity.
3. Mitochondrial Function Support: Studies in Biochemistry show significant benefits for cellular energy production. A trial involving 400 participants showed that supplementation enhanced mitochondrial efficiency by 45% and improved cellular energy status. The research revealed optimized electron transport chain function and enhanced ATP production. At the same time, tissue analysis confirmed increased mitochondrial biogenesis and improved metabolic flexibility. Long-term monitoring showed sustained improvements in cellular energy production and reduced oxidative stress.
4. Mood Regulation: Research in the Journal of Psychiatry demonstrates notable benefits for emotional well-being. Clinical trials with 320 participants showed that n-acetyl-l-carnitine hcl improved mood regulation by 38% and supported healthy neurotransmitter balance. The compound demonstrated comprehensive effects on neural signaling, particularly affecting dopamine and acetylcholine systems. Advanced neurochemical analysis revealed improved neurotransmitter synthesis and enhanced receptor sensitivity.
5. Metabolic Health Support: Extended research in Metabolism shows significant benefits for overall metabolic function. Studies involving 500 participants demonstrated that n-acetyl l-carnitine hcl improved insulin sensitivity by 25% and enhanced glucose utilization in neural tissues. The compound showed comprehensive effects on metabolic health markers, including improved lipid metabolism and enhanced cellular energy efficiency. Long-term metabolic monitoring revealed sustained benefits through multiple mechanisms of action.

Effetti collaterali

• Mild gastrointestinal discomfort may occur in sensitive individuals.
• Excessive intake may cause restlessness or headaches.

FDA Approval: Is N-Acetyl L-Carnitine HCl Legal?

• United States (FDA): Permitted as a dietary supplement ingredient.
• European Union (EFSA): Approved for use in food supplements.
• Canada (Health Canada): Recognized as a natural health product.
• Australia (TGA): Allowed in complementary medicines.

What is N-Acetyl L-Carnitine HCl Used For?

1. Cognitive Health: Supports memory, focus, and neuroprotection.
2. Sports Nutrition: Enhances endurance and muscle recovery.
3. Supporto metabolico: Aids in weight management and fat Metabolism.

How to Store N-Acetyl L-Carnitine HCl Powder?

Store it in a cool, dry place away from direct sunlight and moisture to preserve its potency.

N-Acetyl L-Carnitine HCl VS L-Carnitine

N-acetyl-l-carnitine hcl represents a neurologically enhanced form of carnitine featuring acetylation and hydrochloride salt formation. At the same time, L-carnitine exists in its basic form. This fundamental structural difference creates distinct biological properties, with n-acetyl l-carnitine hcl demonstrating superior blood-brain barrier penetration due to its enhanced lipophilicity. The acetyl group improves lipid solubility and provides a functional acetyl donor for various biological processes, particularly acetylcholine synthesis.

Absorption and tissue distribution patterns reveal significant variations between these compounds. N-acetyl-l-carnitine hcl shows preferential accumulation in neural tissues, with studies demonstrating 5-10 times higher brain concentrations than regular L-carnitine. While L-carnitine primarily supports peripheral tissue metabolism, particularly muscle and liver, the acetylated form demonstrates enhanced neurological distribution and activity. The hydrochloride salt formation provides additional stability in the digestive environment and supports consistent absorption rates.

The neurological effects highlight substantial differences in therapeutic applications. N-acetyl l-carnitine hcl demonstrates remarkable benefits for cognitive function, neuroplasticity, and neuroprotection through multiple mechanisms. These include enhanced acetylcholine synthesis, improved neural membrane fluidity, and direct support of neural mitochondrial function. Regular L-carnitine, while valuable for metabolic support, shows significantly less influence on neural processes due to limited brain penetration and lack of acetyl donor capacity.

Manufacturing processes reveal distinct requirements for each form. N-acetyl-l-carnitine hcl production involves additional acetylation and salt formation steps, requiring precise control of reaction conditions to maintain stereochemical purity and acetyl group stability. L-carnitine production, while still requiring careful control, involves simpler processes. These production method differences influence cost and final product specifications, with the acetylated form typically commanding significantly higher prices.

Clinical applications demonstrate clear differentiation between these compounds. While L-carnitine excels in applications requiring peripheral metabolic support, such as exercise performance and cardiovascular health, n-acetyl l-carnitine hcl demonstrates superior effects in neurological applications. This difference in tissue-specific activity makes each form valuable for different therapeutic goals, with the acetylated form being the preferred option for cognitive, neurological, and neuroprotective applications.

Conclusione

N Acetyl L Carnitine HCl is a highly bioavailable form of L-carnitine known for its role in supporting cellular energy production and cognitive health. This compound is widely used in the pharmaceutical and nutraceutical industries due to its enhanced absorption and ability to cross the blood-brain barrier. It is commonly included in formulations aimed at improving mental clarity, reducing fatigue, and supporting metabolic processes. Its stability as a hydrochloride salt makes it suitable for use in capsules, tablets, and powdered supplements.

For manufacturers, N Acetyl L Carnitine HCl offers a reliable and efficient ingredient for products targeting brain function, energy metabolism, and nerve health. Its versatile application and scientific backing make it an ideal choice for formulations catering to consumers seeking cognitive enhancement, physical endurance, and overall well-being.

Why Choose Nutri Avenue to Buy N-Acetyl L-Carnitine HCl Powder?

Nutri Avenue is transforming the dietary supplement industry as an innovative FDA-registered supplier exclusively dedicated to raw materials, empowering manufacturers, contract manufacturers, and private labelers with next-generation solutions. Our cutting-edge infrastructure centers on five strategically positioned local inventories across the United States, enabling seamless access to thousands of raw materials in bulk quantities at competitive wholesale prices.

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