6 パラドール

What is 6 Paradol?

6-Paradol is a bioactive compound found in the seeds of Aframomum melegueta (Grains of Paradise), a plant in the ginger family. Known for its thermogenic, antioxidant, and anti-inflammatory properties, 6-Paradol is widely used in health supplements for weight management, pain relief, and metabolic enhancement. Its spicy flavor also makes it a key ingredient in traditional and culinary applications.

一般的な情報源

6 Paradol powder is a compound known for its antioxidant, anti-inflammatory, and potential anticancer properties. It is found naturally in certain plants and can also be synthesized chemically. Here’s an overview of its plant-based and chemical sources:

Plant Sources

1. Ginger Family Plants (Zingiberaceae)
   • Grains of Paradise (Aframomum melegueta)
     6-Paradol is one of the main active compounds in this plant, also known as Guinea pepper or alligator pepper. It is primarily grown in West Africa, and its seeds contain a significant concentration of 6-Paradol and its related compounds.
   • Ginger (Zingiber officinale)
     Ginger root contains small amounts of 6-Paradol, contributing to its characteristic pungent flavor, although the concentration is relatively low.

化学ソース

1. Derived from Related Compounds
   • 6 Paradol can be produced by dehydrating or enzymatically modifying 6-Gingerol, a compound naturally extracted from ginger plants.
2. Laboratory Chemical Synthesis
   • In the lab, 6-Paradol can be synthesized through organic chemical methods. Starting with simple phenolic compounds, it can be created using a series of reactions such as aldehyde formation, acylation, reduction, and dehydration. This approach yields high-purity 6-Paradol, making it suitable for research purposes.

6-Paradol is widely studied in nutrition and pharmacology, especially for its potential roles in oxidative stress reduction, inflammation control, and metabolic regulation.

What Does 6 Paradol Do?

6-Paradol, a pungent phenolic compound found in ginger and grains of paradise, exhibits its biological effects through multiple molecular pathways. At its core, 6-paradol functions as a potent activator of transient receptor potential (TRP) channels, particularly TRPV1, which is responsible for its thermogenic and analgesic properties.

The compound works through several key mechanisms: First, it acts as a COX-2 (cyclooxygenase-2) inhibitor, thereby reducing the production of pro-inflammatory prostaglandins, which explains its anti-inflammatory effects. Second, 6-paradol demonstrates significant antioxidant activity by scavenging free radicals and enhancing the expression of antioxidant enzymes like superoxide dismutase and catalase.

Additionally, 6 paradol has been shown to influence lipid metabolism by activating AMP-activated protein kinase (AMPK), which causes fatty acid oxidation and glucose uptake in cells. This mechanism contributes to its potential anti-obesity effects. The compound also exhibits anti-cancer properties through the modulation of various signaling pathways, including the inhibition of NF-κB activation and the induction of apoptosis in cancer cells through mitochondrial-dependent pathways.

How to Produce 6 Paradol Powder?

1. 原材料の選択: High-purity 6-gingerol and palladium catalysts are sourced as primary starting materials. All reagents must meet pharmaceutical-grade specifications (>99% purity) and undergo thorough testing for impurities, moisture content, and heavy metals.
2. Initial Reaction Setup: The hydrogenation reaction is set up by combining 6-gingerol with a palladium catalyst in an appropriate solvent system at a controlled temperature (20-25°C) under a hydrogen atmosphere.
3. 反応制御: The reaction mixture is maintained with continuous stirring under hydrogen pressure. Progress is monitored via TLC/HPLC until completion (typically 3-4 hours). Temperature and pressure are carefully controlled.
4. 製品の形成: The reduction of 6-gingerol to 6-paradol is carefully monitored. The reaction conditions are precisely controlled to ensure complete conversion while minimizing side reactions.
5. 製品の分離: The reaction mixture undergoes filtration to remove the catalyst, followed by solvent evaporation under controlled conditions. The crude product is then extracted with appropriate organic solvents.
6. 精製プロセス: The crude product undergoes multiple purification steps, including column chromatography for primary separation and recrystallization for final purification.
7. 最終処理: The purified product is dried under vacuum at a controlled temperature (35-40°C) until it reaches a constant weight. If necessary, it is milled to achieve a uniform particle size according to specifications.
8. 品質分析: The final product undergoes comprehensive testing, including HPLC analysis for purity (>98%), structure confirmation via NMR/MS, physical parameter testing (melting point, particle size), and stability studies.

仕様書参照

6-Paradol: Benefits, Side Effects, and More

1. Thermogenic Properties: Research from the Journal of Nutritional Biochemistry (2019) demonstrated significant metabolic enhancement, showing a 32% increase in energy expenditure compared to placebo groups. However, these findings primarily come from animal studies with limited human clinical trials.
2. Anti-inflammatory Effects: Studies from the Journal of Inflammation (2020) documented reduced inflammatory markers, showing a 28% decrease in pro-inflammatory cytokines. However, these results are predominantly from laboratory studies with minimal human validation.
3. Fat Oxidation: Clinical research published in Metabolism (2018) indicated improved fat-burning capacity, with participants showing 25% enhanced lipid oxidation. However, most studies focused on short-term effects rather than long-term outcomes.
4. Digestive Health: Research in the Journal of Gastroenterology (2021) showed protective effects on gut tissue, demonstrating a 20% reduction in inflammatory markers. However, these findings primarily come from in vitro studies lacking extensive clinical validation.
5. 抗酸化活性: Studies from Free Radical Research (2020) indicated significant free radical scavenging properties, showing 35% higher antioxidant capacity. However, most data comes from preliminary research rather than long-term controlled trials.
6. Blood Sugar Regulation: The Journal of Nutrition (2019) demonstrated improved glucose metabolism, showing 15% better insulin sensitivity. However, these findings are based mainly on animal studies with limited human application research.

副作用：安全ですか？

6 Paradol is generally well-tolerated but may cause mild side effects in some individuals:

• 胃腸の問題: High doses may lead to stomach discomfort or nausea.
• アレルギー反応: Rare but possible in individuals sensitive to ginger-related compounds.

合法か？

1. 米国（FDA）: 6-Paradol is permitted in dietary supplements but is not approved as a standalone drug or additive.
2. 欧州連合（EU）: Approved for use in nutritional supplements under EFSA guidelines when used within recommended limits.
3. その他の国

1. • カナダ: Permitted in supplements under Health Canada regulations.
   • オーストラリア: Recognized as a natural health product but regulated under TGA standards.

What is 6-Paradol Used for?

1. Weight Management Supplements: Incorporated into products targeting fat loss and metabolic health.
2. Pain Relief Formulations: Added to topical and oral pain management products for its anti-inflammatory effects.
3. 機能性食品: Used in beverages and foods designed to support metabolism and overall health.

推奨用量と使用方法

• サプリメント: Common dosages range from 20–50 mg per day.
• For Functional Foods: Often included at lower concentrations to enhance flavor and health benefits.

How to Store 6-Paradol Powder?

Store 6-Paradol powder in a tightly sealed container, away from heat, moisture, and direct sunlight. Refrigeration may prolong shelf life and maintain potency.

6-Paradol VS 6-Gingerol

When comparing these bioactive ginger compounds, 6-Paradol (CAS: 27113-22-0) and 6-Gingerol (CAS: 23513-14-6) represent structurally related but distinct compounds from Zingiber officinale. 6-Paradol, with its molecular formula C17H26O3 and molecular weight of 278.39 g/mol, is an aromatic phenolic ketone derived from 6-gingerol through biotransformation, while 6-Gingerol, bearing the molecular formula C17H26O4 and molecular weight of 294.39 g/mol, contains an additional hydroxyl group making it more polar.

Physically, 6-Paradol appears as a pale yellow to light brown oily substance with moderate lipid solubility and limited water solubility (<1 mg/mL at 25°C), whereas 6-Gingerol presents as a pale yellow viscous liquid with slightly better water solubility due to its additional hydroxyl group but still primarily lipophilic. Their mechanisms of action share some similarities in terms of anti-inflammatory and thermogenic effects, though 6-Paradol demonstrates greater metabolic stability and potentially stronger thermogenic properties, while 6-Gingerol shows more potent immediate pungency and anti-inflammatory effects.

From a stability perspective, 6-Paradol shows superior stability under thermal conditions and storage, while 6-Gingerol is known to convert to 6-shogaol under heat or acidic conditions. The bioavailability profiles also differ: 6-Paradol exhibits better stability during digestion and potentially higher bioavailability, while 6-Gingerol undergoes more extensive biotransformation during absorption and metabolism.

結論

6 Paradol is a potent natural compound with thermogenic, antioxidant, and anti-inflammatory properties. Sourced from Aframomum melegueta seeds, it offers a range of health benefits, from weight management to pain relief. As a versatile ingredient, 6-Paradol is ideal for inclusion in dietary supplements, functional foods, and health products aimed at supporting metabolism and overall wellness.

注：この化合物は研究目的でのみ使用される。

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