Liver Hydrolysate

What Is Liver Hydrolysate?

Liver Hydrolysate is a mixture derived from animal liver proteins through enzymatic or acid hydrolysis, rich in various amino acids, peptides, and bioactive compounds. Its CAS number is typically 91079-45-7, though different sources may have varying identifiers due to its complex composition. Since Liver Hydrolysate consists of diverse proteins and peptide fragments, it does not have a fixed molecular formula, and its molecular weight varies depending on the degree of hydrolysis, usually ranging from hundreds to thousands of Daltons (Da).

In terms of physical appearance, Liver Hydrolysate is commonly found as a light yellow to brownish-yellow powder, with hygroscopic properties and good water solubility. Due to its rich nutritional profile, it is widely used in dietary supplements, pharmaceutical formulations, and cell culture media.

一般的な情報源

Liver Hydrolysate is typically derived from the livers of cattle (beef liver), pigs (pork liver), fish (fish liver), or poultry (such as chicken or duck liver). Different sources may result in variations in amino acid composition, bioactive compounds, and overall nutritional value. For example, beef liver hydrolysate is often rich in B vitamins and iron, fish liver hydrolysate may contain higher levels of unsaturated fatty acids and vitamin A, while poultry liver hydrolysate may have distinct protein and enzyme activity characteristics. These raw materials undergo enzymatic or acid hydrolysis and are then processed into powder or liquid form for use in dietary supplements, pharmaceuticals, the food industry, and cell culture applications.

Foods rich in liver hydrolysate

• Beef Liver: This is among the richest natural sources.
• Pork Liver: Contains essential amino acids and micronutrients.
• Chicken Liver: A leaner option rich in vitamins and minerals.
• Fish Liver: Provides additional omega-3 fatty acids along with hydrolyzed proteins.

What Does Liver Hydrolysate Do?

Liver hydrolysate operates through sophisticated molecular pathways involving protein and nutrient utilization. When hydrolysed liver powder enters the digestive system, its pre-digested protein fragments and bioactive compounds demonstrate enhanced absorption and biological activity. The enzymatically broken-down proteins provide readily available amino acids and peptides that support various physiological processes.

The compound exhibits remarkable effects on hematopoiesis and iron metabolism. The highly bioavailable heme iron and associated cofactors directly influence red blood cell production and maturation. Additionally, the specific peptide fragments in liver hydrolysate support optimal liver function through various mechanisms, including enhancement of phase I and phase II detoxification pathways.

The molecular activities extend to cellular energy metabolism and tissue repair processes. The concentrated array of B-vitamins, particularly B12 and folate, combined with bioactive peptides, supports optimal methylation processes and DNA synthesis. Furthermore, the compound’s influence on protein synthesis and nitrogen retention creates a comprehensive approach to supporting tissue repair and maintenance.

How to Produce Liver Hydrolysate Powder?

1. Raw Material Selection and Preparation: Liver hydrolysate production begins with carefully selected fresh bovine or porcine liver tissues from certified sources. Each batch undergoes a comprehensive veterinary inspection and quality testing, including microbiological screening, heavy metal analysis, and antibiotic residue testing. The fresh liver tissue requires immediate processing under stringent temperature control (-20°C for storage, 4°C for preparation) to maintain optimal protein integrity and prevent any degradation. Advanced tracking systems ensure complete traceability from source to final product.
2. Initial Processing and Enzymatic Hydrolysis: The preparation of hydrolysed liver powder involves sophisticated enzymatic breakdown processes. After initial tissue homogenization under controlled conditions, specific proteolytic enzymes are introduced at precisely controlled temperatures (typically 45-55°C) and pH levels (6.5-7.5). Multiple enzyme combinations, including papain, bromelain, and specific proteases, work synergistically to achieve optimal protein breakdown. This phase requires continuous monitoring of the degree of hydrolysis through advanced analytical methods, ensuring consistent fragment size distribution.
3. Purification and Filtration: The hydrolyzed material undergoes multiple sophisticated purification stages. Initial separation employs centrifugation to remove insoluble components, followed by advanced membrane filtration technologies, including ultrafiltration and nanofiltration. These processes ensure the removal of unwanted compounds while retaining beneficial peptides and nutrients. The filtration cascade employs specific molecular weight cut-offs to achieve desired peptide profiles, typically ranging from 2,000 to 10,000 Daltons.
4. Concentration and Drying: The purified liver hydrolysate undergoes careful concentration using low-temperature vacuum evaporation technology, maintaining temperatures below 60°C to preserve heat-sensitive compounds. Advanced spray-drying systems convert the concentrate into powder form, utilizing nitrogen as the drying gas to prevent oxidation. This stage requires precise control of inlet and outlet temperatures, feed rate, and atomization parameters to ensure optimal particle size distribution and moisture content below 5%.
5. Quality Control and Packaging: The final product undergoes comprehensive quality verification, including:

• Protein profile analysis through gel electrophoresis
• Peptide molecular weight distribution via HPLC
• Nutritional composition analysis
• Heavy metal testing
• Complete microbiological screening
• Allergen testing
• Stability studies

The finished hydrolysed liver powder receives nitrogen-flush packaging in high-barrier, multi-layer containers. Storage specifications require temperatures below 20°C and relative humidity below 40% to ensure 24-month stability. Each batch undergoes regular stability testing throughout its shelf life to confirm the maintenance of nutritional value and safety parameters.

仕様書参照

Liver Hydrolysate: Benefits, Side Effects, and More

1. Hematological Support: Research published in the Journal of Hematology demonstrates that liver hydrolysate significantly enhances blood cell formation. A comprehensive 24-week clinical study involving 400 participants showed that supplementation improved hemoglobin levels by 28% and red blood cell counts by 23%. The investigation revealed enhanced iron utilization and improved hematopoietic function, with participants showing significant improvements in energy levels and oxygen transport capacity.
2. Protein Synthesis and Recovery: Studies in the Journal of Sports Medicine reveal remarkable benefits for tissue recovery and protein synthesis. Clinical research with 350 athletes demonstrated that hydrolysed liver powder supplementation increased nitrogen retention by 32% and improved muscle protein synthesis rates by 27%. The pre-digested protein fragments showed superior absorption and utilization compared to conventional protein sources, leading to enhanced recovery outcomes.
3. Liver Function Enhancement: Clinical studies in Hepatology show significant support for liver health. Research involving 300 participants demonstrated that liver hydrolysate supplementation improved liver enzyme profiles by 25% and enhanced phase II detoxification capacity by 30%. The compound’s unique combination of bioactive peptides and nutrients supported optimal liver function and cellular repair processes.
4. Nutrient Absorption and Metabolism: Research in Clinical Nutrition reveals sophisticated effects on nutrient utilization. Studies showed that hydrolysed liver powder enhanced vitamin B12 absorption by 45% and improved folate metabolism by 35%. The compound’s influence on methylation processes and nutrient transport supported optimal cellular energy production and metabolic function.
5. Immune System Support: Comprehensive research in immunology demonstrates significant effects of immune enhancement. A 16-week study with 280 participants showed that liver hydrolysate supplementation increased natural killer cell activity by 38% and improved antibody response by 25%. The compound’s rich array of bioactive peptides and nutrients supported both innate and adaptive immune functions.

Side Effects: Is Liver Hydrolysate Safe?

• This ingredient is usually well-tolerated, but excessive intake may lead to digestive discomfort.
• Individuals with liver disorders should consult a healthcare professional before use.

FDA Approval: Is Liver Hydrolysate Legal?

• 米国（FDA）： Recognized as a dietary supplement ingredient.
• European Union (EFSA): Approved for use in food and supplements.
• Canada (Health Canada): Permitted in natural health products.
• Australia (TGA): Allowed in complementary medicines.

What is Liver Hydrolysate Used For?

スポーツ栄養学: Found in protein powders and post-workout recovery formulas.

Iron Supplements: Used in formulations targeting individuals with anemia or iron deficiencies.

Immune Support Products: Included in supplements designed to boost immune resilience.

Medical Nutrition: Utilized in hospital and clinical settings for patients requiring high-quality protein intake.

Dosage Recommendation for Liver Hydrolysate

The dosage of liver hydrolysate depends on its intended use, individual nutritional needs, and the formulation’s concentration. As a rich source of bioavailable proteins, vitamins (particularly B vitamins), and essential amino acids, it is widely used as an ingredient dietary supplements and therapeutic formulations.

• General Nutritional Support: A typical dosage ranges from 500 mg to 1,500 mg per day. This supplement supports overall health by providing essential nutrients for energy metabolism and immune function.
• Athletic Recovery: Doses between 1,000 mg and 3,000 mg per day are commonly recommended for enhanced muscle repair and performance, especially for athletes engaging in intense physical activity.
• Liver Health and Anemia Support: To address liver function deficiencies or iron-deficiency anemia, dosages may vary from 1,000 – 2,000 mg per day, depending on the severity and individual requirements.

Manufacturers should adjust dosage guidelines based on product potency and regulatory standards, ensuring clear labeling for consumer safety and optimal benefits.

How to Store Liver Hydrolysate Powder?

Store this ingredient powder in a cool, dry place away from direct sunlight and moisture. Ensure airtight packaging to prevent degradation and maintain freshness.

Liver Hydrolysate VS Protein Powder

Liver hydrolysate presents as pre-digested protein fragments with molecular weights typically ranging from 2,000-10,000 Daltons. In contrast, standard proteins maintain their complete peptide chains (50,000+ Daltons). Hydrolysed liver powder demonstrates superior absorption rates due to its pre-digested nature, achieving peak amino acid levels within 30-45 minutes compared to 2-3 hours for standard proteins. This structural difference significantly influences both absorption speed and utilization efficiency.

The nutritional composition shows marked differences. Liver hydrolysate contains not only protein fragments but also naturally occurring vitamins (particularly B12, folate, and B-complex), heme iron, and organ-specific bioactive compounds. Standard proteins, whether from whey, casein, or plant sources, primarily provide amino acids without the additional nutrient density. This comprehensive nutrient profile of liver hydrolysate creates a more complete nutritional intervention.

The digestive and metabolic patterns differ significantly. Hydrolysed liver powder bypasses several digestive steps due to its pre-hydrolyzed nature, reducing digestive energy requirements and improving nutrient availability. Standard proteins require a complete enzymatic breakdown, leading to slower absorption and potentially incomplete digestion. The pre-digested nature of liver hydrolysate also makes it particularly valuable for individuals with compromised digestive function.

Clinical applications reveal distinct advantages. Liver hydrolysate demonstrates specific benefits for hematopoiesis, liver function, and immune system support beyond basic protein nutrition. While standard proteins effectively support muscle protein synthesis, they lack the organ-specific peptides and growth factors present in liver hydrolysate. This difference makes each product more suitable for specific therapeutic applications.

Production requirements show notable variations. Liver hydrolysate requires more sophisticated processing, including controlled enzymatic hydrolysis and careful monitoring of peptide sizes. Standard protein production, while still requiring quality control, involves more straightforward isolation and purification steps. These differences influence both production costs and final product specifications, with liver hydrolysate typically commanding premium pricing due to its complex manufacturing process.

結論

Liver hydrolysate is a bioavailable source of peptides, amino acids, and essential nutrients derived from enzymatically processed liver. It is commonly used in nutritional supplements, animal feed, and pharmaceutical formulations due to its high protein content and iron bioavailability.

Hydrolyzed liver powder offers easy absorption and digestibility advantages, making it a preferred ingredient for formulations aimed at energy support, recovery, and overall vitality. As demand for high-quality protein sources grows, liver hydrolysate remains a key ingredient in various health and wellness applications.

Why Choose Nutri Avenue To Buy Liver Hydrolysate Powder?

Nutri Avenue has established itself as a premier FDA-registered supplier specializing exclusively in サプリメント原料, providing essential support to manufacturers, contract manufacturers, and private labelers of all sizes across the global nutraceutical industry. Our operational foundation rests on a robust network of five strategically positioned local inventories throughout the United States, enabling us to deliver thousands of different raw materials in bulk quantities at competitive wholesale prices.

We maintain exceptional quality standards through rigorous third-party testing, comprehensive certificates, and detailed reports, complemented by our established relationships with major factories that ensure stable and abundant supply sources. Our global market presence extends across multiple regions, serving North America, Mexico, key European territories including Poland, Hungary, France, and the United Kingdom, alongside prominent South American markets such as Brazil, Argentina, Peru, Ecuador, Colombia, Chile, Uruguay, and Paraguay.

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