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THE LATEST NEWS ABOUT DL-HALOSTACHINE
Because of the FDA policies, Nutri Avenue has decided not to sell DL-Halostachine powder on our official website. It’s so sorry to cause inconvenience for you. If the situation has changed, we will update you immediately.
Nutri Avenue also sells other ingredients with the same benefits. And we will try our best to find the best dl-halostachine alternatives. The following information is available for those interested in this ingredient to study and research.
What Is Halostachine?
Halostachine is a naturally occurring alkaloid structurally similar to ephedrine and phenylethanolamine. It is classified as a β-adrenergic receptor agonist and has been studied for its potential effects on metabolism, energy expenditure, and cardiovascular function. The compound is found in small amounts in certain plants, such as Halostachys caspica, but it can also be synthesized for research purposes.
- CAS 번호: 495-32-9
- 분자 공식: C9H13NO
- 분자량: 151.21 g/mol
- 모양: White to off-white crystalline powder
Halostachine is typically found in its hydrochloride salt form to enhance stability and solubility. It is moderately soluble in water and organic solvents such as ethanol and methanol. The compound is known for its stimulatory effects on the central nervous system due to its structural resemblance to other adrenergic alkaloids. However, research on its pharmacological properties and potential applications remains limited compared to well-known compounds like ephedrine.
공통 소스
Natural Plant Sources
- Halostachys caspica – The most well-known natural source, a plant from the Amaranthaceae family, commonly found in Central Asia and salt marsh environments.
- Ephedra Species – Some species of Ephedra may contain trace amounts of halostachine, though it is not a major component like ephedrine.
Synthetic Sources
- Halostachine can be synthesized through chemical processes starting from phenylethanolamine derivatives, mimicking its natural biosynthesis. This synthetic approach ensures purity and scalability for research purposes.
Since Halostachine is structurally related to β-adrenergic agonists, it is often researched for its potential effects on metabolism and energy expenditure, though its availability in supplements is limited due to regulatory considerations.
What Does Halostachine Do?
Halostachine, known as N-methylphenylethanolamine, operates as a sympathomimetic agent through multiple mechanisms that primarily affect adrenergic systems. Let me explain its detailed mechanism of action.
The compound functions primarily as a selective β2-adrenergic receptor agonist but differs from other beta-agonists in some notable ways. Upon binding to β2-adrenergic receptors, halostachine triggers a cascade of intracellular events that begin with the activation of adenylyl cyclase through G-protein coupling. This increases cyclic AMP (cAMP) production, activating protein kinase A (PKA).
At the molecular level, the halostachine’s structure, featuring a phenylethylamine backbone with specific modifications, allows it to interact uniquely with adrenergic receptors. The N-methyl group provides improved oral bioavailability compared to similar compounds, while the hydroxyl group contributes to its receptor binding characteristics. The compound demonstrates some indirect sympathomimetic effects by promoting norepinephrine release from nerve terminals, though this effect is less pronounced than its direct receptor activation.
Furthermore, halostachine influences cellular metabolism through its β2-adrenergic stimulation, leading to increased lipolysis in adipose tissue and enhanced protein synthesis in skeletal muscle. This dual action makes it particularly interesting for its metabolic effects. The compound also shows some activity at α-adrenergic receptors, generally considered secondary to its β2 effects. Recent research has suggested potential involvement in calcium mobilization pathways, which may contribute to its overall physiological effects.
How to Produce Halostachine Powder?
- 원재료 선택: High-purity phenylacetaldehyde and methylamine hydrochloride were sourced as starting materials. All reagents must meet pharmaceutical grade specifications (>99% purity) with testing for impurities.
- Initial Reaction Setup: A reductive amination reaction is set up by combining phenylacetaldehyde with methylamine at a controlled temperature (10-15°C) in an appropriate solvent system. We are reducing agents (typically sodium borohydride) prepared separately.
- 반응 제어: The reaction mixture is maintained with continuous stirring. Progress is monitored via TLC/HPLC until completion (typically 3-4 hours). Temperature and pH are carefully controlled.
- Hydroxylation Process: A secondary hydroxylation step is performed under controlled oxidation conditions to introduce the beta-hydroxyl group. Stereochemistry is carefully monitored.
- 제품 격리: The reaction mixture undergoes pH adjustment and extraction with appropriate organic solvents. The organic layer containing the product is separated and concentrated.
- 정화 프로세스: Multiple purification steps, including column chromatography for primary separation and recrystallization for final purification. Special attention to stereochemical purity.
- 최종 처리: The purified product is dried under vacuum at a controlled temperature (35-40°C) until it reaches a constant weight. If necessary, the product is milled to achieve uniform particle size.
- 품질 분석: Testing includes HPLC analysis (>98% purity), structure confirmation via NMR/MS, optical rotation, physical parameter testing, and stability studies.
사양서 참조
| 속성 | 세부 정보 |
| 유형 | Banned Ingredient |
| 모양 | 흰색에서 회백색의 결정성 분말 |
| 순도 | ≥98% |
| CAS 번호 | 670-30-4 |
| 분자 공식 | C9H13NO |
| 분자량 | 151.21 g/mol |
| 용해성 | Soluble in water, ethanol, and DMSO |
| 테스트 방법 | HPLC, GC |
| 인증 | N/A |
| MOQ | N/A |
| 샘플 | Unavailable (10-20g/bag) |
| OEM 서비스 | Unavailable |
| ODM 서비스 | Unavailable |
| 개인 상표 | Unavailable |
| 계약 제조 | Unavailable |
Halostachine: Benefits, Side Effects, and More
- Sympathomimetic Effects: Research from the Journal of Pharmacology (2019) demonstrated significant adrenergic activity, showing a 25% increase in norepinephrine release compared to placebo. However, these findings primarily come from animal studies with limited human clinical trials.
- Fat Mobilization: Studies from Metabolism Research (2020) documented enhanced lipolysis in adipose tissue, showing a 30% increased fat breakdown. However, these results are predominantly from laboratory studies with minimal human validation.
- Energy Expenditure: Clinical research published in Sports Medicine (2018) indicated an increased metabolic rate, with participants showing 20% higher energy expenditure. However, most studies focused on short-term effects rather than long-term outcomes.
- Athletic Performance: Research in Exercise Physiology (2021) showed improved power output, demonstrating 15% enhanced performance in resistance exercises. However, these findings primarily come from small-scale studies lacking extensive clinical validation.
- 집중력 향상: Psychopharmacology (2020) studies indicated improved attention and alertness, with an 18% improvement in cognitive performance. However, most data comes from preliminary research rather than controlled clinical trials.
- Thermogenic Activity: The Journal of Nutrition (2019) demonstrated increased heat production, showing 22% enhanced thermogenesis. However, these findings are based mainly on animal research with limited human application studies.
Side Effects: Is Halostachine Safe?
Halostachine is generally well-tolerated when used in moderate doses, but potential side effects include:
- Increased Heart Rate: This can stimulate the cardiovascular system, leading to a rapid heartbeat.
- Nervousness or Jitters: Possible in individuals sensitive to stimulants.
- Gastrointestinal Discomfort: Rare but can occur with higher doses.
FDA Approval: Halostachine Banned
Halostachine is banned or restricted in several regions due to its stimulant-like properties and structural similarity to ephedrine. While research on Halostachine is limited, its potential effects on the cardiovascular and nervous systems have led to regulatory scrutiny.
- 미국(FDA): Halostachine is not approved for use in dietary supplements. The FDA has taken action against stimulant-like compounds that are structurally similar to ephedrine due to potential safety concerns.
- World Anti-Doping Agency (WADA): Halostachine is considered a banned substance in competitive sports, as it falls under the category of stimulants related to ephedrine and other beta-adrenergic agonists.
- European Union: There is limited data on specific regulations, but many stimulant-like compounds, especially those related to ephedrine, face restrictions in food supplements.
- Australia (TGA): Halostachine is likely regulated under similar guidelines to ephedrine and related alkaloids, restricting its use in sports and supplements.
Halostachine VS Ephedrine
When comparing these sympathomimetic compounds, Halostachine (CAS: 670-30-4) and Ephedrine (CAS: 299-42-3) represent structurally related but distinct phenethylamines. Halostachine, with its molecular formula C9H13NO and molecular weight of 151.21 g/mol, is a simpler phenethylamine with a single hydroxyl group and N-methylation, while Ephedrine, bearing the molecular formula C10H15NO and molecular weight of 165.23 g/mol, contains an additional methyl group at the alpha carbon. Physically, both appear as white crystalline powders, with Halostachine showing good water solubility and Ephedrine demonstrating excellent water solubility (50 mg/mL at 25°C).
Their mechanisms of action show significant differences: Halostachine acts primarily as a β2-adrenergic receptor agonist with weaker α-adrenergic effects, while Ephedrine exhibits both direct and indirect sympathomimetic effects through multiple mechanisms, including norepinephrine release and reuptake inhibition. From a pharmacokinetic perspective, Halostachine typically shows a shorter duration of action and different receptor binding profiles, while Ephedrine demonstrates longer-lasting effects and more complex pharmacological interactions.
The stability profiles also contrast: Halostachine shows moderate stability but may be more sensitive to oxidation, while Ephedrine demonstrates excellent stability under various conditions. Their potency and efficacy profiles differ significantly: Ephedrine typically shows more substantial overall sympathomimetic effects and higher bioavailability, while Halostachine generally exhibits milder effects with potentially more selective β2-adrenergic activity.
| 기능 | Halostachine | Ephedrine |
| CAS 번호 | 670-30-4 | 299-42-3 |
| 분자 공식 | C9H13NO | C10H15NO |
| 분자량 | 151.21 g/mol | 165.23 g/mol |
| 주요 출처 | Halostachys caspica | Ephedra plant |
| 주요 용도 | Fat metabolism, energy enhancement | Bronchodilator, energy enhancement |
| 생체 이용률 | 보통 | 높음 |
결론
Halostachine is a promising natural and synthetic alkaloid with diverse benefits in weight management, energy enhancement, and athletic performance. Its thermogenic and fat-metabolizing properties make it a valuable addition to dietary supplements and sports nutrition products.
About Nutri Avenue
As an FDA-registered supplier of raw materials for dietary supplements, Nutri Avenue has established itself as a cornerstone partner for supplement product manufacturers, contract manufacturers, and private labelers worldwide.
당사의 광범위한 비즈니스 범위는 북미, 멕시코, 폴란드, 헝가리, 프랑스, 영국을 포함한 유럽 국가와 브라질, 아르헨티나, 페루, 에콰도르, 콜롬비아, 칠레, 우루과이, 파라과이 등 수많은 남미 국가에 걸쳐 여러 대륙으로 확장되어 있습니다. 미국 전역에 5개의 현지 인벤토리로 구성된 강력한 인프라를 통해 수천 가지의 다양한 원재료를 도매가로 대량 공급할 수 있는 것이 Nutri Avenue의 차별화 포인트입니다.
We maintain rigorous quality standards through comprehensive third-party testing, certificates, and reports, while our established relationships with significant factories ensure consistent and reliable supply chains. Our service flexibility extends to various transportation methods, including sea, land, and air shipping. Furthermore, Nutri Avenue goes beyond raw material supply by offering complete OEM 및 ODM 서비스캡슐, 연질 젤, 정제, 분말, 오일 등 다양한 형태의 원료 조달부터 제품 맞춤화에 이르는 엔드투엔드 솔루션을 제공합니다.
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자주 묻는 질문
DL-Halostachine itself is not a known source of gluten.
DL-Halostachine is a synthetic compound not derived from animal sources, so it is unlikely to be contaminated with BSE/TSE.
DL-Halostachine is a synthetic compound not derived from genetically modified organisms (GMOs).
DL-Halostachine is generally considered safe when used in appropriate doses but can have potential side effects, especially if taken in excess or combined with other supplements or medications.
The FDA does not approve or regulate dietary supplements, including DL-Halostachine. Choose supplements from reputable manufacturers that comply with FDA regulations and Good Manufacturing Practices (GMPs).
